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11. 发明授权

US07831300B2 Extrapolating ICA knowledge from one epoch to another for improved fetal ECG separation 有权
标题翻译：将ICA知识从一个时代推广到另一个时代，以改善胎儿心电图分离
公开(公告)号：US07831300B2
公开(公告)日：2010-11-09
申请号：US12034129
申请日：2008-02-20
申请人： Sai Kolluri , Bruce A. Friedman , Lawrence T. Hersh , Rush Winslow Hood, Jr.
发明人： Sai Kolluri , Bruce A. Friedman , Lawrence T. Hersh , Rush Winslow Hood, Jr.
IPC分类号： A61B5/0245
CPC分类号： A61B5/0444 , A61B5/4362
摘要： A method of utilizing a maternal-fetal monitoring system to monitor the physiological properties of both a maternal patient and a fetus. A series of ECG electrodes are placed across the maternal patient's abdomen and receives ECG input waveforms across sixteen separate channels. The sixteen channels of information are processed using an ICA algorithm to generate a series of ICA output waveforms and a transfer matrix. Following the current epoch, the transfer matrix is applied to the input waveforms on a continuous basis. The conditioned input waveforms are displayed immediately following the first epoch and prior to the expiration of a subsequent epoch. The transfer matrix for the second epoch is combined with the transfer matrix for the first epoch to generate an updated transfer matrix. Various filtering operations on the transfer matrix coefficients may be used to find the updated transfer matrix before the end of the current epoch.
摘要翻译：一种利用母胎监测系统来监测母亲患者和胎儿的生理特性的方法。一系列ECG电极放置在母亲患者的腹部，并接收跨16个独立通道的ECG输入波形。使用ICA算法处理16个信道的信道，以生成一系列ICA输出波形和传送矩阵。在当前时代之后，传输矩阵连续地应用于输入波形。条件输入波形显示在第一纪元之后，并在随后的时期到期之前。将第二纪元的传递矩阵与第一纪元的传输矩阵组合以生成更新的传送矩阵。可以使用传递矩阵系数上的各种滤波操作来在当前时期结束之前找到更新的传输矩阵。

12. 发明申请

US20090221924A1 METHOD AND SYSTEM FOR NON-INVASIVE BLOOD PRESSURE DETERMINATION 审中-公开
标题翻译：非侵入性血压测定方法与系统
公开(公告)号：US20090221924A1
公开(公告)日：2009-09-03
申请号：US12040379
申请日：2008-02-29
申请人： Bruce Arnold Friedman , Richard Medero , Lawrence T. Hersh , Sai Kolluri
发明人： Bruce Arnold Friedman , Richard Medero , Lawrence T. Hersh , Sai Kolluri
IPC分类号： A61B5/022
CPC分类号： A61B5/022 , A61B5/02141 , A61B5/02225
摘要： A method for non-invasively estimating blood pressure is disclosed herein. The method includes inflating a cuff and collecting first oscillation amplitude data at a first plurality of cuff pressure levels while inflating the cuff. The method also includes deflating the cuff and collecting second oscillation amplitude data at a second plurality of cuff pressure levels while deflating the cuff. The method also includes fitting a curve to the first oscillation amplitude data and to the second oscillation amplitude data and estimating a blood pressure parameter based on the curve. A non-invasive blood pressure system is also disclosed.
摘要翻译：本文公开了非侵入性估计血压的方法。该方法包括使袖带膨胀，并在袖带膨胀的同时以第一多个袖带压力水平收集第一振荡幅度数据。该方法还包括在袖带放气的同时使第二多个袖带压力水平下压缩并收集第二振荡幅度数据。该方法还包括将曲线拟合到第一振荡幅度数据和第二振荡幅度数据，并且基于曲线估计血压参数。还公开了一种非侵入性血压系统。

