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11. 发明申请

US20050220744A1 Polysaccharide/functional compound complex 审中-公开
标题翻译：多糖/功能复合物
公开(公告)号：US20050220744A1
公开(公告)日：2005-10-06
申请号：US11088794
申请日：2005-03-25
申请人： Motoaki Kamachi , Harumi Kamachi , Toyoji Kakuchi , Toshifumi Satoh
发明人： Motoaki Kamachi , Harumi Kamachi , Toyoji Kakuchi , Toshifumi Satoh
IPC分类号： A61K8/67 , A61K8/73 , A61Q19/00 , A61K7/06
CPC分类号： A61Q19/00 , A61K8/676 , A61K8/73
摘要： The present invention provides a polysaccharide/functional compound complex comprising a functional compound and a multi-branched polysaccharide derivative, wherein the multi-branched polysaccharide derivative has a skeleton of a multi-branched polysaccharide composed of a saccharide as a structural unit, and at least one of the hydroxyl groups (OH) of the multi-branched polysaccharide is substituted by OR, wherein R represents a hydrogen atom, a hydrocarbon having 1 to 30 carbon atoms, or a hydrocarbon having 1 to 30 carbon atoms and hetero atom. The functional compound can be efficiently incorporated into polysaccharide derivative, and further by exposing the polysaccharide complex to an environment such as a solution, sustained release of the functional compound can be controlled. By utilizing this property, the complex can be efficiently used in external preparations for skin such as cosmetic products.
摘要翻译：本发明提供了包含功能化合物和多支链多糖衍生物的多糖/功能性复合络合物，其中，多支链多糖衍生物具有由糖类作为结构单元构成的多支链多糖的骨架，至少多支链多糖的羟基（OH）之一被OR取代，其中R表示氢原子，具有1至30个碳原子的烃或具有1至30个碳原子的烃和杂原子。功能性化合物可以有效地并入多糖衍生物中，并且通过将多糖复合物暴露于溶液等环境，可以控制功能性化合物的持续释放。通过利用该性质，可以将复合物有效地用于外用的化妆品等皮肤制剂。

12. 发明授权

US07943351B2 Method for acyltransferase reaction using acyl coenzyme A 有权
标题翻译：使用酰基辅酶A进行酰基转移酶反应的方法
公开(公告)号：US07943351B2
公开(公告)日：2011-05-17
申请号：US12277622
申请日：2008-11-25
申请人： Motoaki Kamachi , Harumi Kamachi , Hirobumi Aoki , Tomoki Erata , Kenji Tajima
发明人： Motoaki Kamachi , Harumi Kamachi , Hirobumi Aoki , Tomoki Erata , Kenji Tajima
IPC分类号： C12P11/00 , C12P7/64 , C12P7/62
CPC分类号： C12P13/02 , C12N9/1029 , C12P7/625 , C12P13/001
摘要： The present invention relates to a method for acyltransferase reaction in which an acyl group of acyl coenzyme A is transferred to an acyl group receptor characterized in that the reaction is carried out by production and/or reproduction of acyl coenzyme A from coenzyme A in a reaction system by a chemical thioester exchange reaction with acylthioester. The present invention, wherein expensive acyl CoA is reproduced nonenzymatically in a reaction system, enables to continuously carry out acyltransferase reaction only by putting a small amount of acyl CoA with a donor and a receptor of an acyl group into a system. Accordingly, the method of the present invention can be applied to an industrial production method of various kinds of compounds including useful biological molecules and synthesis of polymers such as polyester.
摘要翻译：本发明涉及一种酰基转移酶反应的方法，其中酰基辅酶A的酰基被转移到酰基基团受体中，其特征在于反应是通过在反应中由辅酶A生产和/或再生酰基辅酶A 系统通过化学硫酯与酰基硫酯交换反应。其中昂贵的酰基CoA在反应体系中非酶原地再生的本发明使得能够仅通过将少量酰基辅酶A与酰基的供体和受体一起投入系统而连续进行酰基转移酶反应。因此，本发明的方法可以应用于包括有用的生物分子和聚合物如聚酯的合成的各种化合物的工业生产方法。

