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11. 发明申请

US20070260217A1 SYSTEM AND METHOD FOR DELIVERING A STENT TO A BIFURCATED VESSEL 有权
标题翻译：用于将固体输送到分散的容器的系统和方法
公开(公告)号：US20070260217A1
公开(公告)日：2007-11-08
申请号：US11683995
申请日：2007-03-08
申请人： Randolf Von Oepen , Thomas Rieth , Lorcan Coffey , Richard Newhauser , Travis Yribarren
发明人： Randolf Von Oepen , Thomas Rieth , Lorcan Coffey , Richard Newhauser , Travis Yribarren
IPC分类号： A61M25/10
CPC分类号： A61F2/954 , A61F2/91 , A61F2/958 , A61F2002/821 , A61F2250/0098 , A61M25/1002
摘要： A stent delivery catheter system for accurately positioning a stent in a bifurcated vessel is disclosed. The system includes a catheter having a terminal portion and distal tip that is placed in a main branch of the vessel proximate the bifurcation. A fixed guidewire is attached to distal tip. A port is defined in the terminal portion of the catheter. The port is aligned with an ostium of a side branch of the bifurcated vessel to allow the passage of a stent delivery device, such as a balloon catheter having a stent crimped thereon, into the side branch. Radiopaque bands are positioned on opposite ends of the port. A positioning balloon is included on a surface of the catheter opposite the port and is selectively inflatable to position the radiopaque bands adjacent the side branch ostium. The radiopaque bands are referenced to place the stent proximate the side branch ostium.
摘要翻译：公开了一种用于将支架精确定位在分叉血管中的支架输送导管系统。该系统包括具有末端部分和远侧末端的导管，其被放置在靠近分叉处的血管的主分支中。固定的导丝连接到远端。端口被限定在导管的末端部分。端口与分叉血管的侧分支的口对准，以允许支架输送装置（例如具有卷曲在其上的支架的球囊导管）通入侧支。无线电波段位于端口的相对端。定位球囊包括在导管的与端口相对的表面上，并且选择性地可充气以将不透射线的带定位在侧分支口附近。参考不透射线带将支架置于侧分支口附近。

12. 发明授权

US09060892B2 Stent with independent stent rings and transitional attachments 有权
标题翻译：支架具有独立的支架环和过渡附件
公开(公告)号：US09060892B2
公开(公告)日：2015-06-23
申请号：US13063911
申请日：2009-09-11
申请人： Randolf Von Oepen , Lorcan James Coffey , Richard R. Newhauser , Thomas Rieth , Travis R. Yribarren
发明人： Randolf Von Oepen , Lorcan James Coffey , Richard R. Newhauser , Thomas Rieth , Travis R. Yribarren
IPC分类号： A61F2/06 , A61F2/915 , A61F2/91 , A61F2/89 , A61F2/95 , A61F2/958 , A61F2/82
CPC分类号： A61F2/915 , A61F2/89 , A61F2/91 , A61F2/95 , A61F2/958 , A61F2002/30019 , A61F2002/30484 , A61F2002/826 , A61F2002/828 , A61F2002/91583 , A61F2002/91591 , A61F2210/0004 , A61F2210/0014 , A61F2210/0076 , A61F2250/0071
摘要： A vascular endoprosthesis (100, 200, 300, 400, 500, 600) includes a radially-expandable first segment and a radially expandable second segment. The vascular endoprosthesis further includes first and second coupling elements. The first coupling element extends from the proximal end of the first segment toward the distal end of the second segment, and the second coupling element extends from the distal end of the second segment toward the proximal end of the first segment. The first and second coupling elements cooperate one with another to couple the first and second segments together when the vascular endoprosthesis is in a delivery configuration and to decouple the first and second segments when the vascular endoprosthesis is in a deployed configuration.
摘要翻译：血管内假体（100,200,300,400,500,600）包括径向可扩张的第一段和可径向扩张的第二段。血管内假体进一步包括第一和第二联接元件。第一联接元件从第一段的近端延伸到第二段的远端，并且第二联接元件从第二段的远端朝向第一段的近端延伸。当血管内用假体处于输送构型中时，第一和第二联接元件彼此配合以将第一和第二段联接在一起，并且当血管内用假体处于展开构型时将第一和第二段分离。