13. 发明授权

US07288070B2 Method and apparatus for determining extreme blood pressure values 失效
标题翻译：用于确定极端血压值的方法和装置
公开(公告)号：US07288070B2
公开(公告)日：2007-10-30
申请号：US10847934
申请日：2004-05-18
申请人： Sai Kolluri , Lawrence T. Hersh , Bruce Friedman , Richard Medero
发明人： Sai Kolluri , Lawrence T. Hersh , Bruce Friedman , Richard Medero
IPC分类号： A61B5/02 , A61B5/04
CPC分类号： A61B5/02225 , A61B5/0225 , A61B5/0456
摘要： In a method and apparatus for measuring extreme blood pressure values during a single non-invasive blood measurement, the time intervals between sequential heartbeats are measured for a series of heartbeats in an oscillometric blood pressure measurement time period. Oscillometric blood pressure measurement data for the heartbeats of the series is obtained and associated with the heartbeat time intervals. An average time interval between heartbeats is also determined. A first data bin may be defined for blood pressure data associated with time intervals that are longer as compared to the average time interval. A second data bin is defined for blood pressure data with time intervals that are shorter as compared to the average time interval. The measured oscillometric blood pressure data is sorted into the data bins in accordance with the associated time intervals. The data in the first data bin is used to derive a high systolic blood pressure value and a low diastolic blood pressure value. The data in the second bin is used to derive a low systolic blood pressure value and a high diastolic blood pressure value. A typical blood pressure value may also be determined.
摘要翻译：在用于在单次非侵入性血液测量期间测量极端血压值的方法和装置中，测量在示波血压测量时间段内的一系列心跳的连续心跳之间的时间间隔。获得该系列心跳的示波血压测量数据，并与心跳时间间隔相关联。心跳之间的平均时间间隔也被确定。可以为与与平均时间间隔相比较长的时间间隔相关联的血压数据定义第一数据箱。第二个数据仓被定义为与平均时间间隔相比时间间隔更短的血压数据。测量的示波血压数据根据相关联的时间间隔被分类到数据箱中。第一数据箱中的数据用于导出高收缩压值和低舒张压值。第二个仓中的数据用于导出低收缩压值和高舒张压值。也可以确定典型的血压值。

14. 发明授权

US08282567B2 Method and system for determination of pulse rate 有权
标题翻译：脉率测定方法及系统
公开(公告)号：US08282567B2
公开(公告)日：2012-10-09
申请号：US11406201
申请日：2006-04-18
申请人： Sai Kolluri , Lawrence T. Hersh , Richard Medero
发明人： Sai Kolluri , Lawrence T. Hersh , Richard Medero
IPC分类号： A61B5/02
CPC分类号： A61B5/02225 , A61B5/02 , A61B5/022
摘要： A method and system for determining pulse rate of a patient are disclosed. The method and system include acquiring measured information for at least one pulse at a pressure step, determining and storing quality values for the at least one pulse at the pressure step, analyzing pulse matching criteria for the pressure step, and determining pulse rate based on the measured information, quality values, and pulse matching criteria.
摘要翻译：公开了一种用于确定患者脉搏率的方法和系统。该方法和系统包括在压力步骤获取至少一个脉冲的测量信息，确定并存储压力步骤中的至少一个脉冲的质量值，分析压力步骤的脉冲匹配准则，以及基于测量信息，质量值和脉冲匹配标准。

15. 发明授权

US07462152B2 Method and system utilizing SpO2 plethysmograph signal to reduce NIBP determination time 有权
标题翻译：方法和系统利用SpO2体积描记信号降低NIBP测定时间
公开(公告)号：US07462152B2
公开(公告)日：2008-12-09
申请号：US11470698
申请日：2006-09-07
申请人： Sai Kolluri , Lawrence T. Hersh , Richard Medero , Heather Menshouse
发明人： Sai Kolluri , Lawrence T. Hersh , Richard Medero , Heather Menshouse
IPC分类号： A61B5/02
CPC分类号： A61B5/02255 , A61B5/02225
摘要： A method and system for operating a non-invasive blood pressure monitor that utilizes an SpO2 plethysmographic signal to reduce the time required to obtain an estimation of a patient's blood pressure. During operation of the NIBP monitor, the NIBP monitor utilizes the SpO2 plethysmographic signal to determine a timing period and a deflation period for each pulse associated with the patient's heartbeat. Upon receiving an oscillation pulse, the NIBP monitor determines the oscillation amplitude during the timing period and deflates the blood pressure cuff during the deflation period immediately following the timing period. Preferably, the deflation period occurs during the same oscillation pulse used to calculate the oscillation pulse amplitude to decrease the amount of time required to obtain a blood pressure estimate from the patient.
摘要翻译：一种用于操作无创血压监测器的方法和系统，其利用SpO2体积描记信号来减少获得患者血压估计所需的时间。在NIBP监测器的操作期间，NIBP监测器利用SpO2体积描记器信号确定与患者心跳相关联的每个脉冲的定时周期和放气周期。在接收到振荡脉冲时，NIBP监视器确定定时期间的振荡幅度，并且在定时周期之后的放气期间缩小血压袖带。优选地，放气周期发生在用于计算振荡脉冲幅度的相同振荡脉冲期间，以减少从患者获得血压估计所需的时间量。

