基本信息:
- 专利标题： HUMAN ADAM-10 INHIBITORS
- 专利标题（中）：人ADAM-10抑制剂
- 申请号：PCT/US2003/018262 申请日：2003-06-11
- 公开(公告)号：WO2003106381A2 公开(公告)日：2003-12-24
- 发明人： BANNEN, Lynne, Canne , CO, Erick, W. , JAMMALAMADAKA, Vasu , NUSS, John, M. , KIM, Moon, Hwan , LE, Donna, Tra , LEW, Amy , MAC, Morrison, B. , MAMO, Shumeye , WEN, Zhaoyang , XU, Wei
- 申请人： EXELIXIS, INC. , BANNEN, Lynne, Canne , CO, Erick, W. , JAMMALAMADAKA, Vasu , NUSS, John, M. , KIM, Moon, Hwan , LE, Donna, Tra , LEW, Amy , MAC, Morrison, B. , MAMO, Shumeye , WEN, Zhaoyang , XU, Wei
- 申请人地址： P.O. Box 511, 170 Harbor Way, South San Francisco, CA 94083-0511 US
- 专利权人： EXELIXIS, INC.,BANNEN, Lynne, Canne,CO, Erick, W.,JAMMALAMADAKA, Vasu,NUSS, John, M.,KIM, Moon, Hwan,LE, Donna, Tra,LEW, Amy,MAC, Morrison, B.,MAMO, Shumeye,WEN, Zhaoyang,XU, Wei
- 当前专利权人： EXELIXIS, INC.,BANNEN, Lynne, Canne,CO, Erick, W.,JAMMALAMADAKA, Vasu,NUSS, John, M.,KIM, Moon, Hwan,LE, Donna, Tra,LEW, Amy,MAC, Morrison, B.,MAMO, Shumeye,WEN, Zhaoyang,XU, Wei
- 当前专利权人地址： P.O. Box 511, 170 Harbor Way, South San Francisco, CA 94083-0511 US
- 代理机构： GRIEDEL, Brian
- 优先权： US60/388,326 20020612
- 主分类号： C07C
- IPC分类号： C07C
摘要：
The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.
摘要（中）：
本发明提供了用于抑制ADAM-10蛋白质的化合物，具有选择性对MMP-1。 这些化合物可用于体外研究ADAM-10（及其抑制）在生物过程中的作用。 本发明还包括药物组合物，其包含一种或多种本发明的ADAM-10抑制剂与药学上可接受的载体的组合。 这样的组合物可用于治疗癌症，关节炎和与血管发生相关的疾病。 相应地，本发明还包括治疗癌症，关节炎和与血管生成有关的疾病形式的方法，其中ADAM-10起关键作用。
公开/授权文献:
- WO2003106381A3 HUMAN ADAM-10 INHIBITORS 公开/授权日：2003-12-24