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11. 发明申请

US20050187538A1 Remote control device for a medical probe 有权
标题翻译：用于医疗探头的遥控装置
公开(公告)号：US20050187538A1
公开(公告)日：2005-08-25
申请号：US10966754
申请日：2004-10-15
申请人： Jan Boese , Martin Kleen , Marcus Pfister , Norbert Rahn
发明人： Jan Boese , Martin Kleen , Marcus Pfister , Norbert Rahn
IPC分类号： G02B23/24 , A61B1/00 , A61B8/12 , A61B17/00 , A61B19/00 , A61M25/01 , A61M31/00 , G05D1/00
CPC分类号： A61B1/00039 , A61B34/70 , A61B34/74 , A61B34/76 , A61B34/77 , A61M25/0136
摘要： The device according to the invention ensures accurate and in particular sensitive navigation of the probe, which can be inserted into a body, despite the fact that the remote control uses simple means, by means of a movement (MR;MB;MP) corresponding intuitively to the navigation of a probe using the control device (1). Intuitive operation can be converted in particular using an inventive U-shaped embodiment of the control device (1). Sensitive controllability can be increased by transmitting the mechanical interaction between the probe and an environment under examination to the control device (1) and thus directly to the operating hand (3) by means of inventive feedback.
摘要翻译：根据本发明的装置，尽管远程控制使用简单的手段，借助于直观对应的移动（MR; MB; MP），可以确保探头的精确和特别灵敏的导航，其可插入到身体中使用控制装置（1）到探针的导航。可以使用控制装置（1）的本发明的U形实施例特别地转换直观的操作。可以通过发明反馈将探测器和被检查环境之间的机械相互作用传输到控制装置（1），从而直接传递给操作手（3）来增加敏感的可控性。

12. 发明申请

US20050148836A1 Catheter device 有权
标题翻译：导管装置
公开(公告)号：US20050148836A1
公开(公告)日：2005-07-07
申请号：US10992181
申请日：2004-11-18
申请人： Martin Kleen , Norbert Rahn
发明人： Martin Kleen , Norbert Rahn
IPC分类号： A61B5/0408 , A61B1/00 , A61B5/00 , A61B5/0402 , A61B5/042 , A61B5/0478 , A61B5/0492 , A61B5/055 , A61B8/12 , A61B18/12 , A61B18/14 , A61B19/00 , A61B5/04
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/042 , A61B8/12 , A61B18/1492 , A61B90/361 , A61B2018/00839
摘要： Catheter device comprising a catheter (2), particularly an intravascular catheter, for insertion into an organ or vessel of the human or animal body, with a device for ablation of the adjacent organ tissue or vessel tissue using high-frequency currents in the region of the tip of the catheter, a device (3, 11, 12, 18, 19, 23, 24) being integrated for capturing images of the organ or vessel in the region of the tip of the catheter (10, 17, 22).
摘要翻译：导管装置包括导管（2），特别是血管内导管，用于插入到人体或动物体的器官或血管中，其具有用于在邻近的器官组织或血管组织的区域中使用高频电流导管的尖端，被整合用于捕获在导管（10,17,22）的尖端区域中的器官或血管的图像的装置（3,11,12,18,19,23,24）。

13. 发明授权

US08538504B2 Method for merging medical images 有权
标题翻译：合并医学图像的方法
公开(公告)号：US08538504B2
公开(公告)日：2013-09-17
申请号：US11007492
申请日：2004-12-08
申请人： Martin Kleen , Marcus Pfister , Norbert Rahn
发明人： Martin Kleen , Marcus Pfister , Norbert Rahn
IPC分类号： A61B5/05
CPC分类号： A61B5/0073 , A61B5/0071 , A61B5/0084 , A61B5/055 , A61B6/032 , A61B6/5247 , A61B8/00 , A61B8/5238 , G06K9/32 , G06K2209/05 , G06T7/38
摘要： A method for the merged display of first image information captured using a first imaging device with second image information captured using a second imaging device is provided. The first imaging device records fluorescence images of the area under examination. A second 3D image data record of the area under examination is recorded using an examination procedure based on electromagnetic radiation, such as computer tomography (CT) or magnetic resonance imaging (MRI). The 3D fluorescence image data record and the second 3D image data record are registered with one another, and one or more fluorescence-optically marked, relevant areas of the examination volume, on the basis of the mapping rules determined by the registration process, are displayed on a monitor.
摘要翻译：提供了一种用于使用第一成像装置捕获的第一图像信息的合并显示的方法，其具有使用第二成像装置捕获的第二图像信息。第一个成像装置记录被检查区域的荧光图像。使用基于诸如计算机断层摄影（CT）或磁共振成像（MRI）的电磁辐射的检查程序记录被检查区域的第二3D图像数据记录。将3D荧光图像数据记录和第二3D图像数据记录彼此登记，并且基于由注册过程确定的映射规则，显示检查卷的一个或多个荧光光学标记的相关区域在监视器上。

