专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US4663319A 3-(1,3-dithiol-2-ylidene)-2,4-dioxopyrrolidines, -piperidines, and -hexahydroazepines and use thereof against hepatic diseases 失效
标题翻译： 3-（1,3-二硫醇-2-亚基）-2,4-二氧代吡咯烷，哌啶和六氢吖庚因及其用于肝病
公开(公告)号：US4663319A
公开(公告)日：1987-05-05
申请号：US689261
申请日：1985-01-07
申请人： Ikuo Iijima , Koichi Homma , Yutaka Saiga , Yuzo Matsuoka , Mamoru Matsumoto
发明人： Ikuo Iijima , Koichi Homma , Yutaka Saiga , Yuzo Matsuoka , Mamoru Matsumoto
IPC分类号： C07D211/58 , A61K31/45 , A61K31/4523 , A61P1/16 , C07D207/38 , C07D211/86 , C07D211/90 , C07D213/02 , C07D213/38 , C07D213/40 , C07D213/69 , C07D223/10 , C07D295/06 , C07D339/06 , C07D401/06 , C07D409/04 , C07D409/12 , C07D409/14 , A61K31/55 , A61K31/445
CPC分类号： C07D213/40 , C07D207/38 , C07D211/86 , C07D211/90 , C07D213/38 , C07D213/69 , C07D223/10 , C07D339/06 , C07D401/06 , C07D409/04 , C07D409/12 , C07D409/14
摘要： Novel thioketene derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, an alkyl group, a lower alkenyl group, a phenyl group or a group of the formula: --B--Y;Y is a nitrogen-containing monocyclic heterocyclic group or a substituted or unsubstituted phenyl group;B is a straight or branched lower alkylene group;R.sup.2 and R.sup.3 are both a lower alkyl group or are combined together to form a group of the formula: --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--;R.sup.4 is hydrogen atom, a lower alkyl group or a (lower alkoxy)carbonyl group;A is a group of the formula: --(CH.sub.2).sub.n -- or --CH(COOR.sup.5)--;n is an integer of 0, 1 or 2 andR.sup.5 is a lower alkyl group,are disclosed. The compound (I) is useful as an agent for treating and protecting various liver diseases.
摘要翻译：具有下式的新型硫代烯酮衍生物：其中R 1是氢原子，烷基，低级烯基，苯基或下式基团：-B-Y; Y是含氮单环杂环基或取代或未取代的苯基; B是直链或支链低级亚烷基; R 2和R 3都是低级烷基或被结合在一起形成下式的基团：-CH 2 CH 2 - 或-CH = CH-; R4是氢原子，低级烷基或（低级烷氧基）羰基; A是下式的基团： - （CH 2）n - 或-CH（COOR 5） - ; n是0或1或2的整数，R5是低级烷基。化合物（I）可用作治疗和保护各种肝脏疾病的药剂。

12. 发明申请

US20050063902A1 Stabiliser for radiopharmaceuticals 有权
标题翻译：放射性药物稳定剂
公开(公告)号：US20050063902A1
公开(公告)日：2005-03-24
申请号：US10296952
申请日：2001-06-18
申请人： Anthony Storey , Georg Brauers , Koichi Hanaoka , Yoshihito Minosako , Koichi Homma , Yoshifumi Shirakami
发明人： Anthony Storey , Georg Brauers , Koichi Hanaoka , Yoshihito Minosako , Koichi Homma , Yoshifumi Shirakami
IPC分类号： A61K47/02 , A61K47/16 , A61K47/18 , A61K47/22 , A61K47/24 , A61K51/00 , A61K51/04 , A61P43/00 , A61K31/66
CPC分类号： A61K51/0489
摘要： The present invention provides an improved stabiliser for radiopharmaceuticals which inhibits impurities from being produced by two kinds of decomposition mechanisms and exhibits such an effect that the shelf life of a radiopharmaceutical after its preparation is prolonged as compared with conventional ones. The improvement comprises a combination of an amino-substituted aromatic carboxylic acid or its salt, ester or amide in combination with a diphosphonic acid or its salt.
摘要翻译：本发明提供一种用于放射性药物的改进的稳定剂，其通过两种分解机制抑制杂质的产生，并且表现出与常规放射性药物相比，其制备后放射性药物的保质期延长的效果。改进包括氨基取代的芳族羧酸或其盐，酯或酰胺与二膦酸或其盐的组合。