13. 发明申请

US20080085251A1 Hair Processing Agent And Method For Permanent Waving Hair 有权
标题翻译：头发处理剂及烫发方法
公开(公告)号：US20080085251A1
公开(公告)日：2008-04-10
申请号：US11792828
申请日：2005-12-20
申请人： Akira Shibuya , Hidemasa Aoki , Makoto Saito , Motoaki Kamachi , Atsushi Tsuchiya , Akio Okamura
发明人： Akira Shibuya , Hidemasa Aoki , Makoto Saito , Motoaki Kamachi , Atsushi Tsuchiya , Akio Okamura
IPC分类号： A61K8/46 , A61Q5/04
CPC分类号： A61K8/4933 , A61Q5/04
摘要： Provided are hair processing agents capable of permanent waving hair even at a neutral to weakly acidic pH range that causes less irritation to the skin, and hair processing agents in which an unpleasant odor is masked. Hair processing agents contain at least one compound represented by the formula (2). Hair processing agents contain a compound of the formula (2) and at least one compound (ii) selected from thioglycolic acid, thiolactic acid, cysteine, acetylcysteine, cysteamine, acylcysteamine, salts thereof and ester derivatives thereof. Hair processing agents contain a compound of the formula (2), a surfactant and water, and are emulsified. Hair processing agents contain a compound of the formula (2) and a specific perfume. wherein X is a structure selected from —O—, —S—, —NH— and —NR1—; R1 is an alkyl group of 1 to 6 carbon atoms; Y is an oxygen atom or a sulfur atom; in the formula (1), Z is a divalent organic residue having at least one mercapto group; in the formula (2), R is a divalent organic residue optionally having a mercapto group; and R2 is a hydrogen atom or an alkyl group of 1 to 6 carbon atoms.
摘要翻译：提供即使在对皮肤刺激较少的中性至弱酸性pH范围也能永久挥发头发的头发加工剂，以及掩盖有令人不愉快的气味的毛发加工剂。头发处理剂含有至少一种式（2）表示的化合物。头发处理剂含有式（2）化合物和至少一种选自巯基乙酸，硫代乳酸，半胱氨酸，乙酰半胱氨酸，半胱胺，酰基半胱胺，其盐和其酯衍生物的化合物（ii）。头发处理剂含有式（2）的化合物，表面活性剂和水，并被乳化。头发处理剂含有式（2）的化合物和特定的香料。其中X是选自-O - ， - S - ， - NH-和-NR 1 - 的结构。 R 1是1至6个碳原子的烷基; Y是氧原子或硫原子; 在式（1）中，Z是具有至少一个巯基的二价有机残基; 在式（2）中，R是任选具有巯基的二价有机残基; R 2是氢原子或1〜6个碳原子的烷基。

14. 发明申请

US20070202070A1 Moisture Retention Polymer Compound 审中-公开
标题翻译：保湿性高分子化合物
公开(公告)号：US20070202070A1
公开(公告)日：2007-08-30
申请号：US10594925
申请日：2005-03-25
申请人： Motoaki Kamachi , Toyoji Kakuchi , Toshifumi Satoh
发明人： Motoaki Kamachi , Toyoji Kakuchi , Toshifumi Satoh
IPC分类号： A61K8/73 , C08G63/91 , C08F20/00
CPC分类号： A61K8/73 , A61K2800/54 , A61Q19/00 , C08B37/00 , C08B37/0006 , C08G18/6283 , C08G18/6484 , C08G18/73 , C08G83/003 , C08L5/00
摘要： The present invention relates to (1) a moisture retention polymer compound comprising a structural unit including a multi-branched polysaccharide derivative in which the hydroxyl group (OH) may be substituted by OR wherein R represents a hydrogen atom, a hydrocarbon having 1 to 30 carbon atoms, or a hydrocarbon having 1 to 30 carbon atoms and a hetero atom, and a structural unit without a multi-branched polysaccharide derivative, (2) an external preparation for skin comprising 0.1 to 99.9% by mass of the polymer compound, which can provide moist feeling to the skin and exhibit an appropriate viscosity and solubility, and (3) a cosmetic product comprising the external preparation for skin.
摘要翻译：本发明涉及（1）一种保湿性高分子化合物，其含有包含多支链多糖衍生物的结构单元，其中羟基（OH）可以被OR取代，其中R表示氢原子，具有1〜30个碳原子或碳原子数1〜30的烃和杂原子，以及不含多支链多糖衍生物的结构单元，（2）皮肤外用剂，含有0.1〜99.9质量％的高分子化合物，其中，可以赋予皮肤湿润的感觉并显示适当的粘度和溶解性，和（3）包含外用皮肤外用剂的化妆品。

