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11. 发明申请

US20110264128A1 Percutaneous Methods for Apparatus for Creating Native Tissue Venous Valves 有权
标题翻译：用于创建本机组织静脉瓣的装置的经皮方法
公开(公告)号：US20110264128A1
公开(公告)日：2011-10-27
申请号：US12767938
申请日：2010-04-27
申请人： Kevin Mauch , Maria Arreguin
发明人： Kevin Mauch , Maria Arreguin
IPC分类号： A61B17/32
CPC分类号： A61B17/320725 , A61B8/0841 , A61B8/12 , A61B17/3209 , A61B2017/00783 , A61B2017/22061 , A61F2/2463 , A61F2/2475 , A61M25/0105 , A61M25/10 , A61M25/104 , A61M2025/1075 , A61M2025/1081
摘要： Percutaneous methods and apparatuses for forming a venous valve from autologous tissue. A catheter having a retractable dissecting system received therein is delivered to a target location where a new venous valve is to be created. A distal balloon or other radially-expandable component mounted on the catheter is expanded against the vein wall, and the dissecting system is proximally retracted to deploy one or more dissecting components that dissect a subintimal layer of the vein wall. Radial expansion of the dissecting component(s) within the vein wall creates one or more leaflets and corresponding pocket/sinuses in the vein that collectively act as a venous valve, and/or the radially-expandable component of the catheter is subsequently collapsed such that the dissecting component(s) each pull a flap of the dissected tissue towards the vein lumen to create one or more leaflet(s) and corresponding pocket/sinuses in the vein.
摘要翻译：用于从自体组织形成静脉瓣的经皮方法和装置。将其中容纳有可伸缩解剖系统的导管输送到要创建新静脉瓣的目标位置。安装在导管上的远端球囊或其他可径向扩张的部件相对于静脉壁膨胀，并且解剖系统向近端缩回以展开解剖静脉壁的内膜层的一个或多个解剖部件。静脉壁内的解剖组件的径向扩张在静脉中产生一个或多个小叶和静脉中相应的口袋/鼻窦，其共同作为静脉瓣，并且/或导管的可径向扩张的组件随后被塌缩，使得解剖组件每个将解剖组织的瓣片拉向静脉腔，以在静脉中产生一个或多个小叶和相应的口袋/鼻窦。

12. 发明申请

US20110251668A1 Stent With Therapeutic Substance 有权
标题翻译：支架与治疗物质
公开(公告)号：US20110251668A1
公开(公告)日：2011-10-13
申请号：US12755562
申请日：2010-04-07
申请人： Dustin Thompson , Paul Adler , Maria Arreguin , Kevin Mauch , Christopher Storment , Lance Ensign , Stephen Zimmerman
发明人： Dustin Thompson , Paul Adler , Maria Arreguin , Kevin Mauch , Christopher Storment , Lance Ensign , Stephen Zimmerman
IPC分类号： A61F2/84 , B21F45/00
CPC分类号： A61F2/90 , A61F2250/0067 , A61F2250/0068 , B21F45/008
摘要： A stent includes a wave form that includes a cable including a plurality of strands. The wave form has a plurality of struts and a plurality of crowns, with each crown connecting two adjacent struts. The wave form is wrapped around a longitudinal axis at a pitch to define a plurality of helical turns. The stent includes a filler located within the cable. The filler includes a therapeutic substance.
摘要翻译：支架包括波形，其包括包括多个股线的电缆。波形具有多个支柱和多个冠部，每个冠部连接两个相邻的支柱。波形围绕纵向轴线以间距包围以限定多个螺旋形匝。支架包括位于电缆内的填充物。填料包括治疗物质。