13. 发明授权

US5739132A Pyridazinone derivatives and processes for preparing the same 失效
标题翻译：哒嗪酮衍生物及其制备方法
公开(公告)号：US5739132A
公开(公告)日：1998-04-14
申请号：US767444
申请日：1996-12-16
申请人： Akihiko Ishida , Koichi Homma , Harumichi Kono , Koji Tamura , Yasuhiko Sasaki
发明人： Akihiko Ishida , Koichi Homma , Harumichi Kono , Koji Tamura , Yasuhiko Sasaki
IPC分类号： C07D237/04 , A61K31/50
CPC分类号： C07D237/04
摘要： Disclosed are a pyridazinone compound represented by the formula: ##STR1## wherein (1) R.sup.1 is a substituted or unsubstituted C.sub.1-10 alkyl, a C.sub.3-6 cycloalkyl, a lower alkenyl, a heterocyclic group having N, O or S atom or camphor-10-yl; R.sup.3 is hydrogen, a substituted or unsubstituted lower alkyl or a lower alkenyl; or R.sup.1 and R.sup.3 are bonded at terminal ends thereof to form a lower alkylene; and Z is a group represented by the formula: ##STR2## where n is 1 or 2; and D is hydrogen or a halogen; or (2) R.sup.1 is a substituted or unsubstituted C.sub.1-10 alkyl, a substituted or unsubstituted phenyl, a C.sub.3-6 cycloalkyl, a lower alkenyl, a heterocyclic group having N, O or S atom or camphor-10-yl; R.sup.3 is hydrogen, a substituted or unsubstituted lower alkyl or a lower alkenyl; or R.sup.1 and R.sup.3 are bonded at terminal ends thereof to form a lower alkylene; and Z is a group represented by the formula: ##STR3## and R.sup.2 is hydrogen, a substituted or unsubstituted lower alkyl, an aryl or a lower alkenyl; and --A--B-- is an ethylene or vinylene each of which may be substituted by 1 or 2 groups selected from the group consisting of a lower alkyl and phenyl group, or a pharmaceutically acceptable salt thereof, and processes for preparing the same.
摘要翻译：公开了由下式表示的哒嗪酮化合物：其中（1）R1是取代或未取代的C1-10烷基，C3-6环烷基，低级烯基，具有N，O或S的杂环基原子或樟脑-10-基; R3是氢，取代或未取代的低级烷基或低级烯基; 或者R 1和R 3在其末端键合形成低级亚烷基; Z为由下式表示的基团：其中n为1或2; D为氢或卤素; 或（2）R1是取代或未取代的C1-10烷基，取代或未取代的苯基，C3-6环烷基，低级链烯基，具有N，O或S原子的杂环基或樟脑-10-基; R3是氢，取代或未取代的低级烷基或低级烯基; 或者R 1和R 3在其末端键合形成低级亚烷基; Z是由下式表示的基团：＆lt; IMAGE＆gt; R2是氢，取代或未取代的低级烷基，芳基或低级烯基; 并且-A-B-是各自可以被选自低级烷基和苯基的1或2个基团取代的乙烯或亚乙烯基，或其药学上可接受的盐及其制备方法。

