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11. 发明申请

US20130130323A1 PREVENTION AND ALLEVIATION OF STERIC HINDRANCE DURING SINGLE MOLECULE SYNTHESIS 有权
标题翻译：单分子合成期间的绝育情况的预防与评价
公开(公告)号：US20130130323A1
公开(公告)日：2013-05-23
申请号：US13468365
申请日：2012-05-10
申请人： Congcong Ma , Paul Wyatt
发明人： Congcong Ma , Paul Wyatt
IPC分类号： C12P19/34
CPC分类号： C12P19/34 , C12Q1/686
摘要： The present invention provides compositions and methods for reducing steric hindrance in the product of nucleic acid polymerase reaction. Methods and compositions of the invention encompass application of exonucleases, endonucleases, and uracil-DNA glycosylases to a nucleic acid polymerase reaction such that newly formed nucleic acid strands are modified (e.g., cleaved) while the polymerase reaction continues to proceed.
摘要翻译：本发明提供了降低核酸聚合酶反应产物中的空间位阻的组合物和方法。本发明的方法和组合物包括将核酸外切酶，内切核酸酶和尿嘧啶-DNA糖基酶应用于核酸聚合酶反应，使得新聚合酶反应继续进行而修饰（例如，切割）。

12. 发明申请

US20120252015A1 METHODS AND COMPOSITIONS FOR DETECTING GENETIC MATERIAL 审中-公开
标题翻译：用于检测遗传材料的方法和组合物
公开(公告)号：US20120252015A1
公开(公告)日：2012-10-04
申请号：US13400030
申请日：2012-02-17
申请人： Benjamin Hindson , Serge Saxonov , Philip Belgrader , Kevin Ness , Michael Lucero , Billy Colston , Shawn Paul Hodges , Nicholas J. Heredia , Jeffrey Clark Mellen , Camille Bodley Troup , Paul Wyatt
发明人： Benjamin Hindson , Serge Saxonov , Philip Belgrader , Kevin Ness , Michael Lucero , Billy Colston , Shawn Paul Hodges , Nicholas J. Heredia , Jeffrey Clark Mellen , Camille Bodley Troup , Paul Wyatt
IPC分类号： C12Q1/68 , G01N21/64
CPC分类号： C12Q1/6883 , C12Q2521/331 , C12Q2523/125 , C12Q2600/154
摘要： The present disclosure provides methods and compositions for detecting polynucleotides in a sample and for quantifying polynucleotide load in a sample. The polynucleotides can be associated with a disease, disorder, or condition. In some applications, methylated DNA is quantified, e.g., in order to determine the load of polynucleotides in a sample. The present disclosure also provides methods and compositions for determining the load of fetal polynucleotides in a biological sample, e.g., the load of fetal polynucleotides (e.g., DNA, RNA) in maternal plasma. The present disclosure provides methods and compositions for detecting cellular processes such as cellular viability, growth rates, and infection rates. This disclosure also provides compositions and methods for detecting differences in copy number of a target polynucleotide. In some embodiments, the methods and compositions provided herein are useful for diagnosis of fetal genetic abnormalities, when the starting sample is maternal tissue (e.g., blood, plasma).
摘要翻译：本公开提供了用于检测样品中的多核苷酸并用于定量样品中的多核苷酸负载的方法和组合物。多核苷酸可以与疾病，病症或病症相关。在一些应用中，例如为了确定样品中多核苷酸的负载量化甲基化DNA。本公开还提供了用于确定生物样品中胎儿多核苷酸负荷的方法和组合物，例如母体血浆中胎儿多核苷酸（例如DNA，RNA）的负载。本公开提供了用于检测细胞过程如细胞活力，生长速率和感染率的方法和组合物。本公开还提供了用于检测靶多核苷酸的拷贝数差异的组合物和方法。在一些实施方案中，当起始样品是母体组织（例如血液，血浆）时，本文提供的方法和组合物可用于诊断胎儿遗传异常。

13. 发明授权

US08198023B2 Prevention and alleviation of steric hindrance during single molecule nucleic acid synthesis by a polymerase 有权
标题翻译：通过聚合酶预防和减轻单分子核酸合成过程中的空间位阻
公开(公告)号：US08198023B2
公开(公告)日：2012-06-12
申请号：US12535385
申请日：2009-08-04
申请人： Congcong Ma , Paul Wyatt
发明人： Congcong Ma , Paul Wyatt
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12P19/34 , C12Q1/686
摘要： The present invention provides compositions and methods for reducing steric hindrance in the product of nucleic acid polymerase reaction. Methods and compositions of the invention encompass application of exonucleases, endonucleases, and uracil-DNA glycosylases to a nucleic acid polymerase reaction such that newly formed nucleic acid strands are modified (e.g., cleaved) while the polymerase reaction continues to proceed.
摘要翻译：本发明提供了降低核酸聚合酶反应产物中的空间位阻的组合物和方法。本发明的方法和组合物包括将核酸外切酶，内切核酸酶和尿嘧啶-DNA糖基酶应用于核酸聚合酶反应，使得新聚合酶反应继续进行而修饰（例如，切割）。

