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11. 发明申请

US20080300472A1 Method and Device for Optical Imaging of a Turbid Medium 有权
标题翻译：浊度介质的光学成像方法和装置
公开(公告)号：US20080300472A1
公开(公告)日：2008-12-04
申请号：US12094670
申请日：2006-11-17
申请人： Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker
发明人： Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker
IPC分类号： A61B5/1455
CPC分类号： A61B5/4312 , A61B5/0091 , A61B5/1455 , A61B5/14551
摘要： Disclosed is a method and a device for optical imaging of a turbid medium. This method comprises a reference measurement of reference intensities of light emanating from the turbid medium at a reference blood oxygen saturation (SaO2) in the turbid medium and a reference imaging step for reconstructing a reference image of the turbid medium from the measured reference intensities. Furthermore the method comprises a contrast measurement of the contrast intensity of the light emanating from the turbid medium at a contrast blood oxygen saturation (SaO2) level in the turbid medium and a contrast imaging step for reconstructing a contrast image of the turbid medium from the measured contrast intensities. A comparison is made between the contrast image to the reference image of the turbid medium.
摘要翻译：公开了一种用于浑浊介质的光学成像的方法和装置。该方法包括在混浊介质中以参考血氧饱和度（SaO2）从混浊介质发出的光的参考光强度的参考测量值，以及用于根据测量的参考光强度重建浊度介质的参考图像的参考成像步骤。此外，该方法包括在浑浊培养基中以对比血氧饱和度（SaO2）水平从浑浊培养基发出的光的对比度强度的对比度测量，以及用于从所测量的重量中重建浑浊培养基的对比度图像的对比度成像步骤对比强度。对比图像与混浊介质的参考图像之间进行比较。

12. 发明申请

US20080285823A1 Device for Imaging an Interior of a Turbid Medium 审中-公开
标题翻译：用于成像混浊介质内部的装置
公开(公告)号：US20080285823A1
公开(公告)日：2008-11-20
申请号：US12094641
申请日：2006-11-13
申请人： Levinus Pieter Bakker , Michael Cornelis Van Beek , Martinus Bernardus Van Der Mark
发明人： Levinus Pieter Bakker , Michael Cornelis Van Beek , Martinus Bernardus Van Der Mark
IPC分类号： G06K9/00
CPC分类号： G01N21/4795 , A61B5/0091 , G01N21/6456 , G01N2021/1787 , G01N2021/6421
摘要： The invention relates to a device (1) for imaging an interior of a turbid medium (25). The device (1) may be used to accommodate a turbid medium (25) inside a measurement volume (20) and irradiate the turbid medium (25) with light from a light source (5), after which light emanating from the measurement volume (20) is detected and used to determine an image of the interior of the turbid medium (25). The device (1) is adapted such that additional means are introduced for irradiating the turbid medium (25) with light causing fluorescent emission in a contrast agent present in the turbid medium (25), for detecting the fluorescent emission in at least two spectral regions, and for calculating an image reconstruction for the at least two spectral regions detected. By detecting the fluorescent emission spectroscopically, that is as a function of wavelength, information can be obtained from which the concentration of a predetermined component present inside the turbid medium can be determined.
摘要翻译：本发明涉及一种用于对浑浊介质（25）的内部进行成像的装置（1）。装置（1）可以用于容纳测量体积（20）内部的混浊介质（25），并用来自光源（5）的光照射混浊介质（25），之后从测量体积 20）被检测并用于确定混浊介质（25）内部的图像。装置（1）适于使得附加装置被引入以用在浑浊介质（25）中存在的造影剂中引起荧光发射的光照射混浊介质，用于检测至少两个光谱区域中的荧光发射并且用于计算所检测的所述至少两个光谱区域的图像重建。通过检测荧光发射光谱，即作为波长的函数，可以获得可以确定存在于混浊介质内的预定成分的浓度的信息。

