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11. 发明申请

US20080275039A1 Geldanamycin Derivatives and the Method for Biosynthesis Thereof 审中-公开
标题翻译：格尔德霉素衍生物及其生物合成方法
公开(公告)号：US20080275039A1
公开(公告)日：2008-11-06
申请号：US11573503
申请日：2005-08-11
申请人： Jung Joon Lee , Young Soo Hong , Dongho Lee , Jeong-Hyung Lee , Kwang-Soo Sung
发明人： Jung Joon Lee , Young Soo Hong , Dongho Lee , Jeong-Hyung Lee , Kwang-Soo Sung
IPC分类号： A61K31/5377 , C07D225/06 , C07H21/04 , C12N1/20 , C12P17/10 , C12N15/64 , A61P31/04 , A61P37/06 , A61P35/00 , A61P31/12 , A61P31/10
CPC分类号： C07D225/06
摘要： The present invention relates to geldanamycin derivatives, benzoquinone ansamycin biosynthesized by gene manipulation of Streptomyces hygroscopicus subsp. duamyceticus and the method producing them, more particularly to a geldanamycin O-carbamoyl transferase gene(gel8)-inactive mutant, the method producing it and geldanamycin derivatives, 4,5-dihydro-7-O-descarbamoyl-7-hydroxy geldanamycin and 4,5-dihydro-7-O-descarbamoyl-7-hydroxy-17-O-demethyl geldanamycin. Since geldanamycin derivatives of the present invention suppress Hsp90 like geldanamycin, they can effectively be used for antibiotic, antifungal, antiviral, anti-inflammatory and antitumor agents and an immune suppressant.
摘要翻译：本发明涉及通过吸湿链霉菌subsp。的基因操作生物合成的格尔德霉素衍生物，苯醌安莎霉素。杜马霉素及其制备方法，更具体地涉及格尔德霉素O-氨基甲酰基转移酶基因（gel8） - 活性突变体，其制备方法和格尔德霉素衍生物，4,5-二氢-7-O-氨基甲酰基-7-羟基格尔德霉素和4 ，5-二氢-7-O-氨基甲酰基-7-羟基-17-O-脱甲基格尔德霉素。由于本发明的格尔德霉素衍生物抑制类似格尔德霉素的Hsp90，因此它们可以有效地用于抗生素，抗真菌剂，抗病毒剂，抗炎剂和抗肿瘤剂和免疫抑制剂。

12. 发明授权

US07902190B2 Indol derivatives, the method for preparing thereof and composition for the prevention and treatment of metabolic disorder containing the same as an active ingredient 有权
标题翻译：吲哚衍生物，其制备方法和用于预防和治疗含有其作为活性成分的代谢紊乱的组合物
公开(公告)号：US07902190B2
公开(公告)日：2011-03-08
申请号：US12442930
申请日：2007-09-27
申请人： Kyeong Lee , Hyun Sun Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Rho , Jeong Hyung Lee , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
发明人： Kyeong Lee , Hyun Sun Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Rho , Jeong Hyung Lee , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
IPC分类号： A61K31/535
CPC分类号： C07D209/18 , C07D405/12 , C07D409/14
摘要： Disclosed are indole derivatives, a preparation method thereof, and a composition for the prevention and treatment of metabolic diseases, containing the same as an active ingredient. The indole derivatives have inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, the composition is thus useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.
摘要翻译：公开了吲哚衍生物，其制备方法和用于预防和治疗代谢疾病的组合物，其含有活性成分。吲哚衍生物对DGAT（二酰基甘油酰基转移酶）具有抑制作用，其在脂质代谢过程中引起诸如肥胖症和糖尿病等代谢疾病。具有有效控制脂质代谢和能量代谢的能力，因此该组合物可用于预防和治疗诸如肥胖症和糖尿病等代谢疾病。

13. 发明申请

US20100075962A1 INDOL DERIVATIVES, THE METHOD FOR PREPARING THEREOF AND COMPOSITION FOR THE PREVENTION AND TREATMENT OF METABOLIC DISORDER CONTAINING THE SAME AS AN ACTIVE INGREDIENT 有权
标题翻译：吲哚衍生物，其制备方法和组合物，用于预防和治疗含有其作为活性成分的代谢异常
公开(公告)号：US20100075962A1
公开(公告)日：2010-03-25
申请号：US12442930
申请日：2007-09-27
申请人： Kyeong Lee , Hyun Sun Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Roh , Jeong Hyung Lee , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
发明人： Kyeong Lee , Hyun Sun Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Roh , Jeong Hyung Lee , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
IPC分类号： A61K31/5377 , C07D209/04 , C07D401/02 , C07D413/02 , A61K31/405 , A61K31/454 , A61P3/04 , A61P3/10
CPC分类号： C07D209/18 , C07D405/12 , C07D409/14
摘要： Disclosed are indole derivatives a preparation method thereof, and a composition for the prevention and treatment of metabolic diseases, containing the same as an active ingredient. The indole derivatives have inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, the composition is thus useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.
摘要翻译：公开了吲哚衍生物及其制备方法，以及用于预防和治疗代谢疾病的组合物，其含有活性成分。吲哚衍生物对DGAT（二酰基甘油酰基转移酶）具有抑制作用，其在脂质代谢过程中引起诸如肥胖症和糖尿病等代谢疾病。具有有效控制脂质代谢和能量代谢的能力，因此该组合物可用于预防和治疗诸如肥胖症和糖尿病的代谢疾病。

