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11. 发明授权

US07879990B2 Polynucleotides encoding antibodies that bind to the C35 polypeptide 有权
标题翻译：编码结合C35多肽的抗体的多核苷酸
公开(公告)号：US07879990B2
公开(公告)日：2011-02-01
申请号：US12350944
申请日：2009-01-08
申请人： Maurice Zauderer , Elizabeth E. Evans
发明人： Maurice Zauderer , Elizabeth E. Evans
IPC分类号： C07H21/04 , C12P21/04 , C12N15/00 , A61K39/395 , C12P21/08 , C07K16/00
CPC分类号： C07K16/32 , A61K38/00 , C07K14/4748 , C07K2317/56 , C07K2319/00
摘要： The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named C35 that is overexpressed in human breast and bladder carcinoma. This invention also relates to C35 polypeptide, in particular C35 peptide epitopes and C35 peptide epitope analogs, as well as vectors, host cells, antibodies directed to C35 polypeptides, and the recombinant methods for producing the same. The present invention further relates to diagnostic methods for detecting carcinomas, including human breast carcinomas. The present invention further relates to the formulation and use of the C35 gene and polypeptides, in particular C35 peptide epitopes and C35 peptide epitope analogs, in immunogenic compositions or vaccines, to induce antibody or cell-mediated immunity against target cells, such as tumor cells, that express the C35 gene. The invention further relates to screening methods for identifying agonists and antagonists of C35 activity.
摘要翻译：本发明涉及在人癌中差异表达的新型人基因。更具体地，本发明涉及编码在人乳腺癌和膀胱癌中过表达的名为C35的新型人多肽的多核苷酸。本发明还涉及C35多肽，特别是C35肽表位和C35肽表位类似物，以及载体，宿主细胞，针对C35多肽的抗体及其制备方法。本发明还涉及用于检测癌症的诊断方法，包括人乳腺癌。本发明还涉及在免疫原性组合物或疫苗中C35基因和多肽，特别是C35肽表位和C35肽表位类似物的配制和用途，以诱导针对靶细胞例如肿瘤细胞的抗体或细胞介导的免疫，表达C35基因。本发明还涉及鉴定C35活性的激动剂和拮抗剂的筛选方法。

12. 发明授权

US07858559B2 In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells 有权
标题翻译：在真核细胞中产生和鉴定免疫球蛋白分子的体外方法
公开(公告)号：US07858559B2
公开(公告)日：2010-12-28
申请号：US09987456
申请日：2001-11-14
申请人： Maurice Zauderer , Ernest S. Smith
发明人： Maurice Zauderer , Ernest S. Smith
IPC分类号： C40B20/08 , C40B30/04 , C40B40/02 , C40B40/06 , C40B40/10 , C40B50/06 , C12N5/00 , C07K16/00 , C12N15/00
CPC分类号： C07K16/00 , C07K2317/21 , C07K2317/22 , C07K2317/55 , C07K2317/622 , C12N2799/023
摘要： The present invention relates to a high efficiency method of expressing immunoglobulin molecules in eukaryotic cells. The invention is further drawn to a method of producing immunoglobulin heavy and light chain libraries, particularly using the trimolecular recombination method, for expression in eukaryotic cells. The invention further provides methods of selecting and screening for antigen-specific immunoglobulin molecules, and antigen-specific fragments thereof. The invention also provides kits for producing, screening and selecting antigen-specific immunoglobulin molecules. Finally, the invention provides immunoglobulin molecules, and antigen-specific fragments thereof, produced by the methods provided herein.
摘要翻译：本发明涉及在真核细胞中表达免疫球蛋白分子的高效方法。本发明进一步涉及一种生产免疫球蛋白重链和轻链文库的方法，特别是使用三分子重组方法在真核细胞中表达。本发明还提供了选择和筛选抗原特异性免疫球蛋白分子及其抗原特异性片段的方法。本发明还提供用于产生，筛选和选择抗原特异性免疫球蛋白分子的试剂盒。最后，本发明提供了通过本文提供的方法产生的免疫球蛋白分子及其抗原特异性片段。

13. 发明申请

US20090305350A1 Gene Differentially Expressed in Breast and Bladder Cancer and Encoded Polypeptides 有权
公开(公告)号：US20090305350A1
公开(公告)日：2009-12-10
申请号：US12350944
申请日：2009-01-08
申请人： Maurice Zauderer , Elizabeth E. Evans
发明人： Maurice Zauderer , Elizabeth E. Evans
IPC分类号： C12P21/00 , C07H21/00 , C12N15/63 , C12N5/00
CPC分类号： C07K16/32 , A61K38/00 , C07K14/4748 , C07K2317/56 , C07K2319/00
摘要： The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named C35 that is overexpressed in human breast and bladder carcinoma. This invention also relates to C35 polypeptide, in particular C35 peptide epitopes and C35 peptide epitope analogs, as well as vectors, host cells, antibodies directed to C35 polypeptides, and the recombinant methods for producing the same. The present invention further relates to diagnostic methods for detecting carcinomas, including human breast carcinomas. The present invention further relates to the formulation and use of the C35 gene and polypeptides, in particular C35 peptide epitopes and C35 peptide epitope analogs, in immunogenic compositions or vaccines, to induce antibody or cell-mediated immunity against target cells, such as tumor cells, that express the C35 gene. The invention further relates to screening methods for identifying agonists and antagonists of C35 activity.

