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11. 发明申请

US20130266484A1 AUTOMATIC ANALYZER 审中-公开
标题翻译：自动分析仪
公开(公告)号：US20130266484A1
公开(公告)日：2013-10-10
申请号：US13988069
申请日：2011-10-17
申请人： Kumiko Kamihara , Tomonori Mimura
发明人： Kumiko Kamihara , Tomonori Mimura
IPC分类号： G01N21/59
CPC分类号： G01N21/59 , G01N35/00613 , G01N35/00663 , G01N35/00732 , G01N2035/00851
摘要： Realized is an automatic analyzer that allows appropriate setting of analytical parameters which incorporate batch-to-batch variations in characteristics of reagents. The analytical parameters 35, consisting of fixed parameters 37 and variable parameters 38, are stored into a storage unit of the automatic analyzer. The fixed parameters 37 include a reagent-dispensing quantity, a sample-dispensing quantity, measuring wavelength, and the like, each of which becomes a pivot for measurement of a sample, and parameters to be used are selected from an item code and bottle code assigned to a reagent bottle 36. The variable parameters 38 include a linearity check value, a prozone check value, reaction limit absorbance, technical limits, first standard solution absorbance, variation allowable absorbance, and the like, each of which is associated with sample-measurement result checks. The variable parameters 38 have a plurality of versions, and the automatic analyzer has a control unit, which reads bar code information from the reagent bottle and adopts variable parameters of a corresponding version with the item code, the bottle code, and batch information relating to the reagent, as a key.
摘要翻译：实现了一种自动分析仪，允许适当设置分析参数，这些分析参数包含试剂特性的批次间变化。由固定参数37和可变参数38组成的分析参数35被存储在自动分析器的存储单元中。固定参数37包括试剂分注量，样品分注量，测量波长等，其每一个都成为样品的测量的枢轴，并且要使用的参数从项目代码和瓶子代码中选择分配给试剂瓶36.可变参数38包括线性检验值，前区检验值，反应极限吸光度，技术限度，第一标准溶液吸光度，变化允许吸光度等，其中每一个与样品 - 测量结果检查。可变参数38具有多个版本，并且自动分析器具有控制单元，其从试剂瓶读取条形码信息，并且采用相应版本的可变参数与项目代码，瓶子代码以及与试剂，作为关键。

12. 发明授权

US08524153B2 Quality control system 有权
标题翻译：质量控制体系
公开(公告)号：US08524153B2
公开(公告)日：2013-09-03
申请号：US11710424
申请日：2007-02-26
申请人： Tomonori Mimura , Kazumitsu Kawase
发明人： Tomonori Mimura , Kazumitsu Kawase
IPC分类号： G01N21/00
CPC分类号： G01N35/00603 , G01N35/00613 , G01N35/00712 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/2575
摘要： In a clinical laboratory of a hospital, an enormous amount of effort has been required to maintain the quality of an analyzer, standard solution and control samples. An object of the present invention is to provide a control method for controlling a clinical laboratory with reduced cost, and a control apparatus using the same.In order to control data of an analyzer, standard solution, and a control sample, a support center is connected to each analyzer located in each hospital through a network line. Various kinds of analysis parameters and the result of measurements are exchanged so as to provide each clinical laboratory with a control situation in real time.
摘要翻译：在医院的临床实验室，需要大量的努力来保持分析仪，标准溶液和对照样品的质量。本发明的目的是提供一种用于以降低的成本控制临床实验室的控制方法和使用该控制方法的控制装置。为了控制分析仪，标准解决方案和控制样本的数据，支持中心通过网络线连接到位于每个医院的每个分析仪。交换各种分析参数和测量结果，以便为每个临床实验室提供实时的控制情况。

