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11. 发明授权

US5656499A Method for performing automated hematology and cytometry analysis 失效
标题翻译：进行自动血液学和细胞分析的方法
公开(公告)号：US5656499A
公开(公告)日：1997-08-12
申请号：US482678
申请日：1995-06-07
申请人： Vernon L. Chupp , Peter E. Lobban , Young Ran Kim , Roderick Walton Larue , John Paul Stuart
发明人： Vernon L. Chupp , Peter E. Lobban , Young Ran Kim , Roderick Walton Larue , John Paul Stuart
IPC分类号： B01F5/04 , G01N1/00 , G01N15/00 , G01N15/14 , G01N35/00 , G01N35/10 , G01N33/533
CPC分类号： G01N35/109 , B01F5/0453 , B01F5/046 , G01N15/14 , G01N15/1404 , G01N35/0092 , G01N35/1004 , G01N35/1095 , G01N1/14 , G01N2015/0069 , G01N2015/0076 , G01N2015/0084 , G01N2015/1413 , G01N2035/00356 , G01N2035/00524 , G01N2035/1032 , G01N35/10 , Y10S436/805 , Y10T436/11 , Y10T436/119163 , Y10T436/25 , Y10T436/25125 , Y10T436/2575
摘要： A device for analyzing a whole blood sample is provided. The device comprises a conventionl hematology analyzer integrated with a fluorescence cyometry analyzer. A controller is provided for controlling the analyzers, obtaining and utilizing data from both and reporting a quantitative result. Methods are also provided for analyzing a whole blood sample. One such method comprises the steps of performing on a single instrument an analysis of impedance associated with the blood sample, an analysis of light scatter associated with the blood sample, and an analysis of fluorescence associated with the blood sample. Data is collected and utilized. A result is reported.
摘要翻译：提供了用于分析全血样品的装置。该装置包括与荧光测定分析仪集成的常规血液分析仪。提供控制器用于控制分析器，获得和利用来自两者的数据并报告定量结果。还提供了用于分析全血样品的方法。一种这样的方法包括以下步骤：在单个仪器上执行与血液样品相关的阻抗的分析，与血液样品相关联的光散射的分析以及与血液样品相关联的荧光的分析。收集和利用数据。结果报告。

12. 发明授权

US6114122A Fluidics station with a mounting system and method of using 失效
标题翻译：流体站具有安装系统和使用方法
公开(公告)号：US6114122A
公开(公告)日：2000-09-05
申请号：US70689
申请日：1998-04-30
申请人： Donald Besemer , Peter E. Lobban , Michael C. Norris , Steven V. Muller
发明人： Donald Besemer , Peter E. Lobban , Michael C. Norris , Steven V. Muller
IPC分类号： B01F13/00 , B01F13/02 , B01J19/00 , B01L3/00 , B01L7/00 , B01L9/00 , C40B40/06 , G01N35/00 , C12Q1/68 , C07H21/04 , F16B39/284 , G01N1/00
CPC分类号： B01L7/52 , B01F13/0059 , B01F13/02 , B01J19/0046 , B01L3/502715 , B01L9/527 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00659 , B01J2219/00689 , B01J2219/00707 , B01J2219/00722 , B01L2200/027 , B01L2200/143 , B01L2300/0636 , B01L2300/0816 , B01L2300/0877 , B01L2300/1805 , B01L2300/1822 , B01L2400/0487 , B01L3/50273 , C40B40/06 , G01N2035/00158
摘要： The present invention generally provides novel apparatuses for rapidly and efficiently carrying out repeated hybridizations of a target nucleic acid to an array of nucleic acid probes. The apparatus generally includes a fluid delivery system, a fluid mixing system, a temperature control system and a process control system integrated into a single device.
摘要翻译：本发明通常提供用于快速和有效地进行靶核酸重复杂交到核酸探针阵列的新型装置。该装置通常包括流体输送系统，流体混合系统，温度控制系统和集成到单个装置中的过程控制系统。

13. 发明申请

US20090036315A1 Device and methods for detecting and quantifying one or more target agents 审中-公开
标题翻译：用于检测和量化一种或多种目标试剂的装置和方法
公开(公告)号：US20090036315A1
公开(公告)日：2009-02-05
申请号：US11703103
申请日：2007-02-07
申请人： Marc R. Labgold , George G. Jokhadze , I-Min M. Jen , Naiping Shen , Mark T. Kozlowski , Chandramohan V. Ammini , David A. Suhy , Michael C. Norris , Peter E. Lobban
发明人： Marc R. Labgold , George G. Jokhadze , I-Min M. Jen , Naiping Shen , Mark T. Kozlowski , Chandramohan V. Ammini , David A. Suhy , Michael C. Norris , Peter E. Lobban
IPC分类号： C40B10/00 , G01N33/566 , C07H21/04 , G01N27/26 , C40B30/04 , C12Q1/68
CPC分类号： G01N33/54306
摘要： The present invention provides a device and methods for the detection and quantification of one or more target agents in a sample by rapid and specific electrochemical detection. The present invention includes kits, devices and compositions capable of performing rapid, specific and accurate detection of one or more target agents in a sample.
摘要翻译：本发明提供了一种用于通过快速和特异性电化学检测来检测和定量样品中一种或多种目标试剂的装置和方法。本发明包括能够对样品中的一种或多种靶剂进行快速，特异和准确的检测的试剂盒，装置和组合物。