13. 发明授权

US07955346B2 Percutaneous methods for creating native tissue venous valves 有权
标题翻译：用于创建天然组织静脉瓣的经皮方法
公开(公告)号：US07955346B2
公开(公告)日：2011-06-07
申请号：US12335786
申请日：2008-12-16
申请人： Kevin Mauch , Maria Arreguin
发明人： Kevin Mauch , Maria Arreguin
IPC分类号： A61B17/22 , A61M29/00
CPC分类号： A61F2/24 , A61F2/2475 , A61F2/958
摘要： Percutaneous methods of forming a venous valve from autologous tissue are disclosed. The methods include percutaneously creating one or two subintimal dissections for forming one or two flaps of intimal tissue. In one method, a puncture element is delivered by a catheter based delivery system to a treatment site where a new venous valve is to be created. The puncture element is deployed to gain access to a subintimal layer of the vein wall. A dilation balloon is than positioned and inflated within the subintimal layer to create a flap and corresponding pocket/sinus in the vein, which than acts as a one-way monocuspid valve in the manner of a native venous valve. In a similar manner, methods of forming new bicuspid venous valves by subintimal dissections are also disclosed.
摘要翻译：公开了从自体组织形成静脉瓣的经皮方法。所述方法包括经皮创建一个或两个内膜消融以形成一个或两个内膜组织瓣。在一种方法中，穿刺元件通过基于导管的递送系统递送到将要创建新的静脉瓣的治疗部位。部分穿刺元件以进入静脉壁的内膜层。扩张气囊不是在内膜层内定位和充气，以在静脉中产生瓣和相应的口袋/窦，其以天然静脉瓣的方式用作单向单瓣阀。以类似的方式，还公开了通过底内夹层形成新的二尖瓣静脉瓣的方法。

14. 发明授权

US08998894B2 Catheter apparatuses having multi-electrode arrays for renal neuromodulation and associated systems and methods 有权
公开(公告)号：US08998894B2
公开(公告)日：2015-04-07
申请号：US13281361
申请日：2011-10-25
申请人： Kevin Mauch , William Chang , Justin Goshgarian , Leonila Rivera , Martin Rothman
发明人： Kevin Mauch , William Chang , Justin Goshgarian , Leonila Rivera , Martin Rothman
IPC分类号： A61B18/18 , A61B18/14 , A61B18/00 , A61M25/00 , A61M25/01
CPC分类号： A61B18/1492 , A61B2018/00023 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/1435 , A61B2018/1467 , A61M25/0041 , A61M25/0074 , A61M25/0133 , A61M25/0138 , A61M25/0147
摘要： Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers.

15. 发明授权

US08956352B2 Catheter apparatuses having multi-electrode arrays for renal neuromodulation and associated systems and methods 有权
标题翻译：具有用于肾神经调节的多电极阵列的导管装置及其相关系统和方法
公开(公告)号：US08956352B2
公开(公告)日：2015-02-17
申请号：US13281395
申请日：2011-10-25
申请人： Kevin Mauch , Mario Alvarado , Robert Beetel , William Chang , Justin Goshgarian , Leonila Rivera , Sukyoung Shin , Michele Silver , Sina Som , Andrew Wu , Denise Zarins , Juanita Sanchez-Cole , Maria G. Aboytes
发明人： Kevin Mauch , Mario Alvarado , Robert Beetel , William Chang , Justin Goshgarian , Leonila Rivera , Sukyoung Shin , Michele Silver , Sina Som , Andrew Wu , Denise Zarins , Juanita Sanchez-Cole , Maria G. Aboytes
IPC分类号： A61B18/14 , A61B18/04 , A61B18/18 , A61B18/00 , A61M25/00 , A61M25/01
CPC分类号： A61B18/1492 , A61B2018/00023 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/1435 , A61B2018/1467 , A61M25/0041 , A61M25/0074 , A61M25/0133 , A61M25/0138 , A61M25/0147
摘要： Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers.
摘要翻译：本文公开了通过血管内通路实现肾脏神经调节的导管装置，系统和方法。例如，本技术的一个方面涉及具有被配置为输送到肾血管的多电极阵列的治疗装置。阵列可以在传送或低轮廓状态（例如，大致直线形状）和展开状态（例如，径向膨胀，大致螺旋形状）之间选择性地变换。多电极阵列的尺寸和形状使得当阵列处于部署（例如螺旋状态）时，电极或能量递送元件接触肾血管的内壁。电极或能量输送元件构造成用于直接和/或间接施加热和/或电能以加热或以其他方式电调节有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构。

