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11. 发明申请

WO2003092806A1 METHOD AND APPARATUS FOR RATE RESPONSIVE ADJUSTMENTS IN AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于在可植入医疗器械中进行速率调节的方法和装置
公开(公告)号：WO2003092806A1
公开(公告)日：2003-11-13
申请号：PCT/US2003/008433
申请日：2003-03-20
申请人： MEDTRONIC, INC.
发明人： WAHLSTRAND, John, D. , PORTZLINE, Gerald, A. , CHO, Yong, Kyun , BRANDSTETTER, John, S. , MONGEON, Luc, R. , CONDIE, Catherine, R.
IPC分类号： A61N1/365
CPC分类号： A61N1/36542 , A61N1/36521 , G06F19/00 , G06F19/3456 , G16H40/63
摘要： A method and an apparatus for performing rate responsive control in an implantable medical device using a scaling factor (850,860,870). Sensor data (365,375,385) is acquired using a sensor (210) operatively coupled with the implantable medical device (220). At least one setpoint for controlling a rate of therapy is generated (610), the setpoint being based upon the sensor data. A scaling factor adjustment process (620) is performed for scaling the internal sensor data to correlate the sensor data to the setpoint. The rate of therapy is adjusted based upon the scaling factor adjustment (640,890).
摘要翻译：一种用于使用缩放因子（850,860,870）在可植入医疗装置中执行速率响应控制的方法和装置。使用与可植入医疗装置（220）可操作地耦合的传感器（210）来获取传感器数据（365,375,385）。产生用于控制治疗速率的至少一个设定点（610），设定点基于传感器数据。执行缩放因子调整过程（620）以缩放内部传感器数据以将传感器数据与设定点相关联。根据比例因子调整调整治疗率（640,890）。

12. 发明申请

WO2003092803A3 METHOD AND APPARATUS FOR INJECTION OF EXTERNAL DATA 审中-公开
公开(公告)号：WO2003092803A3
公开(公告)日：2003-11-13
申请号：PCT/US2003/010046
申请日：2003-04-02
申请人： MEDTRONIC, INC.
发明人： CONDIE, Catherine, R. , PORTZLINE, Gerald, A. , CHO, Yong, Kyun , BRANDSTETTER, John, S. , MONGEON, Luc, R. , NICHOLS, Lucy, M. , HORNBERGER, Steve
IPC分类号： A61N1/365
摘要： A method and an apparatus for performing implementing external data into an implantable medical device. A first stress test is performed using an external sensor. External data resulting from the initial stress test is acquired. An external data injection process is performed. The external data injection process includes providing the external data to the implantable medical device. A second stress test is performed, the second stress test being substantially similar to the first stress test. Internal data resulting from the second stress test is acquired. Internal data resulting from the second stress test along with the external data resulting from the first stress test, are processed.

13. 发明申请

WO2003063956A3 MEDICAL IMPLANTABLE SYSTEM FOR REDUCING MAGNETIC RESONANCE EFFECTS 审中-公开
公开(公告)号：WO2003063956A3
公开(公告)日：2003-08-07
申请号：PCT/US2003/002258
申请日：2003-01-27
申请人： MEDTRONIC,INC.
发明人： ZEIJEMAKER, Volkert, A. , KALIN, Ron , HRDLICKA, Gregory, A. , CHO, Yong, Kyun , REINKE, James, D. , FOERSTER, Laurie, D.
IPC分类号： A61N1/05
摘要： ABSTRACT OF THE DISCLOSURE Apparatus and methods are disclosed for reducing the potentially harmful effects of electromagnetic waves on an implantable medical device. In one embodiment of the present invention, an implantable medical system comprising a dual threshold magnetic sensor capable of detecting an elevated magnetic field is disclosed. The sensor can comprise a solid-state sensor capable of detecting a static magnetic field in excess of about 1500 Gauss. The magnetic sensor can be operatively coupled to electronics that are capable of altering the operation of the system upon detection of an elevated magnetic field by the magnetic sensor.

14. 发明授权

EP1706174B1 APPARATUS FOR MODIFYING DELIVERY OF A THERAPY IN RESPONSE TO ONSET OF SLEEP 失效转让
标题翻译：设备进行修改治疗的征费，以响应睡眠入场
公开(公告)号：EP1706174B1
公开(公告)日：2009-04-22
申请号：EP04812801.1
申请日：2004-12-01
申请人： MEDTRONIC, INC.
发明人： CHO, Yong, Kyun , MONGEON, Luc, R. , JENSEN, Donald, N.
IPC分类号： A61N1/00
CPC分类号： A61N1/36521 , A61N1/36542 , A61N1/3702
摘要： A method and apparatus for providing a therapy to the patient that includes a therapy component configured to provide the therapy to the patient, sensing circuitry sensing a parameter of the patient, and a microprocessor coupled to the therapy component and the sensing circuitry to determine onset of a first state of the patient in response to the sensed physiologic parameter, and to determine whether the onset of the first state is detected for a predetermined time period.