14. 发明授权

US07268207B2 Gene differentially expressed in breast and bladder cancer, and encoded polypeptides 失效
标题翻译：在乳腺癌和膀胱癌中差异表达的基因和编码的多肽
公开(公告)号：US07268207B2
公开(公告)日：2007-09-11
申请号：US09824787
申请日：2001-04-04
申请人： Maurice Zauderer , Elizabeth E. Evans , Melinda A. Borrello
发明人： Maurice Zauderer , Elizabeth E. Evans , Melinda A. Borrello
IPC分类号： A61K38/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07H5/00 , C07H21/02 , C07H21/00 , C08B37/00 , C08B37/08
CPC分类号： C07K14/47
摘要： The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named C35 that is overexpressed in human breast and bladder carcinoma. This invention also relates to C35 polypeptides, as well as vectors, host cells, antibodies directed to C35 polypeptides, and the recombinant methods for producing the same. The present invention further relates to diagnostic methods for detecting carcinomas, including human breast carcinomas. The present invention further relates to the formulation and use of the C35 gene and polypeptides in immunogenic compositions or vaccines, to induce antibody or cell-mediated immunity against target cells, such as tumor cells, that express the C35 gene. The invention further relates to screening methods for identifying agonists and antagonists of C35 activity.
摘要翻译：本发明涉及在人癌中差异表达的新型人基因。更具体地，本发明涉及编码在人乳腺癌和膀胱癌中过表达的名为C35的新型人多肽的多核苷酸。本发明还涉及C35多肽，以及载体，宿主细胞，针对C35多肽的抗体及其制备方法。本发明还涉及用于检测癌症的诊断方法，包括人乳腺癌。本发明还涉及C35基因和多肽在免疫原性组合物或疫苗中的配制和用途，以诱导针对表达C35基因的靶细胞例如肿瘤细胞的抗体或细胞介导的免疫。本发明还涉及鉴定C35活性的激动剂和拮抗剂的筛选方法。

15. 发明申请

US20070081942A1 Gene differentially expressed in breast and bladder cancer, and encoded polypeptides 审中-公开
标题翻译：在乳腺癌和膀胱癌中差异表达的基因和编码的多肽
公开(公告)号：US20070081942A1
公开(公告)日：2007-04-12
申请号：US11601669
申请日：2006-11-20
申请人： Maurice Zauderer , Elizabeth Evans , Melinda Borrello
发明人： Maurice Zauderer , Elizabeth Evans , Melinda Borrello
IPC分类号： A61K51/00 , C07H21/04 , C12P21/06 , A61K39/395 , C07K16/46
CPC分类号： C07K14/47
摘要： The present invention is directed to antibodies or antigen binding fragments thereof that specifically bind to the cancer specific antigen, C35. This invention also relates to a polynucleotide encoding the antibody or antigen binding fragment thereof as well as vectors and host cells comprising the polynucleotide. The present invention further relates to a composition comprising the antibody or antigen binding fragment thereof or further comprising a chemotherapeutic agent, specifically taxol. The invention is also directed to therapeutic and diagnostic methods of using antibodies against C35, preferably more than one anti-C35 antibody in combination with a chemotherapeutic agent, to treat C35 associated cancer.
摘要翻译：本发明涉及特异性结合癌症特异性抗原C35的抗体或其抗原结合片段。本发明还涉及编码抗体或其抗原结合片段的多核苷酸以及包含多核苷酸的载体和宿主细胞。本发明还涉及包含抗体或其抗原结合片段或进一步包含化学治疗剂，特别是紫杉醇的组合物。本发明还涉及使用针对C35的抗体，优选多于一种抗C35抗体与化学治疗剂组合的治疗和诊断方法来治疗C35相关癌症。

16. 发明授权

US07135278B1 Method of screening for therapeutics for infectious diseases 有权
标题翻译：传染病治疗方法筛选
公开(公告)号：US07135278B1
公开(公告)日：2006-11-14
申请号：US09966746
申请日：2001-10-01
申请人： Maurice Zauderer
发明人： Maurice Zauderer
IPC分类号： C12Q1/00 , G01N33/00 , G01N33/50 , A61K39/00 , A61K39/04 , A61K39/12
CPC分类号： G01N33/56972 , C12Q1/18 , G01N33/6854 , G01N33/6863
摘要： The present invention relates to a method of screening for a host cell gene products which are useful as therapeutics for an infective disease. This method comprises identifying genes which are differentially expressed in infected cells, and screening the differentially expressed gene products for immunogenicity.
摘要翻译：本发明涉及筛选可用作感染性疾病的治疗剂的宿主细胞基因产物的方法。该方法包括鉴定感染细胞中差异表达的基因，以及筛选差异表达的基因产物的免疫原性。