16. 发明授权

US08460323B2 Percutaneous methods for apparatus for creating native tissue venous valves 有权
标题翻译：用于创建天然组织静脉瓣的装置的经皮方法
公开(公告)号：US08460323B2
公开(公告)日：2013-06-11
申请号：US12767938
申请日：2010-04-27
申请人： Kevin Mauch , Maria Arreguin
发明人： Kevin Mauch , Maria Arreguin
IPC分类号： A61B17/32
CPC分类号： A61B17/320725 , A61B8/0841 , A61B8/12 , A61B17/3209 , A61B2017/00783 , A61B2017/22061 , A61F2/2463 , A61F2/2475 , A61M25/0105 , A61M25/10 , A61M25/104 , A61M2025/1075 , A61M2025/1081
摘要： Percutaneous methods and apparatuses for forming a venous valve from autologous tissue. A catheter having a retractable dissecting system received therein is delivered to a target location where a new venous valve is to be created. A distal balloon or other radially-expandable component mounted on the catheter is expanded against the vein wall, and the dissecting system is proximally retracted to deploy one or more dissecting components that dissect a subintimal layer of the vein wall. Radial expansion of the dissecting component(s) within the vein wall creates one or more leaflets and corresponding pocket/sinuses in the vein that collectively act as a venous valve, and/or the radially-expandable component of the catheter is subsequently collapsed such that the dissecting component(s) each pull a flap of the dissected tissue towards the vein lumen to create one or more leaflet(s) and corresponding pocket/sinuses in the vein.
摘要翻译：用于从自体组织形成静脉瓣的经皮方法和装置。将其中容纳有可伸缩解剖系统的导管输送到要创建新静脉瓣的目标位置。安装在导管上的远端球囊或其他可径向扩张的部件相对于静脉壁膨胀，并且解剖系统向近端缩回以展开解剖静脉壁的内膜层的一个或多个解剖部件。静脉壁内的解剖组件的径向扩张在静脉中产生一个或多个小叶和静脉中相应的口袋/鼻窦，其共同作为静脉瓣，并且/或导管的可径向扩张的组件随后被塌缩，使得解剖组件每个将解剖组织的瓣片拉向静脉腔，以在静脉中产生一个或多个小叶和相应的口袋/鼻窦。

17. 发明申请

US20100152843A1 Percutaneous Methods for Creating Native Tissue Venous Valves 有权
标题翻译：用于创建本土组织静脉瓣的经皮方法
公开(公告)号：US20100152843A1
公开(公告)日：2010-06-17
申请号：US12335786
申请日：2008-12-16
申请人： Kevin Mauch , Maria Arreguin
发明人： Kevin Mauch , Maria Arreguin
IPC分类号： A61F2/24 , A61B19/00 , A61F2/06
CPC分类号： A61F2/24 , A61F2/2475 , A61F2/958
摘要： Percutaneous methods of forming a venous valve from autologous tissue are disclosed. The methods include percutaneously creating one or two subintimal dissections for forming one or two flaps of intimal tissue. In one method, a puncture element is delivered by a catheter based delivery system to a treatment site where a new venous valve is to be created. The puncture element is deployed to gain access to a subintimal layer of the vein wall. A dilation balloon is than positioned and inflated within the subintimal layer to create a flap and corresponding pocket/sinus in the vein, which than acts as a one-way monocuspid valve in the manner of a native venous valve. In a similar manner, methods of forming new bicuspid venous valves by subintimal dissections are also disclosed.
摘要翻译：公开了从自体组织形成静脉瓣的经皮方法。所述方法包括经皮创建一个或两个内膜消融以形成一个或两个内膜组织瓣。在一种方法中，穿刺元件通过基于导管的递送系统递送到将要创建新的静脉瓣的治疗部位。部分穿刺元件以进入静脉壁的内膜层。扩张气囊不是在内膜层内定位和充气，以在静脉中产生瓣和相应的口袋/窦，其以天然静脉瓣的方式用作单向单瓣阀。以类似的方式，还公开了通过底内夹层形成新的二尖瓣静脉瓣的方法。

18. 发明申请

US20080015681A1 STENT AND CATHETER ASSEMBLY AND METHOD FOR TREATING BIFURCATIONS 有权
标题翻译： STENT和CATHETER装配和处理分岔的方法
公开(公告)号：US20080015681A1
公开(公告)日：2008-01-17
申请号：US11835146
申请日：2007-08-07
申请人： W. Wilson , Kevin Mauch
发明人： W. Wilson , Kevin Mauch
IPC分类号： A61F2/06
CPC分类号： A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/061 , A61F2002/065 , A61F2002/067 , A61F2002/821 , A61F2002/91508 , A61F2002/91533 , A61F2002/91575 , A61F2250/0014 , A61F2250/0039 , A61F2250/006 , A61M25/10 , A61M2025/1045
摘要： An apparatus and method is provided for stenting bifurcated vessels. A proximal angled stent is configured for implanting in a side-branch vessel wherein the proximal angled stent has an angulated portion that corresponds to the angle formed by the intersection of the side-branch vessel and the main vessel so that all portions of the side-branch vessel at the bifurcation are covered by the proximal angled stent. A main-vessel stent is provided for implanting in the main vessel, wherein the main-vessel stent has an aperture or stent cell that aligns with the opening to the side-branch vessel to permit unobstructed blood flow between the main vessel and the side-branch vessel. Side-branch and main-vessel catheter assemblies are advanced over a pair of guide wires for delivering, appropriately orienting, and implanting the proximal angled stent and the apertured stent.
摘要翻译：提供了用于支架分叉血管的装置和方法。近侧成角度的支架配置成用于植入侧支血管，其中近侧成角度的支架具有对应于由侧支血管与主血管的交叉形成的角度的角度部分，在分叉处的分支血管被近端成角度支架覆盖。提供主血管支架用于植入主血管，其中主血管支架具有与侧支血管的开口对准的孔或支架细胞，以允许主血管和侧支血管之间畅通无阻的血流，分支船。侧支和主血管导管组件在一对导丝上前进，用于输送，适当定向和植入近端成角度支架和有孔支架。

