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11. 发明申请

WO2005036801A2 GROUP CALL MANAGEMENT THROUGH RECEIVE/TRANSMIT SYNCHRONIZATION 审中-公开
标题翻译：通过接收/发送同步进行集体呼叫管理
公开(公告)号：WO2005036801A2
公开(公告)日：2005-04-21
申请号：PCT/US2004/033008
申请日：2004-10-07
申请人： MOTOROLA, INC. , KHAWAND, Charbel , LIU, Bin , MILLER, Jianping, W.
发明人： KHAWAND, Charbel , LIU, Bin , MILLER, Jianping, W.
IPC分类号： H04L
CPC分类号： H04B7/269 , H04W56/002 , H04W56/0035 , H04W92/18
摘要： A method of communicating with a transceiver (120). In one arrangement, the method of communicating with the transceiver can be performed in a systemless group environment. Synchronization information (150) can be received from a mobile transceiver (110) and used to synchronize to the mobile transceiver. The synchronization information can include a timing offset and a frequency offset. Synchronization can be maintained until a predetermined condition is met, for example, a predetermined amount of group inactivity.
摘要翻译：一种与收发器（120）进行通信的方法。在一种布置中，可以在无系统的组环境中执行与收发器通信的方法。可以从移动收发机（110）接收同步信息（150）并用于与移动收发信机同步。同步信息可以包括定时偏移和频率偏移。可以保持同步，直到满足预定条件，例如，预定量的组不活动。

12. 发明申请

WO2003092693A1 METHODS OF TREATMENT OF GLAUCOMA AND OTHER CONDITIONS MEDIATED BY NOS-2 EXPRESSION VIA INHIBITION OF THE EGFR PATHWAY 审中-公开
标题翻译：通过抑制EGFR途径通过NOS-2表达介导的GLAUCOMA和其他条件的治疗方法
公开(公告)号：WO2003092693A1
公开(公告)日：2003-11-13
申请号：PCT/US2003/014484
申请日：2003-05-06
申请人： WASHINGTON UNIVERSITY , LIU, Bin , NEUFELD, Arthur, H.
发明人： LIU, Bin , NEUFELD, Arthur, H.
IPC分类号： A61K31/47
CPC分类号： A61K31/00 , A61K31/47 , A61K31/517 , A61K31/60 , A61K45/06 , A61K2039/505
摘要： Therapeutic methods and compositions for the treatment of glaucoma and other conditions mediated at least in part by the expression of NOS-2 are provided.
摘要翻译：提供了用于治疗青光眼和至少部分地由NOS-2表达介导的其它病症的治疗方法和组合物。

13. 发明申请

WO2018058446A1 SYSTEMS AND METHODS FOR HEALING IMAGES IN DEDUPLICATION STORAGE 审中-公开
标题翻译：系统和方法，用于治疗重复使用储存中的图像
公开(公告)号：WO2018058446A1
公开(公告)日：2018-04-05
申请号：PCT/CN2016/100855
申请日：2016-09-29
申请人： VERITAS TECHNOLOGIES LLC , LIU, Bin , ZHANG, Xianbo , CHENG, Shuai , SHAN, Cheng , JIANG, Wenfeng
发明人： LIU, Bin , ZHANG, Xianbo , CHENG, Shuai , SHAN, Cheng , JIANG, Wenfeng
IPC分类号： G06F11/14
摘要： The disclosed computer-implemented method for healing images in deduplication storage may include (1) detecting that a data segment stored within deduplication storage is corrupted by executing an algorithm on the data segment to generate a numerical identifier for the data segment and determining that the numerical identifier does not match a previously stored numerical identifier for the data segment, (2) checking, during a backup operation, whether a digital fingerprint of a data segment of an image being backed up matches a digital fingerprint of the corrupted data segment that was taken prior to corruption and that is already stored within the deduplication storage, and (3) appending the data segment from the image being backed up to a container that already contains the corrupted data segment rather than replacing the corrupted data segment. Various other methods, systems, and computer-readable media are also disclosed.
摘要翻译：所公开的用于在去重复存储装置中修复图像的计算机实现的方法可以包括（1）通过对数据片段执行算法来检测存储在去重复存储器内的数据片段是否被破坏，以生成用于所述数据段并确定所述数字标识符与所述数据段的先前存储的数字标识符不匹配，（2）在备份操作期间检查正在备份的图像的数据段的数字指纹是否匹配数字指纹损坏的数据段在腐败之前被采用并且已存储在重复数据删除存储器中，以及（3）将数据段从正在备份的映像附加到已经包含损坏的数据段的容器，而不是替换已损坏的数据段。还公开了各种其他方法，系统和计算机可读介质。

