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11. 发明申请

US20060226010A1 INTEGRATED 2D GEL ELECTROPHORESIS METHOD AND SYSTEM 有权
标题翻译：一体化2D凝胶电泳方法和系统
公开(公告)号：US20060226010A1
公开(公告)日：2006-10-12
申请号：US11278975
申请日：2006-04-07
申请人： Mario Curcio , Martin Kopp
发明人： Mario Curcio , Martin Kopp
IPC分类号： B01D61/42 , B01D57/02 , G01N27/00
CPC分类号： G01N27/44773 , G01N27/44795
摘要： Described is a process for the separation of a sample mixture for analytical reason based on two-dimensional gel electrophoresis. The method is involving a first separation in a first gel strip on the basis of isoelectric points and a second separation in a second gel on the basis of molecular size. When starting the separation in the second dimension the buffer solution for transferring the compounds separated in the first dimension into the second dimension gel is containing sodium dodecyl-sulfate (SDS) and by applying an electric field the SDS migrates electrokinetically into the first gel strip, and the compounds are being complexed simultaneously with SDS.
摘要翻译：描述了基于二维凝胶电泳的用于分析原因的样品混合物的分离方法。该方法涉及基于等电点在第一凝胶条中的第一分离，并且基于分子大小在第二凝胶中进行第二次分离。当在第二维开始分离时，用于将在第一维中分离的化合物转移到第二维凝胶中的缓冲溶液含有十二烷基硫酸钠（SDS），并且通过施加电场，SDS电动迁移到第一凝胶条中，并且化合物与SDS同时复合。

12. 发明授权

US07901558B2 Integrated 2D gel electrophoresis method and system 有权
标题翻译：集成2D凝胶电泳方法及系统
公开(公告)号：US07901558B2
公开(公告)日：2011-03-08
申请号：US11278975
申请日：2006-04-07
申请人： Mario Curcio , Martin Kopp
发明人： Mario Curcio , Martin Kopp
IPC分类号： G01N27/26 , G01N27/447
CPC分类号： G01N27/44773 , G01N27/44795
摘要： Described is a process for the separation of a sample mixture for analytical reason based on two-dimensional gel electrophoresis. The method is involving a first separation in a first gel strip on the basis of isoelectric points and a second separation in a second gel on the basis of molecular size. When starting the separation in the second dimension the buffer solution for transferring the compounds separated in the first dimension into the second dimension gel is containing sodium dodecyl-sulfate (SDS) and by applying an electric field the SDS migrates electrokinetically into the first gel strip, and the compounds are being complexed simultaneously with SDS.
摘要翻译：描述了基于二维凝胶电泳的用于分析原因的样品混合物的分离方法。该方法涉及基于等电点在第一凝胶条中的第一分离，并且基于分子大小在第二凝胶中进行第二次分离。当在第二维开始分离时，用于将在第一维中分离的化合物转移到第二维凝胶中的缓冲溶液含有十二烷基硫酸钠（SDS），并且通过施加电场，SDS电动迁移到第一凝胶条中，并且化合物与SDS同时复合。

13. 发明申请

US20060110763A1 Nucleic acid preparation 审中-公开
标题翻译：核酸制备
公开(公告)号：US20060110763A1
公开(公告)日：2006-05-25
申请号：US11280571
申请日：2005-11-16
申请人： Martin Kopp
发明人： Martin Kopp
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/686 , B01L7/52
摘要： The present invention is directed to methods, devices and computer programs for preparing nucleic acids from a template nucleic acid by subjecting a sample to thermocycles. After a first number of thermocycles, a partial amount of the reaction mixture is being subjected to a second number of thermocycles. This two step amplification method speeds up overall reaction time without affecting the limit of detection.
摘要翻译：本发明涉及通过使样品经受热循环从模板核酸制备核酸的方法，装置和计算机程序。在第一数量的热循环之后，部分量的反应混合物经受第二数量的热循环。这两步扩增方法加快了整个反应时间，而不影响检测限。