14. 发明申请

US20110312921A1 N-Myristoyl Transferase Inhibitors 有权
标题翻译： N-肉豆蔻酰转移酶抑制剂
公开(公告)号：US20110312921A1
公开(公告)日：2011-12-22
申请号：US13061811
申请日：2009-08-29
申请人： Stephen Brand , Paul Wyatt , Stephen Thompson , Victoria Smith , Tracy Bayliss , Justin Harrison , Neil Norcross , Laura Cleghorn , Ian Gilbert , Ruth Brenk
发明人： Stephen Brand , Paul Wyatt , Stephen Thompson , Victoria Smith , Tracy Bayliss , Justin Harrison , Neil Norcross , Laura Cleghorn , Ian Gilbert , Ruth Brenk
IPC分类号： A61K31/635 , A61K31/415 , A61K31/4709 , A61K31/5377 , A61K31/437 , A61K31/427 , A61K31/538 , A61P35/00 , A61P31/00 , A61P3/10 , A61P25/00 , A61P33/00 , A61P31/10 , A61P31/12 , A61K31/4155
CPC分类号： C07D231/42 , A61K31/415 , C07D213/75 , C07D239/69 , C07D263/50 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to N-heterocyclic sulphonamide compounds, in particular pyrazole sulphonamide compounds, and their use as N-myristoyl transferase inhibitors.
摘要翻译：本发明涉及N-杂环磺酰胺化合物，特别是吡唑磺酰胺化合物及其作为N-肉豆蔻酰转移酶抑制剂的用途。

15. 发明授权

US07903880B2 Image processing apparatus and method for detecting a feature point in an image 有权
标题翻译：用于检测图像中的特征点的图像处理装置和方法
公开(公告)号：US07903880B2
公开(公告)日：2011-03-08
申请号：US11652501
申请日：2007-01-12
申请人： Paul Wyatt , Hiroaki Nakai
发明人： Paul Wyatt , Hiroaki Nakai
IPC分类号： G06K9/48
CPC分类号： G06K9/48 , G06K9/4609 , G06T7/13
摘要： An apparatus includes: a spatial differential value calculation unit that calculates a primary spatial differential value and a secondary spatial differential value of a brightness value with respect to each of a plurality of directions in each pixel of the image; a maximum and minimum direction estimation unit that estimates a maximum direction and a minimum direction for each pixel, the maximum direction being a direction with which the primary spatial differential value is a maximum value, the minimum direction being a direction with which the primary spatial differential value is a minimum value; and an evaluated value calculation unit that calculates a first evaluated value of each pixel using the primary spatial differential value in the maximum direction, the primary spatial differential value in the minimum direction, and the secondary spatial differential value in the maximum direction.
摘要翻译：一种装置，包括：空间微分值计算单元，其针对图像的每个像素中的多个方向中的每个方向计算亮度值的一次空间微分值和二次空间微分值; 估计每个像素的最大方向和最小方向的最大和最小方向估计单元，最大方向是主要空间微分值是最大值的方向，最小方向是主要空间差异的方向值是最小值; 以及评估值计算单元，其使用最大方向上的一次空间差分值，最小方向上的一次空间微分值和最大方向上的二次空间微分值来计算每个像素的第一评估值。

16. 发明申请

US20060281183A1 Analysis engine and database for manipulating parameters for fluidic systems on a chip 有权
标题翻译：用于处理芯片上流体系统参数的分析引擎和数据库
公开(公告)号：US20060281183A1
公开(公告)日：2006-12-14
申请号：US11408612
申请日：2006-04-20
申请人： Gang Sun , Greg Harris , Andy May , Kyle Self , Kevin Farrell , Paul Wyatt
发明人： Gang Sun , Greg Harris , Andy May , Kyle Self , Kevin Farrell , Paul Wyatt
IPC分类号： G01N35/00
CPC分类号： G01N35/00029 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2300/06 , B01L2300/0654 , B01L2300/0829 , C12Q1/686 , G01N15/1475 , G01N21/6428 , G01N35/00732 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N35/1065 , G01N2035/00148 , G01N2035/00237 , G01N2035/00752 , G01N2035/0091 , G01N2035/1034 , G01N2201/025 , G01N2201/0446 , Y10S901/01 , Y10T436/11
摘要： Systems for managing workflows to perform chemical or biological reactions using microfluidic devices.
摘要翻译：用于管理使用微流体装置进行化学或生物反应的工作流的系统。