14. 发明申请

US20120218703A1 Circuit Board Assemblies and Data Processing Systems Including the Same 审中-公开
标题翻译：电路板组件和包括其的数据处理系统
公开(公告)号：US20120218703A1
公开(公告)日：2012-08-30
申请号：US13240439
申请日：2011-09-22
申请人： Jeong Hyeon Cho , Myung Hee Sung , Kyoung Sun Kim , Seung Jin Seo , Jung Joon Lee
发明人： Jeong Hyeon Cho , Myung Hee Sung , Kyoung Sun Kim , Seung Jin Seo , Jung Joon Lee
IPC分类号： G06F1/16 , H05K1/00 , H05K1/14
CPC分类号： H05K1/141 , G06F1/183 , H05K1/147 , H05K2201/10189
摘要： A circuit board assembly includes a first circuit board having an electrical connection circuit on a surface thereof. A second circuit board is on the surface of the first circuit board. A first memory socket is mounted on the second circuit board. The first memory socket is only electrically connected to the electrical connection circuit through the second circuit board. A second memory socket is mounted on the second circuit board. The second memory socket that is only electrically connected to the electrical connection circuit through the second circuit board.
摘要翻译：电路板组件包括在其表面上具有电连接电路的第一电路板。第二电路板位于第一电路板的表面上。第一个存储器插座安装在第二个电路板上。第一存储器插座仅通过第二电路板电连接到电连接电路。第二个存储器插座安装在第二个电路板上。第二存储器插座仅通过第二电路板电连接到电连接电路。

15. 发明申请

US20130088838A1 DIE PACKAGE, METHOD OF MANUFACTURING THE SAME, AND SYSTEMS INCLUDING THE SAME 审中-公开
标题翻译： DIE包，其制造方法和包括其的系统
公开(公告)号：US20130088838A1
公开(公告)日：2013-04-11
申请号：US13567388
申请日：2012-08-06
申请人： JAE JUN LEE , Jeong Hyeon Cho , Baek Kyu Choi , Sun Won Kang , Jung Joon Lee
发明人： JAE JUN LEE , Jeong Hyeon Cho , Baek Kyu Choi , Sun Won Kang , Jung Joon Lee
IPC分类号： H05K7/00 , H01L21/50 , H01L23/50
CPC分类号： H01L23/647 , H01L23/3128 , H01L24/29 , H01L24/32 , H01L24/45 , H01L24/48 , H01L24/73 , H01L25/0657 , H01L25/16 , H01L25/18 , H01L2224/2919 , H01L2224/32145 , H01L2224/32225 , H01L2224/45124 , H01L2224/45144 , H01L2224/45147 , H01L2224/48091 , H01L2224/48195 , H01L2224/48227 , H01L2224/73265 , H01L2225/0651 , H01L2225/06575 , H01L2924/00014 , H01L2924/01013 , H01L2924/01014 , H01L2924/01029 , H01L2924/1301 , H01L2924/1434 , H01L2924/1436 , H01L2924/1437 , H01L2924/1441 , H01L2924/1443 , H01L2924/14511 , H01L2924/15311 , H01L2924/157 , H01L2924/15787 , H01L2924/15788 , H01L2924/181 , H01L2924/19015 , H01L2924/1902 , H01L2924/19043 , H01L2924/19105 , H01L2924/3011 , H01L2924/00012 , H01L2924/00 , H01L2224/85399 , H01L2224/05599
摘要： A die package includes a substrate, a die mounted on the substrate, and a ZQ resistor disposed in the die package and connected to the substrate and the die. The ZQ resistor may be used to calibrate impedance of the die.
摘要翻译：模具封装包括基板，安装在基板上的管芯和设置在管芯封装中并连接到基板和管芯的ZQ电阻器。 ZQ电阻可用于校准模具的阻抗。