15. 发明公开

EP1501593A1 METHOD AND APPARATUS FOR RATE RESPONSIVE ADJUSTMENTS IN AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：的方法和设备，以便设定速率的可植入医疗装置
公开(公告)号：EP1501593A1
公开(公告)日：2005-02-02
申请号：EP03716704.6
申请日：2003-03-20
申请人： Medtronic, Inc.
发明人： WAHLSTRAND, John D. , PORTZLINE, Gerald A. , CHO, Yong, Kyun , BRANDSTETTER, John S. , MONGEON, Luc R. , CONDIE, Catherine R.
IPC分类号： A61N1/365
CPC分类号： A61N1/36542 , A61N1/36521 , G06F19/00 , G06F19/3456 , G16H40/63
摘要： A method and an apparatus for performing rate responsive control in an implantable medical device using a scaling factor. Sensor data is acquired using a sensor operatively coupled with the implantable medical device. At least one setpoint for controlling a rate of therapy is generated, the setpoint being based upon the sensor data. A scaling factor adjustment process is performed for scaling the internal sensor data to correlate the sensor data to the setpoint. The rate of therapy is adjusted based upon the scaling factor adjustment.

16. 发明申请

WO2003057314A1 AUTOMATIC RATE RESPONSIVE SENSOR MODE SWITCH 审中-公开
标题翻译：自动速率响应传感器模式开关
公开(公告)号：WO2003057314A1
公开(公告)日：2003-07-17
申请号：PCT/US2002/041621
申请日：2002-12-27
申请人： MEDTRONIC,INC.
发明人： CHO, Yong, Kyun , CONDIE, Catherine, R.
IPC分类号： A61N1/365
CPC分类号： A61N1/36585
摘要： An automatic rate response sensor mode switch is implemented in an implantable medical device to monitor and isolate any sensor in an integrated sensor scheme. The isolated sensor is based on identification of problems associated with the sensor. The implantable medical device will switch to operate with the remainder sensor(s). Specifically, an algorithm tests and determines sensor status to initiate and operate the sensor mode switch. The software continuously monitors, isolates or qualifies a sensor to come back on-line automatically.
摘要翻译：在可植入医疗设备中实现自动速率响应传感器模式开关，以监测和隔离集成传感器方案中的任何传感器。隔离传感器基于与传感器相关的问题的识别。可植入医疗设备将切换到与其余传感器一起操作。具体来说，算法测试并确定传感器状态来启动和操作传感器模式开关。该软件可以连续监测，隔离或限定传感器自动返回在线。

17. 发明申请

WO2002087433A1 METHOD AND APPARATUS TO DETECT AND TREAT SLEEP RESPIRATORY EVENTS 审中-公开
标题翻译：检测和治疗睡眠呼吸事件的方法和装置
公开(公告)号：WO2002087433A1
公开(公告)日：2002-11-07
申请号：PCT/US2002/013505
申请日：2002-04-29
申请人： MEDTRONIC, INC.
发明人： CHO, Yong, Kyun , MONGEON, Luc, R. , ERICKSON, Mark, K. , MARKOWITZ, H., Toby
IPC分类号： A61B5/0205
CPC分类号： A61B5/08 , A61B5/0205 , A61B5/4818 , A61N1/3601
摘要： The present invention provides a method and apparatus for detecting and treating sleep respiratory events that includes a plurality of sensors gathering physiological data related to sleep respiratory events. A processor extracts an average cycle length and a frequency of at least one of Cheyne-Stokes respiration and periodic breathing based upon the physiological data, and determines whether therapy is required based on the average cycle length and the frequency.
摘要翻译：本发明提供一种用于检测和治疗睡眠呼吸事件的方法和装置，其包括收集与睡眠呼吸事件有关的生理数据的多个传感器。处理器基于生理数据提取Cheyne-Stokes呼吸和周期性呼吸中的至少一种的平均周期长度和频率，并且基于平均周期长度和频率来确定是否需要治疗。

