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11. 发明申请

WO2010065760A1 IMIDAZO [1,2A] PYRIDINE DERIVATIVES, THEIR USE AS S1P1 AGONISTS AND METHODS FOR THEIR PRODUCTION 审中-公开
标题翻译：咪唑并[1,2A]吡啶衍生物，用作S1P1激动剂及其生产方法
公开(公告)号：WO2010065760A1
公开(公告)日：2010-06-10
申请号：PCT/US2009/066620
申请日：2009-12-03
申请人： EXELIXIS, INC. , CANNE BANNEN, Lynne , CHAN, Diva Sze-ming , GU, Xiao-hui , MAC, Morrison, B. , NG, Stephanie , WANG, Tie-lin , WANG, Yong , XU, Wei
发明人： CANNE BANNEN, Lynne , CHAN, Diva Sze-ming , GU, Xiao-hui , MAC, Morrison, B. , NG, Stephanie , WANG, Tie-lin , WANG, Yong , XU, Wei
IPC分类号： C07D471/04 , A61K31/437 , A61P37/00
CPC分类号： C07D471/04
摘要： The invention is directed to Compounds of Formula (I) as well as methods of making and using the compounds.
摘要翻译：本发明涉及式（I）的化合物以及制备和使用该化合物的方法。

12. 发明申请

WO2010043355A1 A CATALYST FOR THE PRODUCTION OF LINEAR LOW DENSITY POLYETHYLENE 审中-公开
标题翻译：用于生产线性低密度聚乙烯的催化剂
公开(公告)号：WO2010043355A1
公开(公告)日：2010-04-22
申请号：PCT/EP2009/007311
申请日：2009-10-12
申请人： SAUDI BASIC INDUSTRIES CORPORATION , SABIC PETROCHEMICALS B.V. , XU, Wei , ABURAQABAH, Atieh , MOHAMED, Sirajudeen , HAZRA, Srikant
发明人： XU, Wei , ABURAQABAH, Atieh , MOHAMED, Sirajudeen , HAZRA, Srikant
IPC分类号： C08F4/651 , C08F210/16 , C08F4/654
CPC分类号： C08F210/16 , C08F4/651 , C08F4/6546 , C08F210/08 , C08F2500/18 , C08F2500/12
摘要： The invention is directed to a catalyst for the production of linear low density polyethylene. The catalyst is obtained by an one pot process comprising the steps (1) reacting a support with a compound having the formula RMgX or MgR 1 R 2 , wherein R, R 1 and R 2 are selected from the group consisting of alkyl, cycloalkyl, aryl or alkaryl, and X is selected from the group consisting of halogen, OR 3 or OC(O)R 4 wherein R 3 and R 4 are alkyl groups containing 2-50 carbon atoms (2) reacting the magnesium treated support with a compound which is able to react with unreacted magnesium units and (3) reacting the product obtained in step (2) with a compound containing a group IV transition metal component wherein the titanium loading of the catalyst ranges between 1.2 % by weight and 6.0 % by weight relative to the total weight of the catalyst.
摘要翻译：本发明涉及用于生产线性低密度聚乙烯的催化剂。催化剂通过一锅法获得，其包括步骤（1）使载体与式RMgX或MgR1R2的化合物反应，其中R，R 1和R 2选自烷基，环烷基，芳基或烷芳基，和 X选自卤素，OR 3或OC（O）R 4，其中R 3和R 4是含有2-50个碳原子的烷基（2）使镁处理的载体与能够与未反应的镁单元反应的化合物和（3）使步骤（2）中获得的产物与含有IV族过渡金属组分的化合物反应，其中催化剂的钛负载量相对于催化剂的总重量为1.2重量％至6.0重量％。

