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11. 发明申请

WO2011092617A1 LYMPH NODE DETECTION SYSTEM 审中-公开
标题翻译： LYMPH节点检测系统
公开(公告)号：WO2011092617A1
公开(公告)日：2011-08-04
申请号：PCT/IB2011/050282
申请日：2011-01-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HENDRIKS, Bernardus Hendrikus Wilhelmus , LUCASSEN, Gerhardus, Wilhelmus , RUERS, Theodoor Jacques Marie , NACHABE, Rami , DESJARDINS, Adrien , VAN DER VOORT, Marjolein
发明人： HENDRIKS, Bernardus Hendrikus Wilhelmus , LUCASSEN, Gerhardus, Wilhelmus , RUERS, Theodoor Jacques Marie , NACHABE, Rami , DESJARDINS, Adrien , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00
CPC分类号： A61B5/415 , A61B1/043 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/418 , A61B5/6848
摘要： Finding the sentinel lymph node during tumor resection is important for proper cancer staging. Using a fluorescence imaging system significantly improves the procedure. However, for deeply localized nodes this camera system is not sensitive enough due to the limited penetration depth. We propose to combine the fluorescence imaging system with an elongated interventional device both capable of detecting the fluorescence. This imaging system is capable of imaging the global fluorescence distribution of a fluorescent agent distributed in a material while the elongated interventional device is capable of detecting the local distribution of the fluorescent agent.
摘要翻译：在肿瘤切除期间发现前哨淋巴结对于正确的癌症分期是重要的。使用荧光成像系统显着改善手术。然而，对于深度本地化的节点，由于穿透深度有限，该相机系统不够灵敏。我们建议将荧光成像系统与能够检测荧光的细长介入装置相结合。该成像系统能够对分布在材料中的荧光剂的全局荧光分布进行成像，而细长的介入装置能够检测荧光剂的局部分布。

12. 发明申请

WO2010119392A1 NEEDLE WITH INTEGRATED FIBERS IN THE CUTTING FACETS OF THE BEVEL 审中-公开
标题翻译：带有整体纤维的针在水平切割面上
公开(公告)号：WO2010119392A1
公开(公告)日：2010-10-21
申请号：PCT/IB2010/051570
申请日：2010-04-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HENDRIKS, Bernardus , BRAUN, Augustinus , HARBERS, Rik , VAN DER VOORT, Marjolein , DESJARDINS, Adrien , NACHABE, Rami
发明人： HENDRIKS, Bernardus , BRAUN, Augustinus , HARBERS, Rik , VAN DER VOORT, Marjolein , DESJARDINS, Adrien , NACHABE, Rami
IPC分类号： A61B5/00
CPC分类号： A61B5/0084 , A61B5/0075 , A61B5/6848
摘要： A needle comprises a tip part, a holder part, a shaft, and fibers capable of transmitting light, wherein the shaft comprises a distal end connected to the tip part, and a proximal end connected to the holder part, wherein the tip part comprises a bevel, cutting facets, and at least one channel for accomodating a fiber, and wherein an end section of the fiber is located in the channel and an end surface of the fiber is located at one of the cutting facets. By way of the facets an introduction of the needle into tissue may be facilitated. A further aspect of the invention is a method for producing such a needle.
摘要翻译：针包括尖端部分，保持器部分，轴和能够透射光的光纤，其中所述轴包括连接到所述尖端部分的远端以及连接到所述保持器部分的近端，其中所述尖端部分包括斜面，切割面和用于容纳纤维的至少一个通道，并且其中纤维的端部位于通道中，并且纤维的端面位于切割面之一处。通过这些方面，可以促进将针引入组织中。本发明的另一方面是制造这种针的方法。