14. 发明授权

US5686452A Indane derivative and processes for preparing the same 失效
标题翻译：吲哚衍生物及其制备方法
公开(公告)号：US5686452A
公开(公告)日：1997-11-11
申请号：US767392
申请日：1996-12-16
申请人： Akihiko Ishida , Koichi Homma , Michihisa Yato , Shinsuke Nishiyama , Fumikazu Okumura
发明人： Akihiko Ishida , Koichi Homma , Michihisa Yato , Shinsuke Nishiyama , Fumikazu Okumura
IPC分类号： C07D237/14 , C07D401/12 , A61K31/50
CPC分类号： C07D401/12 , C07D237/14
摘要： Disclosed are an indane compound represented by the formula: ##STR1## wherein R.sup.1 represents a lower alkyl group, a lower alkenyl group or a substituted or unsubstituted mono-cyclic aromatic heterocyclic group having nitrogen atom as a hetero atom; R.sup.2 represents hydrogen atom or a lower alkyl group; and A represents a lower alkylene group, or a pharmaceutically acceptable salt thereof and processes for preparing the same.
摘要翻译：公开了下式表示的二氢化茚化合物：其中R 1表示低级烷基，低级链烯基或具有氮原子作为杂原子的取代或未取代的单环芳族杂环基; R2表示氢原子或低级烷基; A表示低级亚烷基或其药学上可接受的盐及其制备方法。

15. 发明授权

US09032925B2 Phase varying apparatus for automobile engine 有权
标题翻译：汽车发动机相变装置
公开(公告)号：US09032925B2
公开(公告)日：2015-05-19
申请号：US14238380
申请日：2011-08-12
申请人： Michihiro Kameda , Masaaki Niiro , Koichi Homma
发明人： Michihiro Kameda , Masaaki Niiro , Koichi Homma
IPC分类号： F01L1/34 , F01L1/344 , F01L1/352
CPC分类号： F01L1/344 , F01L1/352 , F01L2001/3522
摘要： A phase varying apparatus capable of smoothly varying the phase angle of a camshaft relative to a drive rotor by comprising: a drive rotor supported by a camshaft and driven by a crankshaft; a first control rotor integral with the camshaft; a first torquing mechanism for providing the first drive rotor with a torque in one direction, and a reverse rotation mechanism for proving the first control rotor with a torque in the opposite direction, wherein the reverse rotation mechanism comprises a first radius-decreasing guide groove formed in the control rotor, a crank member adapted to rotate about a position offset from the rotational axis of the drive rotor, and a first pin mechanism mounted on the crank member and movable in the radius-decreasing guide groove, and a second operative mechanism for rotating the first control rotor in the opposite rotational direction relative to the drive rotor.
摘要翻译：一种能够相对于驱动转子平滑地改变凸轮轴的相位角的相变装置，包括：由凸轮轴支撑并由曲轴驱动的驱动转子; 与凸轮轴成一体的第一控制转子; 第一扭转机构，用于向第一驱动转子提供一个方向的扭矩;以及反向旋转机构，用于以相反方向的扭矩证明第一控制转子，其中反向旋转机构包括形成的第一半径减小导向槽在所述控制转子中，曲柄构件适于围绕从所述驱动转子的旋转轴线偏移的位置旋转;以及第一销机构，其安装在所述曲柄构件上并且可在所述半径减小的导向槽中移动，以及第二操作机构，使第一控制转子相对于驱动转子在相反的旋转方向旋转。

16. 发明申请

US20140196677A1 PHASE VARYING APPARATUS FOR AUTOMOBILE ENGINE 有权
标题翻译：汽车发动机相变装置
公开(公告)号：US20140196677A1
公开(公告)日：2014-07-17
申请号：US14238380
申请日：2011-08-12
申请人： Michihiro Kameda , Masaaki Niiro , Koichi Homma
发明人： Michihiro Kameda , Masaaki Niiro , Koichi Homma
IPC分类号： F01L1/344
CPC分类号： F01L1/344 , F01L1/352 , F01L2001/3522
摘要： A phase varying apparatus capable of smoothly varying the phase angle of a camshaft relative to a drive rotor by comprising: a drive rotor supported by a camshaft and driven by a crankshaft; a first control rotor integral with the camshaft; a first torquing mechanism for providing the first drive rotor with a torque in one direction, and a reverse rotation mechanism for proving the first control rotor with a torque in the opposite direction, wherein the reverse rotation mechanism comprises a first radius-decreasing guide groove formed in the control rotor, a crank member adapted to rotate about a position offset from the rotational axis of the drive rotor, and a first pin mechanism mounted on the crank member and movable in the radius-decreasing guide groove, and a second operative mechanism for rotating the first control rotor in the opposite rotational direction relative to the drive rotor.
摘要翻译：一种能够相对于驱动转子平滑地改变凸轮轴的相位角的相变装置，包括：由凸轮轴支撑并由曲轴驱动的驱动转子; 与凸轮轴成一体的第一控制转子; 第一扭转机构，用于向第一驱动转子提供一个方向的扭矩;以及反向旋转机构，用于以相反方向的扭矩证明第一控制转子，其中反向旋转机构包括形成的第一半径减小导向槽在所述控制转子中，曲柄构件适于围绕从所述驱动转子的旋转轴线偏移的位置旋转;以及第一销机构，其安装在所述曲柄构件上并且可在所述半径减小的导向槽中移动，以及第二操作机构，使第一控制转子相对于驱动转子在相反的旋转方向旋转。