13. 发明申请

WO2008124636A1 APPARATUS AND METHODS OF MILLING A RESTRICTED CASING SHOE 审中-公开
标题翻译：一种限制性壳体鞋的设备和方法
公开(公告)号：WO2008124636A1
公开(公告)日：2008-10-16
申请号：PCT/US2008/059487
申请日：2008-04-04
申请人： WEATHERFORD/LAMB, INC. , RHINEHART, Bill , STULBERG, Marty , CARTER, Thurman B. , XU, Wei , REDLINGER, Thomas, M. , HALFORD, Hubert, E.
发明人： RHINEHART, Bill , STULBERG, Marty , CARTER, Thurman B. , XU, Wei , REDLINGER, Thomas, M. , HALFORD, Hubert, E.
IPC分类号： E21B10/26 , E21B10/32 , E21B29/10
CPC分类号： E21B10/32 , E21B29/10 , Y10T408/78
摘要： A method of removing a restriction in a tubular located in a well includes providing a drilling assembly with a drill bit and a reamer, the reamer having a cutting structure for removing the restriction; drilling through a lower portion of the tubular; expanding the reamer at a location below the restriction; and urging the reamer back toward the restriction to remove the restriction.
摘要翻译：一种去除位于井中的管状物中的限制的方法包括提供具有钻头和铰刀的钻孔组件，所述铰刀具有用于移除限制的切割结构; 穿过管的下部; 扩大铰刀在限制以下的位置; 并敦促扩孔器返回限制，以消除限制。

14. 发明申请

WO2006108059A1 C-MET MODULATORS AND METHODS OF USE 审中-公开
标题翻译： C-MET调制器及其使用方法
公开(公告)号：WO2006108059A1
公开(公告)日：2006-10-12
申请号：PCT/US2006/012709
申请日：2006-04-06
申请人： EXELIXIS, INC. , FORSYTH, Timothy, Patrick , MAC, Morrison, B. , LEAHY, James, William , NUSS, John, M. , XU, Wei
发明人： FORSYTH, Timothy, Patrick , MAC, Morrison, B. , LEAHY, James, William , NUSS, John, M. , XU, Wei
IPC分类号： C07D401/12 , C07D401/14 , A61K31/47 , A61K31/517
CPC分类号： C07D215/233
摘要： The present invention provides compounds, which have activity for modulating protein kinase enzymatic activity and are potentially useful for modulating cellular activities such as, e.g., proliferation, differentiation, programmed cell death, migration and chemoinvasion. The present invention also provides compositions containing such compounds, and methods for producing and using such compounds and compositions.
摘要翻译：本发明提供具有调节蛋白激酶酶活性的活性并且可能用于调节细胞活性例如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。本发明还提供含有这些化合物的组合物，以及制备和使用这些化合物和组合物的方法。

15. 发明申请

WO2006071819A1 [1H-PYRAZOLO[3, 4-D]PYRIMIDIN-4-YL]-PIPERIDINE OR -PIPERAZINE COMPOUNDS AS SERINE-THEORONINE KINASE MODULATORS (P70S6K, ATK1 AND ATK2) FOR THE TREATMENT OF IMMUNOLOGICAL, INFLAMMATORY AND PROLIFERATIVE DISEASES 审中-公开
标题翻译： [1H-PYRAZOLO [3，4-D] PYRIMIDIN-4-YL] - 哌啶或哌嗪化合物作为丝氨酸 - 神经激素调节因子（P70S6K，ATK1和ATK2）用于治疗免疫，炎症和增殖性疾病
公开(公告)号：WO2006071819A1
公开(公告)日：2006-07-06
申请号：PCT/US2005/046938
申请日：2005-12-27
申请人： EXELIXIS, INC. , RICE, Ken , CO, Erick, Wang , KIM, Moon, Hwan , BANNEN, Lynn, Canne , BUSSENIUS, Joerg , LE, Donna , TSUHAKO, Amy, Lew , NUSS, John , WANG, Yong , XU, Wei , KLEIN, Rhett, Ronald
发明人： RICE, Ken , CO, Erick, Wang , KIM, Moon, Hwan , BANNEN, Lynn, Canne , BUSSENIUS, Joerg , LE, Donna , TSUHAKO, Amy, Lew , NUSS, John , WANG, Yong , XU, Wei , KLEIN, Rhett, Ronald
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P29/00 , A61P37/00
CPC分类号： C07D487/04
摘要： The invention provides compounds of formula (I) and methods for inhibition of kinases, more specifically p70S6 kinases, and more preferably p70S6, Akt-1 and Akt-2 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
摘要翻译：本发明提供式（I）化合物和抑制激酶，更特别是p70S6激酶，更优选p70S6，Akt-1和Akt-2激酶的方法。本发明提供用于调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移，化学侵袭和代谢的化合物。本发明的化合物如上所述抑制，调节和/或调节与细胞活性变化有关的激酶受体信号转导途径，并且本发明包括含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法。