13. 发明授权

US08355131B2 Device and method for acquiring image data from a turbid medium 有权
标题翻译：从混浊介质获取图像数据的装置和方法
公开(公告)号：US08355131B2
公开(公告)日：2013-01-15
申请号：US12525748
申请日：2008-01-29
申请人： Levinus Pieter Bakker , Martinus Bernardus Van Der Mark
发明人： Levinus Pieter Bakker , Martinus Bernardus Van Der Mark
IPC分类号： G01N21/55 , G01N21/00 , A61B5/00 , A61B6/00
CPC分类号： G01N21/4795 , A61B5/0091 , A61B5/4312
摘要： A device and method of acquiring image data from a turbid medium using a diffuse optical tomography device including irradiating the turbid medium at a plurality of first spatial positions, collecting light emanating from the turbid medium at a plurality of second spatial positions, splitting the light collected from each second spatial position into at least two optical channels, measuring the intensity of the split light in each optical channel of the at least two optical channels using photo detectors, and reconstructing an image of the turbid medium from the measured intensities.
摘要翻译：一种使用扩散光学断层摄影装置从混浊介质获取图像数据的装置和方法，包括在多个第一空间位置照射混浊介质，在多个第二空间位置收集从混浊介质发出的光，将收集到的光分开从每个第二空间位置到至少两个光学通道，使用光电检测器测量所述至少两个光学通道的每个光学通道中的分裂光的强度，以及根据测量的强度重建所述混浊介质的图像。

14. 发明申请

US20100262018A1 METHOD OF CONTROLLING A DEVICE FOR IMAGING THE INTERIOR OF TURBID MEDIA, DEVICE FOR IMAGING THE INTERIOR OF TURBID MEDIA AND COMPUTER PROGRAM PRODUCT 审中-公开
标题翻译：控制用于成像涡轮介质内部的装置的方法，用于成像涡轮介质和计算机程序产品的内部装置
公开(公告)号：US20100262018A1
公开(公告)日：2010-10-14
申请号：US12740145
申请日：2008-10-28
申请人： Levinus Pieter Bakker , Bernhard J. Brendel , Rik Harbers , Martinus Bernardus Van Der Mark
发明人： Levinus Pieter Bakker , Bernhard J. Brendel , Rik Harbers , Martinus Bernardus Van Der Mark
IPC分类号： A61B6/00
CPC分类号： G01N21/4795 , A61B5/0091 , A61B5/4312 , G01N21/15 , G01N2021/1787 , G01N2021/4719 , G01N2201/0826 , G01N2201/0833
摘要： A method of controlling a device for imaging the interior of turbid media is provided. The device comprises: a receiving portion (2) for receiving a turbid medium (1) to be examined; at least one light source (6) optically connected to the receiving portion (2) for irradiating the interior of the receiving portion (2); and at least one detector (7) optically connected to the receiving portion (2) for detecting light emanating from the interior of the receiving portion (2). The at least one light source (6) and the at least one detector (7) areoptically connected to the receiving portion (2) such that a plurality of different source-detector position combinations are formed over a complete measurement. The different source-detector position combinations define different light paths through the receiving portion (2). The method comprises a fast-measurement step in which a reduced set of data corresponding to only a part of the plurality of source-detector position combinations is generated for providing fast-information about the interior of the receiving portion (2).
摘要翻译：提供了一种控制用于对浑浊介质内部进行成像的装置的方法。该装置包括：接收部分（2），用于接收待检查的混浊介质（1）; 至少一个光源（6），其光学连接到所述接收部分（2）以照射所述接收部分（2）的内部; 以及光学连接到所述接收部分（2）的至少一个检测器（7），用于检测从所述接收部分（2）的内部发出的光。所述至少一个光源（6）和所述至少一个检测器（7）光学地连接到所述接收部分（2），使得在完整测量上形成多个不同的源 - 检测器位置组合。不同的源 - 检测器位置组合限定穿过接收部分（2）的不同光路。该方法包括快速测量步骤，其中生成仅对应于多个源 - 检测器位置组合的一部分的减少的数据集合，用于提供关于接收部分（2）的内部的快速信息。

15. 发明申请

US20100238441A1 DEVICE FOR IMAGING THE INTERIOR OF AN OPTICALLY TURBID MEDIUM AND RECEPTACLE UNIT FOR SUCH A DEVICE 有权
标题翻译：用于成像用于这种装置的光学涡卷介质和插座单元的内部的装置
公开(公告)号：US20100238441A1
公开(公告)日：2010-09-23
申请号：US12682939
申请日：2008-10-13
申请人： Thomas Koehler , Tim Nielsen , Bernhard Brendel , Andy Ziegler , Ronny Ziegler , Levinus Pieter Bakker , Martinus Bernardus Van Der Mark
发明人： Thomas Koehler , Tim Nielsen , Bernhard Brendel , Andy Ziegler , Ronny Ziegler , Levinus Pieter Bakker , Martinus Bernardus Van Der Mark
IPC分类号： G01N21/49 , G01N21/00
CPC分类号： G01N21/4795 , A61B5/0073 , A61B5/0091 , A61B5/4312 , A61B2562/146 , G01N2021/1787 , G01N2201/0826 , G01N2201/0833
摘要： A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.
摘要翻译：提供了用于对光学混浊介质的内部成像的装置（1）。该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。

