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11. 发明申请

US20050222243A1 Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use 有权
标题翻译：硝化非甾体抗炎化合物，组合物和使用方法
公开(公告)号：US20050222243A1
公开(公告)日：2005-10-06
申请号：US11134358
申请日：2005-05-23
申请人： Richard Earl , Maiko Ezawa , Xinqin Fang , David Garvey , Ricky Gaston , Subhash Khanapure , L. Gordon Letts , Chia-En Lin , Ramani Ranatunga , Stewart Richardson , Joseph Schroeder , Cheri Stevenson , Shiow-Jyi Wey
发明人： Richard Earl , Maiko Ezawa , Xinqin Fang , David Garvey , Ricky Gaston , Subhash Khanapure , L. Gordon Letts , Chia-En Lin , Ramani Ranatunga , Stewart Richardson , Joseph Schroeder , Cheri Stevenson , Shiow-Jyi Wey
IPC分类号： C07D295/08 , A61K31/21 , A61K31/405 , A61K31/445 , A61K45/00 , A61P1/00 , A61P1/04 , A61P1/10 , A61P1/14 , A61P3/04 , A61P17/02 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07C203/04 , C07C205/40 , C07C205/56 , C07C219/10 , C07C229/42 , C07C235/08 , C07C235/12 , C07C235/34 , C07C235/42 , C07C237/08 , C07C243/28 , C07C271/16 , C07C271/64 , C07C291/02 , C07C311/17 , C07C317/18 , C07C317/32 , C07C317/46 , C07C323/12 , C07C327/28 , C07D209/18 , C07D209/28 , C07D211/22 , C07D211/56 , C07D493/04 , C07F9/40 , C07D209/20
CPC分类号： C07D493/04 , C07C291/02 , C07C311/17 , C07C317/18 , C07C323/12 , C07C327/28 , C07D209/18 , C07D211/22 , C07D211/56
摘要： The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.
摘要翻译：本发明描述了新型亚硝化非甾体抗炎药（NSAID）及其药学上可接受的盐，以及包含至少一种亚硝化NSAID的新组合物，以及任选地至少一种捐赠，转移或释放一氧化氮的化合物，刺激一氧化氮的内源性合成升高内源性内源性松弛因子水平，或是一氧化氮合酶的底物和/或至少一种治疗剂。本发明还提供了包含至少一种亚硝化NSAID和至少一种捐赠，转移或释放一氧化氮的化合物的新型组合物，提高内源性内皮衍生的舒张因子水平，刺激一氧化氮的内源性合成，或是一氧化氮的底物合酶和/或至少一种治疗剂。本发明还提供了包含至少一种亚硝化NSAID和任选的至少一种一氧化氮供体和/或至少一种治疗剂的新型试剂盒。本发明还提供了治疗炎症，疼痛和发烧的方法; 用于治疗胃肠道疾病; 促进伤口愈合; 用于治疗和/或预防由使用非甾体抗炎化合物引起的胃肠道，肾脏和/或呼吸道毒性物质; 用于治疗炎性疾病状态和/或病症; 并用于治疗和/或预防眼科疾病和/或病症。

12. 发明申请

US20050141840A1 Laser-written cladding for waveguide formations in glass 有权
标题翻译：用于玻璃波导结构的激光写入包层
公开(公告)号：US20050141840A1
公开(公告)日：2005-06-30
申请号：US11062337
申请日：2005-02-22
申请人： Joseph Schroeder , Alexander Streltsov
发明人： Joseph Schroeder , Alexander Streltsov
IPC分类号： B23K26/00 , C03C23/00 , G02B6/13 , G02B6/10
CPC分类号： G02B6/13 , C03C23/0025 , Y10S430/146
摘要： High-energy pulses of femtosecond lasers form cladding portions of waveguides in bulk glass by producing localized reductions in refractive index. The cladding portions written by the high-energy pulses circumscribe unexposed core portions for defining light-guiding pathways in the bulk glass.
摘要翻译：飞秒激光器的高能脉冲通过产生折射率的局部降低而在体玻璃中形成波导的包层部分。由高能脉冲写入的包层部分限定未曝光的芯部分，用于限定散装玻璃中的导光路径。