14. 发明授权

US5842013A Architecture for modular computer system in which one of the modules is dedicated to user-interface task 失效
标题翻译：模块化计算机系统的架构，其中一个模块专用于用户界面任务
公开(公告)号：US5842013A
公开(公告)日：1998-11-24
申请号：US596127
申请日：1996-02-08
申请人： Martin Kopp
发明人： Martin Kopp
IPC分类号： G06F13/10 , G06F9/50 , G06F13/42 , G06F15/16 , G06F15/177 , G06F15/80 , G06F9/00
CPC分类号： G06F15/8015
摘要： Very large amounts of data may be handled by the user interface of computers. The main processor is thus permanently overloaded, so that the computing power available for the actual application is sharply reduced in a manner that cannot be predicted without limiting the user requests. A new computer architecture is disclosed which allows a higher and more exactly predictable computing power to be achieved. In order to make the rest of the system independent from the user interface, the computer is subdivided in such a way that a first module (part 1) takes over the display and operation tasks of the user interface, a second module (part 2) takes over the processing of the application programs without their user interface, and a third module (part 3) takes over the remaining functional units. All modules have their own internal data paths. An interface between the first and second modules support the exchange of messages and data without affecting the independent processes in the first and second modules. The first and second modules have their own access paths to common devices located in the third module.
摘要翻译： PCT No.PCT / DE94 / 00848 Sec。 371日期1996年2月8日 102（e）日期1996年2月8日PCT提交1994年7月22日PCT公布。公开号WO95 / 04973 日期2005年02月16日计算机的用户界面可能会处理大量数据。主处理器因此永久地过载，使得可用于实际应用的计算能力以不能在不限制用户请求的情况下预测的方式急剧减少。公开了一种新的计算机架构，其允许实现更高和更精确可预测的计算能力。为了使系统的其余部分独立于用户界面，计算机被细分为第一模块（第1部分）接管用户界面的显示和操作任务，第二模块（第2部分）在没有用户界面的情况下接管应用程序的处理，第三模块（第3部分）接管剩余的功能单元。所有模块都有自己的内部数据路径。第一和第二模块之间的接口支持消息和数据的交换，而不影响第一和第二模块中的独立进程。第一和第二模块具有到位于第三模块中的通用设备的自己的访问路径。

15. 发明申请

US20100055770A1 HIGH-DENSITY MULTIWELL-PLATE 有权
标题翻译：高密度多层板
公开(公告)号：US20100055770A1
公开(公告)日：2010-03-04
申请号：US12546940
申请日：2009-08-25
申请人： Martin Kopp
发明人： Martin Kopp
IPC分类号： C12M1/34
CPC分类号： B01L3/50851 , B01L3/50853 , B01L2200/142 , B01L2300/0829 , B01L2300/0854
摘要： A high-density multiwell-plate for performing thermocycled amplification reactions of polynucleotides in liquid samples comprising a plurality of reaction wells is disclosed. In order to provide a better thermal insulation, the plate comprises a rigid well-forming structure placed above a bottom layer, wherein substantially horizontal well-covering areas cover the liquid sample comprised in the wells, and a substantially plane cover placed above the well-forming structure providing a thermal insulating air distance between the well-covering areas and the cover.
摘要翻译：公开了一种用于在包含多个反应孔的液体样品中进行多核苷酸的热循环扩增反应的高密度多孔板。为了提供更好的隔热性，该板包括位于底层上方的刚性成形结构，其中基本上水平的覆盖覆盖区域覆盖包含在井中的液体样品，以及基本上平面的覆盖物，形成结构，在覆盖区域和盖之间提供隔热空气距离。