16. 发明申请

US20100027018A1 DEVICE AND METHOD FOR ACQUIRING IMAGE DATA FROM A TURBID MEDIUM 有权
标题翻译：用于从涡轮介质获取图像数据的装置和方法
公开(公告)号：US20100027018A1
公开(公告)日：2010-02-04
申请号：US12525748
申请日：2008-01-29
申请人： Levinus Pieter Bakker , Martinus Bernardus Van Der Mark
发明人： Levinus Pieter Bakker , Martinus Bernardus Van Der Mark
IPC分类号： G01N21/47
CPC分类号： G01N21/4795 , A61B5/0091 , A61B5/4312
摘要： The invention relates to a method of acquiring image data from a turbid medium (102) using a diffuse optical tomography device, comprising: —irradiating the turbid medium (102) at a plurality of first spatial positions (106), —collecting light emanating from the turbid medium (102) at a plurality of 5 second spatial positions (136), —splitting the light collected from each second spatial position (136) into at least two optical channels (140), —measuring the intensity of the split light in each optical channel of the at least two optical channels (140) using photo detectors (142),10 —reconstructing (152) an image of the turbid medium (102) from the measured intensities.
摘要翻译：本发明涉及一种使用漫射光学断层摄影装置从混浊介质（102）获取图像数据的方法，包括：在多个第一空间位置（106）处照射浑浊介质（102）， - 收集来自在多个5秒空间位置（136）处的混浊介质（102），将从每个第二空间位置（136）收集的光分成至少两个光学通道（140）， - 测量分离光的强度使用光电检测器（142）至少两个光学通道（140）的每个光学通道，根据测量的强度重新构造（152）浑浊介质（102）的图像。

17. 发明授权

US09488574B2 Device for imaging the interior of an optically turbid medium and receptacle unit for such a device 有权
标题翻译：用于对用于这种装置的光学混浊介质和插座单元的内部进行成像的装置
公开(公告)号：US09488574B2
公开(公告)日：2016-11-08
申请号：US12682939
申请日：2008-10-13
申请人： Thomas Koehler , Tim Nielsen , Bernhard Brendel , Andy Ziegler , Ronny Ziegler , Levinus Pieter Bakker , Martinus Bernardus Van Der Mark
发明人： Thomas Koehler , Tim Nielsen , Bernhard Brendel , Andy Ziegler , Ronny Ziegler , Levinus Pieter Bakker , Martinus Bernardus Van Der Mark
IPC分类号： G01N21/47 , A61B5/00 , G01N21/17
CPC分类号： G01N21/4795 , A61B5/0073 , A61B5/0091 , A61B5/4312 , A61B2562/146 , G01N2021/1787 , G01N2201/0826 , G01N2201/0833
摘要： A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.
摘要翻译：提供了用于对光学混浊介质的内部成像的装置（1）。该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。

18. 发明申请

US20100056916A1 SYSTEM, DEVICE, METHOD, COMPUTER-READABLE MEDIUM, AND USE FOR IN VIVO IMAGING OF TISSUE IN AN ANATOMICAL STRUCTURE 审中-公开
标题翻译：系统，装置，方法，计算机可读介质，以及用于在解剖结构中进行组织成像的用途
公开(公告)号：US20100056916A1
公开(公告)日：2010-03-04
申请号：US12515023
申请日：2007-11-16
申请人： Levinus Peter Bakker , Michael Cornelis Van Beek , Martinus Bernardus Van Der Mark , Rene Van Den Ham , Bernardus Hendrikus Wilhelmus Hendriks , Ralf Hoffmann , Nijs Cornelis Van Der Vaart , Marjolein Van Der Voort
发明人： Levinus Peter Bakker , Michael Cornelis Van Beek , Martinus Bernardus Van Der Mark , Rene Van Den Ham , Bernardus Hendrikus Wilhelmus Hendriks , Ralf Hoffmann , Nijs Cornelis Van Der Vaart , Marjolein Van Der Voort
IPC分类号： A61B8/14 , A61B6/00
CPC分类号： A61B5/0095 , A61B5/0035 , A61B5/0084 , A61B5/0086 , A61B8/12 , A61B8/4416
摘要： A system is provided that may be used for locating and diagnosing lesions in the human body in vivo. In some embodiments, once the exact position of a lesion is found, a biopsy may be taken from the lesion using e.g. ultra sound techniques for guidance of the biopsy needle. Use of the system drastically reduces the negative biopsy samples compared to currently used “blind sampling” techniques. This reduces patient discomfort and minimizes infections as the number of biopsy samples is reduced. A method and computer-readable medium is also provided.
摘要翻译：提供了可用于在体内定位和诊断人体损伤的系统。在一些实施例中，一旦发现病变的确切位置，可以使用例如病变从病变中取出活组织检查。超声技术用于指导活检针。与目前使用的“盲采”技术相比，使用该系统大大减少了活检样本的阴性。随着活检样本的数量减少，这减少了患者的不适，并使感染最小化。还提供了一种方法和计算机可读介质。