13. 发明授权

US08292913B2 Method of reducing rigidity of angioplasty balloon sections 有权
标题翻译：降低血管成形术气囊截面刚度的方法
公开(公告)号：US08292913B2
公开(公告)日：2012-10-23
申请号：US13152081
申请日：2011-06-02
申请人： Boris Warnack , Judith Hartwig , Silke Pschibl , Travis Richard Yribarren , Randolf Von Oepen , Thomas Rieth , Lorcan Coffey , Arik Zucker
发明人： Boris Warnack , Judith Hartwig , Silke Pschibl , Travis Richard Yribarren , Randolf Von Oepen , Thomas Rieth , Lorcan Coffey , Arik Zucker
IPC分类号： A61M29/00
CPC分类号： A61M25/104 , A61M25/1034 , A61M25/1038 , A61M2025/1004 , A61M2025/1031 , A61M2025/1086 , A61M2025/1093 , B23K2103/42 , B23K2103/50 , B29C59/165 , B29C2791/009 , B29L2031/7542 , Y10T156/1062
摘要： A dilatation balloon is fabricated according to a process that forms cavities and indentations in the balloon and/or catheter sections. A length of tubing is axially elongated and radially expanded in a form to provide the requisite biaxial orientation and strength. Then, an excimer laser or another type of laser or mechanical material removal tool is used to remove the polymeric material, virtually without thermal effects. Cavities in the sleeve sections of the balloon are defined and if desired, indentations in the cone sections are defined. Material removal, particularly near the balloon sleeves enables a thinner, more flexible bonding area between the catheter shaft and the balloon. Further, the indentations along the cone sections enables tighter wrapping of the balloon for a reduced delivery profile. Rigidity near the sleeves is reduced for better maneuverability of the catheter in tortuous passageways.
摘要翻译：根据在球囊和/或导管部分中形成空腔和凹陷的方法制造扩张球囊。一段长度的管材是轴向伸长的并以一种形式径向扩张以提供必要的双轴取向和强度。然后，使用准分子激光器或其他类型的激光或机械材料去除工具来去除聚合物材料，实际上没有热效应。气囊的套筒部分中的腔被限定，并且如果需要，限定锥形部分中的凹陷。材料去除，特别是靠近气球套筒，能够在导管轴和球囊之间形成更薄，更灵活的粘结区域。此外，沿着锥形部分的凹陷使得气囊能够更紧密地包裹以减少输送轮廓。袖子附近的刚性减少，导致导管在曲折通道中的更好的机动性。

14. 发明申请

US20070260224A1 FLEXIBLE CATHETER TIP HAVING A SHAPED HEAD 审中-公开
标题翻译：柔性导管带有形状的头
公开(公告)号：US20070260224A1
公开(公告)日：2007-11-08
申请号：US11683997
申请日：2007-03-08
申请人： Randolf Von Oepen , Thomas Rieth , Lorcan Coffey , Richard Newhauser , Travis Yribarren
发明人： Randolf Von Oepen , Thomas Rieth , Lorcan Coffey , Richard Newhauser , Travis Yribarren
IPC分类号： A61M25/16
CPC分类号： A61M25/0054 , A61M25/0053 , A61M25/0067 , A61M25/0069 , A61M25/008 , A61M25/0138 , A61M2025/1093
摘要： A catheter tip for attachment with an intravascular balloon catheter that is used within a body lumen is disclosed. The catheter tip includes a body portion having a base that is attached to the balloon catheter. The base defines a proximal end of the catheter tip. A head that is attached to the body portion defines a distal end of the catheter tip. An axial cavity, cooperatively defined by the body portion and the head, extends longitudinally from the proximal to the distal end of the catheter tip. The axial cavity receives a first guidewire along which the catheter is moved within the body lumen. An outer surface of the head is shaped in a predetermined manner to control the magnitude of deflection of a second guidewire that is often twisted about the first guidewire in the lumen so as to prevent catheter obstruction by the guidewires during catheter procedures.
摘要翻译：公开了用于与在体腔内使用的血管内气囊导管连接的导管末端。导管尖端包括具有附接到气囊导管的基部的主体部分。基部限定了导管尖端的近端。附接到主体部分的头限定导管末端的远端。由主体部分和头部协同地限定的轴向腔从导管末端的近端延伸到远端。轴向空腔容纳第一导丝，导管沿着该第一导丝在体腔内移动。头部的外表面以预定的方式成形，以控制通常在内腔中围绕第一导丝扭转的第二导丝的偏转量，以防止在导管过程期间导管阻塞导线。