14. 发明申请

WO2017100461A1 POLYNUCLEOTIDE CONSTRUCTS HAVING AN AUXILIARY MOIETY NON-BIOREVERSIBLY LINKED TO AN INTERNUCLEOSIDE PHOSPHATE OR PHOSPHOROTHIOATE 审中-公开
标题翻译：多核苷酸构建体具有辅助性部分，不可链接到磷酸核糖间磷酸酯或磷酸核糖
公开(公告)号：WO2017100461A1
公开(公告)日：2017-06-15
申请号：PCT/US2016/065639
申请日：2016-12-08
申请人： SOLSTICE BIOLOGICS, LTD. , BRADSHAW, Curt, W. , SAKAMURI, Sukumar , MEADE, Bryan, R. , ELTEPU, Laxman , IACONO, Giuseppe, Dello , LAM, Son , STOCK, Joseph , LIU, Dingguo , LIU, Bin
发明人： BRADSHAW, Curt, W. , SAKAMURI, Sukumar , MEADE, Bryan, R. , ELTEPU, Laxman , IACONO, Giuseppe, Dello , LAM, Son , STOCK, Joseph , LIU, Dingguo , LIU, Bin
IPC分类号： A61K31/7088 , C07F9/02 , C12N15/85 , C12P19/34
CPC分类号： A61K31/7088 , C07F9/65515 , C07F9/65586 , C07F9/65616 , C12N15/85
摘要： The invention features a hybridized polynucleotide construct including a passenger strand, a guide strand loadable into a RISC complex, and one or more auxiliary moieties. At least one of the auxiliary moieties is non-bioreversibly linked to an internucleoside phosphate or phosphorothioate in the passenger strand. The invention further features methods of delivery a polynucleotide construct to a cell and methods of reducing the expression of a protein in a cell. The methods typically involve contacting the cell with the hybridized polynucleotide construct.
摘要翻译：本发明的特征在于包含过客链，可加载到RISC复合物中的引导链和一个或多个辅助部分的杂交多核苷酸构建体。至少一个辅助部分与过客链中的磷酸核苷间磷酸酯或硫代磷酸酯不可逆地连接。本发明进一步描述了将多核苷酸构建体递送至细胞的方法和减少细胞中蛋白质表达的方法。该方法通常涉及使细胞与杂交的多核苷酸构建体接触。

15. 发明申请

WO2013029340A9 BIOCOMPATIBLE NANOPARTICLES WITH AGGREGATION INDUCED EMISSION CHARACTERISTICS AS FLUORESCENT BIOPROBES AND METHODS OF USING THE SAME FOR IN VITRO AND IN VIVO IMAGING 审中-公开
公开(公告)号：WO2013029340A9
公开(公告)日：2013-03-07
申请号：PCT/CN2012/001227
申请日：2012-09-03
申请人： THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY , NATIONAL UNIVERSITY OF SINGAPORE , TANG, Benzhong , QIN, Wei , LIU, Jianzhao , CHEN, Sijie , KWOK, Tsz Kin , LIU, Bin , LI, Kai , DING, Dan , SHI, Haibin , GENG, Jun Long , SUN, Jingzhi , QIN, Anjun , ZHAO, Qiuli
发明人： TANG, Benzhong , QIN, Wei , LIU, Jianzhao , CHEN, Sijie , KWOK, Tsz Kin , LIU, Bin , LI, Kai , DING, Dan , SHI, Haibin , GENG, Jun Long , SUN, Jingzhi , QIN, Anjun , ZHAO, Qiuli
IPC分类号： C09K11/06
摘要： The development of fluorescent bioprobes comprising organic fluorescent compounds that exhibit aggregation induced emission (AIE) properties, methods of producing the same, and their practical applications for in vitro and in vivo bioimaging.