15. 发明授权

US06379935B1 Method of producing &agr;-halo-&agr;,&bgr;-saturated carbonyl compounds from the corresponding &agr;,&bgr;-unsaturated compounds 失效
标题翻译：从相应的α，β-不饱和化合物生产α-卤代-α，β-饱和羰基化合物的方法
公开(公告)号：US06379935B1
公开(公告)日：2002-04-30
申请号：US09369144
申请日：1999-08-05
申请人： Harumi Kamachi , Tadashi Yoneda , Motoaki Kamachi , Nobuyoshi Esaki
发明人： Harumi Kamachi , Tadashi Yoneda , Motoaki Kamachi , Nobuyoshi Esaki
IPC分类号： C12P1710
CPC分类号： C12P7/24 , C12P7/40 , C12P7/52
摘要： A method of producing an &agr;-halo-&agr;,&bgr;-saturated carbonyl compound from an &agr;-halocarbonyl compound having an &agr;, &bgr;-carbon-carbon double bond by reducing said &agr;,&bgr;-carbon-carbon double bond using a microorganism belonging to any one of the genera Acetobacter, Actinomyces, Acinetobacter, Agrobacterium, Aeromonas, Alcaligenes, Arthrobacter, Azotobacter, Bacillus, Brevibacterium, Burkholderia, Cellulomonas, Corynebacterium, Enterobacter, Enterococcus, Escherichia, Flavobacterium, Gluconobacter, Halobacteium, Halococccus, Klebsiella, Lactobacillus, Microbacterium, Micrococcus, Micropolyspora, Mycobacterium, Nocardia, Pseudomonas, Pseudonocardia, Rhodococcus, Rhodobacter, Serratia, Staphylococcus, Streptococcus and Streptomyces, Xanthomonas, or a microbial product thereof. Pseudomonas sp. SD810, SD811 and SD812, Burkholderia sp. SD 816, and mutants thereof having an activity of reducing the &agr;,&bgr;-carbon-carbon double bond of an a-halocarbonyl compound having an &agr;, &bgr;-carbon-carbon double bond.
摘要翻译：一种由具有α，β-碳 - 碳双键的α-卤代羰基化合物生产α-卤代-α，β-饱和羰基化合物的方法，通过使用属于醋杆菌属，放线菌属，不动杆菌属，农杆菌属，气单胞菌属，产碱杆菌属，节杆菌属，固氮菌属，芽孢杆菌属，短杆菌属，伯克霍尔德杆菌属，丝杆菌属，棒状杆菌属，肠杆菌属，肠球菌属，棒状杆菌属，黄杆菌属，葡萄球菌属，卤杆菌属，卤杆菌属，克雷伯菌属，乳杆菌属，微杆菌属，微球菌，微孢子虫，分枝杆菌，诺卡氏菌，假单胞菌属，假诺卡氏菌属，红球菌属，红细菌属，沙雷氏菌属，葡萄球菌属，链球菌属和链霉菌属，黄单胞菌属或其微生物产物。假单胞菌属伯克霍尔德氏菌属SD810，SD811和SD812 SD 816及其具有降低具有α，β-碳 - 碳双键的α-卤代羰基化合物的α，β-碳 - 碳双键活性的突变体。

16. 发明申请

US20070232698A1 Slimming Skin External Preparation and Cosmetic Containing the Same 审中-公开
标题翻译：减肥皮肤外用制剂和化妆品含有它
公开(公告)号：US20070232698A1
公开(公告)日：2007-10-04
申请号：US11597884
申请日：2005-05-31
申请人： Akira Shibuya , Eiko Kato , Motoaki Kamachi , Hirobumi Aoki
发明人： Akira Shibuya , Eiko Kato , Motoaki Kamachi , Hirobumi Aoki
IPC分类号： A61K31/195
CPC分类号： A61K8/365 , A61K8/44 , A61K8/676 , A61K8/678 , A61K31/195 , A61Q19/06
摘要： The invention provides a slimming skin external preparation and a cosmetic that contain a carnitine derivative having excellent skin affinity and percutaneous absorption properties and capable of enhancing the fat metabolism, and that can treat, reduce or prevent the obesity by functioning as a lipolytic agent to enhance the fat metabolism of general or local subcutaneous fat tissues. The slimming skin external preparation contains a particular carnitine derivative and preferably other slimming and skin-care ingredients.
摘要翻译：本发明提供了一种减肥皮肤外用剂和化妆品，其含有具有优异的皮肤亲和性和经皮吸收性能并能够增强脂肪代谢的肉碱衍生物，并且可以通过用作促脂肪分解剂来治疗，减少或预防肥胖症一般或局部皮下脂肪组织的脂肪代谢。减肥皮肤外用制剂含有特定的肉碱衍生物，优选其它减肥和护肤成分。