13. 发明申请

US20130046480A1 AUTOMATIC ANALYSIS DEVICE AND AUTOMATIC ANALYSIS METHOD 审中-公开
标题翻译：自动分析装置及自动分析方法
公开(公告)号：US20130046480A1
公开(公告)日：2013-02-21
申请号：US13641881
申请日：2011-04-05
申请人： Chihiro Manri , Satoshi Mitsuyama , Tomonori Mimura , Kumiko Kamihara
发明人： Chihiro Manri , Satoshi Mitsuyama , Tomonori Mimura , Kumiko Kamihara
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： G01N21/272 , G01N21/78 , G01N35/00584 , G01N35/00693 , G01N2035/00465
摘要： There is provided a technique for automatically determining or predicting a line range specific to a sample that appears in a reaction curve in an automated analyzer for mixing a specimen and a reagent and measuring a change in a mixture of the specimen and the reagent with time. This invention approximates reaction curve data by a function and automatically determines a curve part at an early stage or a second stage of a reaction. The invention determines a line range not including a curve part for each sample and calculates a laboratory test value using absorbance data within the determined line range. This invention also automatically determines a start time of line at the early stage of the reaction on the basis of absorbance data obtained up to a point halfway through the reaction curve, predicts a line range on the basis of the end time of line and a planned end time of line, and calculates a predictive value on the basis of a result of the prediction.
摘要翻译：提供了一种用于自动确定或预测在自动分析器中出现在反应曲线中的样品特异性的线范围的技术，用于混合样品和试剂，并测量样品和试剂的混合物随时间的变化。本发明通过功能近似反应曲线数据，并在反应的早期阶段或第二阶段自动确定曲线部分。本发明确定不包括每个样品的曲线部分的线范围，并使用确定的线范围内的吸光度数据计算实验室测试值。本发明还根据通过反应曲线中途的一点获得的吸光度数据自动确定反应初期的起始时间，基于线的结束时间和计划的预测线范围并且基于预测结果来计算预测值。

14. 发明申请

US20120065898A1 AUTOMATIC ANALYZER 有权
标题翻译：自动分析仪
公开(公告)号：US20120065898A1
公开(公告)日：2012-03-15
申请号：US13318819
申请日：2010-04-12
申请人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
发明人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： G01N35/00613 , G01N2035/0097
摘要： To change a photometric time for each item or to change a measurement time for each specimen so that time required for biochemical measurement can be reduced, an index that indicates an end of a reaction is required. Unfortunately, however, no methods have been available for determining the end of the reaction. In measuring a substance to be measured contained in a sample, a parameter in an approximate expression is calculated using a measured value that changes with time, a degree of convergence of a reaction is determined according to a degree of convergence of the parameter, and a measured value at the end of the reaction is calculated using the parameter at a point in time at which it is determined that the reaction has converged.
摘要翻译：要更改每个项目的光度时间或更改每个样品的测量时间，以便可以减少生物化学测量所需的时间，则需要指示反应结束的指标。然而，不幸的是，没有方法可用于确定反应的结束。在测定样品中含有的待测物质时，使用随时间变化的测定值来计算近似表达式中的参数，根据参数的收敛程度确定反应的收敛程度，使用在确定反应已经收敛的时间点的参数来计算反应结束时的测量值。

15. 发明申请

US20110301917A1 AUTOMATIC ANALYZER 有权
标题翻译：自动分析仪
公开(公告)号：US20110301917A1
公开(公告)日：2011-12-08
申请号：US13133655
申请日：2009-11-11
申请人： Kumiko Kamihara , Tomonori Mimura
发明人： Kumiko Kamihara , Tomonori Mimura
IPC分类号： G06F17/18
CPC分类号： G01N35/00693 , G01N35/00603 , G06F17/18
摘要： Abnormality causes are automatically identified during daily quality control, based on the focused consideration of complex uncertainty factors and, especially, of the causes of device-side abnormalities (i.e., abnormalities of the optical system and the dispenser mechanism), the latter of which are often difficult to identify.The analyzer performance that affects measurement results can be estimated from analysis parameters and calibration results. Thus, uncertainty estimates are automatically calculated for each analysis item during quality control, and the estimates are compared with uncertainties obtained during actual QC sample measurement, thereby monitoring and evaluating the analyzer performance. Also, measurements are performed on QC samples of multiple concentrations that contain substances known to subject to particular influences such as those of the optical system, sample dispenser, and reagent dispenser, so that the causes of abnormalities can be identified. Uncertainty estimates calculated from the parameters set for the analysis items are compared with uncertainties obtained from the QC sample measurements. The data sets that have value deviations are classified on an item-by-item basis, and the classification pattern is used to determine which analyzer component is abnormal.
摘要翻译：基于复杂不确定因素的重点考虑，特别是设备侧异常（即光学系统和分配器机构的异常）的原因，后者是在日常质量控制期间自动识别异常原因往往难以识别。影响测量结果的分析仪性能可以通过分析参数和校准结果进行估算。因此，在质量控制期间，为每个分析项目自动计算不确定性估计，并将估计与实际QC样品测量期间获得的不确定性进行比较，从而监测和评估分析仪性能。此外，对含有已知会受到光学系统，样品分配器和试剂分配器的特定影响的物质的多种浓度的QC样品进行测量，从而可以识别出异常的原因。将从分析项目设置的参数中计算出的不确定度估计与从QC样本测量获得的不确定性进行比较。具有价值偏差的数据集按逐项分类，分类模式用于确定哪个分析器组件异常。