16. 发明申请

WO2012121939A2 AMINOPYRAZINE COMPOUNDS 审中-公开
标题翻译：氨基吡嗪化合物
公开(公告)号：WO2012121939A2
公开(公告)日：2012-09-13
申请号：PCT/US2012/027066
申请日：2012-02-29
申请人： LOCUS PHARMACEUTICALS, INC. , SHETTY, Rupa S. , WONG, Dora Do-York, legal representative/heir of MORIARTY, Kevin J. (Deceased) , KELLY, Martha J. , LIU, Bin , ZOU, Jinming , MOFFETT, Kristofer K. , LEE, Younghee
发明人： SHETTY, Rupa S. , WONG, Dora Do-York, legal representative/heir of MORIARTY, Kevin J. (Deceased) , KELLY, Martha J. , LIU, Bin , ZOU, Jinming , MOFFETT, Kristofer K. , LEE, Younghee
IPC分类号： A61K31/5377
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/14 , C07D409/14 , C07D417/14 , C07D487/04 , C07D491/056
摘要： A compound of formula (I): wherein all symbols have the same meanings as defined in the specification; a salt thereof, a solvate thereof, an N-oxide thereof, or a prodrug thereof, has an Itk inhibitory activity, and is useful as a method for preventing and/or treating atopic dermatitis, and the like.
摘要翻译：式（I）的化合物：其中所有符号具有与说明书中定义的相同的含义; 其盐，其溶剂合物，N-氧化物或其前药具有Itk抑制活性，可用作预防和/或治疗特应性皮炎等的方法。

17. 发明申请

WO2007037843A2 METHOD AND APPARATUS FOR SHARING MEMORY IN A MULTIPROCESSOR SYSTEM 审中-公开
标题翻译：用于在多处理器系统中共享存储器的方法和装置
公开(公告)号：WO2007037843A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/032634
申请日：2006-08-22
申请人： MOTOROLA, INC. , KHAWAND, Charbel , KHAWAND, Jean , LIU, Bin
发明人： KHAWAND, Charbel , KHAWAND, Jean , LIU, Bin
IPC分类号： G06F5/00
CPC分类号： G06F9/5016
摘要： A multiprocessor system (100) for sharing memory has a memory (102), and two or more processors (104). The processors are programmed to establish (202) memory buffer pools between the processors, and for each memory buffer pool, establish (204) an array of buffer pointers that point to corresponding memory buffers. The processors are further programmed to, for each array of buffer pointers, establish (206) a consumption pointer for the processor owning the memory buffer pool, and a release pointer for another processor sharing said memory buffer pool, each pointer initially pointing to a predetermined location of the array, and adjust (208-236) the consumption and release pointers according to buffers consumed and released.
摘要翻译：用于共享存储器的多处理器系统（100）具有存储器（102）和两个或更多个处理器（104）。处理器被编程为在处理器之间建立（202）存储器缓冲池，并且对于每个存储器缓冲池，建立指向相应存储器缓冲器的缓冲器指针阵列（204）。处理器进一步被编程为对于每个缓冲器指针阵列，建立（206）用于处理器拥有存储器缓冲池的消耗指针，以及用于共享所述存储器缓冲池的另一个处理器的释放指针，每个指针最初指向预定的阵列的位置，并根据消耗和释放的缓冲区调整（208-236）消耗和释放指针。

18. 发明申请

WO2006083932A2 METHODS AND COMPOSITIONS FOR AGGREGANT DETECTION 审中-公开
标题翻译：方法和组合物的集合检测
公开(公告)号：WO2006083932A2
公开(公告)日：2006-08-10
申请号：PCT/US2006/003498
申请日：2006-01-31
申请人： THE REGENTS OF THE UNIVERSITY , BAZAN, Guillermo, C. , LIU, Bin
发明人： BAZAN, Guillermo, C. , LIU, Bin
CPC分类号： G01N21/6486 , C08G61/02 , C08G61/123 , C12Q1/6818 , C12Q1/6825 , G01N33/542 , G01N33/54373 , Y10T436/143333 , C12Q2565/113 , C12Q2563/173 , C12Q2565/101
摘要： This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be transferred from an excited state of the first optically active unit to the second optically active unit. The second optically active unit is present in a lesser amount, but its relative concentration is increased upon aggregation, increasing its absorption of energy from the first optically active units. This increase in energy transfer can be detected in variety of formats to produce an aggregation sensing system for various aggregants, including for quantitation. Other variations of the inventions are described further herein.
摘要翻译：本发明涉及用于检测和分析样本中的聚集体的聚集传感器，以及涉及这种传感器的方法，物品和组合物。传感器包括第一和第二光学活性单元，其中能量可以从第一光学活性单元的激发态转移到第二光学活性单元。第二光学活性单元的存在量较小，但其聚集时其相对浓度增加，从而增加了其从第一光学活性单元吸收的能量。能量转移的这种增加可以以各种格式来检测，以产生用于各种聚集体的聚集感应系统，包括用于定量。本发明的其他变体在本文中进一步描述。