13. 发明申请

US20050065161A1 Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses 审中-公开
标题翻译：亚硝化和亚硝酰化的α-肾上腺素能受体拮抗剂化合物，组合物及其用途
公开(公告)号：US20050065161A1
公开(公告)日：2005-03-24
申请号：US10951778
申请日：2004-09-29
申请人： David Garvey , Joseph Schroeder , Inigo De Tejada
发明人： David Garvey , Joseph Schroeder , Inigo De Tejada
IPC分类号： A61K45/06 , C07C381/00 , C07D211/62 , C07D233/24 , C07D239/95 , C07D401/04 , C07D405/12 , C07D459/00 , A61K31/517 , C07D43/02
CPC分类号： C07D459/00 , A61K45/06 , C07C381/00 , C07D211/62 , C07D233/24 , C07D239/95 , C07D401/04 , C07D405/12
摘要： The invention is directed to nitrosated or nitrosylated alpha-adrenergic receptor antagonists, compositions comprising alpha-adrenergic receptor antagonists that are optionally substituted with at least one NO or NO2 moiety and compounds that donate, transfer or release nitric oxide or elevate levels of endogenous endothelium-derived relaxing factor, and methods for treating sexual dysfunctions in males and females. The invention also provides methods for treating female sexual dysfunctions by administering S-nitrosothiol compounds.
摘要翻译：本发明涉及亚硝化或亚硝酰化的α-肾上腺素能受体拮抗剂，包含任选被至少一个NO或NO 2部分取代的α-肾上腺素能受体拮抗剂的组合物和捐赠，转移或释放一氧化氮或提高内源性内皮 - 衍生松弛因子，以及治疗男性和女性性功能障碍的方法。本发明还提供了通过施用S-亚硝基硫醇化合物治疗女性性功能障碍的方法。

14. 发明申请

US20070238735A1 Cyclooxygenase-2 selective inhibitors, compositions and methods of use 审中-公开
标题翻译：环氧合酶-2选择性抑制剂，组合物和使用方法
公开(公告)号：US20070238735A1
公开(公告)日：2007-10-11
申请号：US11802161
申请日：2007-05-21
申请人： David Garvey , Subhash Khanapure , Ramani Ranatunge , Stewart Richardson , Joseph Schroeder
发明人： David Garvey , Subhash Khanapure , Ramani Ranatunge , Stewart Richardson , Joseph Schroeder
IPC分类号： A61K31/495 , A61K31/415 , C07D213/00 , C07D241/10
CPC分类号： C07D213/55 , C07D213/50 , C07D231/12 , C07D231/14
摘要： The invention provides novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions and kits comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.
摘要翻译：本发明提供新型环氧合酶2（COX-2）选择性抑制剂和包含至少一种环加氧酶2（COX-2）选择性抑制剂的新型组合物和试剂盒，以及任选地，至少一种捐赠，转移或释放一氧化氮的化合物，内源性合成一氧化氮，提高内源性内源性松弛因子水平，或是一氧化氮合成酶的底物和/或至少一种治疗剂。本发明的新型环加氧酶2选择性抑制剂可以任选地亚硝化和/或亚硝化。本发明还提供了治疗炎症，疼痛和发烧的方法; 用于治疗和/或改善COX-2选择性抑制剂的胃肠性质; 促进伤口愈合; 用于治疗和/或预防肾和/或呼吸毒性; 用于治疗和/或预防由环氧合酶-2水平升高引起的其他疾病; 并用于改善COX-2选择性抑制剂的心血管外形。

15. 发明申请

US20060219807A1 Color changer for powder coating system with remote activation 审中-公开
标题翻译：换色器粉末涂料系统，远程激活
公开(公告)号：US20060219807A1
公开(公告)日：2006-10-05
申请号：US11446743
申请日：2006-06-05
申请人： Terrence Fulkerson , Terry Thompson , Jeffery Dailidas , Kenneth Kreeger , Joseph Schroeder
发明人： Terrence Fulkerson , Terry Thompson , Jeffery Dailidas , Kenneth Kreeger , Joseph Schroeder
IPC分类号： B05B15/02 , A62C31/00 , A62C5/00
CPC分类号： B05B7/1404 , B05B7/1459 , B05B7/1477 , B05B12/149 , B05B14/48
摘要： A material or color changer has a common feed passage that is connected to two or more inlet passages. The common feed passage can be reverse purged in a direction that is opposite a direction of powder flow through the common feed passage. A valve element seals a supply port that connects the inlet passage to the common feed passage to eliminate dead space and form a near bore line seal. The valve element is an elastic material that expands in response to applied compressed air inside the valve element. A remote activation function may be provided to facilitate initiating a color change procedure. In one embodiment, the remote activation function may be a pneumatic foot switch, while in another embodiment it may be an electrical switch, such as a membrane switch for example, mounted on a spray gun.
摘要翻译：材料或换色器具有连接到两个或更多个入口通道的公共进料通道。公共进料通道可以在与通过共同进料通道的粉末流动方向相反的方向上反向吹扫。阀元件密封供应端口，该供应端口将入口通道连接到公共进料通道以消除死区并形成近孔管线密封。阀元件是弹性材料，其响应于阀元件内施加的压缩空气而膨胀。可以提供远程激活功能以便于启动颜色改变过程。在一个实施例中，远程启动功能可以是气动脚踏开关，而在另一实施例中，其可以是安装在喷枪上的电开关，例如薄膜开关。

