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11. 发明申请

WO2020020850A1 REAGENT FOR MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2020020850A1
公开(公告)日：2020-01-30
申请号：PCT/EP2019/069730
申请日：2019-07-23
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： BAECHER, Silvia , GEIERMANN, Anna-Skrollan , HEINDL, Dieter , JOSEL, Hans-Peter , KOBOLD, Uwe , LEINENBACH, Andreas , LOIBL, Simon Ferdinand , MILIC, Jelena , PIRKL, Nicole , PRENCIPE, Giuseppe , REMPT, Martin , SEIDEL, Christoph
IPC分类号： C07D249/06 , C07D257/04
摘要： The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

12. 发明申请

WO2014019709A2 NEW IRIDIUM-BASED COMPLEXES FOR ECL 审中-公开
标题翻译：用于ECL的新型基于IRIDIUM的复合物
公开(公告)号：WO2014019709A2
公开(公告)日：2014-02-06
申请号：PCT/EP2013/002323
申请日：2013-08-02
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： BERGMANN, Frank , CYSEWSKI, Robert , DE COLA, Luisa , DZIADEK, Sebastian , FERNANDEZ HERNANDEZ, Jesus Miguel , JOSEL, Hans-Peter , SEIDEL, Christoph
IPC分类号： C09K11/06 , C07F15/00
CPC分类号： C07F15/0033 , C09K11/06 , C09K11/07 , C09K2211/1007 , C09K2211/1029 , C09K2211/14 , C09K2211/1408 , C09K2211/1416 , C09K2211/1425 , C09K2211/1441 , C09K2211/1466 , C09K2211/185 , G01N33/582
摘要： The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
摘要翻译：本发明涉及新型的基于铱的Ir（III）发光配合物，包含这些络合物作为标记的缀合物及其应用，例如，在基于电化学发光的分析物检测中。

13. 发明申请

WO2021234004A1 IMIDAZOLIUM REAGENT FOR MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2021234004A1
公开(公告)日：2021-11-25
申请号：PCT/EP2021/063298
申请日：2021-05-19
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： HAHN, Robert , HEINDL, Dieter , JOSEL, Hans-Peter , KOBOLD, Uwe , KUCHELMEISTER, Hannes , MAZZIER, Daniela , PRENCIPE, Giuseppe , REMPT, Martin , SEIDEL, Christoph
IPC分类号： C07D233/90
摘要： The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.

14. 发明申请

WO2018115237A1 METHOD FOR IDENTIFYING A REAGENT DURING A PROCESS IN AN ANALYSIS SYSTEM 审中-公开
公开(公告)号：WO2018115237A1
公开(公告)日：2018-06-28
申请号：PCT/EP2017/084012
申请日：2017-12-21
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： HEINDL, Dieter , KOBOLD, Uwe , SEIDEL, Christoph , REMPT, Martin
IPC分类号： G01N30/06 , G01N30/28 , G01N30/46 , G01N30/72 , G01N33/58
摘要： A method for identifying a reagent during a process in an analysis system (100) is disclosed. The analysis system (100) comprises a liquid chromatograph (102) and a mass spectrometer (104). The method comprises providing a reagent (130), adding at least one chemical substance (134) to the reagent (130) with a concentration being below a detection level of the mass spectrometer (104), enriching the chemical substance (134) within the liquid chromatograph (102) to a concentration above the detection level of the mass spectrometer (104), processing the reagent (130) together with the enriched chemical substance (134) by means of the analysis system (100), and identifying the reagent (130) based on a detection of a substance detection signal of the mass spectrometer (104) representing the chemical substance (134).

15. 发明申请

WO2014019711A1 NEW IRIDIUM-BASED COMPLEXES FOR ECL 审中-公开
公开(公告)号：WO2014019711A1
公开(公告)日：2014-02-06
申请号：PCT/EP2013/002325
申请日：2013-08-02
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： BERGMANN, Frank , CYSEWSKI, Robert , DE COLA, Luisa , DZIADEK, Sebastian , FERNANDEZ HERNANDEZ, Jesus, Miguel , JOSEL, Hans-Peter , LONGHI, Elena , SEIDEL, Christoph
IPC分类号： C07F15/00 , C09K11/06
CPC分类号： C07F15/0033 , C09K11/06 , C09K2211/1007 , C09K2211/1029 , C09K2211/1059 , C09K2211/14 , C09K2211/1416 , C09K2211/1425 , C09K2211/1441 , C09K2211/1466 , C09K2211/1475 , C09K2211/1491 , C09K2211/185 , G01N33/582 , G01N2458/30
摘要： The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.

16. 发明申请

WO2021234003A1 BENZYLPYRIDINIUM REAGENT FOR MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2021234003A1
公开(公告)日：2021-11-25
申请号：PCT/EP2021/063296
申请日：2021-05-19
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： HAHN, Robert , HEINDL, Dieter , HOFFMANN, Thomas , JOSEL, Hans-Peter , KOBOLD, Uwe , KUCHELMEISTER, Hannes , LOIBL, Simon Ferdinand , MAZZIER, Daniela , MILIC, Jelena , PRENCIPE, Giuseppe , REMPT, Martin , SEIDEL, Christoph
IPC分类号： C07D213/46 , C07D213/55 , C07D213/61 , C07D213/86 , C07D401/04
摘要： The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.