13. 发明申请

WO2013001394A1 NEEDLE WITH AN OPTICAL FIBER INTEGRATED IN AN ELONGATED INSERT 审中-公开
标题翻译：带有光纤的针与整体插入在一起
公开(公告)号：WO2013001394A1
公开(公告)日：2013-01-03
申请号：PCT/IB2012/052978
申请日：2012-06-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , HENDRIKS, Bernardus, Hendrikus, Wilhelmus , BIERHOFF, Waltherus, Cornelis, Jozef , LUCASSEN, Gerhardus, Wilhelmus , HORIKX, Jeroen, Jan, Lambertus , VAN DEN BERG-DAMS, Susanne, Dorien , REICH, Christian , VOSS, Stephan , WINKEL, Axel , NACHABÉ, Rami , MÜLLER, Manfred , VAN DER VOORT, Marjolein
发明人： HENDRIKS, Bernardus, Hendrikus, Wilhelmus , BIERHOFF, Waltherus, Cornelis, Jozef , LUCASSEN, Gerhardus, Wilhelmus , HORIKX, Jeroen, Jan, Lambertus , VAN DEN BERG-DAMS, Susanne, Dorien , REICH, Christian , VOSS, Stephan , WINKEL, Axel , NACHABÉ, Rami , MÜLLER, Manfred , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00
CPC分类号： A61B1/00009 , A61B1/0646 , A61B1/0684 , A61B1/07 , A61B5/0071 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6848 , A61B10/0233 , F04C2270/0421 , Y10T29/49826
摘要： A needle is proposed including a cannula or hollow shaft with a multilumen insert inside. The insert comprises at least two lumen. Both the insert as well as the cannula have bevelled ends. In the insert substantially straight cleaved fibers are present that may be connected at the proximal end to a console. At least one of the distal fiber ends in the insert may protrude more than half the fiber diameter out of the insert. Furthermore, the bevel angle of the insert is different from the bevel angle of the cannula such that combination cannula and insert is such that the fiber ends do not protrude the bevel surface of the cannula.
摘要翻译：提出了一种针头，其中包括插入件或空心轴，其中具有多孔插入件。插入件包括至少两个内腔。插入件以及套管均具有倾斜端部。在插入件中，存在基本上直的切割的纤维，其可以在近端连接到控制台。插入件中的远端纤维端部中的至少一个可以突出超过插入件的纤维直径的一半以上。此外，插入件的斜角与插管的斜角不同，使得组合插管和插入件使得纤维端部不突出套管的斜面。

14. 发明申请

WO2010143119A3 ALGORITHM FOR PHOTONIC NEEDLE CONSOLE 审中-公开
公开(公告)号：WO2010143119A3
公开(公告)日：2010-12-16
申请号：PCT/IB2010/052514
申请日：2010-06-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NACHABE, Rami , HENDRIKS, Bernardus Hendrikus Wilhelmus , BRAUN, Augustinus Laurentius , VAN DER VOORT, Marjolein , DESJARDINS, Adrien , BABIC, Drazenko , MIHAJLOVIC, Nenad
发明人： NACHABE, Rami , HENDRIKS, Bernardus Hendrikus Wilhelmus , BRAUN, Augustinus Laurentius , VAN DER VOORT, Marjolein , DESJARDINS, Adrien , BABIC, Drazenko , MIHAJLOVIC, Nenad
IPC分类号： A61B5/00 , A61B8/08 , A61B5/145 , A61B17/34 , G06F19/00 , A61B17/00
摘要： Needles are widely used in interventional radiology. Each medical application requires a specific needle type. The same holds for the photonic needles which analysis depends on the type of application the clinician aims for. Therefore, it is relevant to have the X-ray machine recognize the type of needle that is being used and to load the required software for the tissue analysis. It is therefore proposed to have a data link established between the imaging modality used for the acquisition of the patient anatomy (X-ray, CT, MR or US) and the system that processes optical data from the needle, so that the information from this imaging modality can be used to guide the processing. In a preferred embodiment the selection is made by reading out the code present in the disposable needle when it is connected to the console.

15. 发明申请

WO2008062354A1 A SYSTEM, DEVICE, METHOD, COMPUTER-READABLE MEDIUM, AND USE FOR IN VIVO IMAGING OF TISSUE IN AN ANATOMICAL STRUCTURE 审中-公开
标题翻译：系统，装置，方法，计算机可读介质和用于在解剖结构中进行组织成像的用途
公开(公告)号：WO2008062354A1
公开(公告)日：2008-05-29
申请号：PCT/IB2007/054674
申请日：2007-11-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , VAN DEN HAM, Rene , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
发明人： BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , VAN DEN HAM, Rene , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00 , A61B8/12
CPC分类号： A61B5/0095 , A61B5/0035 , A61B5/0084 , A61B5/0086 , A61B8/12 , A61B8/4416
摘要： A system is provided that may be used for locating and diagnosing lesions in the human body in vivo. In some embodiments, once the exact position of a lesion is found, a biopsy may be taken from the lesion using e.g. ultra sound techniques for guidance of the biopsy needle. Use of the system drastically reduces the negative biopsy samples compared to currently used "blind sampling" techniques. This reduces patient discomfort and minimizes infections as the number of biopsy samples is reduced. A method and computer- readable medium is also provided.
摘要翻译：提供了可用于在体内定位和诊断人体损伤的系统。在一些实施例中，一旦发现病变的确切位置，可以使用例如病变从病变中取出活组织检查。超声技术用于指导活检针。与目前使用的“盲采”技术相比，使用该系统大大减少了活检样本的阴性。这减少了患者的不适，并使活检样本的数量减少了感染的最小程度。还提供了一种方法和计算机可读介质。

