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11. 发明申请

US20080288228A1 BIOLOGICAL SIMULATION SYSTEM AND COMPUTER PROGRAM PRODUCT 审中-公开
标题翻译：生物仿真系统和计算机程序产品
公开(公告)号：US20080288228A1
公开(公告)日：2008-11-20
申请号：US12043752
申请日：2008-03-06
申请人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike
发明人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike
IPC分类号： G06F9/455 , G06F7/06 , G06F17/30
CPC分类号： G09B23/30 , G16H50/50
摘要： With an object to seek parameters of a biological model corresponding to individual patents, the present invention provides a biological simulation system comprises an internal parameter set generating section which generates internal parameter sets constituting a biological model, a biological model computing section computing output of a biological model which emulates a biological response of a biological organ based on the generated internal parameter set, and a template database having a plurality of combinations of a reference output value of the biological model and an internal parameter set corresponding to the reference output value, wherein the internal parameter set generating section comprises a database referring means which selects a reference output approximate to an actual biological response from said template database and which selects an internal parameter set corresponding to the selected reference output value.
摘要翻译：本发明提供一种生物模拟系统，其特征在于，具备生成构成生物体模型的内部参数组的内部参数组生成部，生物体模型计算部，模型，其基于所生成的内部参数集模拟生物器官的生物反应;以及模板数据库，其具有生物模型的参考输出值和对应于所述参考输出值的内部参数集合的多个组合，其中，内部参数集生成部分包括数据库参考装置，其从所述模板数据库中选择近似于实际生物反应的参考输出，并且选择与所选择的参考输出值对应的内部参数集。

12. 发明申请

US20070288216A1 Simulation system of function of biological organ 失效
标题翻译：生物器官功能模拟系统
公开(公告)号：US20070288216A1
公开(公告)日：2007-12-13
申请号：US11805743
申请日：2007-05-24
申请人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike
发明人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike
IPC分类号： G06G7/60
CPC分类号： G16H50/50 , G06F19/00
摘要： A simulation system for simulating a function of a biological organ using a biological model in which the function of the biological organ are represented by a mathematical model with a computer is provided. The present system receives input of time-series actual measurement data representing the biological response of a subject, estimates the biological response of the subject at a time point at which the measurement is not performed by using the input time-series actual measurement data, and generates time-series reference data representing the biological response of the subject. The present system further generates a virtual biological organ virtually constructed in a computer system using the times-series reference data. The virtual biological organ corresponds to the function of a biological organ of the subject.
摘要翻译：提供了一种使用生物器官功能模拟生物器官的功能的模拟系统，其中生物器官的功能由计算机的数学模型表示。本系统接收表示对象生物学响应的时间序列实际测量数据的输入，通过使用输入的时间序列实际测量数据来估计未进行测量的时间点的对象的生物学响应，以及生成表示对象的生物反应的时间序列参考数据。本系统还使用时间序列参考数据生成虚拟构建在计算机系统中的虚拟生物器官。虚拟生物器官对应于受试者的生物器官的功能。

13. 发明申请

US20050256690A1 Simulation system for simulating material concentration in a living body and storage medium 审中-公开
标题翻译：用于模拟生物体和储存介质中物质浓度的模拟系统
公开(公告)号：US20050256690A1
公开(公告)日：2005-11-17
申请号：US11126627
申请日：2005-05-11
申请人： Yasuhiro Kouchi , Takeo Saitou , Yasuhiro Naitou , Hiromu Nakajima
发明人： Yasuhiro Kouchi , Takeo Saitou , Yasuhiro Naitou , Hiromu Nakajima
IPC分类号： G06F19/00 , G06G7/48 , G06G7/58
CPC分类号： G16H50/50 , G06F19/324
摘要： A system for computer simulation of object material concentration in a living body using a biological simulation model configured by a blocks readily corresponding to organs of a living body is provided. The functions of organs in a living body related to the object material are described using the biological simulation model to simulate the change over time in the object material concentration in a living body using a computer. The blocks are mutually linked so as to enable the transference of data among blocks. A computer-readable storage medium is also disclosed.
摘要翻译：提供一种使用由容易对应于生物体的器官的块构成的生物模拟模型来计算机模拟生物体内物质浓度的系统。使用生物模拟模型描述与物体材料相关的活体中器官的功能，以模拟使用计算机的活体中物体浓度中随时间的变化。这些块是相互链接的，以便能够在块之间传输数据。还公开了一种计算机可读存储介质。