14. 发明授权

US5939326A Method and apparatus for performing automated analysis 失效
标题翻译：执行自动分析的方法和装置
公开(公告)号：US5939326A
公开(公告)日：1999-08-17
申请号：US816712
申请日：1997-03-13
申请人： Vernon L. Chupp , Peter E. Lobban , Young Ran Kim , Roderick Walton Larue , John Paul Stuart
发明人： Vernon L. Chupp , Peter E. Lobban , Young Ran Kim , Roderick Walton Larue , John Paul Stuart
IPC分类号： B01F5/04 , G01N1/00 , G01N15/00 , G01N15/14 , G01N35/00 , G01N35/10 , G01N33/533
CPC分类号： G01N35/109 , B01F5/0453 , B01F5/046 , G01N15/14 , G01N15/1404 , G01N35/0092 , G01N35/1004 , G01N35/1095 , G01N1/14 , G01N2015/0069 , G01N2015/0076 , G01N2015/0084 , G01N2015/1413 , G01N2035/00356 , G01N2035/00524 , G01N2035/1032 , G01N35/10 , Y10S436/805 , Y10T436/11 , Y10T436/119163 , Y10T436/25 , Y10T436/25125 , Y10T436/2575
摘要： A device for analyzing a whole blood sample is provided. The device comprises a conventionl hematology analyzer integrated with a fluorescence cyometry analyzer. A controller is provided for controlling the analyzers, obtaining and utilizing data from both and reporting a quantitative result. Methods are also provided for analyzing a whole blood sample. One such method comprises the steps of performing on a single instrument an analysis of impedance associated with the blood sample, an analysis of light scatter associated with the blood sample, and an analysis of fluorescence associated with the blood sample. Data is collected and utilized. A result is reported.
摘要翻译：提供了用于分析全血样品的装置。该装置包括与荧光测定分析仪集成的常规血液分析仪。提供控制器用于控制分析器，获得和利用来自两者的数据并报告定量结果。还提供了用于分析全血样品的方法。一种这样的方法包括以下步骤：在单个仪器上执行与血液样品相关的阻抗的分析，与血液样品相关联的光散射的分析以及与血液样品相关联的荧光的分析。收集和利用数据。结果报告。

15. 发明授权

US06391623B1 Fluidics station injection needles with distal end and side ports and method of using 有权
标题翻译：流体站注射针头具有钝端和侧端口及使用方法
公开(公告)号：US06391623B1
公开(公告)日：2002-05-21
申请号：US09501095
申请日：2000-02-09
申请人： Donald Besemer , Peter E. Lobban , Michael C. Norris , Steven V. Muller
发明人： Donald Besemer , Peter E. Lobban , Michael C. Norris , Steven V. Muller
IPC分类号： C12M134
CPC分类号： B01L7/52 , B01F13/0059 , B01F13/02 , B01J19/0046 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00659 , B01J2219/00689 , B01J2219/00707 , B01J2219/00722 , B01L3/502715 , B01L3/50273 , B01L9/527 , B01L2200/027 , B01L2200/143 , B01L2300/0636 , B01L2300/0816 , B01L2300/0877 , B01L2300/1805 , B01L2300/1822 , B01L2400/0487 , C40B40/06 , G01N2035/00158
摘要： The present invention generally provides novel apparatuses for rapidly and efficiently carrying out repeated hybridizations of a target nucleic acid to an array of nucleic acid probes. The apparatus generally includes a fluid delivery system, a fluid mixing system, a temperature control system and a process control system integrated into a single device.
摘要翻译：本发明通常提供用于快速和有效地进行靶核酸重复杂交到核酸探针阵列的新型装置。该装置通常包括流体输送系统，流体混合系统，温度控制系统和集成到单个装置中的过程控制系统。

