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11. 发明专利

CA2130800A1 PLANT GENES ENCODING FLAVONOID-3',5'-HYDROXYLASE 未知
公开(公告)号：CA2130800A1
公开(公告)日：1993-09-03
申请号：CA2130800
申请日：1992-11-20
申请人： KYOWA HAKKO KOGYO KK
发明人： KIKUCHI YASUHIRO , KIYOKAWA SHIGETO , SHIMADA YUKIHISA , OHBAYASHI MASAYA , SHIMADA RITSUKO , OKINAKA YASUSHI
IPC分类号： A01H5/00 , A01H5/02 , C12N9/02 , C12N15/11 , C12N15/29 , C12N15/53 , C12N15/55 , C12N15/82 , C07H21/04 , C12N5/10 , C12N15/10
摘要： The present invention relates to a DNA which encodes a polypeptide having flavonoid-3',5'-hydroxylase activity, a recombinant DNA containing said DNA, and a plant having a pigment pattern which the plant does not originally have and which is acquired by transformation with said recombinant DNA.

12. 发明专利

AU5263401A Myocardial cell proliferation-associated genes 未知
公开(公告)号：AU5263401A
公开(公告)日：2001-11-12
申请号：AU5263401
申请日：2001-04-27
申请人： KYOWA HAKKO KOGYO KK
发明人： YAMADA YOJI , SEKINE SUSUMU , KIKUCHI YASUHIRO , SAKURADA KAZUHIRO
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/475 , C07K16/18 , C12N1/15 , C12N1/19 , C12Q1/68 , C12Q1/6883 , C12N5/00 , C12N7/00 , C12N15/00 , C12P21/02
摘要： Genes showing different expression levels between fetal heart and adult heart were obtained. Thus, proteins useful in searching for therapeutic agents for repairing tissues injured by myocardial degeneration, DNAs encoding these proteins, antibodies recognizing these proteins, and methods of using the same are provided.

13. 发明专利

AU4461501A Proliferative glomerular nephritis-associated gene 未知
公开(公告)号：AU4461501A
公开(公告)日：2001-10-08
申请号：AU4461501
申请日：2001-03-29
申请人： KYOWA HAKKO KOGYO KK
发明人： TAKEUCHI KYOKO , SEKINE SUSUMU , KIKUCHI YASUHIRO , SAKURADA KAZUHIRO
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C12Q1/68
摘要： A gene which is useful in searching for a therapeutic agent which restores tissue that suffered damage in a renal disease, a polypeptide encoded by the gene and an antibody which recognizes the polypeptide, are provided. A gene whose expression level changes depending on progression and recovery of the pathology in a proliferative glomerulonephritis model animal is obtained, and a polypeptide encoded by the gene and an antibody which recognizes the polypeptide are produced. These gene, polypeptide and antibody can be used in the search for an agent for restoring kidney tissue that suffered damage and an agent for diagnosing kidney disorder.

14. 发明专利

CA2365599A1 NOVEL PLANT GENES 未知
公开(公告)号：CA2365599A1
公开(公告)日：1993-09-16
申请号：CA2365599
申请日：1992-11-20
申请人： KYOWA HAKKO KOGYO KK
发明人： SHIMADA RITSUKO , SHIMADA YUKIHISA , OHBAYASHI MASAYA , KIYOKAWA SHIGETO , OKINAKA YASUSHI , KIKUCHI YASUHIRO
IPC分类号： A01H5/00 , C12N5/04 , C12N5/10
摘要： The present invention relates to a DNA which encodes a polypeptide having flavonoid-3',5'-hydroxylase activity, a recombinant DNA containing said DNA, and a plant having a pigment pattern which the plant does not originally have and which is acquired by transformation with said recombinant DNA.

15. 发明公开

EP1026234A4 PROCESS FOR PREPARING DISTILLED LIQUOR 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG DISTILLIERTEN SPIRITUOSEN
公开(公告)号：EP1026234A4
公开(公告)日：2001-04-04
申请号：EP98941724
申请日：1998-09-04
申请人： KYOWA HAKKO KOGYO KK
发明人： AGO SHOJI , KIKUCHI YASUHIRO , FUKUDA KAZURO , KOBATA KENICHIRO
IPC分类号： C12G3/12
CPC分类号： C12G3/12
摘要： A process for preparing a distilled liquor, characterized by adding a fat to mash; and another process for preparing a distilled liquor, characterized by adding a fat and lipase to mash.
摘要翻译：一种制备蒸馏酒的方法，其特征在于加入油脂以捣碎; 和另一种制备蒸馏酒的方法，其特征在于加入脂肪和脂肪酶以捣碎。

16. 发明公开

EP1266961A4 KIDNEY REPAIRING FACTOR 审中-公开
标题翻译：治肝因子
公开(公告)号：EP1266961A4
公开(公告)日：2004-12-08
申请号：EP01912419
申请日：2001-03-16
申请人： KYOWA HAKKO KOGYO KK
发明人： TAKEUCHI KYOKO , KATO YOKO , SEKINE SUSUMU , KIKUCHI YASUHIRO , SAKURADA KAZUHIRO
IPC分类号： A61K38/00 , A61P13/12 , C07K14/47 , C12P21/08 , C12N5/12
CPC分类号： C07K14/47 , A61K38/00
摘要： By taking out a protein (kidney repairing factor: KRGF-1) which shows an increase in expression in repairing damaged tissues in patients with kidney diseases, a DNA encoding this protein and an antibody recognizing this protein are produced. These substances are usable in searching for remedies for repairing damaged kidney tissues and diagnosing kidney failures.