15. 发明授权

US08986339B2 Method of reducing rigidity of angioplasty balloon sections 有权
标题翻译：降低血管成形术气囊截面刚度的方法
公开(公告)号：US08986339B2
公开(公告)日：2015-03-24
申请号：US13615096
申请日：2012-09-13
申请人： Boris Warnack , Judith Hartwig , Silke Pschibl , Travis Richard Yribarren , Randolf Von Oepen , Thomas Rieth , Lorcan Coffey , Arik Zucker
发明人： Boris Warnack , Judith Hartwig , Silke Pschibl , Travis Richard Yribarren , Randolf Von Oepen , Thomas Rieth , Lorcan Coffey , Arik Zucker
IPC分类号： A61M29/00 , A61M25/10 , B23K26/40 , B29C59/16 , B29L31/00
CPC分类号： A61M25/104 , A61M25/1034 , A61M25/1038 , A61M2025/1004 , A61M2025/1031 , A61M2025/1086 , A61M2025/1093 , B23K2103/42 , B23K2103/50 , B29C59/165 , B29C2791/009 , B29L2031/7542 , Y10T156/1062
摘要： A dilatation balloon is fabricated according to a process that forms cavities and indentations in the balloon and/or catheter sections. A length of tubing is axially elongated and radially expanded in a form to provide the requisite biaxial orientation and strength. Then, an excimer laser or another type of laser or mechanical material removal tool is used to remove the polymeric material, virtually without thermal effects. Cavities in the sleeve sections of the balloon are defined and if desired, indentations in the cone sections are defined. Material removal, particularly near the balloon sleeves enables a thinner, more flexible bonding area between the catheter shaft and the balloon. Further, the indentations along the cone sections enables tighter wrapping of the balloon for a reduced delivery profile. Rigidity near the sleeves is reduced for better maneuverability of the catheter in tortuous passageways.
摘要翻译：根据在球囊和/或导管部分中形成空腔和凹陷的方法制造扩张球囊。一段长度的管材是轴向伸长的并以一种形式径向扩张以提供必要的双轴取向和强度。然后，使用准分子激光器或其他类型的激光或机械材料去除工具来去除聚合物材料，实际上没有热效应。气囊的套筒部分中的腔被限定，并且如果需要，限定锥形部分中的凹陷。材料去除，特别是靠近气球套筒，能够在导管轴和球囊之间形成更薄，更灵活的粘结区域。此外，沿着锥形部分的凹陷使得气囊能够更紧密地包裹以减少输送轮廓。袖子附近的刚性减少，导致导管在曲折通道中的更好的机动性。

16. 发明申请

US20080097404A1 Catheter having markers to indicate rotational orientation 审中-公开
标题翻译：导管具有指示旋转取向的标记
公开(公告)号：US20080097404A1
公开(公告)日：2008-04-24
申请号：US11505697
申请日：2006-08-16
申请人： Travis R. Yribarren , Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Arik Zucker
发明人： Travis R. Yribarren , Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Arik Zucker
IPC分类号： A61M25/098 , A61M29/00 , A61F2/06 , A61F2/00
CPC分类号： A61M25/0108 , A61F2/856 , A61F2/954 , A61F2/958 , A61F2250/0098 , A61M2025/0008 , A61M2025/1079
摘要： Various improved catheter marking arrangements are described. In a first aspect of the invention, a first longitudinally extending radiopaque marker is positioned on the catheter. A second longitudinally extending radiopaque marker is positioned opposite the first marker at a rotational orientation that is approximately 180 degrees offset from the first marker. The second marker has a length that is sufficiently different from the first marker such that a surgeon utilizing the catheter in a surgical procedure would be able to readily differentiate the first and second markers in a fluoroscopic image based on their respective lengths in order to determine the rotational orientation of the catheter.In some embodiments, the catheter includes a lumen that has a side port that opens to a side of the catheter. The first marker is composed of a pair of axially aligned marker segments located on opposite ends of the side port. The length of the first longitudinal extending marker defined as an end-to-end length of the pair of axially aligned marker segments is longer than the length of the second marker. The markers may be formed from any suitable materials that can be clearly detected by an imaging system.
摘要翻译：描述了各种改进的导管标记装置。在本发明的第一方面，第一纵向延伸的不透射线的标记位于导管上。第二纵向延伸的不透射线标记物以与第一标记物大约180度偏离的旋转方向定位成与第一标记相对。第二标记具有与第一标记足够不同的长度，使得在外科手术中利用导管的外科医生能够根据它们各自的长度容易地区分荧光镜图像中的第一和第二标记，以便确定导管的旋转取向。在一些实施例中，导管包括具有向导管侧面开口的侧端口的内腔。第一标记由位于侧端口的相对端上的一对轴向对齐的标记段组成。被定义为一对轴向对准的标记段的端到端长度的第一纵向延伸标记的长度比第二标记的长度长。标记可以由能够被成像系统清楚地检测到的任何合适的材料形成。