16. 发明申请

WO2005030140A2 C-MET MODULATORS AND METHODS OF USE 审中-公开
标题翻译： C-MET调制器及其使用方法
公开(公告)号：WO2005030140A2
公开(公告)日：2005-04-07
申请号：PCT/US2004/031523
申请日：2004-09-24
申请人： EXELIXIS, INC. , BANNEN, Lynne Canne , CHAN, Diva Sze-Ming , CHEN, Jeff , DALRYMPLE, Lisa Esther , FORSYTH, Timothy Patrick , HUYNH, Tai Phat , JAMMALAMADAKA, Vasu , KHOURY, Richard George , LEAHY, James William , MAC, Morrison B. , MANN, Grace , MANN, Larry W. , NUSS, John M. , PARKS, Jason Jevious , TAKEUCHI, Craig Stacy , WANG, Yong , XU, Wei
发明人： BANNEN, Lynne Canne , CHAN, Diva Sze-Ming , CHEN, Jeff , DALRYMPLE, Lisa Esther , FORSYTH, Timothy Patrick , HUYNH, Tai Phat , JAMMALAMADAKA, Vasu , KHOURY, Richard George , LEAHY, James William , MAC, Morrison B. , MANN, Grace , MANN, Larry W. , NUSS, John M. , PARKS, Jason Jevious , TAKEUCHI, Craig Stacy , WANG, Yong , XU, Wei
IPC分类号： A61K
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
摘要翻译：本发明提供用于调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。更具体地，本发明提供抑制，调节和/或调节激酶受体，特别是c-Met，KDR，c-Kit，flt-3和flt-4，与细胞活性变化相关的信号转导途径的喹啉和喹啉含有这些化合物的组合物，以及使用它们治疗激酶依赖性疾病和病症的方法。本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。

17. 发明申请

WO2005020921A2 C-KIT MODULATORS AND METHODS OF USE 审中-公开
标题翻译： C-KIT调节器及其使用方法
公开(公告)号：WO2005020921A2
公开(公告)日：2005-03-10
申请号：PCT/US2004/028001
申请日：2004-08-27
申请人： EXELIXIS, INC. , CHENG, Wei , CO, Erick, Wang , KIM, Moon, Hwan , KLEIN, Rhett, Ronald , LE, Donna, T. , LEW, Amy , NUSS, John, M. , XU, Wei , BAJJALIEH, William
发明人： CHENG, Wei , CO, Erick, Wang , KIM, Moon, Hwan , KLEIN, Rhett, Ronald , LE, Donna, T. , LEW, Amy , NUSS, John, M. , XU, Wei , BAJJALIEH, William
IPC分类号： A61K
CPC分类号： A61K31/41 , A61K31/495 , C07D207/333 , C07D207/404 , C07D209/12 , C07D213/30 , C07D215/14 , C07D239/26 , C07D241/12 , C07D249/06 , C07D257/04 , C07D261/08 , C07D307/42 , C07D307/91 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Even more specifically, the invention provides compounds for modulating c-Kit kinase activity and methods of treating diseases mediated by c-Kit activity utilizing the compounds and pharmaceutical compositions thereof.
摘要翻译：本发明提供用于调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。甚至更具体地，本发明提供用于调节c-Kit激酶活性的化合物和利用其化合物及其药物组合物治疗由c-Kit活性介导的疾病的方法。

18. 发明申请

WO2003106381A3 HUMAN ADAM-10 INHIBITORS 审中-公开
公开(公告)号：WO2003106381A3
公开(公告)日：2003-12-24
申请号：PCT/US2003/018262
申请日：2003-06-11
申请人： EXELIXIS, INC. , BANNEN, Lynne, Canne , CO, Erick, W. , JAMMALAMADAKA, Vasu , NUSS, John, M. , KIM, Moon, Hwan , LE, Donna, Tra , LEW, Amy , MAC, Morrison, B. , MAMO, Shumeye , WEN, Zhaoyang , XU, Wei
发明人： BANNEN, Lynne, Canne , CO, Erick, W. , JAMMALAMADAKA, Vasu , NUSS, John, M. , KIM, Moon, Hwan , LE, Donna, Tra , LEW, Amy , MAC, Morrison, B. , MAMO, Shumeye , WEN, Zhaoyang , XU, Wei
IPC分类号： A61K31/495
摘要： The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.