16. 发明申请

WO2004058058A1 ANALYSIS APPARATUS AND METHOD 审中-公开
标题翻译：分析装置和方法
公开(公告)号：WO2004058058A1
公开(公告)日：2004-07-15
申请号：PCT/IB2003/005732
申请日：2003-12-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LUCASSEN, Gerhardus, W. , PUPPELS, Gerwin, J. , VAN DER VOORT, Marjolein
发明人： LUCASSEN, Gerhardus, W. , PUPPELS, Gerwin, J. , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00
CPC分类号： G01J3/44 , A61B5/0059 , A61B5/0068 , G01N21/65 , G01N2021/656
摘要： The present invention relates to an analysis apparatus, in particular a spectroscopic analysis apparatus, for analysing an object, such as the blood of a patient, and a corresponding analysis method. An excitation system (exs) emits an excitation beam (exb) to excite a target region and a beam separation unit (hm) separates at least part of elastically scattered radiation from inelastically scattered radiation, said scattered radiation being generated by the excitation beam (exb) at the target region. A monitoring system (lso) generates an image of the target region using the elastically scattered or the inelastically scattered radiation and defines a region of interest in said image. To increase efficiency of the recording of Raman spectra, a control unit (ctrl) is provided for controlling the excitation system (exs) such that the defined region of interest of the target region is excited and/or for controlling the detection system (dsy) such that only signals from the defined region of interest are detected, and a detection system (dsy) is provided for detecting scattered radiation from the defined region of interest generated by the excitation beam. Preferably the signal from the defined region of interest is averaged by distributing the laser excitation power over the defined region of interest area.
摘要翻译：本发明涉及一种用于分析诸如患者血液的物体的分析装置，特别是光谱分析装置和相应的分析方法。励磁系统（exs）发射激发光束（exb）以激发目标区域，并且光束分离单元（hm）将至少部分弹性散射辐射与非弹性散射辐射分离，所述散射辐射由激发光束（exb ）在目标区域。监测系统（lso）使用弹性散射或非弹性散射的辐射产生目标区域的图像，并且定义所述图像中的感兴趣区域。为了提高拉曼光谱记录的效率，提供控制单元（ctrl）以控制激励系统（exs），使得目标区域的限定的目标区域被激发和/或用于控制检测系统（dsy）使得仅检测到来自限定的感兴趣区域的信号，并且提供检测系统（dsy），用于检测来自由激发光束产生的所定义的感兴趣区域的散射辐射。优选地，通过在所定义的感兴趣区域区域上分布激光激发功率来平均来自限定的感兴趣区域的信号。

17. 发明申请

WO2013001423A1 AN APPARATUS FOR OPTICAL ANALYSIS OF AN ASSOCIATED TISSUE SAMPLE 审中-公开
标题翻译：用于相关组织样品的光学分析的装置
公开(公告)号：WO2013001423A1
公开(公告)日：2013-01-03
申请号：PCT/IB2012/053133
申请日：2012-06-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , MUELLER, Manfred , HENDRIKS, Bernardus Hendrikus Wilhelmus , BIERHOFF, Waltherus Cornelis Jozef , LUCASSEN, Gerhardus Wilhelmus , HORIKX, Jeroen Jan Lambertus , NACHABE, Rami , VAN DER VOORT, Marjolein
发明人： MUELLER, Manfred , HENDRIKS, Bernardus Hendrikus Wilhelmus , BIERHOFF, Waltherus Cornelis Jozef , LUCASSEN, Gerhardus Wilhelmus , HORIKX, Jeroen Jan Lambertus , NACHABE, Rami , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00
CPC分类号： A61B5/0071 , A61B5/0075 , A61B5/0084
摘要： In order to improve fluorescence measurements, there is provided an apparatus and, a method and a computer program for optical analysis of an associated tissue sample, the apparatus comprising a spectrometer comprising an optical detector, a light source, a first light emitter 219 arranged for emitting photons into the associated tissue sample, a first light collector 221 arranged for receiving photons from the associated tissue sample, a second light emitter 223, a second light collector 225, wherein a reflectance spectrum is obtained via the first light emitter 219 and collector 221 and a fluorescence spectrum is obtained via the second light emitter 223 and collector 225, and where a first distance d1 between the first light emitter and collector is larger than a second distance d2 between the second light emitter and collector. By combining the data thus obtained, an intrinsic fluorescence spectrum may be obtained.
摘要翻译：为了改进荧光测量，提供了一种用于相关组织样本的光学分析的装置和方法以及计算机程序，该装置包括光谱仪，该光谱仪包括光学检测器，光源，第一光发射器219，将光子发射到相关联的组织样本中，布置成从相关联的组织样本接收光子的第一光收集器221，第二光发射器223，第二光收集器225，其中通过第一光发射器219和集电极221获得反射光谱并且通过第二光发射器223和集电极225获得荧光光谱，并且其中第一光发射器和集电极之间的第一距离d1大于第二发光体和集电极之间的第二距离d2。通过组合由此获得的数据，可以获得固有的荧光光谱。

