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11. 发明授权

US07091007B2 DNA molecules encoding BMP receptor proteins 失效
标题翻译：编码BMP受体蛋白的DNA分子
公开(公告)号：US07091007B2
公开(公告)日：2006-08-15
申请号：US10600645
申请日：2003-06-23
申请人： John M. Wozney , Anthony J. Celeste , R. Scott Thies , Noboru Yamaji
发明人： John M. Wozney , Anthony J. Celeste , R. Scott Thies , Noboru Yamaji
IPC分类号： C12N15/00 , C12N15/85 , C12N15/63 , C07H21/04 , C07K14/00
CPC分类号： C07K14/71 , A61K38/00 , C07K14/51
摘要： Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding the BMP receptor proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to the BMP receptor proteins.
摘要翻译：公开了新的丝氨酸/苏氨酸受体蛋白质和BMP受体蛋白质，以及编码BMP受体蛋白质的DNA分子和使用受体蛋白质的方法。还公开了截短的BMP受体蛋白质和作为BMP受体蛋白质的配体的分子。

12. 发明授权

US5532339A Fusion protein between human macif and a heterologous pi anchor domain 失效
标题翻译：人类macif和异源pi锚定域之间的融合蛋白
公开(公告)号：US5532339A
公开(公告)日：1996-07-02
申请号：US291339
申请日：1994-08-17
申请人： Motowo Tomita , Yuji Sugita , Toshiyuki Takemoto , Kiyoshi Furuichi , Makoto Takayama , Ko Yasukawa , Katsuhisa Ito , Noboru Yamaji , Shinya Yano
发明人： Motowo Tomita , Yuji Sugita , Toshiyuki Takemoto , Kiyoshi Furuichi , Makoto Takayama , Ko Yasukawa , Katsuhisa Ito , Noboru Yamaji , Shinya Yano
IPC分类号： C12N1/21 , A61K38/00 , C07K4/12 , C07K14/705 , C07K14/81 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , C12R1/91 , C07K14/47 , C07K19/00
CPC分类号： C07K14/8107 , C07K14/70596 , A61K38/00
摘要： Fusion proteins comprising the extracellular domain of the human MACIF (Membrane Attack Complex Inhibition Factor) gene product and a heterologous phosphatidylinositol (PI) anchor domain are provided.
摘要翻译：提供了包含人MACIF（膜攻击复合物抑制因子）基因产物和异源磷脂酰肌醇（PI）锚结构域的细胞外结构域的融合蛋白。

13. 发明申请

US20080119404A1 Antiobesity Drug 审中-公开
标题翻译：抗肥胖药
公开(公告)号：US20080119404A1
公开(公告)日：2008-05-22
申请号：US11547567
申请日：2005-03-30
申请人： Kunio Yasunaga , Noboru Yamaji , Toshio Suda , Yuichi Oike
发明人： Kunio Yasunaga , Noboru Yamaji , Toshio Suda , Yuichi Oike
IPC分类号： A61K38/16 , A61P3/10 , A61P3/04 , A61K31/711
CPC分类号： C07K14/515 , A23L33/18 , A61K38/00 , A61K48/00
摘要： An antiobesity agent, an antidiabetic agent, and/or a hypolipidemic agent comprising an angiopoietin-related growth factor (AGF) or a polynucleotide encoding the same as an active ingredient a polypeptide are disclosed. Further, a functional food or a health food for alleviating obesity, diabetes, and/or hyperlipemia, comprising the AGF as an active ingredient is disclosed. Furthermore, a method for treating or preventing obesity, diabetes, and/or hyperlipemia, comprising administering to a subject the AGF or a polynucleotide encoding the same is disclosed. Furthermore, use of the AGF or a polynucleotide encoding the same in the manufacture of an antiobesity agent, an antidiabetic agent, and/or a hypolipidemic agent is disclosed.
摘要翻译：公开了包含血管生成素相关生长因子（AGF）的抗肥胖药，抗糖尿病药和/或降血脂剂或编码与多肽的活性成分相同的多核苷酸。此外，公开了包含AGF作为活性成分的用于减轻肥胖，糖尿病和/或高脂血症的功能性食品或保健食品。此外，公开了一种治疗或预防肥胖症，糖尿病和/或高脂血症的方法，其包括对受试者施用AGF或其编码该多核苷酸的多核苷酸。此外，公开了在制造抗肥胖剂，抗糖尿病药和/或降血脂药中使用AGF或其编码该多核苷酸的多核苷酸。