14. 发明申请

US20100018281A1 METHOD OF MANUFACTURING PLUG USED TO PIERCE AND ROLL METAL MATERIAL, METHOD OF MANUFACTURING METAL PIPE AND PLUG USED TO PIERCE AND ROLL METAL MATERIAL 有权
标题翻译：制造用于金属和金属材料的电极的方法，制造用于金属和金属材料的金属管和插入物的方法
公开(公告)号：US20100018281A1
公开(公告)日：2010-01-28
申请号：US12533390
申请日：2009-07-31
申请人： YASUYOSHI HIDAKA , Naoya Hirase , Yasuhiro Kouchi
发明人： YASUYOSHI HIDAKA , Naoya Hirase , Yasuhiro Kouchi
IPC分类号： B21B23/00 , B21K5/00
CPC分类号： B21B25/00 , B21B19/04 , C23C8/14
摘要： A plug material having a prescribed shape is prepared, the prepared plug material is thermally treated in a heat treatment atmosphere that contains at least 1.0 vol. % oxygen at a heat treatment temperature of at least 950° C. and less than 1050° C. and thus a plug having an oxide scale layer 30 on the surface is manufactured. According to the manufacturing method, pores PO that extend along the surface SF of the plug material are formed under outer scale layer 20 in the oxide scale layer 30, which allows cracks to be more easily propagated in the outer scale layer 20. Therefore, the outer scale layer 20 is more easily peeled off than the conventional one.
摘要翻译：制备具有规定形状的塞子材料，将所制备的塞子材料在含有至少1.0体积％的热处理气氛中进行热处理。在氧化处理温度为至少950℃且低于1050℃的氧气中制造氧气，因此制造了表面上具有氧化皮层30的塞子。根据制造方法，在氧化皮层30中的外标尺层20上形成有沿插塞材料的表面SF延伸的孔PO，这允许裂纹在外标尺层20中更容易传播。因此，外标层20比常规剥离更容易。

15. 发明申请

US20060282245A1 Biological simulation system and computer program product 审中-公开
标题翻译：生物仿真系统和计算机程序产品
公开(公告)号：US20060282245A1
公开(公告)日：2006-12-14
申请号：US11431961
申请日：2006-05-11
申请人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike , Yasuhiro Naitou
发明人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike , Yasuhiro Naitou
IPC分类号： G06G7/48 , G06G7/58
CPC分类号： G09B23/28 , G16H50/50
摘要： With an object to seek parameters of a biological model corresponding to individual patients, the present invention provides a biological simulation system comprises an internal parameter set generating section which generates internal parameter sets constituting a biological model, and a biological model computing section computing output of a biological model which emulates a biological response of a biological organ based on the generated internal parameter set, wherein the internal parameter set generating section comprises a means for automatically generating a plurality of different internal parameter sets, and a selecting means which determines an approximation between a biological model output calculated applying the automatically generated internal parameter set and an actual biological response corresponding to said output and which selects an appropriate internal parameter set from a plurality of the generated internal parameter sets.
摘要翻译：本发明提供一种生物模拟系统，该生物模拟系统包括生成构成生物模型的内部参数集的内部参数集生成部，以及计算生物体模型计算部生物模型，其基于所生成的内部参数集模拟生物器官的生物反应，其中所述内部参数组生成部分包括用于自动生成多个不同内部参数集的装置，以及选择装置，其确定a 计算的生物模型输出应用自动生成的内部参数集和对应于所述输出的实际生物反应，并且从多个生成的内部参数集中选择合适的内部参数集。

