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    • 11. 发明公开
    • A percutaneous absorption, a tape plaster and a method of promoting percutaneous absorption
    • Perkutaner吸收促进剂,Pflaster和Verfahren zurFörderungder perkutanen吸收
    • EP0815871A1
    • 1998-01-07
    • EP97114794.7
    • 1992-08-28
    • LINTEC Corporation
    • Suzuki, EijiOkabe, HideakiSaito, Takanori
    • A61K47/18
    • A61K9/7061A61K9/0014A61K47/18A61K47/183Y10S514/946Y10S514/947
    • A percutaneous absorption promoter comprises a derivative of amino acid in which the amino group has or does not have an acyl substituent or a hydrocarbon substituent, the carboxylic group has a hydrocarbon substituent and the part between the amino group and the carboxylic group has a specified structure. A tape plaster comprises the percutaneous absorption promoter described above. The method utilizes the the percutaneous absorption promoter described above.
      The percutaneous promoter of the invention has excellent ability of promoting the percutaneous absorption of pharmacologically active substances and excellent safety simultaneously, capable of delivering the desired pharmacologically active substances rapidly to the location of treatment or to all parts of the body through the circulating system and effective for curing various kinds of disease. The tape plaster comprising it and the method of promoting percutaneous absorption by utilizing it have the same advantages.
    • 经皮吸收促进剂包含其中氨基具有或不具有酰基取代基或烃取代基的氨基酸衍生物,羧基具有烃取代基,氨基与羧基之间的部分具有特定结构 。 胶带包含上述的经皮吸收促进剂。 该方法利用上述经皮吸收促进剂。 本发明的经皮促进剂具有优异的促进药理活性物质的经皮吸收和优异安全性的能力,能够通过循环系统快速将期望的药理活性物质快速递送至身体的所有部位, 用于治疗各种疾病。 包含它的胶带膏和通过利用它促进经皮吸收的方法具有相同的优点。
    • 18. 发明公开
    • Transdermal therapeutic formulation
    • 变形药物治疗
    • EP0582727A1
    • 1994-02-16
    • EP92113659.4
    • 1992-08-11
    • LINTEC Corporation
    • Okabe, HideakiTsuchida, IchiroSaito, Takanori
    • A61K9/70A61K47/32
    • A61K9/7061A61K47/32
    • A transdermal therapeutic formulation is made of a composition comprising a polymer and ingredients mixed with the polymer which are a pharmacologically active substance, an alcohol, a percutaneous absorption promoter utilized according to necessity and water utilized according to necessity. The polymer comprises lipophillic monomer units and hydrophillic monomer units in a specific ratio. The alcohol, the percutaneous absorption promoter and water are mixed with the polymer in specific amounts.
      The transdermal therapeutic formulation has excellent percutaneous absorption, has many kinds of applicable pharmacologically active substances, shows good stability of percutaneous absorption with time because of absence of crystallization of the pharmacologically active substance, has good adhesive strength and thus favorably utilized as transdermal therapeutic plaster.
    • 透皮治疗制剂由包含聚合物和与聚合物混合的成分组成的组合物制成,所述组合物是药理活性物质,醇,根据需要使用的经皮吸收促进剂和根据需要使用的水。 聚合物包含特定比例的亲油单体单元和亲水单体单元。 将醇,经皮吸收促进剂和水与特定量的聚合物混合。 透皮治疗剂具有优异的经皮吸收作用,具有多种适用的药理活性物质,由于不存在药理活性物质结晶,经皮吸收随时间而呈现良好的稳定性,具有良好的粘合强度,因此有利地用作透皮治疗膏药。