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11. 发明授权

US06673102B1 Covered endoprosthesis and delivery system 有权
标题翻译：涵盖内假体和输送系统
公开(公告)号：US06673102B1
公开(公告)日：2004-01-06
申请号：US09489604
申请日：2000-01-20
申请人： Michael J. Vonesh , Joseph R. Armstrong , Edward H. Cully , Margaret L. Gallegos
发明人： Michael J. Vonesh , Joseph R. Armstrong , Edward H. Cully , Margaret L. Gallegos
IPC分类号： A61F206
CPC分类号： A61F2/90 , A61F2/07 , A61F2/89 , A61F2002/072 , A61F2002/075 , A61F2230/0013 , A61F2230/0054
摘要： The present invention is an improved endovascular device particularly useful for use in transjugular intrahepatic portosystemic shunt (TIPS) procedures. The device employs a two-part stent-graft construction that provides a low permeability membrane to line the shunt and an uncovered stent portion designed to reside in the portal vein. The device provides numerous benefits over previous stents and stent-grafts used in TIPS procedures, including being more compact to deliver, being easier to accurately deploy, a controlled compacted surface with tucked apices, an improved stent winding pattern, and being more flexible in delivery and use.
摘要翻译：本发明是改进的血管内装置，特别适用于经颈静脉肝内门体分流术（TIPS）手术。该装置采用两部分的支架移植结构，其提供低渗透性膜以分流并且设计为驻留在门静脉中的未覆盖的支架部分。该设备与TIPS程序中使用的以前的支架和支架移植物相比具有许多优点，包括更紧凑的输送，更容易准确的部署，具有褶皱顶点的受控压实表面，改进的支架绕组模式，并且在运送中更灵活并使用。

12. 发明授权

US08177832B2 Endoluminal expansion system 有权
标题翻译：腔内扩张系统
公开(公告)号：US08177832B2
公开(公告)日：2012-05-15
申请号：US12876779
申请日：2010-09-07
申请人： Joseph R. Armstrong , Edward H. Cully , Craig T. Nordhausen , Mark J. Ulm , Michael J. Vonesh
发明人： Joseph R. Armstrong , Edward H. Cully , Craig T. Nordhausen , Mark J. Ulm , Michael J. Vonesh
IPC分类号： A61F2/82
CPC分类号： A61F2/958 , A61F2/95 , A61F2/97 , A61F2002/9511
摘要： An endoprosthesis expansion system having, in combination, a delivery component such as a length of catheter tubing having at its distal end an intermediate sheath component, and an inner tube within the full length of the delivery catheter and intermediate sheath component. The inner tube has a protrusion affixed to its distal end, and an expandable endoprosthesis is fitted in a compacted state about the intermediate sheath, immediately proximal to the protrusion. If the endoprosthesis is a self-expanding endoprosthesis (as is preferred), an exterior constraining sheath is required around the outer surface of the endoprosthesis. Following insertion of the endoprosthesis and delivery system into a body conduit (such as a blood vessel) and transport of the endoprosthesis to the desired site within the body conduit, the endoprosthesis is deployed by axially moving the protrusion against the system, thereby applying a radially directed outward force and causing simultaneous dilatation of the intermediate sheath and disruption of the exterior constraining sheath. Disruption of the exterior constraining sheath, in the case of a self-expanding prosthesis, releases the stored energy in the formerly constrained prosthesis, allowing it to expand and accomplish full deployment against the luminal surface of the body conduit at the desired site.
摘要翻译：一种内置假体扩张系统，其组合具有输送部件，例如一段长度的导管，其远端具有中间护套部件，并且在输送导管和中间护套部件的整个长度内具有内管。内管具有固定在其远端的突起，并且可伸缩的内假体围绕中间护套紧密地装配在紧固突起的近侧。如果内置假体是自扩张的内置假体（如优选的），则需要在内假体的外表面周围的外约束护套。在将内假体和输送系统插入身体导管（例如血管）中并将内假体运送到体导管内的期望部位之后，通过将凸起轴向移动抵靠系统来展开内假体，从而施加径向引导向外的力并引起中间鞘的同时扩张和外部约束鞘的破坏。在自扩张假体的情况下，外部约束护套的破坏释放在先前约束的假体中的储存能量，允许其膨胀并且在所需位置处对体导管的腔表面完全完全展开。