17. 发明申请

US20130192552A1 PHASE VARYING APPARATUS FOR AUTOMOBILE ENGINE TECHNICAL 有权
标题翻译：汽车发动机技术的相变装置
公开(公告)号：US20130192552A1
公开(公告)日：2013-08-01
申请号：US13879274
申请日：2010-10-12
申请人： Masaaki Niiro , Michihiro Kameda , Koichi Homma , Masayasu Nagado
发明人： Masaaki Niiro , Michihiro Kameda , Koichi Homma , Masayasu Nagado
IPC分类号： F01L1/344
CPC分类号： F01L1/34409 , F01L1/34
摘要： The inventive phase varying apparatus (50) has a drive rotor (51) driven by the crankshaft of the engine, a phase angle varying mechanism (54) for varying the phase angle of the camshaft relative to the crankshaft, and a self-locking mechanism (56) for preventing a gap in phase angle between the drive rotor and the camshaft due to an externally input disturbing torque. The self-locking mechanism has a cylinder section (69) mounted on the drive rotor, a circular eccentric cam (64) integrated with the camshaft and having inside thereof a cam holding groove (68a), and a lock plate (68) rotatably supporting the periphery of the circular eccentric cam and having on the outer periphery thereof at least four radial abutment protrusions (74-77) that are adapted to abut against the inner periphery (69a) of the cylinder section (69) to perform self-locking.
摘要翻译：本发明的相变装置（50）具有由发动机的曲轴驱动的驱动转子（51），用于改变凸轮轴相对于曲轴的相位角的相位角变化机构（54），以及自锁机构（56），用于防止由于外部输入的干扰转矩而导致的驱动转子和凸轮轴之间的相位角的间隙。所述自锁机构具有安装在所述驱动转子上的圆筒部（69），与所述凸轮轴一体且具有凸轮保持槽（68a）的圆形偏心凸轮（64），以及可旋转地支承圆偏心凸轮的周边并且在其外周上具有适于抵靠气缸部分（69）的内周（69a）的至少四个径向邻接凸起（74-77）以执行自锁。

18. 发明授权

US08387577B2 Phase changing device for automobile engine 失效
标题翻译：汽车发动机相变装置
公开(公告)号：US08387577B2
公开(公告)日：2013-03-05
申请号：US12920530
申请日：2009-02-24
申请人： Minoru Shiino , Masaaki Niiro , Koichi Homma , Michihiro Kameda , Masayasu Nagado
发明人： Minoru Shiino , Masaaki Niiro , Koichi Homma , Michihiro Kameda , Masayasu Nagado
IPC分类号： F01L1/34
CPC分类号： F01L1/352 , F01L1/022 , F01L1/344 , F01L2001/0476 , F01L2001/0537
摘要： A phase changing device for automobile engine, the device comprising curved first guide grooves formed in the control rotor, each groove skewed with respect to a circumference of a circle centered at the rotational axis; oblique guide grooves each groove formed in the middle rotor and extending at an angle with respect to a radius crossing the groove; second guide grooves formed in the drive rotor and skewed with respect to the circumference of a circle centered at the rotational axis, block sections each extending along, and movable in, the respective first guide; first slide members each protruding from the respective block section for engagement with, and for movement in, the respective skewed guide groove; and phase varying members each having a second slide member that extends through an escape groove formed in the middle rotor and engages the respective second guide groove to move in the second guide groove.
摘要翻译：一种用于汽车发动机的相变装置，该装置包括形成在控制转子中的弯曲的第一引导槽，每个槽相对于以旋转轴为中心的圆的圆周倾斜; 倾斜导向槽，每个凹槽形成在中间转子中并且相对于与凹槽交叉的半径成一定角度延伸; 形成在所述驱动转子中并相对于以所述旋转轴线为中心的圆的圆周倾斜的第二引导槽，每个所述第一引导槽沿相应的第一引导件延伸并移动; 第一滑动构件，其各自从相应的块部分突出，用于与相应的倾斜导向槽接合和移动; 以及相变构件，每个构件具有第二滑动构件，所述第二滑动构件延伸穿过形成在所述中间转子中的逃逸槽，并且与所述第二引导槽接合以在所述第二引导槽中移动。

