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11. 发明授权

US08355797B2 Systems and methods for delivering neural therapy correlated with patient status 有权
公开(公告)号：US08355797B2
公开(公告)日：2013-01-15
申请号：US12703683
申请日：2010-02-10
申请人： Anthony V. Caparso , Jon Parker , Andre B. Walker , Yougandh Chitre
发明人： Anthony V. Caparso , Jon Parker , Andre B. Walker , Yougandh Chitre
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/025 , A61N1/3605 , A61N1/36071 , A61N1/36132 , A61N1/37235 , G06F19/00 , G06F19/3418 , G06F19/3481 , G16H10/60 , G16H20/40 , G16H20/70
摘要： Therapy systems for treating a patient are disclosed. Representative therapy systems include an implantable pulse generator, a signal delivery device electrically coupled to the pulse generator, and a remote control in electrical communication with the implantable pulse generator. The pulse generator can have a computer-readable medium containing instructions for performing a process that comprises collecting the patient status and stimulation parameter; analyzing the collected patient status and stimulation parameter; and establishing a preference baseline containing a preferred stimulation parameter corresponding to a particular patient status.

12. 发明授权

US08126561B2 Implantable and rechargeable neural stimulator 有权
标题翻译：可植入和可充电的神经刺激器
公开(公告)号：US08126561B2
公开(公告)日：2012-02-28
申请号：US12613094
申请日：2009-11-05
申请人： Abhi V. Chavan , Anthony V. Caparso , Avram Scheiner
发明人： Abhi V. Chavan , Anthony V. Caparso , Avram Scheiner
IPC分类号： A61N1/00
CPC分类号： A61N1/36117 , A61N1/3605 , A61N1/36071 , A61N1/36135 , A61N1/37205 , A61N1/37217 , A61N1/37288 , A61N1/3787
摘要： One aspect of the present subject matter relates to an implantable medical device. An embodiment of the device comprises a rechargeable power supply adapted to be recharged through an ultrasound signal, a neural stimulator connected to the rechargeable power supply, and a controller connected to the rechargeable power supply. The neural stimulator is adapted to generate a neural stimulation signal for delivery to a neural stimulation target through an electrode. The controller is further connected to the neural stimulator to control the neural stimulator according to a neural stimulation protocol. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及可植入医疗装置。该装置的实施例包括适于通过超声信号再充电的可再充电电源，连接到可再充电电源的神经刺激器和连接到可再充电电源的控制器。神经刺激器适于产生用于通过电极递送到神经刺激靶的神经刺激信号。控制器进一步连接到神经刺激器，以根据神经刺激方案来控制神经刺激器。本文提供了其他方面。

13. 发明授权

US07937147B2 High frequency stimulation for treatment of atrial fibrillation 失效
标题翻译：高频刺激治疗房颤
公开(公告)号：US07937147B2
公开(公告)日：2011-05-03
申请号：US11680322
申请日：2007-02-28
申请人： Haris Sih , Mark Schwartz , Anthony V. Caparso
发明人： Haris Sih , Mark Schwartz , Anthony V. Caparso
IPC分类号： A61N1/36
CPC分类号： A61N1/0556 , A61N1/05 , A61N1/0587 , A61N1/36114 , A61N1/3621 , A61N1/3624 , A61N1/395 , A61N1/3962
摘要： The invention relates to methods and devices for treating and/or preventing atrial fibrillation. In an embodiment, the invention includes a method of treating and/or preventing atrial fibrillation including applying an oscillating electrical stimulus to a tissue of a patient, the oscillating electrical stimulus sufficient to block transmission of electrical signals through the tissue. In an embodiment, the invention includes an implantable medical device including a stimulator configured to generate an oscillating electrical stimulus at a frequency and amplitude sufficient to block transmission of electrical signals through a tissue, a stimulation electrode in communication with the stimulator, the stimulation electrode configured to deliver the oscillating electrical stimulus to the tissue, and control circuitry in communication with the stimulator, the control circuitry configured to selectively deliver the oscillating electrical stimulus to treat and/or prevent atrial fibrillation. Other embodiments are also described herein.
摘要翻译：本发明涉及用于治疗和/或预防房颤的方法和装置。在一个实施方案中，本发明包括治疗和/或预防房颤的方法，包括将振荡电刺激施加到患者的组织，所述振荡电刺激足以阻止电信号通过组织传播。在一个实施例中，本发明包括可植入医疗装置，其包括刺激器，所述刺激器被配置为产生振荡电刺激，其频率和幅度足以阻止通过组织的电信号的传输，与所述刺激器通信的刺激电极，将振荡电刺激递送到组织，以及与刺激器通信的控制电路，所述控制电路被配置为选择性地递送振荡电刺激以治疗和/或预防房颤。本文还描述了其它实施例。