16. 发明申请

US20060194861A1 Cyclooxygenase-2 selective inhibitors, compositions and methods of use 失效
标题翻译：环氧合酶-2选择性抑制剂，组合物和使用方法
公开(公告)号：US20060194861A1
公开(公告)日：2006-08-31
申请号：US11418187
申请日：2006-05-05
申请人： Ipul Bandarage , Richard Earl , Maiko Ezawa , Xinqin Fang , David Garvey , Subhash Khanapure , Ramani Ranatunge , Stewart Richardson , Joseph Schroeder , Cheri Stevenson , Shiow-Jyi Wey
发明人： Ipul Bandarage , Richard Earl , Maiko Ezawa , Xinqin Fang , David Garvey , Subhash Khanapure , Ramani Ranatunge , Stewart Richardson , Joseph Schroeder , Cheri Stevenson , Shiow-Jyi Wey
IPC分类号： C07D231/06 , A61K31/415
CPC分类号： C07D231/12 , C07D261/08 , C07D401/04
摘要： The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one COX-2 selective inhibitor, optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.
摘要翻译：本发明描述了新型环氧合酶2（COX-2）选择性抑制剂和包含至少一种环氧合酶2（COX-2）选择性抑制剂的新型组合物，以及任选地至少一种捐赠，转移或释放一氧化氮的化合物，刺激内源性合成的一氧化氮，提高内源性内源性释放因子水平，或者是一氧化氮合酶的底物和/或至少一种治疗剂。本发明还提供了包含至少一种COX-2选择性抑制剂，任选地亚硝基化和/或亚硝基化的新的试剂盒，以及任选的至少一种一氧化氮供体，和/或任选的至少一种治疗剂。本发明的新型环加氧酶2选择性抑制剂可以任选地亚硝化和/或亚硝化。本发明还提供了治疗炎症，疼痛和发烧的方法; 用于治疗和/或改善COX-2选择性抑制剂的胃肠性质; 促进伤口愈合; 用于治疗和/或预防肾和/或呼吸毒性; 用于治疗和/或预防由环氧合酶-2水平升高引起的其他疾病; 并用于改善COX-2选择性抑制剂的心血管外形。

17. 发明申请

US20060084348A1 Method for backside sealing organic light emitting diode (OLED) displays 审中-公开
标题翻译：背面密封有机发光二极管（OLED）显示器的方法
公开(公告)号：US20060084348A1
公开(公告)日：2006-04-20
申请号：US11095144
申请日：2005-03-30
申请人： Keith Becken , Stephan Logunov , Kamjula Reddy , Joseph Schroeder , Holly Strzepek
发明人： Keith Becken , Stephan Logunov , Kamjula Reddy , Joseph Schroeder , Holly Strzepek
IPC分类号： H05B33/10 , H05B33/04
CPC分类号： C03C27/06 , H01L51/5246 , Y10T428/23 , Y10T428/24777
摘要： A hermetically sealed glass package and method for manufacturing the hermetically sealed glass package are described herein. In one embodiment, the hermetically sealed glass package is suitable to protect thin film devices which are sensitive to the ambient environment. Some examples of such glass packages are organic emitting light diode (OLED) displays, sensors, and other optical devices. The present invention is demonstrated using an OLED display as an example.
摘要翻译：本文描述了一种气密密封的玻璃封装及其制造方法。在一个实施例中，密封玻璃封装适合于保护对环境环境敏感的薄膜器件。这种玻璃封装的一些实例是有机发光二极管（OLED）显示器，传感器和其它光学器件。以OLED显示器为例进行了说明。