14. 发明授权

US07641650B2 Remote control device for a medical probe 有权
标题翻译：用于医疗探头的遥控装置
公开(公告)号：US07641650B2
公开(公告)日：2010-01-05
申请号：US10966754
申请日：2004-10-15
申请人： Jan Boese , Martin Kleen , Marcus Pfister , Norbert Rahn
发明人： Jan Boese , Martin Kleen , Marcus Pfister , Norbert Rahn
IPC分类号： A61B17/00
CPC分类号： A61B1/00039 , A61B34/70 , A61B34/74 , A61B34/76 , A61B34/77 , A61M25/0136
摘要： The device according to the invention ensures accurate and in particular sensitive navigation of the probe, which can be inserted into a body, despite the fact that the remote control uses simple means, by means of a movement (MR;MB;MP) corresponding intuitively to the navigation of a probe using the control device (1). Intuitive operation can be converted in particular using an inventive U-shaped embodiment of the control device (1). Sensitive controllability can be increased by transmitting the mechanical interaction between the probe and an environment under examination to the control device (1) and thus directly to the operating hand (3) by means of inventive feedback.
摘要翻译：根据本发明的装置，尽管远程控制使用简单的手段，借助于直观对应的移动（MR; MB; MP），可以确保探头的精确和特别灵敏的导航，其可插入到身体中使用控制装置（1）到探针的导航。可以使用控制装置（1）的本发明的U形实施例特别地转换直观的操作。可以通过发明反馈将探测器和被检查环境之间的机械相互作用传输到控制装置（1），从而直接传递给操作手（3）来增加敏感的可控性。

15. 发明授权

US07620711B2 Method of using configuration files for configuring technical devices 有权
标题翻译：使用配置文件配置技术设备的方法
公开(公告)号：US07620711B2
公开(公告)日：2009-11-17
申请号：US11375987
申请日：2006-03-15
申请人： Jan Boese , Martin Kleen , Norbert Rahn
发明人： Jan Boese , Martin Kleen , Norbert Rahn
IPC分类号： G06F15/173
CPC分类号： G06Q30/0603 , G06Q10/06 , H04L41/0846 , H04L41/0856 , H04L41/18 , H04L67/104 , H04L67/1063 , H04L67/303 , Y10S707/99937 , Y10S707/99953
摘要： Method for the provision and use of configuration files for configuring technical devices.The present invention relates to a method for the provision and use of configuration files containing essential configuration data for configuring technical devices. With the method the configuration data is uploaded by one or more participants in the method via a network onto a server and downloaded by users of the technical devices as configuration files from the server via the network. When a configuration file is downloaded by a user or when a downloaded configuration file is used by a user to configure a technical device, the participant who uploaded the configuration data of the downloaded or used configuration file onto the server receives a reimbursement. The present method simplifies the configuration of units for the users of technical devices and represents an incentive for experienced users to make the configurations they have created themselves also available to other users.
摘要翻译：提供和使用配置文件配置技术设备的方法。本发明涉及一种提供和使用包含配置技术设备的基本配置数据的配置文件的方法。使用该方法，配置数据由方法中的一个或多个参与者通过网络上传到服务器上，并且通过技术设备的用户作为配置文件从服务器经由网络下载。当用户下载配置文件或用户使用下载的配置文件配置技术设备时，将下载或使用的配置文件的配置数据上传到服务器上的参与者收到报销。本方法简化了技术设备用户的单元配置，并表示有经验的用户激励自己创建的配置也可供其他用户使用。