17. 发明申请

US20060148048A1 Process for acyl-transfer enzyme reactions with acyl-coenzyme a 有权
标题翻译：用酰基辅酶a进行酰基转移酶反应的方法
公开(公告)号：US20060148048A1
公开(公告)日：2006-07-06
申请号：US10542733
申请日：2004-01-21
申请人： Motoaki Kamachi , Harumi Kamachi , Hirobumi Aoki , Tomoki Erata , Kenji Tajima
发明人： Motoaki Kamachi , Harumi Kamachi , Hirobumi Aoki , Tomoki Erata , Kenji Tajima
IPC分类号： C12P7/64 , C12P7/62
CPC分类号： C12P13/02 , C12N9/1029 , C12P7/625 , C12P13/001
摘要： The present invention relates to a method for acyltransferase reaction in which an acyl group of acyl coenzyme A is transferred to an acyl group receptor characterized in that the reaction is carried out by production and/or reproduction of acyl coenzyme A from coenzyme A in a reaction system by a chemical thioester exchange reaction with acylthioester. The present invention, wherein expensive acyl CoA is reproduced nonenzymatically in a reaction system, enables to continuously carry out acyltransferase reaction only by putting a small amount of acyl CoA with a donor and a receptor of an acyl group into a system. Accordingly, the method of the present invention can be applied to an industrial production method of various kinds of compounds including useful biological molecules and synthesis of polylmers such as polyester.
摘要翻译：本发明涉及一种酰基转移酶反应的方法，其中酰基辅酶A的酰基被转移到酰基基团受体中，其特征在于反应是通过在反应中由辅酶A生产和/或再生酰基辅酶A 系统通过化学硫酯与酰基硫酯交换反应。其中昂贵的酰基CoA在反应体系中非酶原地再生的本发明使得能够仅通过将少量酰基辅酶A与酰基的供体和受体一起投入系统而连续进行酰基转移酶反应。因此，本发明的方法可以应用于包括有用的生物分子和聚合物如聚酯的合成的各种化合物的工业生产方法。

18. 发明申请

US20050022952A1 Method for producing cellulose derivatives 审中-公开
标题翻译：纤维素衍生物的制造方法
公开(公告)号：US20050022952A1
公开(公告)日：2005-02-03
申请号：US10925099
申请日：2004-08-24
申请人： Yoshitaka Noguchi , Motoaki Kamachi
发明人： Yoshitaka Noguchi , Motoaki Kamachi
IPC分类号： C08B11/00 , C08B11/02 , C08B11/12 , C12N9/24 , C12P19/04 , D21C1/00 , D21C9/00
CPC分类号： C08B11/02 , C08B11/00 , C08B11/12 , D21C9/002
摘要： Pulp is treated with a hemicellulase, e.g. a xylanase such as that derived from Bacillus sp. SD902, prior to being chemically modified. This results in excellent cellulose derivatives that could not be obtained by any conventional methods. Specifically, the cellulose derivatives produced by this method have improved filterability and increased water-solubility. In addition, according to this method, the formation of microgel is minimized, and the distribution of the substituents in the cellulose derivatives through the intramolecular substitution in the method is made more uniform.
摘要翻译：纸浆用半纤维素酶处理，例如例如衍生自芽孢杆菌属（Bacillus sp。）的木聚糖酶。 SD902，化学改性之前。这导致了通过任何常规方法无法获得的优异的纤维素衍生物。具体地说，通过该方法制造的纤维素衍生物具有改善的过滤性和增加的水溶性。此外，根据该方法，使微凝胶的形成最小化，并且通过该方法中的分子内取代使纤维素衍生物中的取代基的分布更均匀。

