专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明专利

JPH09151102A NEW ANTIBIOTIC AGENT 失效
公开(公告)号：JPH09151102A
公开(公告)日：1997-06-10
申请号：JP33432395
申请日：1995-11-30
申请人： MEIJI MILK PROD CO LTD
发明人： IKEGAMI HIDEJI , TAKAHASHI MASAHIRO , KOJIMA YOSHIYUKI , ODA MUNEHIRO , SUZUKI TADAYUKI , SANO HARUHIKO
IPC分类号： A01N37/40
摘要： PROBLEM TO BE SOLVED: To obtain the subject compound having proliferation suppressing action on algae, giving low load on environment and having low toxicity to human body. SOLUTION: The objective antibiotic agent contains a gallic acid compound of formula I (R is H, CH2 CH2 CH3 or a group expressed by formula II; R , R and R are each H) as an active component. The gallic acid compound is selected from gallic acid, n-propyl gallate or m-galloylgallic acid. The antibiotic agent may be used in the form of an emulsion by adding an emulsifier such as a glycerol fatty acid ester or in a powdery form by attaching the compound to a solid carrier.

12. 发明专利

JPS611382A VARIANT KYM-A 失效
公开(公告)号：JPS611382A
公开(公告)日：1986-01-07
申请号：JP7930085
申请日：1985-04-16
申请人： MEIJI MILK PROD CO LTD
发明人： IMADA MASARU , YOSHIYAMA HIROSHI , ODA MUNEHIRO
IPC分类号： C12N5/00 , C12N5/07 , C12N5/071 , C12N9/64 , C12R1/91
摘要： NEW MATERIAL:Variant KYM-A of human rhabdomyosarcoma having the following properties. The cell shape is spherical form having bending: existing as a single or aggregated (2-100) floating culture, capable of being subjected to suspension spinner culture; being converted into an adherent cell by a conditioned medium; forming a tumor by hypodermic implantation to nude mouse; the most frequent chrosome number is 46 and 47; producing plasminogen activator (PA for short)-KYM. USE:Preparing a thrombolytic drug having low side effect such as hemorrhagic tendency, etc. PREPARATION:The titled variant is removed, separated, cultivated, and isolated from a culture of cell KYM-I separated from human rhabdomyosarcoma. In order to prepare PA-KYM, variant PA-KYM cell is cultivated preferably in a medium containing 10wt% bovine fetal serum, converted into a medium containing no serum at stationary phase, inoculated at a cell density of 10 -10 cell/ml, and cultivated at 37 deg.C.

13. 发明专利

JPS60158115A PLASMINOGEN-ACTIVATOR KYM AND ITS PREPARATION 失效
公开(公告)号：JPS60158115A
公开(公告)日：1985-08-19
申请号：JP1339784
申请日：1984-01-30
申请人： MEIJI MILK PROD CO LTD
发明人： IMADA MASARU , YOSHIYAMA HIROSHI , ODA MUNEHIRO
IPC分类号： C12N9/64 , A61K35/12 , A61K35/13 , A61K38/00 , A61K38/02 , A61K38/36 , A61K38/46 , A61K38/48 , C12N9/72 , C12R1/91
摘要： NEW MATERIAL:Plasminogen activator KYM produced by the mutant KYM-A of human rhabdomyosarcoma cell. Appearance, white powder; molecular weight, two bands between 56,000 and 62,000 (nonreduced type) and between 32,000 and 36,000 (reduced type) by SDS-polyacrylamide gel electrophoresis; solubility, 50mug/ ml in water and salt solution, insoluble in ethanol and ether. USE:Thrombolytic agent. It is a weakly basic glycoprotein having stronger fibrin- bonding capability than urokinase. It is prepared preferably in the form administrable by intravenous injection. PREPARATION:The cell KYM-I separated from human rhabdomyosarcoma (presented by Dr. Morimasa Sekiguchi, Medical Science Laboratory, Tokyo University) is cultured, and the mutant KYM-A prepared by the repeated separation, selection and culture of the cell is subjected to the suspension culture under agitation to obtain the titled substance on an industrial scale.