19. 发明授权

US07920287B2 Layout apparatus, layout method, and program product 有权
标题翻译：布局设备，布局方法和程序产品
公开(公告)号：US07920287B2
公开(公告)日：2011-04-05
申请号：US12111343
申请日：2008-04-29
申请人： Hideki Adachi , Koichi Homma , Hiroshi Yamaguchi , Joji Oki , Naohiro Yoshikawa , Hideyuki Fujiwara , Akira Negishi , Shuji Someya
发明人： Hideki Adachi , Koichi Homma , Hiroshi Yamaguchi , Joji Oki , Naohiro Yoshikawa , Hideyuki Fujiwara , Akira Negishi , Shuji Someya
IPC分类号： G06F3/12 , G06F17/00 , G06F3/00 , G06K15/00 , G03F3/08
CPC分类号： G06F3/1204 , G06F3/1208 , G06F3/125 , G06F3/1257 , G06F3/1285
摘要： A layout apparatus lays out a document by referencing personal information registered on a per user basis. Even if no particular print setting is input for a print job by a user, excellent prints customized for each user are thus provided.
摘要翻译：布局装置通过参考在每个用户基础上注册的个人信息来布置文档。即使用户没有为打印作业输入特定的打印设置，因此提供了为每个用户定制的优秀打印。

20. 发明授权

US08726867B2 Phase varying apparatus for automobile engine technical 有权
标题翻译：汽车发动机技术相变装置
公开(公告)号：US08726867B2
公开(公告)日：2014-05-20
申请号：US13879274
申请日：2010-10-12
申请人： Masaaki Niiro , Michihiro Kameda , Koichi Homma , Masayasu Nagado
发明人： Masaaki Niiro , Michihiro Kameda , Koichi Homma , Masayasu Nagado
IPC分类号： F01L1/34
CPC分类号： F01L1/34409 , F01L1/34
摘要： The inventive phase varying apparatus (50) has a drive rotor (51) driven by the crankshaft of the engine, a phase angle varying mechanism (54) for varying the phase angle of the camshaft relative to the crankshaft, and a self-locking mechanism (56) for preventing a gap in phase angle between the drive rotor and the camshaft due to an externally input disturbing torque. The self-locking mechanism has a cylinder section (69) mounted on the drive rotor, a circular eccentric cam (64) integrated with the camshaft and having inside thereof a cam holding groove (68a), and a lock plate (68) rotatably supporting the periphery of the circular eccentric cam and having on the outer periphery thereof at least four radial abutment protrusions (74-77) that are adapted to abut against the inner periphery (69a) of the cylinder section (69) to perform self-locking.
摘要翻译：本发明的相变装置（50）具有由发动机的曲轴驱动的驱动转子（51），用于改变凸轮轴相对于曲轴的相位角的相位角变化机构（54），以及自锁机构（56），用于防止由于外部输入的干扰转矩而导致的驱动转子和凸轮轴之间的相位角的间隙。所述自锁机构具有安装在所述驱动转子上的圆筒部（69），与所述凸轮轴一体且具有凸轮保持槽（68a）的圆形偏心凸轮（64），以及可旋转地支承圆偏心凸轮的周边并且在其外周上具有适于抵靠气缸部分（69）的内周（69a）的至少四个径向邻接凸起（74-77）以执行自锁。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式