16. 发明申请

US20090222213A1 AUTOMATIC ANALYZER 审中-公开
标题翻译：自动分析仪
公开(公告)号：US20090222213A1
公开(公告)日：2009-09-03
申请号：US12388845
申请日：2009-02-19
申请人： Yuko HAMAZUMI , Tomonori Mimura , Yuki Fukuyama
发明人： Yuko HAMAZUMI , Tomonori Mimura , Yuki Fukuyama
IPC分类号： G01N33/48 , G06F19/00
CPC分类号： G01N35/00663 , G01N2035/00673
摘要： The present invention provides an index that makes it possible to use, in an automatic analyzer, an approximate expression based on a theoretical chemical reaction formula derived from reaction process data, and automatically check for apparatus abnormalities, reagent deteriorations, and improper accuracy control during each continuous or individual inspection.Reaction process data, which is measured when the automatic analyzer determines the relationship between reaction absorbance and time, is approximated to ABS=A0+A1 (1−e−kt) by the least-squares method. The resulting reaction start point absorbance A0, final reaction absorbance A1, reaction rate constant k, and residual error, which is the aggregate sum of differences between approximate values and measured values, are then used as the index of reaction status.
摘要翻译：本发明提供一种能够在自动分析装置中使用基于从反应过程数据导出的理论化学反应式的近似表达式的指标，并且可以自动检查装置异常，试剂恶化和每次检测中的不正确的精度控制连续或个别检查。当自动分析仪确定反应吸光度和时间之间的关系时测量的反应过程数据通过最小二乘法近似为ABS = A0 + A1（1-e-kt）。然后将所得到的反应起点吸光度A0，最终反应吸光度A1，反应速率常数k和剩余误差（即近似值和测量值之间的差值的总和）用作反应状态的指标。

17. 发明申请

US20070217949A1 Quality control system 有权
标题翻译：质量控制体系
公开(公告)号：US20070217949A1
公开(公告)日：2007-09-20
申请号：US11710424
申请日：2007-02-26
申请人： Tomonori Mimura , Kazumitsu Kawase
发明人： Tomonori Mimura , Kazumitsu Kawase
IPC分类号： G01N33/00
CPC分类号： G01N35/00603 , G01N35/00613 , G01N35/00712 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/2575
摘要： In a clinical laboratory of a hospital, an enormous amount of effort has been required to maintain the quality of an analyzer, standard solution and control samples. An object of the present invention is to provide a control method for controlling a clinical laboratory with reduced cost, and a control apparatus using the same.In order to control data of an analyzer, standard solution, and a control sample, a support center is connected to each analyzer located in each hospital through a network line. Various kinds of analysis parameters and the result of measurements are exchanged so as to provide each clinical laboratory with a control situation in real time.
摘要翻译：在医院的临床实验室，需要大量的努力来保持分析仪，标准溶液和对照样品的质量。本发明的目的是提供一种用于以降低的成本控制临床实验室的控制方法和使用该控制方法的控制装置。为了控制分析仪，标准解决方案和控制样本的数据，支持中心通过网络线连接到位于每个医院的每个分析仪。交换各种分析参数和测量结果，以便为每个临床实验室提供实时的控制情况。