18. 发明申请

WO2004062724A1 SYSTEM AND METHOD FOR AUTOMATICALLY MONITORING AND DELIVERING THERAPY FOR SLEEP-RELATED DISORDERED BREATHING 审中-公开
标题翻译：用于自发监测和传递治疗睡眠相关疾病呼吸的系统和方法
公开(公告)号：WO2004062724A1
公开(公告)日：2004-07-29
申请号：PCT/US2004/000672
申请日：2004-01-09
申请人： MEDTRONIC, INC.
发明人： CHO, Yong, Kyun , ERICKSON, Mark, K. , MARKOWITZ, H., Toby
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/36514
摘要： The invention relates generally to a system and method for monitoring and automatically delivering a therapy for sleep-related disordered breathing. In one form the present invention relates to an external device for monitoring for sleep-related disordered breathing in communication with an implantable medical device for delivering an electrical stimulation therapy. In another form the present invention relates to an implantable medical device for detecting sleep-related disordered breathing episode(s) and an external apparatus (e.g., a CPAP machine) for providing therapy to terminate, and/or reduce, said episode(s). In this form of the invention, the implantable medical device communicates with the external apparatus so that the therapy provided corresponds in magnitude and duration to the severity and/or length of the episode(s). In yet another form, an implantable apparatus detects said disordered breathing episode(s) and a hybrid therapy is provided by both the implantable apparatus and an external apparatus.
摘要翻译：本发明一般涉及用于监测和自动递送针对睡眠相关无序呼吸的治疗的系统和方法。在一种形式中，本发明涉及一种用于监测与可植入医疗装置进行通信以进行电刺激治疗的睡眠相关无序呼吸的外部装置。在另一种形式中，本发明涉及一种用于检测睡眠相关的无序呼吸发作的可植入医疗装置和用于提供终止和/或减少所述发作的治疗的外部装置（例如，CPAP机）。在本发明的这种形式中，可植入医疗装置与外部装置通信，使得所提供的治疗剂的大小和持续时间与剧集的严重程度和/或长度相对应。在另一种形式中，可植入装置检测所述无序呼吸事件，并且由可植入装置和外部装置两者提供混合治疗。

19. 发明申请

WO2003063946A3 APPARATUS AND METHOD FOR SHUNTING INDUCED CURRENTS IN AN ELECTRICAL LEAD 审中-公开
公开(公告)号：WO2003063946A3
公开(公告)日：2003-08-07
申请号：PCT/US2003/001892
申请日：2003-01-22
申请人： MEDTRONIC,INC.
发明人： ZEIJLEMAKER, Volkert, A. , KALIN, Ron , HRDLICKA, Gregory, A. , CHO, Yong, Kyun , REINKE, James, D. , FOERSTER, Laurie, D.
IPC分类号： A61N1/05
摘要： An electrical lead includes an elongate body having a proximal end portion and a distal end portion, a first electrode disposed adjacent and joined to the distal end portion of the elongate body. Current flow within the first electrode is limited when a predetermined condition occurs, such as the generation of an electromagnetic field having a predetermined frequency range. The medical electrical lead may further comprise one or more second electrodes disposed adjacent the first electrode and joined to the elongate body to shunt current to body tissue when the predetermined condition occurs.

20. 发明申请

WO2003092804A1 ALGORITHM FOR THE AUTOMATIC DETERMINATION OF OPTIMAL AV AND VV INTERVALS 审中-公开
标题翻译：用于自动确定最佳AV和VV间隔的算法
公开(公告)号：WO2003092804A1
公开(公告)日：2003-11-13
申请号：PCT/US2003/010074
申请日：2003-04-02
申请人： MEDTRONIC, INC.
发明人： BURNES, John, E. , CHO, Yong, Kyun , IGEL, David, A. , MONGEON, Luc, R. , RUETER, John, C. , STONE, Harry , ZILINSKI, Jody
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： Methods and devices for determining optimal Atrial to Ventricular (AV) pacing intervals and Ventricular to Ventricular (VV) delay intervals in order to optimize cardiac output. Impedance, preferably sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change.
摘要翻译：用于确定最佳心房与心室（AV）起搏间隔和心室间室（VV）延迟间隔的方法和装置，以优化心输出量。在选择的心脏周期时间内，跨心脏测量阻抗，优选亚阈值阻抗，作为腔室扩张或收缩的量度。为了设定AV间隔，一个实施例测量长AV间隔上的阻抗以获得指示最大心室扩张的最小阻抗。另一个实施例测量一个周期的阻抗变化，并且改变二进制搜索中的AV步速间隔以收敛于AV间隔，从而引起指示最大心室输出的最大阻抗变化。另一种方法将右心室改变为左心室（VV）间隔，以收敛于指示最终心脏收缩最小心脏容积的阻抗最大值。另一实施例改变VV间隔以最大化阻抗变化。

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