16. 发明申请

US20050118070A1 Flow triggering device 审中-公开
标题翻译：流量触发装置
公开(公告)号：US20050118070A1
公开(公告)日：2005-06-02
申请号：US10971859
申请日：2004-10-22
申请人： Patrick Griss , Vuk Siljegovic , Martin Kopp
发明人： Patrick Griss , Vuk Siljegovic , Martin Kopp
IPC分类号： G01N35/08 , B01J19/00 , B01L3/00 , B81B1/00 , F15C5/00 , F16K99/00 , G01N37/00 , B01L3/02 , B32B5/02 , B32B27/04 , B32B27/12 , B65D37/00
CPC分类号： F16K99/0017 , B01L3/502738 , B01L2200/0621 , B01L2300/0864 , B01L2400/0406 , B01L2400/0688 , F16K99/0001 , F16K2099/0074 , F16K2099/0076 , F16K2099/0084
摘要： The present invention is related to a microfluidic device capable of conveying a liquid by capillary forces. The microfluidic device comprises a microfluidic channel system comprising i) a liquid supply compartment; ii) a first channel connected to the liquid supply compartment, having at least one non-closing valve located downstream of the liquid supply compartment; and iii) a second channel. The second channel branches-off from the first channel downstream of the liquid supply compartment but upstream of the at least one non-closing valve and which re-unites with the first channel at the location of the non-closing valve to form an outlet channel. The second channel does not contain any non-closing or closing valve thus creating an unobstructed liquid flow path connecting the liquid supply compartment with the outlet channel.
摘要翻译：本发明涉及能够通过毛细管力输送液体的微流体装置。微流体装置包括微流体通道系统，其包括i）液体供应室; ii）连接到液体供应室的第一通道，具有位于液体供应室下游的至少一个非闭合阀; 和iii）第二通道。第二通道从液体供应室的下游的第一通道分支，而在至少一个非关闭阀的上游分支，并且在非关闭阀的位置处与第一通道重新组合以形成出口通道。第二通道不包含任何非闭合或关闭阀，从而产生连接液体供应室与出口通道的无障碍液体流路。

17. 发明授权

US08980621B2 High-density multiwell-plate 有权
标题翻译：高密度多孔板
公开(公告)号：US08980621B2
公开(公告)日：2015-03-17
申请号：US12546940
申请日：2009-08-25
申请人： Martin Kopp
发明人： Martin Kopp
IPC分类号： C12M3/00 , B01L3/00
CPC分类号： B01L3/50851 , B01L3/50853 , B01L2200/142 , B01L2300/0829 , B01L2300/0854
摘要： A high-density multiwell-plate for performing thermocycled amplification reactions of polynucleotides in liquid samples comprising a plurality of reaction wells is disclosed. In order to provide a better thermal insulation, the plate comprises a rigid well-forming structure placed above a bottom layer, wherein substantially horizontal well-covering areas cover the liquid sample comprised in the wells, and a substantially plane cover placed above the well-forming structure providing a thermal insulating air distance between the well-covering areas and the cover.
摘要翻译：公开了一种用于在包含多个反应孔的液体样品中进行多核苷酸的热循环扩增反应的高密度多孔板。为了提供更好的隔热性，该板包括位于底层上方的刚性成形结构，其中基本上水平的覆盖覆盖区域覆盖包含在井中的液体样品，以及基本上平面的覆盖物，形成结构，在覆盖区域和盖之间提供隔热空气距离。

18. 发明授权

US07959581B2 Test magazine and method for processing the same 有权
标题翻译：测试杂志和处理方法相同
公开(公告)号：US07959581B2
公开(公告)日：2011-06-14
申请号：US11537791
申请日：2006-10-02
申请人： Irio G. Calasso , Martin Kopp , Charles Raney , Steven N. Roe
发明人： Irio G. Calasso , Martin Kopp , Charles Raney , Steven N. Roe
IPC分类号： A61B5/00 , A61B17/14 , A61B17/32 , B65D81/00 , G01N21/00 , G01N31/00 , G01N33/00 , G01N35/00
CPC分类号： A61B5/15169 , A61B5/1411 , A61B5/14532 , A61B5/150022 , A61B5/150358 , A61B5/150419 , A61B5/150503 , A61B5/15146 , A61B5/15151 , A61B5/15155 , A61B5/15167 , A61B5/15171 , A61B5/15173 , A61B5/15178 , A61B5/15184 , A61B5/157 , Y10T436/110833
摘要： A test magazine with two film strips (12, 14), which are joined to one another in a sandwich-like manner, can be wound up, and between which holding cells (16) for test elements are kept free. The test magazine also comprises a multitude of test elements (18, 20) each having a puncturing unit (18) for inserting into body tissue and a test unit (20) for being subjected to body fluid. To this end, the puncturing units (18) and test units (20) are placed in separate holding cells (16) whereby separating them from one another.
摘要翻译：可以卷起具有以夹心状连接的两个胶片条（12,14）的测试盒，并且在其间保持用于测试元件的保持盒（16）。测试盒还包括多个测试元件（18,20），每个测试元件具有用于插入身体组织的穿刺单元（18）和用于体液的测试单元（20）。为此，将穿刺单元（18）和测试单元（20）放置在分离的保持单元（16）中，从而将它们彼此分离。