17. 发明申请

WO2020020851A1 REAGENT FOR MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2020020851A1
公开(公告)日：2020-01-30
申请号：PCT/EP2019/069731
申请日：2019-07-23
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： BAECHER, Silvia , GEIERMANN, Anna-Skrollan , HEINDL, Dieter , JOSEL, Hans-Peter , KOBOLD, Uwe , LEINENBACH, Andreas , LOIBL, Simon Ferdinand , MILIC, Jelena , PIRKL, Nicole , PRENCIPE, Giuseppe , REMPT, Martin , SEIDEL, Christoph
IPC分类号： C07D249/06 , C07D257/04
摘要： The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

18. 发明申请

WO2020020849A1 REAGENT FOR MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2020020849A1
公开(公告)日：2020-01-30
申请号：PCT/EP2019/069729
申请日：2019-07-23
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： BAECHER, Silvia , GEIERMANN, Anna-Skrollan , HAHN, Robert , HEINDL, Dieter , JOSEL, Hans-Peter , KOBOLD, Uwe , LEINENBACH, Andreas , LOIBL, Simon Ferdinand , MILIC, Jelena , PIRKL, Nicole , PRENCIPE, Giuseppe , REMPT, Martin , SEIDEL, Christoph
IPC分类号： C07D249/06 , C07D257/04
摘要： The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

19. 发明申请

WO2018115243A1 METHOD FOR TRACKING A SAMPLE IDENTITY DURING A PROCESS IN AN ANALYSIS SYSTEM 审中-公开
公开(公告)号：WO2018115243A1
公开(公告)日：2018-06-28
申请号：PCT/EP2017/084023
申请日：2017-12-21
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： HEINDL, Dieter , KOBOLD, Uwe , REMPT, Martin , SEIDEL, Christoph
IPC分类号： G01N30/06 , G01N33/58 , G01N30/28 , G01N30/34 , G01N30/46 , G01N30/72
摘要： A method for tracking a sample identity during a process in an analysis system (112) is disclosed. The analysis system (112) comprises a liquid chromatograph (102) and a mass spectrometer (104). The method comprises providing a sample (108), adding a composition (130) of different chemical substances (132) to the sample (108) with a concentration being above a detection level of the mass spectrometer (104), processing the sample (108) together with the composition (130) by means of the analysis system (112), detecting and measuring a component and/or components of the sample (108) by means of the mass spectrometer (104), detecting and measuring the composition (130) or parts of the composition (130) of different chemical substances (132) by means of the mass spectrometer (104), and identifying the sample (108) based on a detection of a substance detection signal pattern of the mass spectrometer (104) including substance detection signals representing the composition (130) of chemical substances (132).

20. 发明申请

WO2015082540A1 IMPROVED PROCESS FOR PRODUCING MAGNETIC MONODISPERSE POLYMER PARTICLES 审中-公开
标题翻译：用于生产磁性单体聚合物颗粒的改进方法
公开(公告)号：WO2015082540A1
公开(公告)日：2015-06-11
申请号：PCT/EP2014/076404
申请日：2014-12-03
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： SEIDEL, Christoph , BOLLE, Jens Christian , RECKLIES, Sandra
IPC分类号： H01F1/00 , C08F257/02
CPC分类号： H01F1/44 , C08F257/00 , C08K9/10 , C08K2201/01 , H01F1/0054 , C08F212/36 , C08F212/08 , C08F2/44
摘要： Disclosed in here is a simplified process for producing magnetic polymer particles, the process comprising the steps of (a) providing a composition with the following components, a liquid monomer which is radical polymerizable, a radical initiator which is soluble in the monomer, a steric stabilizer, and a ferrofluid comprising surfactant-coated colloidal magnetic particles in a carrier fluid which is miscible with the monomer; (b) preparing an emulsion from a polar solvent which is immiscible with the monomer, and the composition of step (a); (c) adding seed polymer particles to the emulsion, mixing to form a seeded emulsion, and incubating the seeded emulsion, thereby swelling the seed polymer particles; (d) activating the radical initiator and polymerizing the monomer in the swollen seed polymer particles; thereby producing the magnetic polymer particles. As a result of the process monodisperse magnetic particles can be provided. The particles are characterized by a uniform distribution of magnetic material, and an absence of magnetite bleeding.
摘要翻译：这里公开了一种制备磁性聚合物颗粒的简化方法，该方法包括以下步骤：（a）提供具有以下组分的组合物：可自由基聚合的液体单体，可溶于单体的自由基引发剂，立体异构体稳定剂和含有表面活性剂的胶体磁性颗粒在与该单体混溶的载体流体中的铁磁流体; （b）从与单体不混溶的极性溶剂和步骤（a）的组成制备乳液; （c）将种子聚合物颗粒加入到乳液中，混合形成接种的乳液，并孵育接种的乳液，从而使种子聚合物颗粒溶胀; （d）活化自由基引发剂并使单体在溶胀的种子聚合物颗粒中聚合; 从而产生磁性聚合物颗粒。作为该方法的结果，可以提供单分散的磁性颗粒。颗粒的特征在于磁性材料的分布均匀，并且不存在磁铁矿渗出。

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