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11. 发明申请

US20090004705A1 PSOD Expression Units 有权
标题翻译： PSOD表达单位
公开(公告)号：US20090004705A1
公开(公告)日：2009-01-01
申请号：US12030575
申请日：2008-02-13
申请人： Burkhard Kroger , Oskar Zelder , Corinna Klopprogge , Hartwing Schroder , Stefan Haefner
发明人： Burkhard Kroger , Oskar Zelder , Corinna Klopprogge , Hartwing Schroder , Stefan Haefner
IPC分类号： C12P13/12 , C12N1/21 , C07H21/04 , C12P13/08 , C12N15/63
CPC分类号： C12N15/77
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译：本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。

12. 发明申请

US20090281353A1 Use of dimethyl disulfide for methionine production in microoragnisms 有权
标题翻译：二甲基二硫化物用于微生物中的甲硫氨酸生产
公开(公告)号：US20090281353A1
公开(公告)日：2009-11-12
申请号：US11988971
申请日：2006-07-18
申请人： Oskar Zelder , Stefan Haefner , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , R. Rogers Yocum , Mark K. Williams
发明人： Oskar Zelder , Stefan Haefner , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , R. Rogers Yocum , Mark K. Williams
IPC分类号： C12P13/12 , C07C323/03 , C12N1/21 , C12N15/31 , C12Q1/68 , C12N9/00
CPC分类号： C12P13/12
摘要： The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a ΔmetF organism or a ΔmetE AmetH organism, for example, mutants of C. glutamicum or E. coli, can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/MetE and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A ΔmetF ΔmetB strain of C. glutamicum can use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS.
摘要翻译：本发明的特征在于用于生产甲硫氨酸的改进方法和生物体。本发明证明，DeltametF生物体或DeltametE AmetH生物体，例如谷氨酸棒状杆菌或大肠杆菌的突变体可以使用甲基封端的硫化物源，例如二甲基二硫醚（DMDS）作为硫和甲基，绕过MetH / MetE和MetF活性的需要，需要还原硫酸盐，用于合成甲硫氨酸。该专利中还描述的是涉及MetY（也称为MetZ）作为将甲基封端的硫化物源例如DMDS掺入甲硫氨酸的酶的数据。谷氨酸棒状病毒的DeltametF DeltametB菌株可以使用甲基封端的硫化物源，例如DMDS，作为硫化物和甲基两者的来源。此外，通过加入甲基封端的硫化物源（例如DMDS），改善过量产生O-乙酰高丝氨酸的工程化原养殖生物体的甲硫氨酸生产。

13. 发明申请

US20090053778A1 Microorganisms for producing sulfur-containing compounds 审中-公开
标题翻译：用于生产含硫化合物的微生物
公开(公告)号：US20090053778A1
公开(公告)日：2009-02-26
申请号：US11632693
申请日：2005-07-20
申请人： Uwe Sauer , Jorg Mampel , Oskar Zelder , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , Stefan Haefner
发明人： Uwe Sauer , Jorg Mampel , Oskar Zelder , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , Stefan Haefner
IPC分类号： C12P13/12 , C12N1/21 , C12P13/04 , C12P17/18 , C12P17/16 , C12P7/64
CPC分类号： C12P13/12 , C12P11/00 , C12P17/167 , C12P17/186 , C12P19/40 , C12P21/02
摘要： The present invention relates to microorganisms and methods for producing at least one sulfur-containing compound.
摘要翻译：本发明涉及用于生产至少一种含硫化合物的微生物和方法。

14. 发明授权

US08399214B2 Use of dimethyl disulfide for methionine production in microoraganisms 有权
标题翻译：用二甲基二硫化物在微生物激素中生产甲硫氨酸
公开(公告)号：US08399214B2
公开(公告)日：2013-03-19
申请号：US11988971
申请日：2006-07-18
申请人： Oskar Zelder , Stefan Haefner , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , R. Rogers Yocum , Mark K. Williams
发明人： Oskar Zelder , Stefan Haefner , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , R. Rogers Yocum , Mark K. Williams
IPC分类号： C12P1/00
CPC分类号： C12P13/12
摘要： The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a ΔmetF organism or a ΔmetE AmetH organism, for example, mutants of C. glutamicum or E. coli, can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/MetE and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A ΔmetF ΔmetB strain of C. glutamicum can use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS.
摘要翻译：本发明的特征在于用于生产甲硫氨酸的改进方法和生物体。本发明证明，一种有机蛋白（MetF）生物体或一种具有谷氨酸棒状杆菌或大肠杆菌的突变体的MetE生物体可以使用例如二甲基二硫醚（DMDS）的甲基封端硫化物源作为硫和甲基，绕过MetH / MetE和MetF活性的需要，需要还原硫酸盐，用于合成甲硫氨酸。该专利中还描述的是涉及MetY（也称为MetZ）作为将甲基封端的硫化物源例如DMDS掺入甲硫氨酸的酶的数据。 A＆Dgr; metF＆Dgr;谷氨酸棒杆菌的metB菌株可以使用甲基封端的硫化物源，例如DMDS，作为硫化物和甲基的来源。此外，通过加入甲基封端的硫化物源（例如DMDS），改善过量产生O-乙酰高丝氨酸的工程化原养殖生物体的甲硫氨酸生产。