13. 发明授权

US06981982B2 Method of producing low profile stent and graft combination 有权
公开(公告)号：US06981982B2
公开(公告)日：2006-01-03
申请号：US10083451
申请日：2002-02-25
申请人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
发明人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
IPC分类号： A61M29/00
CPC分类号： A61F2/07 , A61F2/844 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2/91 , A61F2/954 , A61F2/97 , A61F2002/067 , A61F2002/072 , A61F2002/075 , A61F2002/825 , A61F2002/9505 , A61F2002/9511 , A61F2002/9522 , A61F2220/0075 , A61F2230/0054 , Y10T29/53987
摘要： Large diameter self-expanding endoprosthetic devices, such as stents and stent grafts for delivery to large diameter vessels, such as the aorta, are disclosed having very small compacted delivery dimensions. Devices with deployed dimensions of 26 to 40 mm or more are disclosed that are compacted to extremely small dimensions of 5 mm or less, enabling percutaneous delivery of said devices without the need for surgical intervention. Compaction efficiencies are achieved by combining unique material combinations with new forms of restraining devices, compaction techniques, and delivery techniques. These inventive devices permit consistent percutaneous delivery of large vessel treatment devices. Additionally, small endoprosthetic devices are disclosed that can be compacted to extremely small dimensions for delivery through catheter tubes of less than 1 mm diameter.

14. 发明授权

US09119937B2 Puncturable catheter 有权
标题翻译：可导管
公开(公告)号：US09119937B2
公开(公告)日：2015-09-01
申请号：US13186198
申请日：2011-07-19
申请人： Joseph R. Armstrong , Edward H. Cully , Keith M. Flury , Michael J. Vonesh
发明人： Joseph R. Armstrong , Edward H. Cully , Keith M. Flury , Michael J. Vonesh
IPC分类号： A61M25/00 , A61M25/10 , A61F2/958 , A61M25/01
CPC分类号： A61M25/0043 , A61F2/958 , A61M25/005 , A61M25/0052 , A61M25/10 , A61M2025/0183 , A61M2025/0188 , A61M2025/1056 , A61M2025/1081
摘要： A catheter provided with a guidewire catheter lumen having a thin covering that is easily punctured by a guidewire at virtually any desired point along the catheter length. The thin covering may be integral with the catheter shaft, or may be a separate component that covers only the portion of the catheter shaft immediately adjacent the outer portion of the guidewire lumen, or may be a thin tubular construct that surrounds the entire catheter shaft. The covering is preferably relatively translucent, allowing for good visualization of the location of the end of the guidewire to enable puncturing of the covering at the desired location along the length of the catheter shaft. The covering is also preferably tear resistant at puncture sites. The catheter shaft is preferably made of a material having a color that provides good visibility against an operating field, and more preferably is phosphorescent either entirely or in part. Materials suitable for the catheter shaft are polymeric materials well known in the art; the catheter shaft may optionally be provided with metallic stiffening components such as wires or hypotubes along all or part of the catheter length.
摘要翻译：导管，其具有导线导管管腔，该导管管腔具有薄的覆盖层，其在导管长度的几乎任何所需点处被导丝容易地刺穿。薄的覆盖物可以与导管轴成一体，或者可以是仅覆盖导管轴的紧邻导丝管腔的外部的部分的单独的部件，或者可以是围绕整个导管轴的薄的管状结构。覆盖物优选地是相对半透明的，允许良好地可视化导丝端部的位置，以使得能够沿着导管轴的长度在期望的位置刺穿覆盖物。覆盖物也优选在穿刺部位具有抗撕裂性。导管轴优选由具有对操作场提供良好可见性的颜色的材料制成，更优选地，全部或部分地是磷光。适用于导管轴的材料是本领域公知的聚合材料; 导管轴可以可选地沿着导管长度的全部或部分设置有金属加强部件，例如电线或海波管。