14. 发明申请

US20110082515A1 TRANSCUTANEOUS NEUROSTIMULATOR FOR TREATING HYPERTENSION 有权
标题翻译： TRANSCUTANEOUS神经细胞治疗高血压
公开(公告)号：US20110082515A1
公开(公告)日：2011-04-07
申请号：US12969023
申请日：2010-12-15
申请人： Imad Libbus , Anthony V. Caparso , Andrew P. Kramer
发明人： Imad Libbus , Anthony V. Caparso , Andrew P. Kramer
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/36017 , Y10S128/907
摘要： A neurostimulation device includes an external neurostimulator worn by a patient using a bracing element that braces a portion of the patient's body. The external neurostimulator delivers neurostimulation to modulate a cardiovascular function of the patient. In one embodiment, the external stimulator delivers the neurostimulation transcutaneously to a stimulation target in the patient's body using surface stimulation electrodes placed on the body approximately over the stimulation target.
摘要翻译：神经刺激装置包括由患者佩戴的外部神经刺激器，其使用支撑患者身体的一部分的支撑元件。外部神经刺激仪提供神经刺激来调节患者的心血管功能。在一个实施例中，外部刺激器将神经刺激经皮递送到患者身体中的刺激目标，其中使用位于身体上的表面刺激电极大致超过刺激目标。

15. 发明申请

US20100324628A1 METHOD AND APPARATUS FOR OPTIMIZING VAGAL NERVE STIMULATION USING LARYNGEAL ACTIVITY 有权
标题翻译：使用Larynge活动优化VAGAL神经刺激的方法和装置
公开(公告)号：US20100324628A1
公开(公告)日：2010-12-23
申请号：US12872408
申请日：2010-08-31
申请人： Randy Westlund , Anthony V. Caparso , Mark Bly
发明人： Randy Westlund , Anthony V. Caparso , Mark Bly
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61B5/04001 , A61B5/0402 , A61B5/1104 , A61B5/6822 , A61B5/7203 , A61N1/0551 , A61N1/36114 , A61N1/36542 , A61N1/37247 , A61N1/37288
摘要： A neural stimulation system delivers neural stimulation to the vagus nerve and senses a signal indicative of laryngeal activity resulting from the neural stimulation. The signal indicative of laryngeal activity is used, for example, to guide electrode placement, determine stimulation threshold, detect lead/electrode problems, detect neural injury, and monitor healing processing following the electrode placement inside the body of a patient.
摘要翻译：神经刺激系统将神经刺激传递给迷走神经，并感测到指示由神经刺激引起的喉部活动的信号。例如，使用指示喉部活动的信号来引导电极放置，确定刺激阈值，检测铅/电极问题，检测神经损伤，以及在患者体内的电极放置之后监测愈合过程。