16. 发明授权

US06347039B1 Memory module and memory module socket 有权
标题翻译：内存模块和内存模块插座
公开(公告)号：US06347039B1
公开(公告)日：2002-02-12
申请号：US09364677
申请日：1999-07-30
申请人： Jung Joon Lee
发明人： Jung Joon Lee
IPC分类号： H05K118
CPC分类号： H05K7/1431 , H01R12/721 , H05K1/0295 , H05K1/117 , H05K2201/09954 , H05K2201/10159
摘要： A memory module includes a plurality of semiconductor memory devices mounted on a printed wiring board (PWB); longitudinal contact terminals that are for connection to a computer mother board and are arranged along at least one longitudinal edge of the PWB; and transverse contact terminals that are for connection to the computer mother board and are arranged along at least one transverse edge of the PWB. A socket for the module includes at least one longitudinal part into which the longitudinal contact terminals are inserted and at least one transverse part into which the transverse contact terminals are inserted. Each transverse socket part can be mounted on a pivot attached to the longitudinal part and rotated to engage a PWB inserted in the longitudinal part. Alternatively, each transverse part can be a flexible circuit carrier.
摘要翻译：存储模块包括安装在印刷电路板（PWB）上的多个半导体存储器件; 用于连接到计算机母板并且沿着所述PWB的至少一个纵向边缘布置的纵向接触端子; 以及用于连接到计算机母板并且沿着PWB的至少一个横向边缘布置的横向接触端子。用于模块的插座包括插入纵向接触端子的至少一个纵向部分和横向接触端子插入其中的至少一个横向部分。每个横向插座部分可以安装在附接到纵向部分的枢轴上并且旋转以接合插入在纵向部分中的PWB。或者，每个横向部分可以是柔性电路载体。

17. 发明授权

US08940936B2 Aryloxy phenoxy acrylic compound having HIF-1 inhibition activity, method for preparing same, and pharmaceutical composition containing same as an active ingredient 有权
标题翻译：具有HIF-1抑制活性的芳氧基苯氧基丙烯酸化合物及其制备方法，以及含有它们作为活性成分的药物组合物
公开(公告)号：US08940936B2
公开(公告)日：2015-01-27
申请号：US13880642
申请日：2011-10-17
申请人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
发明人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
IPC分类号： C07C233/07 , A61K31/167 , C07C235/28 , C07C311/16 , C07D295/088
CPC分类号： A61K31/5375 , A61K9/0019 , A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/167 , A61K31/196 , A61K31/24 , A61K31/34 , A61K31/40 , A61K31/417 , A61K31/4409 , C07C233/07 , C07C235/28 , C07C311/16 , C07C311/46 , C07C317/40 , C07C2603/74 , C07D295/088
摘要： The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis. Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.
摘要翻译：本发明涉及抑制HF-1活性的化合物，其制备方法以及含有该化合物作为活性成分的药物组合物。本发明的化合物通过非选择性细胞毒性表现出抗癌活性，但通过抑制HIF-1的活性，该转录因子在癌细胞生长和转移中起重要作用。因此，根据本发明的化合物或其药学上可接受的盐抑制HIF-1活性，因此可以用作结肠癌，肝癌，胃癌和乳腺癌等实体瘤的治疗剂。此外，根据本发明的化合物或其药学上可接受的盐可以用作用于糖尿病性视网膜病变或关节炎的治疗剂的活性成分，当HIF-1的缺氧诱导的VEGF表达增加时，可能变差。

18. 发明申请

US20130237542A1 ARYLOXY PHENOXY ACRYLIC COMPOUND HAVING HIF-1 INHIBITION ACTIVITY, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ACTIVE INGREDIENT 有权
标题翻译：具有HIF-1抑制活性的芳族羟基丙烯酸酯化合物，其制备方法和含有活性成分的药物组合物
公开(公告)号：US20130237542A1
公开(公告)日：2013-09-12
申请号：US13880642
申请日：2011-10-17
申请人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
发明人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
IPC分类号： C07C235/28 , C07D295/088 , C07C311/16
CPC分类号： A61K31/5375 , A61K9/0019 , A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/167 , A61K31/196 , A61K31/24 , A61K31/34 , A61K31/40 , A61K31/417 , A61K31/4409 , C07C233/07 , C07C235/28 , C07C311/16 , C07C311/46 , C07C317/40 , C07C2603/74 , C07D295/088
摘要： The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis. Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.
摘要翻译：本发明涉及抑制HF-1活性的化合物，其制备方法以及含有该化合物作为活性成分的药物组合物。本发明的化合物通过非选择性细胞毒性表现出抗癌活性，但通过抑制HIF-1的活性，该转录因子在癌细胞生长和转移中起重要作用。因此，根据本发明的化合物或其药学上可接受的盐抑制HIF-1活性，因此可以用作结肠癌，肝癌，胃癌和乳腺癌等实体瘤的治疗剂。此外，根据本发明的化合物或其药学上可接受的盐可以用作用于糖尿病性视网膜病变或关节炎的治疗剂的活性成分，当HIF-1的缺氧诱导的VEGF表达增加时，可能变差。

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