14. 发明专利

JPS58219121A Preparation of nutrimental composition for patient with advanced disease 失效
标题翻译：具有先进疾病患者的营养成分的制备
公开(公告)号：JPS58219121A
公开(公告)日：1983-12-20
申请号：JP10133882
申请日：1982-06-15
申请人： Meiji Milk Prod Co Ltd
发明人： UEDA KAZUSUKE , KANBE MICHIO , ODA MUNEHIRO , TAKETOMO TADAO
IPC分类号： A61K35/20 , A23C9/137 , A23L35/00 , A61K35/64 , A61K35/74
摘要： PURPOSE: To obtain the titled composition, storable at room temperature for a long term, and orally or parenterally administrable, by incorporating a fermented a fermented milk with honey and a specific stabilizer, homogenizing the resultant mixture, and instantaneously pasteurizing the resultant homogenized mixture at an ultrahigh temperature.
CONSTITUTION: A nutrimental composition prepared by incorporating 100pts.wt. fermented milk with 18W22pts.wt. honey and further ultrahigh methoxypectin (UHM pectin) and propylene glycol ester (PGA) of alginic acid as a stabilizer without causing the separation and settling of the contents even on the instantaneous pasteurization at an ultrahigh temperature. Preferably, the above-mentioned UHM pectin is added in an amount of 0.1W1.0%, and the PGA is added in an amount of 0.05W0.5%. The above-mentioned fermented milk is obtained by adding skimmilk powder, water and if necessary a fat or oil to a cow's milk, and inoculating the prepared milk with a lactic acid bacterial starter, and cultivating the bacterial starter at 3.5W4.5pH.
COPYRIGHT: (C)1983,JPO&Japio
摘要翻译：目的：为了获得长期储存的口服或肠胃外给药的标题化合物，通过将发酵的发酵乳与蜂蜜和特定稳定剂混合，使所得混合物均化，并将所得均匀混合物瞬间巴氏杀菌超高温。构成：通过加入100pts.wt。发酵乳与18-22pts.wt。蜂蜜和进一步的超高甲氧基蛋白（UHM果胶）和丙二醇酯（PGA）作为稳定剂，即使在超高温下即时进行巴氏消毒也不会引起内容物的分离和沉降。优选上述UHM果胶的添加量为0.1〜1.0％，PGA的添加量为0.05〜0.5％。上述发酵乳是通过将牛奶粉，水，如果需要的话，向牛奶中加入脂肪或油，并用乳酸菌发酵剂接种制备的乳，并以3.5-4.5pH培养细菌起始物获得的。

15. 发明专利

JPS58204001A Macromolecular polysaccharide substance mps-83 and its use 失效
标题翻译：大分子多糖物质MPS-83及其用途
公开(公告)号：JPS58204001A
公开(公告)日：1983-11-28
申请号：JP8659382
申请日：1982-05-24
申请人： Meiji Milk Prod Co Ltd
发明人： OZAKI MICHIO , OBARA NAOHIRO , TSUCHIYA FUMIYASU , KANEKO SHIYOUHEI , KANBE MICHIO , ODA MUNEHIRO , TAKETOMO TADAO , OOYAMA YOSHIO
IPC分类号： C08B37/00 , A61K31/715 , A61K35/74 , A61P35/00 , C12P19/04 , C12R1/225
摘要： PURPOSE: To obtain an excellent immunity-activating agent, antitumoric agent or thickneing agent, by using a novel macromolecular polysaccharide substance MPS-83 which is produced from macromolecular polysaccharide substance MPS- 83-producing bacteria belonging to genus Lactobacillus as an effective component.
CONSTITUTION: Macromolecular polysaccharide substance MPS-83 is obtained by culturing macromolecular polysaccharide substance MPS-83-producing bacteria (e.g., Lactobacillus S-10-LR, FERM BP-127, which are bacteria separated from a dairy product and deposited with the Fermentation Research Institute) and then separating and recovering the substance from the liquid and bacterial fractins of the culture. As a culture medium, a lactic acid bacteria-culturing medium containing skim milk, whey or the like is preferred. The culturing is performed satisfactorily under conditions including, for example, 20W45°C, CO
2 atmosphere and stationary culture.
COPYRIGHT: (C)1983,JPO&Japio
摘要翻译：目的：通过使用由属于乳杆菌属的MPS-83生产菌的大分子多糖物质产生的新型大分子多糖物质MPS-83作为有效成分，获得优异的免疫活性剂，抗肿瘤剂或增稠剂。构成：大分子多糖物质MPS-83是通过培养大分子多糖物质MPS-83生产菌（例如，乳杆菌S-10-LR，FERM BP-127，它们是从乳制品中分离的细菌并保藏在发酵研究中研究所），然后从培养物的液体和细菌分裂物中分离和回收物质。作为培养基，优选含有脱脂乳，乳清等的乳酸菌培养基。在包括例如20-45℃，二氧化碳气氛和静止培养的条件下令人满意地进行培养。

16. 发明专利

JPS5862118A IMMUNOLOGICAL ACTIVATOR 失效
公开(公告)号：JPS5862118A
公开(公告)日：1983-04-13
申请号：JP16028081
申请日：1981-10-09
申请人： MEIJI MILK PROD CO LTD
发明人： TSUCHIYA FUMIYASU , KANBE MICHIO , ODA MUNEHIRO , KIDO SHICHIROU , ARAKUBO TAKESHI
IPC分类号： A61K31/70 , A61K35/74 , A61K36/07
摘要： PURPOSE:An immunological acitivator, containing a carcinostatic agent derived from basidiomycetes and a carcinostatic polysaccharide derived from bacteria, and having synergistically improved carcinostatic activity. CONSTITUTION:An immunological activator containing a carcinostatic agent derived from basidiomycetes, e.g. an extract from Ganoderma lucidum Karst. or Coriolus versicolor Quel., and a carcinostatic polysaccharide derived from bacteria, e.g. high polymeric polysaccharide MPS-80 or xanthan gum. The MPS-80 is obtained by cultivating a microorganism capable of producing the high polymeric polysaccharide MPS-80, e.g. Lactobacillus jugurti No.851 (FERM-P No. 5851), at 20-45 deg.C by the stationary culture method. Both active constituents have very low toxicity, and administrable in a large amount. The dose thereof is 10-10,000mg/kg/day, and both are conveniently mixed and administered in a given dosage form. The dosage form includes an injection, drug for internal use, suppository, etc.