17. 发明申请

US20060194843A1 3,4-Disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinase and glycogen synthase kinase-3 modulators 有权
公开(公告)号：US20060194843A1
公开(公告)日：2006-08-31
申请号：US11336599
申请日：2006-01-20
申请人： Valerio Berdini , Michael O'Brien , Maria Carr , Theresa Early , Adrian Gill , Gary Trewartha , Alison Woolford , Andrew Woodhead , Paul Wyatt
发明人： Valerio Berdini , Michael O'Brien , Maria Carr , Theresa Early , Adrian Gill , Gary Trewartha , Alison Woolford , Andrew Woodhead , Paul Wyatt
IPC分类号： A61K31/454 , A61K31/416 , A61K31/4152 , C07D403/02
CPC分类号： C07D231/38 , A61K31/415 , A61K31/4152 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/4196 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , C04B35/632 , C07D231/14 , C07D231/40 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04
摘要： The invention provides compounds of the formula (0) or salts or tautomers or N-oxides or solvates thereof for use in the prophylaxis or treatment of disease states and conditions such as cancers mediated by cyclin-dependent kinase and glycogen synthase kinase-3. In formula (0): X is a group R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C═O, NRg(C═O) or O(C═O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g. fluorine), hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy (e.g. methoxy); or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy); R3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy).

18. 发明申请

US20160060224A1 N-MYRISTOYL TRANSFERASE INHIBITORS 有权
标题翻译： N-肉豆蔻酰转移酶抑制剂
公开(公告)号：US20160060224A1
公开(公告)日：2016-03-03
申请号：US14840660
申请日：2015-08-31
申请人： Stephen Brand , Paul Wyatt , Stephen Thompson , Victoria Smith , Tracy Bayliss , Justin Harrison , Neil Norcross , Laura Cleghorn , Ian Gilbert , Ruth Brenk
发明人： Stephen Brand , Paul Wyatt , Stephen Thompson , Victoria Smith , Tracy Bayliss , Justin Harrison , Neil Norcross , Laura Cleghorn , Ian Gilbert , Ruth Brenk
IPC分类号： C07D231/42 , C07D401/12 , C07D403/12 , C07D401/14
CPC分类号： C07D231/42 , A61K31/415 , C07D213/75 , C07D239/69 , C07D263/50 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to N-heterocyclic sulphonamide compounds, in particular pyrazole sulphonamide compounds, and their use as N-myristoyl transferase inhibitors.
摘要翻译：本发明涉及N-杂环磺酰胺化合物，特别是吡唑磺酰胺化合物及其作为N-肉豆蔻酰转移酶抑制剂的用途。

19. 发明授权

US07883669B2 Analysis engine and database for manipulating parameters for fluidic systems on a chip 有权
标题翻译：用于处理芯片上流体系统参数的分析引擎和数据库
公开(公告)号：US07883669B2
公开(公告)日：2011-02-08
申请号：US11408612
申请日：2006-04-20
申请人： Gang Sun , Greg Harris , Andy May , Kyle Self , Kevin Farrell , Paul Wyatt
发明人： Gang Sun , Greg Harris , Andy May , Kyle Self , Kevin Farrell , Paul Wyatt
IPC分类号： B01L3/02
CPC分类号： G01N35/00029 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2300/06 , B01L2300/0654 , B01L2300/0829 , C12Q1/686 , G01N15/1475 , G01N21/6428 , G01N35/00732 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N35/1065 , G01N2035/00148 , G01N2035/00237 , G01N2035/00752 , G01N2035/0091 , G01N2035/1034 , G01N2201/025 , G01N2201/0446 , Y10S901/01 , Y10T436/11
摘要： Systems for managing workflows to perform chemical or biological reactions using microfluidic devices.
摘要翻译：用于管理使用微流体装置进行化学或生物反应的工作流的系统。

20. 发明申请

US20100035269A1 PREVENTION AND ALLEVIATION OF STERIC HINDRANCE DURING SINGLE MOLECULE SYNTHESIS 有权
标题翻译：单分子合成期间的绝育情况的预防与评价
公开(公告)号：US20100035269A1
公开(公告)日：2010-02-11
申请号：US12535385
申请日：2009-08-04
申请人： Congcong Ma , Paul Wyatt
发明人： Congcong Ma , Paul Wyatt
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12P19/34 , C12Q1/686
摘要： The present invention provides compositions and methods for reducing steric hindrance in the product of nucleic acid polymerase reaction. Methods and compositions of the invention encompass application of exonucleases, endonucleases, and uracil-DNA glycosylases to a nucleic acid polymerase reaction such that newly formed nucleic acid strands are modified (e.g., cleaved) while the polymerase reaction continues to proceed.
摘要翻译：本发明提供了降低核酸聚合酶反应产物中的空间位阻的组合物和方法。本发明的方法和组合物包括将核酸外切酶，内切核酸酶和尿嘧啶-DNA糖基酶应用于核酸聚合酶反应，使得新聚合酶反应继续进行而修饰（例如，切割）。

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