16. 发明授权

US07590442B2 Method for determining the position of an instrument with an x-ray system 有权
标题翻译：用X射线系统确定仪器位置的方法
公开(公告)号：US07590442B2
公开(公告)日：2009-09-15
申请号：US11358853
申请日：2006-02-21
申请人： Jan Boese , Martin Kleen , Norbert Rahn
发明人： Jan Boese , Martin Kleen , Norbert Rahn
IPC分类号： A61B5/05 , G06K9/00
CPC分类号： G06T19/00 , A61B6/12 , A61B6/4441 , A61B6/466 , A61B6/504 , A61B34/20 , A61B90/36 , A61B90/37 , A61B2034/105 , A61B2034/2065 , A61B2090/364 , A61B2090/376 , G06T2210/41
摘要： The present invention relates to a method for determining the position of an instrument in a structure of an object with an x-ray system, in which a 3D image data record is provided for at least one area of the object relevant for determining the position, the x-ray system is registered with the 3D image data record, after the introduction of the instrument into the structure at least one 2D x-ray image of the relevant area is recorded from at least one direction of projection with a known projection geometry with the x-ray system and a 2D position of a first location of the instrument is recorded in the 2D x-ray image. In the method a projection line in accordance with the known projection geometry is placed through the 3D image data record at the 2D position and a 3D position of the first location of the instrument in the 3D image data record is determined from an intersection of the projection line with the structure. The method enables the 3D position to be determined with a simple monoplanar x-ray system.
摘要翻译：本发明涉及一种用于确定具有x射线系统的物体的结构中的器械的位置的方法，其中为与所述位置有关的所述物体的至少一个区域提供3D图像数据记录，将X射线系统与3D图像数据记录对齐，在将仪器引入结构之后，从具有已知投影几何形状的至少一个投影方向记录相关区域的至少一个2D X射线图像， x射线系统和仪器的第一位置的2D位置被记录在2D x射线图像中。在该方法中，根据已知的投影几何形状的投影线通过2D位置处的3D图像数据记录放置，并且3D图像数据记录中的仪器的第一位置的3D位置由投影的交点确定符合结构。该方法使得可以用简单的单平面x射线系统来确定3D位置。

17. 发明授权

US07480398B2 Method of registering a sequence of 2D image data with 3D image data 有权
标题翻译：使用3D图像数据注册2D图像数据序列的方法
公开(公告)号：US07480398B2
公开(公告)日：2009-01-20
申请号：US11076536
申请日：2005-03-08
申请人： Martin Kleen , Marcus Pfister , Norbert Rahn
发明人： Martin Kleen , Marcus Pfister , Norbert Rahn
IPC分类号： G06K9/00 , G06K9/36 , A61B5/05
CPC分类号： G06T3/0037 , A61B8/12 , A61B8/483 , A61B8/5238 , G06T7/33 , G06T7/38 , G06T7/66 , G06T2207/30101
摘要： The present invention relates to a method for registration of a sequence of 2D image data (5) of a hollow channel (2), in particular of a vessel, recorded with an imaging endoluminal instrument (1) when the relative displacement positions of the instrument (1) in the hollow channel (2) are known, with 3D image data (8) of the hollow channel (2). In the method a three-dimensional path of a central axis (10) of a definable section of the hollow channel (2) is determined from the 3D image data (8), the three-dimensional path of the central axis (10) is converted into a rectilinear path by a first transformation of the 3D image data (8) of the definable section of the hollow channel (2) and transformation parameters required for the first transformation are stored. A combined 3D image data record (11) is generated from the sequence of 2D image data (5) by a parallel side-by-side arrangement on a central straight line in accordance with the known relative displacement positions, and is first registered with the transformed 3D image data (9) by equating the central straight line with the rectilinear path of the central axis (10) and suitable translation for superposition of a shared reference point. The combined 3D image data record (11) or 2D image data (5) contained therein is then registered with the 3D image data (3), taking into account the stored transformation parameters.
摘要翻译：本发明涉及用于记录仪器的相对位移位置时记录有成像腔内仪器（1）的中空通道（2）的二维图像数据序列（2）的序列的方法，特别是记录有成像腔内仪器（1）的容器（2）中的3D图像数据（8）已知在空心通道（2）中的（1）。在该方法中，根据3D图像数据（8）确定空心通道（2）的可定义部分的中心轴线（10）的三维路径，中心轴线（10）的三维路径为通过中空通道（2）的可定义部分的3D图像数据（8）的第一变换，转换为直线路径，并存储第一变换所需的变换参数。根据已知的相对位移位置，通过平行并排布置在中央直线上从2D图像数据（5）的序列生成组合的3D图像数据记录（11），并且首先与通过将中心直线与中心轴线（10）的直线路径相等，以及用于叠加共享参考点的合适的平移来改变3D图像数据（9）。然后将其中包含的组合3D图像数据记录（11）或2D图像数据（5）与3D图像数据（3）一起注册，同时考虑所存储的变换参数。

18. 发明授权

US07479141B2 Ablation tip catheter device with integrated imaging, ECG and positioning devices 有权
标题翻译：消融尖端导管装置具有集成成像，ECG和定位装置
公开(公告)号：US07479141B2
公开(公告)日：2009-01-20
申请号：US10992181
申请日：2004-11-18
申请人： Martin Kleen , Norbert Rahn
发明人： Martin Kleen , Norbert Rahn
IPC分类号： A61B18/18
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/042 , A61B8/12 , A61B18/1492 , A61B90/361 , A61B2018/00839
摘要： Catheter device comprising a catheter (2), particularly an intravascular catheter, for insertion into an organ or vessel of the human or animal body, with a device for ablation of the adjacent organ tissue or vessel tissue using high-frequency currents in the region of the tip of the catheter, a device (3, 11, 12, 18, 19, 23, 24) being integrated for capturing images of the organ or vessel in the region of the tip of the catheter (10, 17, 22).
摘要翻译：导管装置包括导管（2），特别是血管内导管，用于插入到人体或动物体的器官或血管中，其具有用于在邻近的器官组织或血管组织的区域中使用高频电流导管的尖端，被整合用于捕获在导管（10,17,22）的尖端区域中的器官或血管的图像的装置（3,11,12,18,19,23,24）。