15. 发明申请

US20090298136A1 Methionine producing recombinant microorganisms 审中-公开
标题翻译：产生甲硫氨酸的重组微生物
公开(公告)号：US20090298136A1
公开(公告)日：2009-12-03
申请号：US11988962
申请日：2006-07-18
申请人： Oskar Zelder , Stefan Haefner , Corinna Klopprogge , Hartwig Schroder , Andrea Herold , Thomas A. Patterson , Theron Hermann , R. Rogers Yocum , Mark K. William , Janice G. Pero
发明人： Oskar Zelder , Stefan Haefner , Corinna Klopprogge , Hartwig Schroder , Andrea Herold , Thomas A. Patterson , Theron Hermann , R. Rogers Yocum , Mark K. William , Janice G. Pero
IPC分类号： C12P13/12 , C12N1/21
CPC分类号： C12P13/12 , C12N15/52
摘要： This invention relates to methionine producing recombinant microorganisms. Specifically, this invention relates to recombinant strains of Corynebacterium that produce increased levels of methionine compared to their wild-type counterparts and further to methods of generating such microorganisms.
摘要翻译：本发明涉及产生甲硫氨酸的重组微生物。具体而言，本发明涉及棒状杆菌的重组菌株，其与野生型对应物相比产生较高水平的甲硫氨酸，并且还涉及产生这种微生物的方法。

16. 发明申请

US20080268502A1 Multiple Promoters and the Use Thereof For Gene Expression 有权
标题翻译：多重启动子及其用于基因表达的用途
公开(公告)号：US20080268502A1
公开(公告)日：2008-10-30
申请号：US12048599
申请日：2008-03-14
申请人： Stefan Haefner , Hartwig Schroder , Oskar Zelder , Corinna Klopprogge , Andrea Herold
发明人： Stefan Haefner , Hartwig Schroder , Oskar Zelder , Corinna Klopprogge , Andrea Herold
IPC分类号： C12P21/04 , C12N15/11 , C12N15/00 , C12P19/34 , C12P7/64 , C12N15/74 , C12P13/04 , C12N1/20 , C12P1/00
CPC分类号： C07K14/34 , C12N15/77
摘要： The present invention relates to multiple promoters and to expression units comprising them; to the use thereof for regulating transcription and expression of genes; to expression cassettes which comprise multiple promoters or expression units of this kind; to vectors which comprise such expression cassettes; to genetically modified microorganisms which comprise vectors and/or expression units of this kind; and to processes for preparing biosynthetic products by culturing said genetically modified microorganisms.
摘要翻译：本发明涉及多种启动子和包含它们的表达单元; 用于调节基因的转录和表达; 包括多种启动子或这种表达单位的表达盒; 包含这种表达盒的载体; 涉及包含这种载体和/或表达单元的转基因微生物; 以及通过培养所述转基因微生物来制备生物合成产物的方法。

17. 发明申请

US20090191610A1 Microorganisms With Increased Efficiency for Methionine Synthesis 审中-公开
标题翻译：提高甲硫氨酸合成效率的微生物
公开(公告)号：US20090191610A1
公开(公告)日：2009-07-30
申请号：US11989369
申请日：2006-08-18
申请人： Oskar Zelder , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , Stefan Haefner , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice G. Pero , R. Rogers Yocum , Thomas A. Patterson , Mark Williams , Theron Herman
发明人： Oskar Zelder , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , Stefan Haefner , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice G. Pero , R. Rogers Yocum , Thomas A. Patterson , Mark Williams , Theron Herman
IPC分类号： C12N1/21 , C12N15/10 , C12N1/19 , G01N33/48 , C12N5/10
CPC分类号： C12N15/52 , C12P13/12
摘要： The present invention relates to methods for the production of microorganisms with increased efficiency for methionine synthesis, microorganisms with increased efficiency for methionine synthesis, and methods for determining the optimal metabolic flux for organisms with respect to methionine synthesis.
摘要翻译：本发明涉及用于生产具有增加甲硫氨酸合成效率的微生物的方法，提高甲硫氨酸合成效率的微生物以及确定生物相对于甲硫氨酸合成的最佳代谢通量的方法。