19. 发明授权

US06645752B2 Microorganisms useful in a method of producing &agr;-halo-&agr;, &bgr;-saturated carbonyl compounds 失效
标题翻译：用于生产α-卤代-α，β-饱和羰基化合物的方法的微生物
公开(公告)号：US06645752B2
公开(公告)日：2003-11-11
申请号：US09962252
申请日：2001-09-26
申请人： Harumi Kamachi , Tadashi Yoneda , Motoaki Kamachi , Nobuyoshi Esaki
发明人： Harumi Kamachi , Tadashi Yoneda , Motoaki Kamachi , Nobuyoshi Esaki
IPC分类号： C12N112
CPC分类号： C12P7/24 , C12P7/40 , C12P7/52
摘要： A method of producing an &agr;-halo-&agr;,&bgr;-saturated carbonyl compound from an &agr;-halocarbonyl compound having an &agr;,&bgr;-carbon-carbon double bond by reducing said &agr;,&bgr;-carbon-carbon double bond using a microorganism belonging to any one of the genera Acetobacter, Actinomyces, Acinetobacter, Agrobacterium, Aeromonas, Alcaligenes, Arthrobacter, Azotobacter, Bacillus, Brevibacterium, Burkholderia, Cellulomonas, Corynebacterium, Enterobacter, Enterococcus, Escherichia, Flavobacterium, Gluconobacter, Halobacteium, Halococccus, Klebsiella, Lactobacillus, Microbacterium, Micrococcus, Micropolyspora, Mycobacterium, Nocardia, Pseudomonas, Pseudonocardia, Rhodococcus, Rhodobacter, Serratia, Staphylococcus, Streptococcus and Streptomyces, Xanthomonas, or a microbial product thereof. Pseudomonas sp. SD810, SD811 and SD812, Burkholderia sp. SD 816, and mutants thereof having an activity of reducing the &agr;,&bgr;-carbon-carbon double bond of an &agr;-halocarbonyl compound having an &agr;,&bgr;-carbon-carbon double bond.
摘要翻译：一种由具有α，β-碳 - 碳双键的α-卤代羰基化合物生产α-卤代-α，β-饱和羰基化合物的方法，通过使用属于醋杆菌属，放线菌属，不动杆菌属，农杆菌属，气单胞菌属，产碱杆菌属，节杆菌属，固氮菌属，芽孢杆菌属，短杆菌属，伯克霍尔德杆菌属，丝杆菌属，棒状杆菌属，肠杆菌属，肠球菌属，棒状杆菌属，黄杆菌属，葡萄球菌属，卤杆菌属，卤杆菌属，克雷伯菌属，乳杆菌属，微杆菌属，微球菌，微孢子虫，分枝杆菌，诺卡氏菌，假单胞菌属，假诺卡氏菌属，红球菌属，红细菌属，沙雷氏菌属，葡萄球菌属，链球菌属和链霉菌属，黄单胞菌属或其微生物产物。假单胞菌属伯克霍尔德氏菌属SD810，SD811和SD812 SD 816及其具有降低具有α，β-碳 - 碳双键的α-卤代羰基化合物的α，β-碳 - 碳双键活性的突变体。

20. 发明授权

US08961946B2 Hair processing agent and method for permanent waving hair 有权
标题翻译：头发处理剂及烫发方法
公开(公告)号：US08961946B2
公开(公告)日：2015-02-24
申请号：US11792828
申请日：2005-12-20
申请人： Akira Shibuya , Hidemasa Aoki , Makoto Saito , Motoaki Kamachi , Atsushi Tsuchiya , Akio Okamura
发明人： Akira Shibuya , Hidemasa Aoki , Makoto Saito , Motoaki Kamachi , Atsushi Tsuchiya , Akio Okamura
IPC分类号： A61K8/46 , A61Q5/04 , A61K8/49
CPC分类号： A61K8/4933 , A61Q5/04
摘要： Provided are hair processing agents capable of permanent waving hair even at a neutral to weakly acidic pH range that causes less irritation to the skin, and hair processing agents in which an unpleasant odor is masked. Hair processing agents contain at least one compound represented by the formula (2). Hair processing agents contain a compound of the formula (2) and at least one compound (ii) selected from thioglycolic acid, thiolactic acid, cysteine, acetylcysteine, cysteamine, acylcysteamine, salts thereof and ester derivatives thereof. Hair processing agents contain a compound of the formula (2), a surfactant and water, and are emulsified. Hair processing agents contain a compound of the formula (2) and a specific perfume. wherein X is a structure selected from —O—, —S—, —NH— and —NR1—; R1 is an alkyl group of 1 to 6 carbon atoms; Y is an oxygen atom or a sulfur atom; in the formula (1), Z is a divalent organic residue having at least one mercapto group; in the formula (2), R is a divalent organic residue optionally having a mercapto group; and R2 is a hydrogen atom or an alkyl group of 1 to 6 carbon atoms.
摘要翻译：提供即使在对皮肤刺激较少的中性至弱酸性pH范围也能永久挥发头发的头发加工剂，以及掩盖有令人不愉快的气味的毛发加工剂。头发处理剂含有至少一种式（2）表示的化合物。头发处理剂含有式（2）化合物和至少一种选自巯基乙酸，硫代乳酸，半胱氨酸，乙酰半胱氨酸，半胱胺，酰基半胱胺，其盐和其酯衍生物的化合物（ii）。头发处理剂含有式（2）的化合物，表面活性剂和水，并被乳化。头发处理剂含有式（2）的化合物和特定的香料。其中X是选自-O - ， - S - ， - NH-和-NR 1 - 的结构。 R1是1-6个碳原子的烷基; Y是氧原子或硫原子; 在式（1）中，Z是具有至少一个巯基的二价有机残基; 在式（2）中，R是任选具有巯基的二价有机残基; R2为氢原子或碳原子数1〜6的烷基。

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