18. 发明申请

WO2012127378A1 AN APPARATUS FOR OPTICAL ANALYSIS OF AN ASSOCIATED TISSUE SAMPLE 审中-公开
标题翻译：用于相关组织样品的光学分析的装置
公开(公告)号：WO2012127378A1
公开(公告)日：2012-09-27
申请号：PCT/IB2012/051247
申请日：2012-03-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NACHABE, Rami , HENDRIKS, Bernardus, Hendrikus, Wilhelmus , LUCASSEN, Gerhardus, Wilhelmus , VAN DER VOORT, Marjolein , HORIKX, Jeroen, Jan, Lambertus , MÜLLER, Manfred , BIERHOFF, Waltherus, Cornelis, Jozef , DESJARDINS, Adrien, Emmanuel , RUERS, Theodoor, Jacques, Marie
发明人： NACHABE, Rami , HENDRIKS, Bernardus, Hendrikus, Wilhelmus , LUCASSEN, Gerhardus, Wilhelmus , VAN DER VOORT, Marjolein , HORIKX, Jeroen, Jan, Lambertus , MÜLLER, Manfred , BIERHOFF, Waltherus, Cornelis, Jozef , DESJARDINS, Adrien, Emmanuel , RUERS, Theodoor, Jacques, Marie
IPC分类号： G01N21/47 , G01N21/64 , A61B5/00
CPC分类号： A61B5/0075 , A61B5/0071 , A61B5/0091 , G01N21/474 , G01N21/6486 , G01N2021/6484 , G01N2021/6491 , G01N2201/0846 , G01N2201/129
摘要： The present invention relates to an apparatus (100) and, a method and a computer program for optical analysis of an associated tissue sample (116), the apparatus being adapted to determine a concentration of collagen and/or elastin with two independent methods. With two independent methods, the concentrations determined with each method may be held up against the other, and if the difference is too large a user may be informed that at least one of the measured values is not reliable. In a particular embodiment, the two independent methods are Diffuse Reflectance Spectroscopy (DRS) and fluorescence spectroscopy, and the absorption and scattering determined with DRS may be used when interpreting the fluorescence spectroscopy spectra so as to be able to obtain quantitative information regarding concentration of collagen and elastin from both methods. According to a specific embodiment, the apparatus further comprises an interventional device (112).
摘要翻译：本发明涉及一种用于相关组织样本（116）的光学分析的装置（100）以及用于光学分析的方法和计算机程序，所述装置适于用两种独立方法确定胶原和/或弹性蛋白的浓度。使用两种独立的方法，用每种方法确定的浓度可以相对于另一种方法来保持，并且如果差异太大，则可以向用户通知至少一个测量值不可靠。在一个具体实施方案中，两种独立的方法是漫反射光谱（DRS）和荧光光谱法，并且在解释荧光光谱谱时可以使用DRS测定的吸收和散射，以便能够获得有关胶原浓度的定量信息和弹性蛋白。根据具体实施例，该装置还包括介入装置（112）。