15. 发明授权

US09056001B2 Method of producing low profile stent and graft combination 有权
公开(公告)号：US09056001B2
公开(公告)日：2015-06-16
申请号：US12567562
申请日：2009-09-25
申请人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
发明人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
IPC分类号： B30B11/22 , A61F2/07 , A61F2/844 , A61F2/86 , A61F2/954 , A61F2/97 , A61F2/90 , A61F2/91 , A61F2/06 , A61F2/82 , A61F2/95 , A61F2/89
CPC分类号： A61F2/07 , A61F2/844 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2/91 , A61F2/954 , A61F2/97 , A61F2002/067 , A61F2002/072 , A61F2002/075 , A61F2002/825 , A61F2002/9505 , A61F2002/9511 , A61F2002/9522 , A61F2220/0075 , A61F2230/0054 , Y10T29/53987
摘要： Large diameter self-expanding endoprosthetic devices, such as stents and stent grafts for delivery to large diameter vessels, such as the aorta, are disclosed having very small compacted delivery dimensions. Devices with deployed dimensions of 26 to 40 mm or more are disclosed that are compacted to extremely small dimensions of 5 mm or less, enabling percutaneous delivery of said devices without the need for surgical intervention. Compaction efficiencies are achieved by combining unique material combinations with new forms of restraining devices, compaction techniques, and delivery techniques. These inventive devices permit consistent percutaneous delivery of large vessel treatment devices. Additionally, small endoprosthetic devices are disclosed that can be compacted to extremely small dimensions for delivery through catheter tubes of less than 1 mm diameter.

16. 发明申请

US20100331956A1 ENDOLUMINAL EXPANSION SYSTEM 有权
标题翻译：内膜扩张系统
公开(公告)号：US20100331956A1
公开(公告)日：2010-12-30
申请号：US12876779
申请日：2010-09-07
申请人： Joseph R. Armstrong , Edward H. Cully , Craig T. Nordhausen , Mark J. Ulm , Michael J. Vonesh
发明人： Joseph R. Armstrong , Edward H. Cully , Craig T. Nordhausen , Mark J. Ulm , Michael J. Vonesh
IPC分类号： A61F2/84
CPC分类号： A61F2/958 , A61F2/95 , A61F2/97 , A61F2002/9511
摘要： An endoprosthesis expansion system having, in combination, a delivery component such as a length of catheter tubing having at its distal end an intermediate sheath component, and an inner tube within the full length of the delivery catheter and intermediate sheath component. The inner tube has a protrusion affixed to its distal end, and an expandable endoprosthesis is fitted in a compacted state about the intermediate sheath, immediately proximal to the protrusion. If the endoprosthesis is a self-expanding endoprosthesis (as is preferred), an exterior constraining sheath is required around the outer surface of the endoprosthesis. Following insertion of the endoprosthesis and delivery system into a body conduit (such as a blood vessel) and transport of the endoprosthesis to the desired site within the body conduit, the endoprosthesis is deployed by axially moving the protrusion against the system, thereby applying a radially directed outward force and causing simultaneous dilatation of the intermediate sheath and disruption of the exterior constraining sheath. Disruption of the exterior constraining sheath, in the case of a self-expanding prosthesis, releases the stored energy in the formerly constrained prosthesis, allowing it to expand and accomplish full deployment against the luminal surface of the body conduit at the desired site.
摘要翻译：一种内置假体扩张系统，其组合具有输送部件，例如一段长度的导管，其远端具有中间护套部件，并且在输送导管和中间护套部件的整个长度内具有内管。内管具有固定在其远端的突起，并且可伸缩的内假体围绕中间护套紧密地装配在紧固突起的近侧。如果内置假体是自扩张的内置假体（如优选的），则需要在内假体的外表面周围的外约束护套。在将内假体和输送系统插入身体导管（例如血管）中并将内假体运送到体导管内的期望部位之后，通过将凸起轴向移动抵靠系统来展开内假体，从而施加径向引导向外的力并引起中间鞘的同时扩张和外部约束鞘的破坏。在自扩张假体的情况下，外部约束护套的破坏释放在先前约束的假体中的储存能量，允许其膨胀并且在所需位置处对体导管的腔表面完全完全展开。