16. 发明授权

US07797050B2 Neural stimulator to treat sleep disordered breathing 有权
标题翻译：神经刺激剂治疗睡眠呼吸紊乱
公开(公告)号：US07797050B2
公开(公告)日：2010-09-14
申请号：US12691392
申请日：2010-01-21
申请人： Imad Libbus , Anthony V. Caparso , M. Jason Brooke , Jonathan Kwok , Kent Lee , Yachuan Pu
发明人： Imad Libbus , Anthony V. Caparso , M. Jason Brooke , Jonathan Kwok , Kent Lee , Yachuan Pu
IPC分类号： A61N1/00
CPC分类号： A61N1/36185 , A61N1/3611
摘要： Various aspects relate to an implantable device. Various device embodiments include at least one sensor for use in detecting sleep disordered breathing, a pulse generator adapted to deliver a first electrical signal through at least one electrode to stimulate a neural target, and a controller adapted to communicate with the at least one sensor and with the pulse generator. The controller is adapted to detect sleep disordered breathing using the at least one sensor and provide a therapy for sleep disordered breathing in response to a detected apneic event. The therapy for sleep disordered breathing is adapted to deliver the first electrical signal through the at least one electrode to induce a cough reflex to terminate the apneic event. Various embodiments stimulate a superior laryngeal nerve, various embodiments stimulate a recurrent laryngeal nerve, and various embodiments stimulate a vagus nerve. Other aspects and embodiments are provided herein.
摘要翻译：各种方面涉及可植入装置。各种装置实施例包括用于检测睡眠无序呼吸的至少一个传感器，适于通过至少一个电极传递第一电信号以刺激神经靶的脉冲发生器，以及适于与至少一个传感器和与脉冲发生器。所述控制器适于使用所述至少一个传感器检测睡眠呼吸障碍，并响应于检测到的呼吸暂停事件提供针对睡眠呼吸障碍的治疗。用于睡眠呼吸紊乱的治疗适于通过至少一个电极传递第一电信号以引起咳嗽反射以终止呼吸暂停事件。各种实施方案刺激上喉神经，各种实施方案刺激复发性喉神经，并且各种实施方案刺激迷走神经。本文提供了其它方面和实施例。

17. 发明授权

US07797041B2 Transcutaneous neurostimulator for modulating cardiovascular function 有权
标题翻译：用于调节心血管功能的经皮神经刺激器
公开(公告)号：US07797041B2
公开(公告)日：2010-09-14
申请号：US11548359
申请日：2006-10-11
申请人： Imad Libbus , Anthony V. Caparso , Andrew P. Kramer
发明人： Imad Libbus , Anthony V. Caparso , Andrew P. Kramer
IPC分类号： A61N1/18
CPC分类号： A61N1/36114 , A61N1/36017 , Y10S128/907
摘要： A neurostimulation device includes an external neurostimulator worn by a patient using a bracing element that braces a portion of the patient's body. The external neurostimulator delivers neurostimulation to modulate a cardiovascular function of the patient. In one embodiment, the external stimulator delivers the neurostimulation transcutaneously to a stimulation target in the patient's body using surface stimulation electrodes placed on the body approximately over the stimulation target.
摘要翻译：神经刺激装置包括由患者佩戴的外部神经刺激器，其使用支撑患者身体的一部分的支撑元件。外部神经刺激仪提供神经刺激来调节患者的心血管功能。在一个实施例中，外部刺激器将神经刺激经皮递送到患者身体中的刺激目标，其中使用位于身体上的表面刺激电极大致超过刺激目标。

18. 发明申请

US20090204173A1 Multi-Frequency Neural Treatments and Associated Systems and Methods 审中-公开
标题翻译：多频神经治疗及相关系统与方法
公开(公告)号：US20090204173A1
公开(公告)日：2009-08-13
申请号：US12264836
申请日：2008-11-04
申请人： Zi-Ping Fang , Anthony V. Caparso , Brain J. Erickson
发明人： Zi-Ping Fang , Anthony V. Caparso , Brain J. Erickson
IPC分类号： A61N1/34
CPC分类号： A61N1/0551 , A61N1/36071 , A61N1/36171 , A61N1/3787
摘要： Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz.
摘要翻译：公开了多频神经治疗及相关系统和方法。根据特定实施例的方法包括至少通过以高达约1500Hz的第一频率范围的频率将第一电信号施加到患者脊髓区域的第一目标位置来减少患者疼痛，并且施加第二电信号电信号以约2,500Hz至约100,000Hz的第二频率范围内的患者脊髓区域的第二目标位置。