17. 发明专利

JPS57117503A High polymeric polysaccharide substance mps-80 and its preparation 失效
标题翻译：高聚物多糖物质MPS-80及其制备方法
公开(公告)号：JPS57117503A
公开(公告)日：1982-07-22
申请号：JP303981
申请日：1981-01-14
申请人： Meiji Milk Prod Co Ltd
发明人： TSUCHIYA FUMIYASU , MIYAZAWA KIYUUSHICHI , KANBE MICHIO , ODA MUNEHIRO , EBISAWA NAOYUKI
IPC分类号： C08B37/00 , A61K31/715 , C12P19/04 , C12R1/225 , C12R1/46
CPC分类号： C12P19/04 , A61K31/715
摘要： NEW MATERIAL:A high polymeric polysaccharide substance having the following physico-chemcial properties: (1) Elementary analysis (%): C, 42.2; H, 6.9; O, 50.4. (2) Molecular weight: 7.98S (S is the Svedberg unit) measured by ultracentrifugation method. (3) Melting point (decomposition point): Discolors at about 262°C; and blackens at 263W264°C. (4) Specific rotatory power[α]D
18 =+33.2 (C=0.5%). (5) Solubility: Soluble in water, and insoluble in methanol, acetone, ether, etc. (6) Color reactions: Positive to the Molisch and anthrone reactions, etc. and negative to the aniline-hydrochloric acid reactions, etc.
USE: An antitumor agent useful as a viscosity increasing agent due to a high viscocity.
PROCESS: A strain of the genus Lactobacillus or Streptococcus, e.g. Lactobacillus jugurti No. 851 (FERM-P No. 5851) or Streptococcus thermophilus NO. 127 (FERM-P No. 5850), is cultivated.
COPYRIGHT: (C)1982,JPO&Japio
摘要翻译：新材料：具有以下物理化学性质的高分子多糖物质：（1）元素分析（％）：C，42.2; H，6.9; O，50.4。（2）通过超速离心法测定分子量：7.98S（S为Svedberg单位）。（3）熔点（分解点）：约262℃的脱色; 并在263-264摄氏度变黑。（4）比旋光度αD 18 = + 33.2（C = 0.5％）。（5）溶解性：易溶于水，不溶于甲醇，丙酮，乙醚等。（6）显色反应：对Molisch和蒽酮反应等均为正，反应为苯胺 - 盐酸反应等。用作粘度增加剂的抗肿瘤剂，由于粘度高。方法：乳杆菌属或链球菌属的菌株，例如乳酸乳杆菌851号（FERM-P No.5851）或嗜热链球菌NO。 127（FERM-P No. 5850）。

18. 发明专利

AU733451B2 Novel use of MK family as hematopoietic factor 未知
公开(公告)号：AU733451B2
公开(公告)日：2001-05-17
申请号：AU3459397
申请日：1997-07-10
申请人： MEIJI MILK PROD CO LTD
发明人： KIKUCHI MAKOTO , IKEMATSU SHINYA , ODA MUNEHIRO , SAKUMA SADATOSHI , MURAMATSU TAKASHI
IPC分类号： A61K35/28 , A61K38/18 , A61K38/19 , A61K38/20 , C12N5/0789 , A61K38/22 , A61K48/00 , A61K35/14
摘要： The present invention provides novel use of the MK family that is used alone as an agent for proliferating hematopoietic stem cells and hematopoietic precursor cells. The invention also provides an agent for remarkably enhancing the above-described effect for promoting the proliferation of hematopoietic stem cells and hematopoietic precursor cells, comprising the MK family in combination with known hematopoietic factors such as IL-3, IL-6, G-CSF, GM-CSF, M-CSF, SCF, and EPO.

19. 发明专利

FR2497809B1 未知
公开(公告)号：FR2497809B1
公开(公告)日：1986-07-18
申请号：FR8122548
申请日：1981-12-02
申请人： MEIJI MILK PROD CO LTD
发明人： TSUCHIYA FUMIYASU , MIYAZAWA KYUSHICHI , KANBE MICHIO , ODA MUNEHIRO , EBISAWA NAOYUKI
IPC分类号： C08B37/00 , A61K31/715 , C12P19/04 , C12R1/225 , C12R1/46

20. 发明专利

DE3147954A1 未知
公开(公告)号：DE3147954A1
公开(公告)日：1982-09-02
申请号：DE3147954
申请日：1981-12-03
申请人： MEIJI MILK PROD CO LTD
发明人： TSUCHIYA FUMIYASU , MIYAZAWA KYUSHICHI , KANBE MICHIO , ODA MUNEHIRO , EBISAWA NAOYUKI
IPC分类号： C08B37/00 , A61K31/715 , C12P19/04 , C12R1/225 , C12R1/46

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式