17. 发明申请

US20090292241A1 BALLOON CATHETER 审中-公开
标题翻译：气球导管
公开(公告)号：US20090292241A1
公开(公告)日：2009-11-26
申请号：US12506066
申请日：2009-07-20
申请人： Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Travis R. Yribarren , Arik Zucker
发明人： Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Travis R. Yribarren , Arik Zucker
IPC分类号： A61M25/10 , B29C41/00
CPC分类号： A61F2/958 , A61M25/1002 , A61M25/1011 , A61M25/1027 , A61M25/1029 , A61M29/02 , A61M2025/0183 , A61M2025/1056 , A61M2025/107
摘要： A catheter arrangement is described that is arranged to permit a guide wire or other structure to be fed laterally from the region of an expandable working element. The catheter includes an elongate flexible tubular member and an inflatable structure carried by a distal portion of the flexible tubular member. The flexible tubular member has a guide wire lumen and at least one fluid supply lumen that is in fluid communication with the inflatable structure. The inflatable structure includes at least one, and preferably two, inflatable members (which may take the form of balloons). In the case of two inflatable members, the first and second inflatable members are radially spaced about the guide wire lumen such that at least one gap is formed between the inflatable members. With this arrangement, the distal end of a guide wire may be advanced through the guide lumen and out of a side opening such that the guide wire passes laterally between the first and second inflatable members. With such an arrangement, a guide wire passing out of the side opening in the region between the inflatable members can readily be directed into a second branch of a vessel bifurcation while the device is positioned in a first branch.
摘要翻译：描述了布置成允许导丝或其他结构从可扩张工作元件的区域横向地供给的导管装置。导管包括细长的柔性管状构件和由柔性管状构件的远侧部分承载的可膨胀结构。柔性管状构件具有导丝腔和与可充气结构流体连通的至少一个流体供应腔。可膨胀结构包括至少一个，优选两个可膨胀构件（其可以采取气球的形式）。在两个可膨胀构件的情况下，第一和第二可膨胀构件围绕导丝管腔径向隔开，使得在可膨胀构件之间形成至少一个间隙。通过这种布置，导丝的远端可以通过引导腔前进并且从侧开口排出，使得导丝横向地在第一和第二可膨胀构件之间通过。通过这样的布置，在可膨胀构件之间的区域中的侧开口中的引导线可以容易地被引导到容器分叉的第二分支中，同时装置位于第一分支中。

18. 发明申请

US20080140174A1 Method of increasing balloon flexibility in a balloon catheter 审中-公开
标题翻译：球囊导管增加球囊柔韧性的方法
公开(公告)号：US20080140174A1
公开(公告)日：2008-06-12
申请号：US11506243
申请日：2006-08-17
申请人： Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Travis R. Yribarren , Arik Zucker
发明人： Randolf von Oepen , Lorcan Coffey , Thomas Rieth , Travis R. Yribarren , Arik Zucker
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61M25/1027 , A61M2025/1031
摘要： A variety of methods are described that pre-condition a balloon used in a balloon catheter in order to increase its flexibility. Generally, the membrane that forms the balloon is crumpled in order to induce a large number of irregular crumples in the balloon. The crinkling of the balloon improves its flexibility and thus the flexibility of the catheter. Most typically, torsion and/or compression are applied to the balloon membrane in order to induce the crumpling. The described crumpling can be used to increase the flexibility of a balloon of a given strength in a variety of catheters, including angioplasty catheters and stent delivery catheters. In stent delivery catheters, the resulting crinkles also have the additional benefit of improving stent retention.
摘要翻译：描述了预先调节气球导管中使用的球囊以增加其灵活性的各种方法。通常，形成气囊的膜被弄皱，以便在气球中引起大量的不规则褶皱。气球的皱缩改善了其灵活性，从而提高了导管的灵活性。最典型地，将扭转和/或压缩施加到球囊膜以引起皱巴巴。所描述的皱巴巴可用于增加各种导管（包括血管成形术导管和支架输送导管）中给定强度的球囊的柔性。在支架输送导管中，所产生的皱纹还具有改善支架保留的额外益处。