18. 发明申请

US20050279860A1 Color change for powder coating material application system 有权
标题翻译：粉末涂料应用系统的变色
公开(公告)号：US20050279860A1
公开(公告)日：2005-12-22
申请号：US11144878
申请日：2005-06-03
申请人： Terrence Fulkerson , Terry Thompson , Jeffery Dailidas , Kenneth Kreeger , Joseph Schroeder
发明人： Terrence Fulkerson , Terry Thompson , Jeffery Dailidas , Kenneth Kreeger , Joseph Schroeder
IPC分类号： B05B7/14 , B05B7/30 , B05B7/32 , B05B12/14 , B05B15/12 , F23D11/24 , F23D11/34 , F23D11/38 , F23D14/28 , F23D14/34 , F23D14/50 , F23D14/60
CPC分类号： B05B15/52 , B05B7/1404 , B05B7/1459 , B05B12/14 , B05B12/149 , B05B14/48
摘要： A color changer has a common feed passage that is connected to two or more inlet passages. The common feed passage can be reverse purged in a direction that is opposite a direction of powder flow through the common feed passage. A valve element seals a supply port that connects the inlet passage to the common feed passage to eliminate dead space and form a near bore line seal. The valve element is an elastic material that expands in response to applied compressed air inside the valve element.
摘要翻译：换色器具有连接到两个或更多个入口通道的公共进料通道。公共进料通道可以在与通过共同进料通道的粉末流动方向相反的方向上反向吹扫。阀元件密封供应端口，该供应端口将入口通道连接到公共进料通道以消除死区并形成近孔管线密封。阀元件是弹性材料，其响应于阀元件内施加的压缩空气而膨胀。

19. 发明申请

US20150087799A1 METHOD TO PRODUCE SEMI-CRYSTALLINE POLYLACTIDES 有权
标题翻译：生产半结晶聚乙烯的方法
公开(公告)号：US20150087799A1
公开(公告)日：2015-03-26
申请号：US14343912
申请日：2012-09-11
申请人： Hisanori Kishida , Takashi Hasegawa , Nobuyoshi Nomura , Makoto Takahashi , Joseph Schroeder , Manuel Natal
发明人： Hisanori Kishida , Takashi Hasegawa , Nobuyoshi Nomura , Makoto Takahashi , Joseph Schroeder , Manuel Natal
IPC分类号： C08G63/08
CPC分类号： C08G63/08 , C08G63/823
摘要： This invention provides a method for synthesizing semi-crystalline polylactides (PLA) even from a lactide mixture including meso-LA and rac-LA. According to the invention, when a mixture of racemic lactide and meso-lactide ispolymerized using a catalyst capable of iso-selectively polymerizing L-lactide and D-lactide, an amorphous poly (meso-lactide) block is formed from meso-lactide and a semi-crystalline poly (racemic lactide) block is formed from racemic lactide by separately polymerizing racemic lactide and meso-lactide by taking advantage of a difference in physicochemical properties between racemic lactide and meso-lactide, whereby polylactide which is semi-crystalline as a whole is produced.
摘要翻译：本发明提供了即使由包括meso-LA和rac-LA的丙交酯混合物合成半结晶聚交酯（PLA）的方法。根据本发明，当外消旋丙交酯和内消旋丙交酯的混合物使用能够同时选择性聚合L-丙交酯和D-丙交酯的催化剂进行聚合时，由内消旋丙交酯形成无定形的聚（内消旋丙交酯）嵌段，通过利用外消旋丙交酯和内消旋丙交酯之间的物理化学性质的差异，通过分别外消旋丙交酯和内消旋丙交酯聚合形成半结晶聚（外消旋丙交酯）嵌段，由此作为整体是半结晶的聚丙交酯生产。

20. 发明授权

US08463398B2 Electrode surface modification for imparting current density directionality in lead electrodes 有权
标题翻译：用于在引线电极中赋予电流密度方向性的电极表面改性
公开(公告)号：US08463398B2
公开(公告)日：2013-06-11
申请号：US12946214
申请日：2010-11-15
申请人： Timothy R. Jackson , Joseph Schroeder
发明人： Timothy R. Jackson , Joseph Schroeder
IPC分类号： A61B5/05 , A61B5/04 , A61N1/00
CPC分类号： A61N1/056 , A61N2001/0585 , Y10T29/49208
摘要： An implantable medical lead having a modified electrode surface for imparting current density directionality within an electrode is disclosed. An implantable medical lead includes a lead body having a proximal section and a distal section having a pre-biased shape configured to secure the lead to an inner wall of a blood vessel. An electrode coupled to the distal section of the lead body includes a number of surface features on an inactive portion of the electrode that impart a current density directionality towards an active portion of the electrode that contacts the inner wall of the vessel. Methods for imparting current density directionality within an implantable lead electrode are also disclosed.
摘要翻译：公开了一种植入式医用引线，其具有用于在电极内施加电流密度方向性的改性电极表面。可植入医疗引线包括具有近端部分的引线主体和具有被配置为将引线固定到血管内壁的预偏置形状的远端部分。耦合到引线主体的远端部分的电极包括在电极的非活性部分上的许多表面特征，其向接触容器的内壁的电极的有源部分赋予电流密度方向性。还公开了在可植入引线电极内赋予电流密度方向性的方法。

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