19. 发明申请

US20100002233A1 IMAGING OF TURBID MEDIUM 审中-公开
标题翻译：涡轮介质成像
公开(公告)号：US20100002233A1
公开(公告)日：2010-01-07
申请号：US12447669
申请日：2007-10-24
申请人： Maarten Marinus Johannes Wilhelm Van Herpen , Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek
发明人： Maarten Marinus Johannes Wilhelm Van Herpen , Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek
IPC分类号： A61B5/00 , G01N21/00
CPC分类号： G01N21/4795 , A61B5/0091 , A61B5/4312 , A61B2562/146
摘要： The invention relates to imaging of a turbid medium, for example in connection with optical mammography. A device for imaging a turbid medium (20) is disclosed, the device comprising: a holder (20) arranged for receiving the turbid medium and a matching fluid (21); one or more radiation sources (24) and one or more photodetectors (25). The matching fluid is a vapor with one or more optical properties of the matching fluid substantially matching the corresponding one or more optical properties of the turbid medium. In an embodiment, the matching fluid (21) is a composite vapor comprising at least two components.
摘要翻译：本发明涉及例如结合光学乳腺摄影术的混浊介质的成像。公开了一种用于对浑浊介质（20）进行成像的装置，该装置包括：安置用于接收混浊介质的保持器（20）和匹配流体（21）; 一个或多个辐射源（24）和一个或多个光电检测器（25）。匹配流体是具有匹配流体的一个或多个光学性质的蒸气，其基本上与混浊介质的对应的一个或多个光学特性相匹配。在一个实施例中，匹配流体（21）是包括至少两个组分的复合蒸气。

20. 发明申请

US20110270093A1 OPTICAL EXAMINATION DEVICE ADAPTED TO BE AT LEAST PARTIALLY INSERTED INTO A TURBID MEDIUM 审中-公开
标题翻译：光学检查装置适用于至少部分插入涡轮介质
公开(公告)号：US20110270093A1
公开(公告)日：2011-11-03
申请号：US13142485
申请日：2010-01-18
申请人： Adrien Emmanuel Desjardins , Martinus Bernardus Van Der Mark , Bernardus Hendrikus Wilhelmus Hendriks , Gert 'T Hooft
发明人： Adrien Emmanuel Desjardins , Martinus Bernardus Van Der Mark , Bernardus Hendrikus Wilhelmus Hendriks , Gert 'T Hooft
IPC分类号： A61B6/00 , H01L27/00 , G01J3/00 , H01J5/02 , G01J1/42
CPC分类号： A61B5/0075 , A61B5/0062 , A61B5/0084 , A61B5/6848
摘要： An optical examination device (10) adapted to be at least partially inserted into a turbid medium is provided. The optical examination device comprises a shaft portion (21) adapted to be inserted into the turbid medium, the shaft portion (21) comprising a tip portion (22) adapted to be the foremost portion during insertion into the turbid medium. At least one light source device adapted to emit abeam (11) of broad-band light is provided in the region of the tip portion (21). The beam (11) of broad-band light comprises different wavelength bands (2a, 2b, . . . , 2n) which are differently modulated. At least one photodetector (27a, 27b, 27c) for detecting broad-band light is provided in a region adapted to be inserted into the turbid medium of the shaft portion (21).
摘要翻译：提供了适于至少部分地插入混浊介质中的光学检查装置（10）。光学检查装置包括适于插入混浊介质的轴部分（21），该轴部分（21）包括在插入混浊介质期间适于最前部分的末端部分（22）。在尖端部分（21）的区域中设置适于发射宽带光的光束（11）的至少一个光源装置。宽带光束（11）包括不同调制的不同波长带（2a，2b，...，2n）。用于检测宽带光的至少一个光电检测器（27a，27b，27c）设置在适于插入到轴部（21）的混浊介质中的区域中。

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