16. 发明申请

US20080243009A1 METHOD OF CONTROLLING INFLATION OF A CUFF IN BLOOD PRESSURE DETERMINATION 审中-公开
标题翻译：控制血压在血压测定中的运动方法
公开(公告)号：US20080243009A1
公开(公告)日：2008-10-02
申请号：US11694178
申请日：2007-03-30
申请人： Lawrence T. Hersh , Sai Kolluri , Bruce Friedman , Richard Medero
发明人： Lawrence T. Hersh , Sai Kolluri , Bruce Friedman , Richard Medero
IPC分类号： A61B5/02
CPC分类号： A61B5/02255 , A61B5/02225
摘要： The present application discloses a method of calculating an initial inflation pressure during a blood pressure determination using an NIB system. The cuff provided with the system is inflated towards a default initial inflation pressure and a plurality of oscillometric pulses are obtained during inflation. A quick systolic pressure is estimated from a pre-defined function having a physiologically- expected shape of an oscillometric envelope fitted to oscillometric data obtained during the inflation. In an embodiment, the parameters within the function are specifically found by fitting a plurality of oscillometric pulse amplitudes along with their corresponding cuff pressures obtained during inflation to the pre-defined function. The cuff is inflated up to a calculated initial inflation pressure, which is found from the estimated quick systolic pressure. After the cuff is brought to the initial inflation pressure, deflation is begun for determining the actual systolic and diastolic pressures for output to a user.
摘要翻译：本申请公开了一种使用NIB系统计算在血压测定期间的初始充气压力的方法。提供有系统的袖带朝向默认的初始充气压力充气，并且在充气期间获得多个示波脉冲。从预先定义的功能估计出快速的收缩压，该功能具有适应于在充气期间获得的示波数据的示波包络的生理预期形状。在一个实施例中，功能中的参数通过将多个示波脉冲幅度及其在充气期间获得的相应袖带压力拟合到预定义功能而具体发现。袖带充气到计算的初始充气压力，这是从估计的快速收缩压中发现的。在袖带被带到初始通货膨胀压力之后，开始通货紧缩来确定输出给用户的实际收缩压和舒张压。

17. 发明申请

US20080082006A1 METHOD AND SYSTEM UTILIZING SpO2 PLETHYSMOGRAPH SIGNAL TO REDUCE NIBP DETERMINATION TIME 有权
标题翻译：方法和系统利用SpO2 PLETHYSMOGRAPH信号降低NIBP测定时间
公开(公告)号：US20080082006A1
公开(公告)日：2008-04-03
申请号：US11470698
申请日：2006-09-07
申请人： Sai Kolluri , Lawrence T. Hersh , Richard Medero , Heather Menshouse
发明人： Sai Kolluri , Lawrence T. Hersh , Richard Medero , Heather Menshouse
IPC分类号： A61B5/02
CPC分类号： A61B5/02255 , A61B5/02225
摘要： A method and system for operating a non-invasive blood pressure monitor that utilizes an SpO2 plethysmographic signal to reduce the time required to obtain an estimation of a patient's blood pressure. During operation of the NIBP monitor, the NIBP monitor utilizes the SpO2 plethysmographic signal to determine a timing period and a deflation period for each pulse associated with the patient's heartbeat. Upon receiving an oscillation pulse, the NIBP monitor determines the oscillation amplitude during the timing period and deflates the blood pressure cuff during the deflation period immediately following the timing period. Preferably, the deflation period occurs during the same oscillation pulse used to calculate the oscillation pulse amplitude to decrease the amount of time required to obtain a blood pressure estimate from the patient.
摘要翻译：一种用于操作使用SpO 2体积描记信号的非侵入性血压监测器的方法和系统，以减少获得对患者血压的估计所需的时间。在NIBP监视器的操作期间，NIBP监视器利用SpO 2体积描记信号来确定与患者心跳相关联的每个脉冲的定时周期和放气周期。在接收到振荡脉冲时，NIBP监视器确定定时期间的振荡幅度，并且在定时周期之后的放气期间缩小血压袖带。优选地，放气周期发生在用于计算振荡脉冲幅度的相同振荡脉冲期间，以减少从患者获得血压估计所需的时间量。