17. 发明授权

US07691109B2 Method of producing low profile stent and graft combination 有权
标题翻译：生产薄型支架和移植物组合的方法
公开(公告)号：US07691109B2
公开(公告)日：2010-04-06
申请号：US11230757
申请日：2005-09-19
申请人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
发明人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
IPC分类号： A61F11/00 , A61M29/00
CPC分类号： A61F2/07 , A61F2/844 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2/91 , A61F2/954 , A61F2/97 , A61F2002/067 , A61F2002/072 , A61F2002/075 , A61F2002/825 , A61F2002/9505 , A61F2002/9511 , A61F2002/9522 , A61F2220/0075 , A61F2230/0054 , Y10T29/53987
摘要： Large diameter self-expanding endoprosthetic devices, such as stents and stent grafts for delivery to large diameter vessels, such as the aorta, are disclosed having very small compacted delivery dimensions. Devices with deployed dimensions of 26 to 40 mm or more are disclosed that are compacted to extremely small dimensions of 5 mm or less, enabling percutaneous delivery of said devices without the need for surgical intervention. Compaction efficiencies are achieved by combining unique material combinations with new forms of restraining devices, compaction techniques, and delivery techniques. These inventive devices permit consistent percutaneous delivery of large vessel treatment devices. Additionally, small endoprosthetic devices are disclosed that can be compacted to extremely small dimensions for delivery through catheter tubes of less than 1 mm diameter.
摘要翻译：公开了大直径自膨胀假体内装置，例如用于输送到大直径血管，例如主动脉的支架和支架移植物，具有非常小的紧凑的输送尺寸。公开了具有26至40mm或更大的尺寸的装置，其被压实至5mm或更小的极小尺寸，能够经皮地输送所述装置，而不需要外科手术。压实效率通过将独特的材料组合与新形式的约束装置，压实技术和输送技术相结合来实现。这些本发明的装置允许大容量处理装置的一致的经皮输送。此外，公开了可以压缩至极小尺寸的小型假体内装置，以通过小于1mm直径的导管输送。