17. 发明公开

EP0818535A4 NOVEL YEAST GENES 失效
标题翻译： HEFE-GENE
公开(公告)号：EP0818535A4
公开(公告)日：2001-11-21
申请号：EP96942669
申请日：1996-12-27
申请人： KYOWA HAKKO KOGYO KK
发明人： KAWASAKI HIDEKI , TOKAI MASAYA , KIKUCHI YASUHIRO , OUCHI KOZO
IPC分类号： A21D8/04 , C07K14/395 , C12N15/31 , C12N15/81 , C12P7/06 , C12N1/18
CPC分类号： C07K14/395 , A21D8/047 , C12N15/81 , C12P7/06 , Y02E50/17
摘要： A protein consisting of the amino acid sequence represented by SEQ ID NO: 1; a protein consisting of an amino acid sequence wherein one or more amino acids in the amino acid sequence represented by SEQ ID NO: 1 have been added, deleted or substituted and complementing a mutation showing the cold-sensitivity of fermentability; a gene encoding the protein; a gene comprising a DNA consisting of the base sequence represented by SEQ ID NO: 1 or another DNA consisting of a base sequence wherein one or more DNAs in the base sequence represented by SEQ ID NO: 1 have been added, deleted or substituted and complementing a mutation showing the cold-sensitivity of fermentability; a yeast showing the cold-sensitivity of fermentability and belonging to the genus Saccharomyces wherein the above-mentioned gene on its chromosome has been inactivated; a dough containing this yeast; a process for producing bread comprising adding the yeast to a dough; and a process for producing ethanol comprising incubating the yeast in a medium, thus accumulating ethanol in the culture medium and then harvesting the ethanol from the culture medium.
摘要翻译：本发明涉及具有由SEQ ID NO：1表示的氨基酸序列的蛋白质，或能够补充表现出低温敏感性发酵能力的突变，并具有氨基酸序列的蛋白质，其中一个或多个氨基酸残基为在SEQ ID NO：1所示的氨基酸序列中添加，缺失或取代; 编码所述蛋白质的基因; 以及包含具有SEQ ID NO：1所示的核苷酸序列的DNA的基因，或包含能够补充表现出低温敏感性发酵性的突变的DNA，并具有其中添加一个或多个DNA，缺失或取代的核苷酸序列的DNA 本发明还涉及属于酵母属的酵母，具有低温敏感的发酵能力，其特征在于上述染色体上的基因是失活的; 含有酵母的面团; 制造面包的方法，其包括将所述酵母加入面团中; 以及生产乙醇的方法，其包括在培养基中培养所述酵母，使乙醇在培养物中积聚，并从培养物中回收乙醇。

18. 发明专利

CA2407656A1 MYOCARDIAL CELL PROLIFERATION-ASSOCIATED GENES 未知
公开(公告)号：CA2407656A1
公开(公告)日：2001-11-08
申请号：CA2407656
申请日：2001-04-27
申请人： KYOWA HAKKO KOGYO KK
发明人： SAKURADA KAZUHIRO , YAMADA YOJI , KIKUCHI YASUHIRO , SEKINE SUSUMU
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/475 , C07K16/18 , C12N1/15 , C12N1/19 , C12Q1/68 , C12Q1/6883 , C12N15/12 , C12N5/00 , C12N7/00 , A61P9/00 , C12P21/02 , C07H21/04 , A61K38/17 , C12N15/63 , C12N15/86
摘要： Genes showing different expression doses in fetal heart from adult heart are acquired. Thus proteins useful in searching for remedies for repairing tissu es injured by myocardial necrosis, DNAs encoding these proteins, antibodies recognizing these proteins and methods of using the same are provided.

19. 发明专利

AU4116601A Kidney repairing factor 未知
公开(公告)号：AU4116601A
公开(公告)日：2001-09-24
申请号：AU4116601
申请日：2001-03-16
申请人： KYOWA HAKKO KOGYO KK
发明人： TAKEUCHI KYOKO , KATO YOKO , SEKINE SUSUMU , KIKUCHI YASUHIRO , SAKURADA KAZUHIRO
IPC分类号： A61K38/00 , A61P13/12 , C07K14/47 , C12P21/08 , C12N5/12 , C12N15/63 , C12N5/10 , C07K16/18 , C12Q1/68 , G01N33/53 , A61K38/17 , A61K39/395 , A61K48/00 , C12P21/02
摘要： A protein Äkidney regeneration factor (KRGF-1)Ü whose expression is increased at the time of regeneration of damaged tissues in patients with renal diseases is isolated, and a DNA encoding the protein and an antibody recognizing the protein are produced. These materials can be utilized in screening of therapeutic agents for regenerating damaged renal tissues and in diagnosis of renal damage.

20. 发明专利

AU7025700A Polymorphisms in a klotho gene 未知
公开(公告)号：AU7025700A
公开(公告)日：2001-04-17
申请号：AU7025700
申请日：2000-09-08
申请人： KYOWA HAKKO KOGYO KK
发明人： HASEGAWA KAZUHIDE , KIKUCHI YASUHIRO , NAKANO HIROFUMI , MOLLOY HELEN , CHIANO MATHIAS
IPC分类号： C12N15/09 , A61K38/22 , A61K45/00 , A61P3/00 , A61P3/04 , A61P9/00 , A61P11/00 , A61P17/00 , A61P19/08 , A61P19/10 , A61P35/00 , A61P43/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/68

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