19. 发明申请

WO2006074471A2 CATIONIC CONJUGATED POLYMERS SUITABLE FOR STRAND-SPECIFIC POLYNUCLEOTIDE DETECTION IN HOMOGENEOUS AND SOLID STATE ASSAYS 审中-公开
标题翻译：适用于均质和固体状态测定中特异性多核苷酸检测的阳离子共轭聚合物
公开(公告)号：WO2006074471A2
公开(公告)日：2006-07-13
申请号：PCT/US2006/000882
申请日：2006-01-10
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BAZAN, Guillermo, C. , LIU, Bin
发明人： BAZAN, Guillermo, C. , LIU, Bin
CPC分类号： C08G61/02 , C08G61/122 , C08G61/123 , C12Q1/6818 , C12Q1/6837 , G01N21/6428 , G01N21/6452 , G01N2021/6419 , G01N2021/6439 , C12Q2563/131 , C12Q2537/119 , C12Q2525/107
摘要： The invention further relates to polycationic multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. In some aspects biological assays are provided in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations. The multichromophore may interact at least in part electrostatically with the sensor and/or the target, and an increase in energy transfer with the polymer may occur upon binding of the sensor and the target. Other variations of the inventions are described further herein.
摘要翻译：本发明还涉及可以是共轭聚合物的阳离子多色素，以及如本文所述使用它们的方法，制品和组合物。在一些方面，本发明涉及用于检测和分析样品中生物分子的方法，制品和组合物。提供的测定包括测定样品中靶生物分子的存在或其相对量的那些，或者测定可以是定量或半定量的。该方法可以在衬底上进行。这些方法可以以阵列格式在基底上进行，其可以是传感器。在一些实施方案中，使用不包含能够与阳离子多重色素交换能量的荧光团的传感器生物分子来提供检测测定。在一些方面，提供生物测定，其中在所有置换中，能量在一个或多个多色素，目标生物分子上的标记，传感器生物分子上的标记和/或多核苷酸特异的荧光染料之间转移。多重色淀可以至少部分地与传感器和/或靶相互作用，并且当传感器和目标物结合时，聚合物的能量传递的增加可能发生。本文进一步描述了本发明的其它变型。

20. 发明申请

WO2006062982A2 UREA INHIBITORS OF MAP KINASES 审中-公开
标题翻译：地图动物的尿素抑制剂
公开(公告)号：WO2006062982A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/044141
申请日：2005-12-07
申请人： LOCUS PHARMACEUTICALS, INC. , MICHELOTTI, Enrique, Luis , SPRINGMAN, Eric, Bruce , NGUYEN, Duyan , SHETTY, Rupa, S. , LEE, Younghee , MOFFETT, Kristofer, Kent , LUDINGTON, Jennifer, Lee , FUJIMOTO, Ted, Tsutomu , KONTEATIS, Zenon, D. , LIU, Bin , HOLLINGER, Frank , DORSEY, Bruce, D.
发明人： MICHELOTTI, Enrique, Luis , SPRINGMAN, Eric, Bruce , NGUYEN, Duyan , SHETTY, Rupa, S. , LEE, Younghee , MOFFETT, Kristofer, Kent , LUDINGTON, Jennifer, Lee , FUJIMOTO, Ted, Tsutomu , KONTEATIS, Zenon, D. , LIU, Bin , HOLLINGER, Frank , DORSEY, Bruce, D.
IPC分类号： C07D417/02 , C07D413/02 , C07D409/02
CPC分类号： C07D333/38 , C07D231/40 , C07D243/08 , C07D277/48 , C07D277/56 , C07D295/192 , C07D333/36 , C07D403/06 , C07D405/06 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/14 , C07D495/04
摘要： The present invention is directed to a compound having the formula (I) wherein R 1 , R 2 , G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases such as MAP Kinases, in particular p38 kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease. The present invention is also directed to a method of treating or preventing a protein kinase-mediated condition.
摘要翻译：本发明涉及具有式（I）的化合物，其中R 1，R 2，G和Q在本文中定义。本发明的化合物可用作蛋白激酶如MAP激酶，特别是p38激酶的抑制剂。本发明还涉及包含根据上式的化合物的组合物。本文所述的化合物和组合物可用于治疗和预防炎性疾病或疾病。本发明还涉及治疗或预防蛋白激酶介导的病症的方法。

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