19. 发明申请

US20070270769A1 STENT AND CATHETER ASSEMBLY AND METHOD FOR TREATING BIFURCATIONS 失效
标题翻译： STENT和CATHETER装配和处理分岔的方法
公开(公告)号：US20070270769A1
公开(公告)日：2007-11-22
申请号：US11835077
申请日：2007-08-07
申请人： W. Wilson , Kevin Mauch
发明人： W. Wilson , Kevin Mauch
IPC分类号： A61M25/01
CPC分类号： A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/061 , A61F2002/065 , A61F2002/067 , A61F2002/821 , A61F2002/91508 , A61F2002/91533 , A61F2002/91575 , A61F2250/0014 , A61F2250/0039 , A61F2250/006 , A61M25/10 , A61M2025/1045
摘要： An apparatus and method is provided for stenting bifurcated vessels. A proximal angled stent is configured for implanting in a side-branch vessel wherein the proximal angled stent has an angulated portion that corresponds to the angle formed by the intersection of the side-branch vessel and the main vessel so that all portions of the side-branch vessel at the bifurcation are covered by the proximal angled stent. A main-vessel stent is provided for implanting in the main vessel, wherein the main-vessel stent has an aperture or stent cell that aligns with the opening to the side-branch vessel to permit unobstructed blood flow between the main vessel and the side-branch vessel. Side-branch and main-vessel catheter assemblies are advanced over a pair of guide wires for delivering, appropriately orienting, and implanting the proximal angled stent and the apertured stent.
摘要翻译：提供了用于支架分叉血管的装置和方法。近侧成角度的支架配置成用于植入侧支血管，其中近侧成角度的支架具有对应于由侧支血管与主血管的交叉形成的角度的角度部分，在分叉处的分支血管被近端成角度支架覆盖。提供主血管支架用于植入主血管，其中主血管支架具有与侧支血管的开口对准的孔或支架细胞，以允许主血管和侧支血管之间畅通无阻的血流，分支船。侧支和主血管导管组件在一对导丝上前进，用于输送，适当定向和植入近端成角度支架和有孔支架。

20. 发明申请

US20060052858A1 Stent and catheter assembly and method for treating bifurcations 失效
公开(公告)号：US20060052858A1
公开(公告)日：2006-03-09
申请号：US11252081
申请日：2005-10-17
申请人： W. Wilson , Kevin Mauch
发明人： W. Wilson , Kevin Mauch
IPC分类号： A61F2/06
CPC分类号： A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2002/067 , A61F2002/821 , A61F2002/91508 , A61F2002/91516 , A61F2002/91533 , A61F2002/91575 , A61F2250/0014 , A61F2250/006 , A61M25/10 , A61M2025/1045
摘要： An apparatus and method is provided for stenting bifurcated vessels. A proximal angled stent is configured for implanting in a side-branch vessel wherein the proximal angled stent has an angulated portion that corresponds to the angle formed by the intersection of the side-branch vessel and the main vessel so that all portions of the side-branch vessel at the bifurcation are covered by the proximal angled stent. A main-vessel stent is provided for implanting in the main vessel, wherein the main-vessel stent has an aperture or stent cell that aligns with the opening to the side-branch vessel to permit unobstructed blood flow between the main vessel and the side-branch vessel. Side-branch and main-vessel catheter assemblies are advanced over a pair of guide wires for delivering, appropriately orienting, and implanting the proximal angled stent and the apertured stent.

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