16. 发明申请

US20060277016A1 Biological simulation system and computer program product 审中-公开
标题翻译：生物仿真系统和计算机程序产品
公开(公告)号：US20060277016A1
公开(公告)日：2006-12-07
申请号：US11431962
申请日：2006-05-11
申请人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike
发明人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike
IPC分类号： G06G7/48 , G06G7/58
CPC分类号： G09B23/30 , G16H50/50
摘要： With an object to seek parameters of a biological model corresponding to individual patents, the present invention provides a biological simulation system comprises an internal parameter set generating section which generates internal parameter sets constituting a biological model, a biological model computing section computing output of a biological model which emulates a biological response of a biological organ based on the generated internal parameter set, and a template database having a plurality of combinations of a reference output value of the biological model and an internal parameter set corresponding to the reference output value, wherein the internal parameter set generating section comprises a database referring means which selects a reference output approximate to an actual biological response from said template database and which selects an internal parameter set corresponding to the selected reference output value.
摘要翻译：本发明提供一种生物模拟系统，其特征在于，具备生成构成生物体模型的内部参数组的内部参数组生成部，生物体模型计算部，模型，其基于所生成的内部参数集模拟生物器官的生物反应;以及模板数据库，其具有生物模型的参考输出值和对应于所述参考输出值的内部参数集合的多个组合，其中，内部参数集生成部分包括数据库参考装置，其从所述模板数据库中选择近似于实际生物反应的参考输出，并且选择与所选择的参考输出值对应的内部参数集。

17. 发明申请

US20060277015A1 Simulation system for functions of biological organs and recording medium in which program therefor is recorded 审中-公开
标题翻译：用于生物器官和记录介质功能的仿真系统，其中记录有程序
公开(公告)号：US20060277015A1
公开(公告)日：2006-12-07
申请号：US11430557
申请日：2006-05-09
申请人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike , Hiromu Nakajima
发明人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike , Hiromu Nakajima
IPC分类号： G06G7/48 , G06G7/58
CPC分类号： G16H50/50
摘要： A simulation system for simulating functions of biological organs, comprising a biological model in which the functions of the biological organs are expressed by mathematical models. The biological model comprises a hepatic metabolism model block having specified input and output relating to hepatic function for simulating the hepatic function. The system further comprises arithmetic means for calculating an output value by using measurable status variables of a liver based on input value to the hepatic metabolism model block.
摘要翻译：一种用于模拟生物器官功能的模拟系统，包括一个生物模型，其中生物器官的功能由数学模型表达。该生物学模型包括肝脏代谢模型块，具有与用于模拟肝功能的肝功能相关的输入和输出。该系统还包括用于基于肝代谢模型块的输入值通过使用肝脏的可测量状态变量来计算输出值的算术装置。

18. 发明授权

US08793144B2 Treatment effect prediction system, a treatment effect prediction method, and a computer program product thereof 有权
标题翻译：治疗效果预测系统，治疗效果预测方法及其计算机程序产品
公开(公告)号：US08793144B2
公开(公告)日：2014-07-29
申请号：US11431594
申请日：2006-05-11
申请人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike
发明人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike
IPC分类号： G06Q50/00 , G06F19/20 , G06F19/00 , G06Q50/24
CPC分类号： G06F19/20 , G06F19/00 , G06F19/34 , G06F19/3481 , G06Q50/24 , G16H50/50 , G16H50/70
摘要： A treatment effect prediction system, comprising: a processor; and a memory, under control of the processor, including instructions enabling the processor to carry out operations comprising: determining a patient pathological condition information, which represents a feature of pathological condition of a patient, based on diagnostic data of the patient; accessing a database of stored pathological condition information and corresponding treatment effects occurring when predetermined treatment is provided; and retrieving, from the database, a specific treatment effect corresponding to the one of the stored pathological condition information that is similar to the patient pathological condition information, is disclosed. A treatment effect prediction method and a computer program product thereof are also disclosed.
摘要翻译：一种治疗效果预测系统，包括：处理器; 以及在所述处理器的控制下的存储器，包括使得所述处理器能够执行操作的指令，所述指令基于所述患者的诊断数据来确定患者病理状况信息，其表示患者病理状态的特征; 访问存储的病理状况信息的数据库和提供预定治疗时发生的相应治疗效果; 并且从数据库中检索与存储的病理状况信息相对应的与患者病理状况信息相似的特定治疗效果。还公开了一种治疗效果预测方法及其计算机程序产品。