19. 发明申请

US20080319513A1 NEURAL STIMULATION WITH RESPIRATORY RHYTHM MANAGEMENT 有权
标题翻译：神经刺激与呼吸环境管理
公开(公告)号：US20080319513A1
公开(公告)日：2008-12-25
申请号：US11767901
申请日：2007-06-25
申请人： Yachuan Pu , Anthony V. Caparso , Gerrard M. Carlson , Joseph M. Pastore
发明人： Yachuan Pu , Anthony V. Caparso , Gerrard M. Carlson , Joseph M. Pastore
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61B5/0816 , A61B5/4035 , A61N1/3601 , A61N1/36053 , A61N1/36114 , A61N1/36117
摘要： A system embodiment comprises at least one respiration sensor, a neural stimulation therapy delivery module, and a controller. The respiration sensor is adapted for use in monitoring respiration of the patient. The neural stimulation therapy delivery module is adapted to generate a neural stimulation signal for use in stimulating the autonomic neural target of the patient for the chronic neural stimulation therapy. The controller is adapted to receive a respiration signal from the at least one respiration sensor indicative of the patient's respiration, and adapted to control the neural stimulation therapy delivery module using a respiratory variability measurement derived using the respiration signal.
摘要翻译：系统实施例包括至少一个呼吸传感器，神经刺激治疗传递模块和控制器。呼吸传感器适用于监测患者的呼吸。神经刺激治疗递送模块适于产生用于刺激患者的自主神经靶标用于慢性神经刺激治疗的神经刺激信号。控制器适于接收来自指示患者呼吸的至少一个呼吸传感器的呼吸信号，并且适于使用使用呼吸信号导出的呼吸变异性测量来控制神经刺激治疗递送模块。

20. 发明授权

US09456836B2 Apparatus and method for delivering a neurostimulator into the pterygopalatine fossa 有权
标题翻译：将神经刺激器输送到翼腭窝的装置和方法
公开(公告)号：US09456836B2
公开(公告)日：2016-10-04
申请号：US13476224
申请日：2012-05-21
申请人： Carl Lance Boling , Anthony V. Caparso , Ryan Powell , Jennifer Teng , Morgan Clyburn
发明人： Carl Lance Boling , Anthony V. Caparso , Ryan Powell , Jennifer Teng , Morgan Clyburn
IPC分类号： A61N1/05 , A61B17/24 , A61B17/34 , A61N1/36 , A61B17/02 , A61B17/3211 , A61B17/32 , A61N1/375
CPC分类号： A61B17/24 , A61B17/02 , A61B17/3211 , A61B17/3468 , A61B2017/320052 , A61N1/0526 , A61N1/0546 , A61N1/0548 , A61N1/36 , A61N1/3605 , A61N1/36057 , A61N1/375
摘要： One aspect of the present disclosure includes a neurostimulator delivery apparatus. The apparatus includes a handle portion, an elongate shaft extending from the handle portion, and a distal deployment portion. The distal deployment portion is configured to releasably mate with a neurostimulator. The neurostimulator is sized and configured for implantation into a craniofacial region of a subject.
摘要翻译：本公开的一个方面包括神经刺激器输送装置。该装置包括手柄部分，从把手部分延伸的细长轴和远端展开部分。远侧展开部分构造成可释放地与神经刺激器配合。神经刺激器的尺寸和构造适于植入受试者的颅面区域。

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