19. 发明申请

US20070144907A1 Integrated two-dimensional gel electrophoresis 审中-公开
标题翻译：集成二维凝胶电泳
公开(公告)号：US20070144907A1
公开(公告)日：2007-06-28
申请号：US11643729
申请日：2006-12-21
申请人： Martin Kopp , Roger Sandoz , Mario Curcio , Michael Glauser
发明人： Martin Kopp , Roger Sandoz , Mario Curcio , Michael Glauser
IPC分类号： C07K1/26 , G01N27/00
CPC分类号： G01N27/44773 , C07K1/26 , C07K1/285
摘要： A disposable electrophoresis device for separation of a complex protein sample, using two-dimensional gel electrophoresis and method thereof are disclosed. The device comprises a carrier with a first area for a first dimension gel strip and a second area for a second dimension gel, where the two areas are directly in contact with each other. The device further comprises a body made of a hard component and an elastic component layer at a variable distance from the carrier. The body further comprises at least one cavity for external actuation of at least one valve, wherein the valve is represented by the elastic component layer.
摘要翻译：公开了使用二维凝胶电泳分离复合蛋白质样品的一次性电泳装置及其方法。该装置包括具有用于第一尺寸凝胶带的第一区域和用于第二维度凝胶的第二区域的载体，其中两个区域彼此直接接触。该装置还包括一个由硬质部件制成的主体和一个距离载体可变距离的弹性部件层。该主体还包括用于至少一个阀的外部致动的至少一个空腔，其中该阀由弹性部件层表示。

20. 发明申请

US20070038150A1 TEST MAGAZINE AND METHOD FOR PROCESSING THE SAME 有权
标题翻译：测试杂志及其处理方法
公开(公告)号：US20070038150A1
公开(公告)日：2007-02-15
申请号：US11537791
申请日：2006-10-02
申请人： Irio Calasso , Martin Kopp , Charles Raney , Steven Roe
发明人： Irio Calasso , Martin Kopp , Charles Raney , Steven Roe
IPC分类号： A61B5/00 , A61B17/32
CPC分类号： A61B5/15169 , A61B5/1411 , A61B5/14532 , A61B5/150022 , A61B5/150358 , A61B5/150419 , A61B5/150503 , A61B5/15146 , A61B5/15151 , A61B5/15155 , A61B5/15167 , A61B5/15171 , A61B5/15173 , A61B5/15178 , A61B5/15184 , A61B5/157 , Y10T436/110833
摘要： A test magazine with two film strips (12, 14), which are joined to one another in a sandwich-like manner, can be wound up, and between which holding cells (16) for test elements are kept free. The test magazine also comprises a multitude of test elements (18, 20) each having a puncturing unit (18) for inserting into body tissue and a test unit (20) for being subjected to body fluid. To this end, the puncturing units (18) and test units (20) are placed in separate holding cells (16) whereby separating them from one another.
摘要翻译：可以卷起具有以夹心状连接的两个胶片条（12,14）的测试盒，并且在其间保持用于测试元件的保持盒（16）。测试盒还包括多个测试元件（18,20），每个测试元件具有用于插入身体组织的穿刺单元（18）和用于体液的测试单元（20）。为此，将穿刺单元（18）和测试单元（20）放置在分离的保持单元（16）中，从而将它们彼此分离。

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