16. 发明授权

US06612737B1 System and method for self-calibrating measurement 有权
公开(公告)号：US06612737B1
公开(公告)日：2003-09-02
申请号：US09475209
申请日：1999-12-29
申请人： Peter E. Lobban
发明人： Peter E. Lobban
IPC分类号： G01K718
CPC分类号： G01K1/026 , G01K15/00
摘要： The present invention provides systems and methods for self-calibrated measurements, for example temperature sensing. The system includes a controller, a multiplexer of low on-resistance, at least two calibration reference resistors, and a current-to-frequency converter that performs self-calibrated temperature sensing with temperature sensing devices such as resistance temperature detectors (RTDs). In general, the system provides a self-calibrated temperature sensing by the current-to-frequency converter providing a constant voltage sequentially to at least two calibration resistors and one or more RTDs using switches of low on-resistance in the multiplexer, which is controlled by the controller. The value of one of the reference resistors provided is correlate to the resistive value of the RTD at the minimum temperature of the operating temperature range for the processing equipment to be monitored, the value of another reference resistor provided is correlate to the resistive value of the RTD at the maximum temperature of the operating temperature range for the processing equipment, and the values of the remaining reference resistors, if provided, may correlate to the resistive values of the RTD at selected intermediate temperatures within the temperature range for the processing equipment. The frequency output by the current-to-frequency converter varies directly with current variation and thus inversely with the resistance of the individual calibration resistor or RTD. The controller determines-composite resistance for the calibration resistors and RTDs inclusive of the other component connecting the calibration resistors and RTDs to the current-to-frequency converter, from the frequencies output by the current-to-frequency converter. A calculation is performed using these resistances to determine an accurate self-calibrated temperature for the RTDs and the equipment to which it is associated. Further, the present invention provides the measurement system may be constructed so as to provide self-calibrated temperature measurements of one or more locations in a processing chamber which may operate within different temperature ranges or to provide self-calibrated temperature measurements of one or more a processing chambers. The present invention may also provide even more accurate self-calibrated temperature measurements by utilizing multiple reference resistors so as to provide piecewise linear calibration within the temperature operating range of the processing equipment.

17. 发明授权

US5631165A Method for performing automated hematology and cytometry analysis 失效
标题翻译：进行自动血液学和细胞分析的方法
公开(公告)号：US5631165A
公开(公告)日：1997-05-20
申请号：US488532
申请日：1995-06-07
申请人： Vernon L. Chupp , Peter E. Lobban , Young R. Kim , Roderick W. Larue , John P. Stuart
发明人： Vernon L. Chupp , Peter E. Lobban , Young R. Kim , Roderick W. Larue , John P. Stuart
IPC分类号： B01F5/04 , G01N1/00 , G01N15/00 , G01N15/14 , G01N35/00 , G01N35/10 , G01N33/533
CPC分类号： B01F5/0453 , B01F5/046 , G01N15/14 , G01N15/1404 , G01N35/0092 , G01N35/1004 , G01N35/109 , G01N1/14 , G01N2015/0076 , G01N2015/0084 , G01N2015/1413 , G01N2035/00356 , G01N2035/00524 , G01N2035/1032 , G01N35/10 , Y10S436/805 , Y10T436/11 , Y10T436/119163 , Y10T436/25 , Y10T436/25125 , Y10T436/2575
摘要： A device for analyzing a whole blood sample is provided. The device comprises a conventional hematology analyzer integrated with a fluorescence cytometry analyzer. A controller is provided for controlling the analyzers, obtaining and utilizing data from both and reporting a quantitative result. Methods are also provided for analyzing a whole blood sample. One such method comprises the steps of performing on a single instrument an analysis of impedance associated with the blood sample, an analysis of light scatter associated with the blood sample, and an analysis of fluorescence associated with the blood sample. Data is collected and utilized. A result is reported.
摘要翻译：提供了用于分析全血样品的装置。该装置包括与荧光细胞分析仪集成的常规血液分析仪。提供控制器用于控制分析器，获得和利用来自两者的数据并报告定量结果。还提供了用于分析全血样品的方法。一种这样的方法包括以下步骤：在单个仪器上执行与血液样品相关的阻抗的分析，与血液样品相关联的光散射的分析以及与血液样品相关联的荧光的分析。收集和利用数据。结果报告。

18. 发明授权

US4622468A Fluorescence intensity compensation method and device 失效
标题翻译：荧光强度补偿方法及装置
公开(公告)号：US4622468A
公开(公告)日：1986-11-11
申请号：US754659
申请日：1985-07-15
申请人： Andrew Stefanski , Alfred H. Sturtevant , Michael G. Konicek , Peter E. Lobban
发明人： Andrew Stefanski , Alfred H. Sturtevant , Michael G. Konicek , Peter E. Lobban
IPC分类号： G01J1/36 , G01N21/64
CPC分类号： G01N21/64 , G01J1/36 , G01N2201/127 , G01N2201/12753
摘要： Variations in the intensity of a light source and the sensitivity of a fluorescence detector photo-multiplier tube are simultaneously compensated by measuring the intensity (I.sub.LS1) of the light source at the sample excitation frequency with a silicon detector, measuring the intensity (I.sub.LS2) of the light source at the emission frequency with another silicon detector, measuring with the photo-multiplier detector the intensity (I.sub.S) of the sample's fluorescence and the intensity (I.sub.LS3) of the light source at the emission frequency of the sample and then calculating a value F as representative of the sample's fluorescence according to the formula: ##EQU1##
摘要翻译：通过用硅检测器测量样品激发频率下的光源的强度（ILS1），同时补偿光源强度的变化和荧光检测器光电倍增管的灵敏度，测量光源的强度（ILS2）用另一硅检测器的发射频率的光源，用光电倍增管检测器测量样品的荧光强度（IS）和光源在样品发射频率下的强度（ILS3），然后计算值 F作为样品荧光的代表，根据以下公式：

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