19. 发明申请

US20080045896A1 Catheter having intermediate position markers 审中-公开
标题翻译：导管具有中间位置标记
公开(公告)号：US20080045896A1
公开(公告)日：2008-02-21
申请号：US11506309
申请日：2006-08-17
申请人： Travis R. Yribarren , Randolf Von Oepen , Arik Zucker , Lorcan Coffey , Thomas Rieth
发明人： Travis R. Yribarren , Randolf Von Oepen , Arik Zucker , Lorcan Coffey , Thomas Rieth
IPC分类号： A61M29/00 , A61M31/00 , A61M37/00
CPC分类号： A61F2/958 , A61F2/856 , A61F2/954 , A61F2250/0098 , A61M2025/105 , A61M2025/1072
摘要： Various improved catheter marking arrangements are described. In a first aspect of the invention, the catheter includes an expandable member (such as for example, a balloon, a stent, etc.). A pair of radiopaque end markers mark the distal and proximal ends of the expandable member. Additionally, a radiopaque intermediate marker is provided that marks an intermediate position on the expandable member. The intermediate marker may be used to mark important points on the expandable member. The markers are sized and positioned such that a surgeon utilizing the catheter in a surgical procedure would be able to readily differentiate the markers in a fluoroscopic image to determine the location of the item marked by the orientation of the catheter. In various other aspects of the invention, the intermediate marker is arranged to mark a position on the expandable member that constitutes a line of demarcation for an agent (such as a drug) carried by a balloon.
摘要翻译：描述了各种改进的导管标记装置。在本发明的第一方面，导管包括可扩张构件（例如气球，支架等）。一对不透射线的端标记标记可扩张构件的远端和近端。另外，提供标记可扩张构件上的中间位置的不透射线的中间标记。中间标记可用于标记可扩张构件上的重要点。标记物的大小和定位使得在外科手术中利用导管的外科医生将能够容易地在荧光透视图像中区分标记物，以确定由导管的取向标记的物品的位置。在本发明的各种其他方面，中间标记被布置成标记可膨胀构件上构成由气球承载的试剂（例如药物）的界线的位置。

20. 发明申请

US20070213802A1 Bifurcation Stent Delivery Catheter and Method 审中-公开
标题翻译：分叉支架输送导管和方法
公开(公告)号：US20070213802A1
公开(公告)日：2007-09-13
申请号：US11683899
申请日：2007-03-08
申请人： Randolf Von Oepen , Thomas Rieth , Lorcan Coffey , Richard Newhauser , Travis Yribarren
发明人： Randolf Von Oepen , Thomas Rieth , Lorcan Coffey , Richard Newhauser , Travis Yribarren
IPC分类号： A61F2/84
CPC分类号： A61F2/95
摘要： A stent delivery system is disclosed for delivering and deploying a radially expandable stent at a strategic orientation and location in a body vessel. The delivery system includes an elongated flexible tubular shaft sized suitably for insertion into the body vessel, first and second inflatable members disposed adjacent the distal end of the elongated shaft and an endoprosthesis disposed about the first and second inflatable members. The delivery system further includes a tip assembly which during to advancement of the delivery system is configured as a single tip assembly, wherein prior to deployment of the expandable endoprosthesis, the tip assembly is split into a first tip and a second tip, wherein one of the tips remains in a main branch and the second tip is advanced into a side branch lumen to align the endoprosthesis prior to deployment.
摘要翻译：公开了用于在体内容器中的战略取向和位置处递送和展开径向可扩张的支架的支架输送系统。递送系统包括细长的柔性管状轴，其尺寸适于插入身体容器中，邻近细长轴的远端设置的第一和第二可膨胀构件以及围绕第一和第二可膨胀构件设置的内假体。输送系统还包括尖端组件，其在输送系统的进行期间被配置为单个尖端组件，其中在展开可膨胀内置假体之前，将尖端组件分成第一尖端和第二尖端，其中，尖端保持在主分支中，并且第二尖端前进到侧分支内腔以在部署之前对准内假体。

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