18. 发明申请

US20070009387A1 Chemical analysis apparatus and chemical analysis method 有权
标题翻译：化学分析仪器和化学分析方法
公开(公告)号：US20070009387A1
公开(公告)日：2007-01-11
申请号：US11522379
申请日：2006-09-18
申请人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
发明人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
IPC分类号： G01N33/00
CPC分类号： G01N35/1002 , B01F11/0283 , B01F2215/0037 , G01N35/025 , G01N2035/00554 , Y10S707/962 , Y10S707/99933 , Y10S707/99942 , Y10S707/99943 , Y10S707/99956
摘要： A chemical analysis apparatus in which a sample to be analyzed and a reagent are placed into a reaction container, and sound waves are irradiated to said reaction container so as to agitate them, wherein said chemical analysis apparatus comprises a piezoelectric element producing said sound waves, and drivers for driving said piezoelectric element, said sound waves being intermittently irradiated into said reaction container.
摘要翻译：一种化学分析装置，其中将待分析样品和试剂置于反应容器中，并且将声波照射到所述反应容器以搅拌它们，其中所述化学分析装置包括产生所述声波的压电元件，以及用于驱动所述压电元件的驱动器，所述声波被间歇地照射到所述反应容器中。

19. 发明申请

US20060110288A1 Analyzer system having sample rack transfer line 有权
公开(公告)号：US20060110288A1
公开(公告)日：2006-05-25
申请号：US11324299
申请日：2006-01-04
申请人： Tomonori Mimura , Hiroshi Mitsumaki , Tadashi Ohishi , Taku Sakazume
发明人： Tomonori Mimura , Hiroshi Mitsumaki , Tadashi Ohishi , Taku Sakazume
IPC分类号： G01N35/00
CPC分类号： G01N35/00663 , G01N35/0092 , G01N35/02 , G01N35/026 , G01N2035/00326 , G01N2035/00673 , G01N2035/0453 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831
摘要： A plurality of analyzer units for serum, a plurality of analyzer units for blood plasma and a plurality of analyzer units for urine are arranged along a main transfer line for transferring a sample rack from a rack providing portion to a rack storage portion. A reagent bottle for inspecting liver function is contained in each reagent delivery mechanism of two analyzer units among the plurality of analyzer units for serum. When the reagent for inspecting liver function in one of the two analyzer units is to be short, analysis for the liver function analysis item to samples can be continued by transferring a sample rack from the rack providing portion to the other analyzer unit.

20. 发明申请

US20060039823A1 Chemical analysis apparatus 审中-公开
标题翻译：化学分析仪
公开(公告)号：US20060039823A1
公开(公告)日：2006-02-23
申请号：US11204344
申请日：2005-08-16
申请人： Hironobu Yamakawa , Hideo Enoki , Kunio Harada , Sakuichiro Adachi , Tomonori Mimura
发明人： Hironobu Yamakawa , Hideo Enoki , Kunio Harada , Sakuichiro Adachi , Tomonori Mimura
IPC分类号： G01N35/00
CPC分类号： G01N35/1016 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01L3/502746 , B01L3/502784 , B01L2200/0605 , B01L2300/0654 , B01L2300/0867 , B01L2300/089 , B01L2400/0427 , F04B19/006 , G01N2035/00158 , G01N2035/00237 , G01N2035/102
摘要： A chemical analysis apparatus is equipped with analysis sections having openings, means for supplying samples or reagents from the openings, means for combining and mixing samples with reagents to obtain droplets as liquids to be measured, and means for measuring the physical properties of the liquids to be measured during reaction or after completion of reaction. Furthermore, plate members are provided facing each other in analysis sections and a plurality of electrodes are provided on the plate member faces that face each other. Voltage is applied from the plurality of electrodes to the droplets of the samples and the reagents.
摘要翻译：化学分析装置配备有具有开口的分析部分，用于从开口供应样品或试剂的装置，用于将样品与试剂混合并混合以获得待测量液体的液滴的装置，以及用于测量液体的物理性质的装置在反应期间或反应完成后测量。此外，在分析部分中彼此面对地设置板构件，并且在彼此相对的板构件面上设置多个电极。电压从多个电极施加到样品和试剂的液滴。

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