14. 发明申请

US20060172296A1 Novel gene associated with rheumatoid arthritis 审中-公开
标题翻译：与类风湿关节炎有关的新基因
公开(公告)号：US20060172296A1
公开(公告)日：2006-08-03
申请号：US10521940
申请日：2003-07-18
申请人： Masahiro Takeuchi , Noboru Yamaji , Jun Takasaki , Masahiko Akamatsu , Kazuhisa Tsunoyama , Masayoshi Harigai
发明人： Masahiro Takeuchi , Noboru Yamaji , Jun Takasaki , Masahiko Akamatsu , Kazuhisa Tsunoyama , Masayoshi Harigai
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/54
CPC分类号： C07K14/4713 , C12Q1/6883 , C12Q2600/158
摘要： It is disclosed that novel polypeptides which has enhanced expression levels in the synovial tissues of human chronic rheumatoid arthritis (RA) patients compared with the synovial tissues of human osteoarthritis (OA) patients, polynucleotides encoding the polypeptides, vectors comprising the polynucleotides, transformant cells comprising the vectors and an antibody against the polypeptide. It is also disclosed that polynucleotides specifically hybridizing with the polynucleotides and having at least 15 nucleotides, a detection method which is useful for RA diagnosis, and a detection kit which is useful for RA diagnosis.
摘要翻译：公开了与人类骨关节炎（OA）患者的滑膜组织相比，在人类慢性类风湿性关节炎（RA）患者的滑膜组织中具有增强的表达水平的新型多肽，编码多肽的多核苷酸，包含多核苷酸的载体，转化体细胞包含载体和针对多肽的抗体。还公开了与多核苷酸特异性杂交并具有至少15个核苷酸的多核苷酸，可用于RA诊断的检测方法以及可用于RA诊断的检测试剂盒。

15. 发明申请

US20050272647A1 Arthrodial cartilage extracellular matrix degradation inhibitor 审中-公开
标题翻译：关节软骨细胞外基质降解抑制剂
公开(公告)号：US20050272647A1
公开(公告)日：2005-12-08
申请号：US10525015
申请日：2003-08-19
申请人： Noboru Yamaji , Nobuaki Shindou , Yoh Terada
发明人： Noboru Yamaji , Nobuaki Shindou , Yoh Terada
IPC分类号： A61K31/00 , A61K31/16 , A61K31/167 , A61K31/19 , A61K31/4045 , A61K31/4406 , A61K38/15 , A61P19/02 , A61P43/00 , A61K38/12
CPC分类号： A61K31/4406 , A61K31/00 , A61K31/16 , A61K31/167 , A61K31/19 , A61K31/4045 , A61K38/15
摘要： An agent for inhibiting articular cartilage extracellular matrix degradation of the present invention, comprising a histone deacetylase-inhibiting compound as an active ingredient, is effective for the prevention and treatment of diseases and pathological conditions involving the degradation and degeneration of the articular cartilage extracellular matrix, in particular, arthrosteitis, rheumatic arthritis, osteoarthritis, and the like.
摘要翻译：包含组蛋白脱乙酰酶抑制化合物作为活性成分的本发明抑制关节软骨细胞外基质降解的药剂对于预防和治疗涉及关节软骨细胞外基质降解和变性的疾病和病理状况是有效的，特别是关节炎，风湿性关节炎，骨关节炎等。

16. 发明授权

US06610513B2 Receptor proteins 失效
标题翻译：受体蛋白
公开(公告)号：US06610513B2
公开(公告)日：2003-08-26
申请号：US09874628
申请日：2001-06-05
申请人： John M. Wozney , Anthony J. Celeste , R. Scott Thies , Noboru Yamaji
发明人： John M. Wozney , Anthony J. Celeste , R. Scott Thies , Noboru Yamaji
IPC分类号： C12P2106
CPC分类号： C07K14/71 , A61K38/00 , C07K14/51
摘要： Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding these proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to these BMP receptor proteins.
摘要翻译：公开了新的丝氨酸/苏氨酸受体蛋白质和BMP受体蛋白质，以及编码这些蛋白质的DNA分子和使用受体蛋白质的方法。进一步公开的是截短的BMP受体蛋白质和作为这些BMP受体蛋白质的配体的分子。

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