19. 发明授权

US08073629B2 Simulation system of function of biological organ 失效
标题翻译：生物器官功能模拟系统
公开(公告)号：US08073629B2
公开(公告)日：2011-12-06
申请号：US11805743
申请日：2007-05-24
申请人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike
发明人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike
IPC分类号： G06F19/00
CPC分类号： G16H50/50 , G06F19/00
摘要： A simulation system for simulating a function of a biological organ using a biological model in which the function of the biological organ are represented by a mathematical model with a computer is provided. The present system receives input of time-series actual measurement data representing the biological response of a subject, estimates the biological response of the subject at a time point at which the measurement is not performed by using the input time-series actual measurement data, and generates time-series reference data representing the biological response of the subject. The present system further generates a virtual biological organ virtually constructed in a computer system using the times-series reference data. The virtual biological organ corresponds to the function of a biological organ of the subject.
摘要翻译：提供了一种使用生物器官功能模拟生物器官的功能的模拟系统，其中生物器官的功能由计算机的数学模型表示。本系统接收表示对象生物学响应的时间序列实际测量数据的输入，通过使用输入的时间序列实际测量数据来估计未进行测量的时间点的对象的生物学响应，以及生成表示对象的生物反应的时间序列参考数据。本系统还使用时间序列参考数据生成虚拟构建在计算机系统中的虚拟生物器官。虚拟生物器官对应于受试者的生物器官的功能。

20. 发明申请

US20050234311A1 Diagnostic support system for diabetes and storage medium 有权
标题翻译：糖尿病和存储介质的诊断支持系统
公开(公告)号：US20050234311A1
公开(公告)日：2005-10-20
申请号：US11083332
申请日：2005-03-17
申请人： Yasuhiro Kouchi , Takeo Saitou , Hiromu Nakajima
发明人： Yasuhiro Kouchi , Takeo Saitou , Hiromu Nakajima
IPC分类号： G01N33/48 , G01N33/66 , G06F19/00 , G06Q50/22 , G06G7/48 , G06G7/58 , A61B5/00 , A61K31/415 , A01N43/50
CPC分类号： G16H15/00 , G06F19/00 , G06F19/3456 , G16H10/60 , G16H50/50
摘要： A diagnostic support system for diabetes including an input device used for inputting diagnostic data including clinical testing data; a biological model having parameters and which represents a organ function related to diabetes as a numerical model; an predicting means for predicting parameter values suited for a patient based on the diagnostic data and the biological model; a pathological condition analyzing means for analyzing a diabetic pathological condition of a patient based on the parameter values predicted by the predicting means; a diagnostic support information generating means for generating diagnostic support information based on the analyzed pathological condition; and a diagnostic support information outputting means for outputting information obtained by the diagnostic support information generating means. A computer-readable storage medium is also disclosed.
摘要翻译：一种用于糖尿病的诊断支持系统，包括用于输入包括临床测试数据的诊断数据的输入设备; 具有参数并且表示与糖尿病相关的器官功能的生物模型作为数值模型; 用于基于诊断数据和生物模型预测适合于患者的参数值的预测装置; 病理状态分析装置，用于根据由预测装置预测的参数值分析患者的糖尿病病理状态; 诊断支持信息产生装置，用于基于所分析的病理状况产生诊断支持信息; 以及诊断支持信息输出装置，用于输出由诊断支持信息产生装置获得的信息。还公开了一种计算机可读存储介质。

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