19. 发明申请

WO2003106381A2 HUMAN ADAM-10 INHIBITORS 审中-公开
标题翻译：人ADAM-10抑制剂
公开(公告)号：WO2003106381A2
公开(公告)日：2003-12-24
申请号：PCT/US2003/018262
申请日：2003-06-11
申请人： EXELIXIS, INC. , BANNEN, Lynne, Canne , CO, Erick, W. , JAMMALAMADAKA, Vasu , NUSS, John, M. , KIM, Moon, Hwan , LE, Donna, Tra , LEW, Amy , MAC, Morrison, B. , MAMO, Shumeye , WEN, Zhaoyang , XU, Wei
发明人： BANNEN, Lynne, Canne , CO, Erick, W. , JAMMALAMADAKA, Vasu , NUSS, John, M. , KIM, Moon, Hwan , LE, Donna, Tra , LEW, Amy , MAC, Morrison, B. , MAMO, Shumeye , WEN, Zhaoyang , XU, Wei
IPC分类号： C07C
CPC分类号： C07D241/04 , C07C309/87 , C07D213/70 , C07D401/06 , C07D401/12 , C07D403/06 , C07D413/06
摘要： The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.
摘要翻译：本发明提供了用于抑制ADAM-10蛋白质的化合物，具有选择性对MMP-1。这些化合物可用于体外研究ADAM-10（及其抑制）在生物过程中的作用。本发明还包括药物组合物，其包含一种或多种本发明的ADAM-10抑制剂与药学上可接受的载体的组合。这样的组合物可用于治疗癌症，关节炎和与血管发生相关的疾病。相应地，本发明还包括治疗癌症，关节炎和与血管生成有关的疾病形式的方法，其中ADAM-10起关键作用。

20. 发明申请

WO2002058768A1 IMPROVED HYPODERMIC NEEDLE AND FLUID INJECTION DEVICE 审中-公开
标题翻译：改进的氢氟酸针和流体注射装置
公开(公告)号：WO2002058768A1
公开(公告)日：2002-08-01
申请号：PCT/GB2002/000048
申请日：2002-01-04
申请人： UNIVERSITY OF DUNDEE , CUSCHIERI, Alfred , FRANK, Timothy, Graham , XU, Wei
发明人： CUSCHIERI, Alfred , FRANK, Timothy, Graham , XU, Wei
IPC分类号： A61M5/32
CPC分类号： A61M25/0084 , A61M2025/0086
摘要： The invention relates to an improved hypodermic needle and to a fluid injection device. In one embodiment, a hypodermic needle (10) is disclosed, and a fluid injection device comprises the hypodermic needle (10) and driving means coupled to the needle (10). The hypodermic needle (10) itself comprises a first, hollow needle 12) adapted to have movably secured therein at least one further, hollow needle (14), the at least one further needle (14) and part of the hypodermic needle (10) being movable relative to one another between a stressed position of the at least one furtheer needle (14) is substantially parallel to the first needle (12), and an unstressed position of the at least one further needle (14), in which the free end of the at least one further needle (14) lies beyond the axial and/or radial terminus of the first needle (12). The driving means serves for driving fluid from the at least one further hollow needle (14) at a substantially constant fluid flow rate.
摘要翻译：本发明涉及改进的皮下注射针和流体注射装置。在一个实施例中，公开了皮下注射针（10），并且流体注射装置包括皮下注射针（10）和联接到针（10）的驱动装置。皮下注射针（10）本身包括适于具有可移动地固定在其中的至少一个另外的中空针（14）的第一中空针12，所述至少一个另外的针（14）和所述皮下注射针（10）的一部分，在所述至少一个毛皮针（14）的受应力位置基本上平行于所述第一针（12）和所述至少一个另外的针（14）的无应力位置之间相对于彼此可移动，其中所述自由至少一个另外的针（14）的端部位于第一针（12）的轴向和/或径向末端之外。驱动装置用于以基本恒定的流体流速从至少一个另外的空心针（14）驱动流体。

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