19. 发明申请

WO2010058344A1 NEEDLE WITH OPTICAL FIBERS 审中-公开
标题翻译：带有光纤的针
公开(公告)号：WO2010058344A1
公开(公告)日：2010-05-27
申请号：PCT/IB2009/055128
申请日：2009-11-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HENDRIKS, Bernardus, H., W. , BRAUN, Augustinus, L. , HARBERS, Rik , VAN DER VOORT, Marjolein , DESJARDINS, Adrien, E. , NACHABE, Rami
发明人： HENDRIKS, Bernardus, H., W. , BRAUN, Augustinus, L. , HARBERS, Rik , VAN DER VOORT, Marjolein , DESJARDINS, Adrien, E. , NACHABE, Rami
IPC分类号： A61B5/00 , A61B10/00
CPC分类号： A61B5/0084 , A61B5/0075 , A61B5/1459 , A61B5/6848 , A61B10/0233 , A61B10/0283 , A61B17/3401 , A61B18/1477 , A61B2017/00057 , A61B2018/1425
摘要： Needle interventions are widely used in the field of oncology for taking biopsies of tissue in order to inspect whether tissue is cancerous or not. To make these interventions more reliable feedback of what kind of tissue is in front of the needle is required. A way to achieve this is by making use of optical spectroscopy. This requires integration of fibers into the needle. These fibers are used to deliver light to illuminate the tissue in front of the needle and to collect back the reflected light from the tissue. The present invention proposes to integrate the fiber distal ends in the slanted bevel of the needle in such a way that at least one source-detector fiber pair has a distance that is larger than the outer diameter of the needle.
摘要翻译：针刺干预广泛用于肿瘤学领域，用于检查组织的活组织检查，以检查组织是否是癌性的。要使这些干预措施更加可靠，就需要针头前面的什么样的组织的反馈信息。实现这一目标的一个方法是利用光谱学。这需要将纤维整合到针中。这些纤维用于传递光以照射针前面的组织并收集来自组织的反射光。本发明提出将光纤远端整合到针的倾斜斜面中，使得至少一个源 - 检测器光纤对的距离大于针的外径。

20. 发明申请

WO2010058302A1 NEEDLE WITH INTEGRATED FIBERS 审中-公开
标题翻译：带有集成纤维的针头
公开(公告)号：WO2010058302A1
公开(公告)日：2010-05-27
申请号：PCT/IB2009/052539
申请日：2009-06-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BRAUN, Augustinus, L. , HENDRIKS, Bernardus, H., W. , HARBERS, Rik , VAN DER VOORT, Marjolein , DESJARDINS, Adrien, E. , NACHABE, Rami , WASSINK, Bernardus, W., J. , VAN GAAL, Franciscus, M., A., M. , MIHAJLOVIC, Nenad , BABIC, Drazenko
发明人： BRAUN, Augustinus, L. , HENDRIKS, Bernardus, H., W. , HARBERS, Rik , VAN DER VOORT, Marjolein , DESJARDINS, Adrien, E. , NACHABE, Rami , WASSINK, Bernardus, W., J. , VAN GAAL, Franciscus, M., A., M. , MIHAJLOVIC, Nenad , BABIC, Drazenko
IPC分类号： A61B5/00
CPC分类号： A61B5/6848 , A61B5/0075 , A61B5/0084
摘要： Needles equipped with fibres allow tissue inspection based on optical spectroscopy to diagnose whether tissue is cancerous or not. This requires integration of optical fibers into needles. The problem is how to manufacture the needle having at least one fiber exit at the distal end of the needle, where the fiber does not obstruct the hollow part of the needle if present as well as does not extend beyond the outer cylinder geometry. To solve this problem we propose to manufacture the needle consisting of four parts: an inner cylinder tube, an outer hollow cylinder tube, a needle tip part with integrated fiber exit and a holder part, wherein the hollow spacing between the inner and the outer cylinder is larger or equal to the outer diameter of the fibers, the inner and the outer cylinder are mounted in the holder part and where the tip part is mounted on the two cylinders.
摘要翻译：配备纤维的针头允许基于光谱的组织检查来诊断组织是否是癌变的。这需要将光纤集成到针中。问题是如何制造在针的远端具有至少一个纤维出口的针，其中纤维不会阻塞针的中空部分，如果存在，并且不延伸超出外筒几何形状。为了解决这个问题，我们建议制造由四个部分组成的针：内筒管，外中空筒管，具有集成纤维出口的针尖部分和保持器部分，其中内筒和外筒之间的中空间隔大于或等于纤维的外径，内筒和外筒安装在保持器部分中，并且尖端部分安装在两个气缸上。

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