19. 发明申请

US20070238952A1 Registering intra-operative image data sets with pre-operative 3D image data sets on the basis of optical surface extraction 有权
标题翻译：基于光学表面提取，将手术前图像数据集与术前3D图像数据集进行注册
公开(公告)号：US20070238952A1
公开(公告)日：2007-10-11
申请号：US11496069
申请日：2006-07-28
申请人： Jan Boese , Martin Kleen , Klaus Klingenbeck-Regn , Marcus Pfister , Norbert Rahn
发明人： Jan Boese , Martin Kleen , Klaus Klingenbeck-Regn , Marcus Pfister , Norbert Rahn
IPC分类号： A61B5/05
CPC分类号： G06T7/55 , G06T7/38 , G06T7/50 , G06T2207/30004
摘要： The invention relates to a method for registering intra-operative image data set with pre-operative 3D image data set, comprising: spatial calibrating an optical 3D sensor system with an intra-operative imaging modality, intra-operative detecting the surface of an examination area of interest with the 3D sensor system to produce an intra-operative surface mask, intra-operative recording the area of interest for examination with the intra-operative modality at least partly containing the intra-operative surface mask to obtain an intra-operative image data set, computing the same surface from the pre-operative 3D image data set containing the detected surface to obtain a pre-operative surface mask, registering the intra-operative and pre-operative surface mask with each other, determining a mapping specification between pre-operative 3D image data set and intra-operative image data set based on the calibration and the registration, and overlaying the intra-operative image data set with the pre-operative 3D data set based on the mapping specification.
摘要翻译：本发明涉及一种用于记录术前图像数据组与手术前3D图像数据集的方法，包括：用术中成像模态对光学3D传感器系统进行空间校准，手术中检测检查区域的表面感兴趣的3D传感器系统以产生术中表面掩模，用至少部分地包含术中表面掩模的手术内模式手术内记录用于检查的感兴趣区域以获得手术中图像数据设置，从包含检测到的表面的术前3D图像数据集计算相同的表面，以获得术前表面掩模，将手术前和手术前表面掩模彼此对准，基于校准和注册的手术3D图像数据集和手术中图像数据集，并且将术中图像数据集合与t 他基于映射规范进行手术前3D数据集。

20. 发明申请

US20070167700A1 Method for accurate in vivo delivery of a therapeutic agent to a target area of an organ 审中-公开
标题翻译：将治疗剂精确体内递送至器官的靶区域的方法
公开(公告)号：US20070167700A1
公开(公告)日：2007-07-19
申请号：US11314589
申请日：2005-12-21
申请人： Norbert Rahn , Jan Boese , Martin Kleen
发明人： Norbert Rahn , Jan Boese , Martin Kleen
IPC分类号： A61B5/05
CPC分类号： A61B17/3478 , A61B34/20 , A61B90/36 , A61B2017/00247 , A61B2018/00392 , A61B2034/2051 , A61B2090/374 , A61B2090/376 , A61K35/12 , A61M25/0082 , A61M25/0084 , A61M2025/0091
摘要： In a method for accurately delivering a therapeutic agent to a target area of an organ of a living subject, such as for injecting stem cells into the myocardium of the heart, a 3D image, in which the target area and a delivery path thereto are visible, is obtained prior to delivery of the therapeutic agent. The 3D image is displayed, and a catheter is introduced into the subject and a real time positional indication of the catheter in the subject is obtained and incorporated into the displayed image, providing visual support for guiding the catheter to the target area. When the catheter is at the target area, the therapeutic agent is injected into the target area via the catheter. The distribution of the injected therapeutic agent relative to the target area is then monitored in the displayed image.
摘要翻译：在将用于将干细胞注入心脏心脏的活体受试者的器官的目标区域精确输送的方法中，其中目标区域和其输送路径可见的3D图像在递送治疗剂之前获得。显示3D图像，并且将导管引入到对象中，并且获得被检体内的导管的实时位置指示并将其合并到所显示的图像中，从而提供用于将导管引导到目标区域的视觉支撑。当导管位于目标区域时，经由导管将治疗剂注入目标区域。然后在所显示的图像中监测注射的治疗剂相对于目标区域的分布。

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