17. 发明授权

US07067251B2 Methods of directly selecting cells expressing inserts of interest 有权
标题翻译：直接选择表达目的片段的细胞的方法
公开(公告)号：US07067251B2
公开(公告)日：2006-06-27
申请号：US09818991
申请日：2001-03-28
申请人： Maurice Zauderer , Ernest S. Smith
发明人： Maurice Zauderer , Ernest S. Smith
IPC分类号： C12Q1/68 , C12N15/86 , C12N15/87 , C07H21/04
CPC分类号： C12N15/1079 , C12N15/1034 , C12N2799/023
摘要： The present invention relates to a high efficiency method of introducing DNA into linear DNA viruses such as poxvirus, a method of producing libraries in linear DNA viruses such as poxvirus, and methods of selecting polynucleotides of interest based on cell nonviability or other phenotypes.
摘要翻译：本发明涉及将DNA引入线性DNA病毒如痘病毒的高效方法，在线性DNA病毒如痘病毒中产生文库的方法，以及基于细胞不稳定性或其他表型选择目的多核苷酸的方法。

18. 发明申请

US20050158323A1 Methods of killing tumor cells by targeting internal antigens exposed on apoptotic tumor cells 审中-公开
标题翻译：通过靶向暴露于凋亡性肿瘤细胞的内部抗原来杀死肿瘤细胞的方法
公开(公告)号：US20050158323A1
公开(公告)日：2005-07-21
申请号：US11003819
申请日：2004-12-06
申请人： Elizabeth Evans , Mark Paris , Deepak Sahasrabudhe , Maurice Zauderer , Ernest Smith
发明人： Elizabeth Evans , Mark Paris , Deepak Sahasrabudhe , Maurice Zauderer , Ernest Smith
IPC分类号： A61K20060101 , A61K39/395 , C07H21/04 , C07K16/00 , C07K16/30 , C12N5/06 , G01N33/574
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/73
摘要： The invention provides in vitro and in vivo methods of killing cancer cells, including therapeutic methods in humans, and also provides antibodies specific for the cancer specific antigen C35, and polynucleotides encoding such antibodies, as well as therapeutic and diagnostic methods of using such antibodies.
摘要翻译：本发明提供了杀死癌细胞的体外和体内方法，包括在人体中的治疗方法，并且还提供了特异于癌症特异性抗原C35的抗体，以及编码这种抗体的多核苷酸以及使用这种抗体的治疗和诊断方法。

19. 发明授权

US08741810B2 In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells 有权
标题翻译：在真核细胞中产生和鉴定免疫球蛋白分子的体外方法
公开(公告)号：US08741810B2
公开(公告)日：2014-06-03
申请号：US11892027
申请日：2007-08-17
申请人： Maurice Zauderer , Ernest S. Smith
发明人： Maurice Zauderer , Ernest S. Smith
IPC分类号： C40B10/00
CPC分类号： C07K16/00 , C07K2317/21 , C07K2317/22 , C07K2317/55 , C07K2317/622 , C12N2799/023
摘要： The present invention relates to a high efficiency method of expressing immunoglobulin molecules in eukaryotic cells. The invention is further drawn to a method of producing immunoglobulin heavy and light chain libraries, particularly using the trimolecular recombination method, for expression in eukaryotic cells. The invention further provides methods of selecting and screening for antigen-specific immunoglobulin molecules, and antigen-specific fragments thereof. The invention also provides kits for producing, screening and selecting antigen-specific immunoglobulin molecules. Finally, the invention provides immunoglobulin molecules, and antigen-specific fragments thereof, produced by the methods provided herein.
摘要翻译：本发明涉及在真核细胞中表达免疫球蛋白分子的高效方法。本发明进一步涉及一种生产免疫球蛋白重链和轻链文库的方法，特别是使用三分子重组方法在真核细胞中表达。本发明还提供了选择和筛选抗原特异性免疫球蛋白分子及其抗原特异性片段的方法。本发明还提供用于产生，筛选和选择抗原特异性免疫球蛋白分子的试剂盒。最后，本发明提供了通过本文提供的方法产生的免疫球蛋白分子及其抗原特异性片段。

20. 发明授权

US08637026B2 Anti-C35 antibody combination therapies and methods 有权
标题翻译：抗C35抗体联合疗法和方法
公开(公告)号：US08637026B2
公开(公告)日：2014-01-28
申请号：US12810743
申请日：2008-12-23
申请人： Maurice Zauderer , Elizabeth E. Evans
发明人： Maurice Zauderer , Elizabeth E. Evans
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K2039/507 , A61K2039/545 , C07K16/32 , C07K2317/73
摘要： The present invention is directed to methods of killing cancer cells, the methods comprising administering at least one C35 antibody and either at least one HER2 or at least one EGFR antibody. In some embodiments, the antibodies are administered with a therapeutic agent. The present invention is further directed to C35, HER2 and EGFR antibodies useful in these methods.
摘要翻译：本发明涉及杀死癌细胞的方法，所述方法包括施用至少一种C35抗体和至少一种HER2或至少一种EGFR抗体。在一些实施方案中，抗体与治疗剂一起施用。本发明还涉及可用于这些方法的C35，HER2和EGFR抗体。

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