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11. 发明专利

AU2018269544A1 Self-righting articles 未知
公开(公告)号：AU2018269544A1
公开(公告)日：2019-11-28
申请号：AU2018269544
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S
IPC分类号： A61K9/20 , A61K9/22 , A61K9/48
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

12. 发明专利

CA3063712A1 SELF-RIGHTING ARTICLES 未知
公开(公告)号：CA3063712A1
公开(公告)日：2018-11-22
申请号：CA3063712
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S
IPC分类号： A61K9/48 , A61M5/20 , A61M5/32 , A61M31/00
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

13. 发明专利

AU2018269704A1 Self-righting systems, methods, and related components 未知
公开(公告)号：AU2018269704A1
公开(公告)日：2019-11-28
申请号：AU2018269704
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： BENSEL TAYLOR , LANGER ROBERT S , TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO
IPC分类号： A61J3/07 , A61K9/00 , A61M5/00 , A61M5/14
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

14. 发明专利

AU2018269550A1 Components with high API loading 未知
公开(公告)号：AU2018269550A1
公开(公告)日：2019-11-28
申请号：AU2018269550
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S
IPC分类号： A61M37/00 , A61M31/00
摘要： Components with relatively high loading of active pharmaceutical ingredients are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent and a supporting material such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt% versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, Gl mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle. In some cases, a physiologically relevant dose may be present in a single tissue interfacing component.

15. 发明专利

CA3063426A1 TISSUE ANCHORING ARTICLES 未知
公开(公告)号：CA3063426A1
公开(公告)日：2018-11-22
申请号：CA3063426
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , DELLAL DAVID , LANGER ROBERT S
IPC分类号： A61M31/00
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

16. 发明专利

CA3063418A1 SELF-ACTUATING ARTICLES 未知
公开(公告)号：CA3063418A1
公开(公告)日：2018-11-22
申请号：CA3063418
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S
IPC分类号： A61M31/00 , A61M5/20 , A61M5/32
摘要： Self-actuating articles including, for example, self-actuating needles and/or self- actuating biopsy punches, are generally provided. Advantageously, the self-actuating articles described herein may be useful as a general platform for delivery of a wide variety of pharmaceutical drugs that are typically delivered via injection directly into tissue due to degradation in the GI tract. The self-actuating articles described herein may also be used to deliver sensors and/or take biopsies without the need for an endoscopy. In some embodiments, the article comprises a spring (e.g., a coil spring, a beam, a material having particular mechanical recovery characteristics). Those of ordinary skill in the art would understand that the term spring is not intended to be limited to coil springs, but generally encompass any reversibly compressive material and/or component which, after releasing an applied compressive force on the material/component, the material/component substantially returns to an uncompressed length of the material/component (e.g., the within 95% of the length of the material/component prior to compression).

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