18. 发明授权

US08048651B2 Methods for the preparation of lysine by fermentation of Corynebacterium glutamicum 有权
标题翻译：谷氨酸棒杆菌发酵制备赖氨酸的方法
公开(公告)号：US08048651B2
公开(公告)日：2011-11-01
申请号：US12533677
申请日：2009-07-31
申请人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Haefner , Burkhard Kröger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
发明人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Haefner , Burkhard Kröger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
IPC分类号： C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P23/00 , C12N9/16 , C12N15/70 , C12N1/20 , C12N15/74 , C07H21/04
CPC分类号： C12P13/08 , C12N9/16
摘要： The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
摘要翻译：本发明的特征在于通过使酶编码基因（即果糖-1,6-二磷酸酶）失调来增加精细化学品例如来自微生物例如棒状杆菌的赖氨酸的生产方法。在优选的实施方案中，本发明提供了通过增加果糖-1,6-二磷酸酶活性的表达来增加谷氨酸棒杆菌中赖氨酸的产生的方法。本发明还提供了通过调节向草酰乙酸（OAA）的碳通量来生产赖氨酸的新方法。在优选的实施方案中，本发明提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。

19. 发明授权

US07968699B2 Multiple promoters and the use thereof for gene expression 有权
标题翻译：多重启动子及其用于基因表达的用途
公开(公告)号：US07968699B2
公开(公告)日：2011-06-28
申请号：US12048599
申请日：2008-03-14
申请人： Stefan Haefner , Hartwig Schroder , Oskar Zelder , Corinna Klopprogge , Andrea Herold
发明人： Stefan Haefner , Hartwig Schroder , Oskar Zelder , Corinna Klopprogge , Andrea Herold
IPC分类号： C07H21/04 , C12N15/85
CPC分类号： C07K14/34 , C12N15/77
摘要： The present invention relates to multiple promoters and to expression units comprising them; to the use thereof for regulating transcription and expression of genes; to expression cassettes which comprise multiple promoters or expression units of this kind; to vectors which comprise such expression cassettes; to genetically modified microorganisms which comprise vectors and/or expression units of this kind; and to processes for preparing biosynthetic products by culturing said genetically modified microorganisms.
摘要翻译：本发明涉及多种启动子和包含它们的表达单元; 用于调节基因的转录和表达; 包括多种启动子或这种表达单位的表达盒; 包含这种表达盒的载体; 涉及包含这种载体和/或表达单元的转基因微生物; 以及通过培养所述转基因微生物来制备生物合成产物的方法。

20. 发明授权

US07566557B2 Gene variants coding for proteins from the metabolic pathway of fine chemicals 有权
标题翻译：编码精细化学物质代谢途径蛋白质的基因变体
公开(公告)号：US07566557B2
公开(公告)日：2009-07-28
申请号：US10583404
申请日：2004-12-16
申请人： Corinna Klopprogge , Oskar Zelder , Burkhard Kröger , Hartwig Schröder , Stefan Haefner , Uwe Ruffer , Claudia Isabella Graef , Gregor Haberhauer
发明人： Corinna Klopprogge , Oskar Zelder , Burkhard Kröger , Hartwig Schröder , Stefan Haefner , Uwe Ruffer , Claudia Isabella Graef , Gregor Haberhauer
IPC分类号： C12N9/10 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C07K14/34
摘要： The present invention relates to mutated nucleic acids and proteins of the metabolic pathway of fine chemicals, to processes for preparing genetically modified producer organisms, to processes for preparing fine chemicals by culturing genetically modified organisms, and to genetically modified organisms themselves.
摘要翻译：本发明涉及精细化学品的代谢途径的突变核酸和蛋白质，制备经遗传修饰的生物体生物体的方法，通过培养经遗传修饰的生物体来制备精细化学品的方法以及转基因生物本身。

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