18. 发明授权

US07198604B2 Method and system for determination of pulse rate 失效
标题翻译：脉率测定方法及系统
公开(公告)号：US07198604B2
公开(公告)日：2007-04-03
申请号：US10390822
申请日：2003-03-18
申请人： Sai Kolluri , Lawrence T. Hersh , Richard Medero
发明人： Sai Kolluri , Lawrence T. Hersh , Richard Medero
IPC分类号： A61B5/00
CPC分类号： A61B5/02225 , A61B5/02 , A61B5/022
摘要： A method and system for determining pulse rate of a patient are disclosed. The method and system include acquiring measured information for at least one pulse at a pressure step, determining and storing quality values for the at least one pulse at the pressure step, analyzing pulse matching criteria for the pressure step, and determining pulse rate based on the measured information, quality values, and pulse matching criteria.
摘要翻译：公开了一种用于确定患者脉搏率的方法和系统。该方法和系统包括在压力步骤获取至少一个脉冲的测量信息，确定并存储压力步骤中的至少一个脉冲的质量值，分析压力步骤的脉冲匹配准则，以及基于测量信息，质量值和脉冲匹配标准。

19. 发明授权

US07300404B1 Method and system utilizing SpO2 plethysmograph signal to qualify NIBP pulses 失效
标题翻译：使用SpO2体积描记器信号来限定NIBP脉冲的方法和系统
公开(公告)号：US07300404B1
公开(公告)日：2007-11-27
申请号：US11470701
申请日：2006-09-07
申请人： Sai Kolluri , Lawrence T. Hersh , Richard Medero
发明人： Sai Kolluri , Lawrence T. Hersh , Richard Medero
IPC分类号： A61B5/00
CPC分类号： A61B5/02255 , A61B5/02225
摘要： A method and system for operating a non-invasive blood pressure monitor that utilizes an SpO2 plethysmographic signal to reduce the time required to obtain an estimation of a patient's blood pressure. During operation of the NIBP monitor, the NIBP monitor utilizes the SpO2 plethysmographic signal to determine a timing period and a deflation period for each pulse associated with the patient's heartbeat. Upon receiving an oscillation pulse, the NIBP monitor determines the oscillation amplitude during the timing period and deflates the blood pressure cuff during the deflation period immediately following the timing period. Preferably, the deflation period occurs during the same oscillation pulse used to calculate the oscillation pulse amplitude to decrease the amount of time required to obtain a blood pressure estimate from the patient.
摘要翻译：一种用于操作使用SpO 2体积描记信号的非侵入性血压监测器的方法和系统，以减少获得对患者血压的估计所需的时间。在NIBP监视器的操作期间，NIBP监视器利用SpO 2体积描记信号来确定与患者心跳相关联的每个脉冲的定时周期和放气周期。在接收到振荡脉冲时，NIBP监视器确定定时期间的振荡幅度，并且在定时周期之后的放气期间缩小血压袖带。优选地，放气周期发生在用于计算振荡脉冲幅度的相同振荡脉冲期间，以减少从患者获得血压估计所需的时间量。

20. 发明授权

US06893403B2 Oscillometric determination of blood pressure 失效
标题翻译：示波测定血压
公开(公告)号：US06893403B2
公开(公告)日：2005-05-17
申请号：US10374240
申请日：2003-02-25
申请人： Sai Kolluri , Lawrence T. Hersh , Richard Medero
发明人： Sai Kolluri , Lawrence T. Hersh , Richard Medero
IPC分类号： A61B5/022 , A61B5/00
CPC分类号： A61B5/02225
摘要： A method and system for eliminating artifacts in an oscillation envelope are disclosed. The method and system comprise evaluating conformance of the oscillometric envelope blood pressure data with a predetermined expected pattern and excluding one or more data points of the oscillometric envelope blood pressure data based on non-conformance with the expected pattern. The expected pattern is based upon generally known physiological principles relating to oscillometric envelopes, a curve fit representing an oscillometric envelope from a previous determination, or other types of criteria.
摘要翻译：公开了一种用于消除振荡包络中的假象的方法和系统。所述方法和系统包括评估所述示波包络血压数据与预定预期模式的一致性，并且基于与所述期望模式的不一致性排除所述示波包络血压数据的一个或多个数据点。预期模式基于与示波包络相关的通常已知的生理原理，表示来自先前确定的示波包络的曲线拟合或其他类型的标准。

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