18. 发明授权

US06827731B2 Deployment system for intraluminal devices 有权
标题翻译：管腔内装置的部署系统
公开(公告)号：US06827731B2
公开(公告)日：2004-12-07
申请号：US10054772
申请日：2002-01-22
申请人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
发明人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
IPC分类号： A61F206
CPC分类号： A61F2/97 , A61F2/86 , A61F2/95 , A61F2/958 , A61F2002/9511 , A61F2002/9522 , A61F2002/9583 , A61F2250/0071
摘要： A constraining sheath for use around an endoprosthesis (e.g., a stent device, with or without a graft covering), which may be a balloon expandable endoprosthesis but more preferably is a self-expanding prosthesis. The endoprosthesis is coaxially enclosed within the constraining sheath, which is an outer, disruptable, preferably implantable tubular sheath, preferably made of ePTFE. The constraining sheath and endoprosthesis are preferably mounted together as an assembly on an angioplasty balloon for delivery. Deployment of the endoprosthesis entails inflating the angioplasty balloon to a pressure sufficient to disrupt or break the constraining sheath in a prescribed fashion, thereby allowing a self-expanding endoprosthesis to spontaneously deploy. The constraining sheath of ePTFE may be attached to the endoprosthesis and implanted along with the device, or alternatively attached to the balloon catheter shaft and removed with the balloon catheter. The angioplasty balloon's working length is preferably shorter than the length of the endoprosthesis. An endoprosthesis assembly incorporating a constraining sheath according to one embodiment of the invention is also provided with an additional packaging sheath.
摘要翻译：用于内置假体周围使用的约束护套（例如，具有或不具有移植物覆盖物的支架装置），其可以是球囊可膨胀内置假体，但更优选是自膨胀假体。内置假体同轴地封闭在约束护套内，约束鞘是外部的，可破坏的，优选可植入的管状护套，优选地由ePTFE制成。约束鞘和内假体优选地作为组件安装在血管成形术气囊上用于递送。内窥镜假体的部署需要将血管成形术气囊膨胀至足以以规定的方式破坏或打破约束鞘的压力，从而允许自膨胀内置假体自发部署。 ePTFE的约束鞘可以连接到内置假体并与装置一起植入，或者替代地附接到球囊导管轴并且用球囊导管去除。血管成形术球囊的工作长度优选地短于内假体的长度。根据本发明的一个实施例的包含约束护套的假体内装配体还具有附加的包装护套。

19. 发明授权

US09381018B2 Device for rapid repair of body conduits 有权
公开(公告)号：US09381018B2
公开(公告)日：2016-07-05
申请号：US13149696
申请日：2011-05-31
申请人： Edward H. Cully , Jeffrey B. Duncan , Keith M. Flury , Paul D. Goodman , Wayne D. House , Vrad W. Levering , Philip P. Off , Daniel M. O'Shea , Michael J. Vonesh , Jason M. Wiersdorf
发明人： Edward H. Cully , Jeffrey B. Duncan , Keith M. Flury , Paul D. Goodman , Wayne D. House , Vrad W. Levering , Philip P. Off , Daniel M. O'Shea , Michael J. Vonesh , Jason M. Wiersdorf
IPC分类号： A61F2/84 , A61B17/11 , A61F2/07 , A61F2/97 , A61B17/06 , A61F2/06 , A61F2/30 , A61F2/89
CPC分类号： A61F2/07 , A61B17/06166 , A61B17/11 , A61B2017/1107 , A61F2/064 , A61F2/844 , A61F2/848 , A61F2/88 , A61F2/89 , A61F2/958 , A61F2/97 , A61F2002/075 , A61F2002/30713 , A61F2220/0075 , A61F2220/0091 , A61F2250/0087
摘要： A self-expanding stent-graft provided in a diametrically compacted state for implantation and retained preferably by a constraining sheath, useful for the temporary or permanent repair of injured, partially or entirely transected body conduits including blood vessels. It may be used under direct visualization to quickly stop or substantially reduce loss of blood from such damaged vessels and to quickly re-establish perfusion distal to the injury site. The device would typically be implanted under emergency room conditions but also be used in field situations by trained medical technicians. After an end of the device is inserted into a blood vessel through the injury access, deployment preferably initiates from the device end in a direction moving toward the middle of the length of the device by directionally releasing the constraining sheath. In a preferred embodiment, the two opposing ends of the device are individually deployable from the compacted, small diameter intended for insertion into a vessel, to the larger diameter at which they fit interferably into a portion of the vessel.

20. 发明申请

US20120289997A1 Embolic Filter Frame Having Looped Support Strut Elements 有权
标题翻译：具有环形支撑支柱元件的栓塞过滤器框架
公开(公告)号：US20120289997A1
公开(公告)日：2012-11-15
申请号：US13555543
申请日：2012-07-23
申请人： Edward H. Cully , Michael J. Vonesh
发明人： Edward H. Cully , Michael J. Vonesh
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , B23P11/00 , Y10T29/49826
摘要： An embolic frame having looped support struts. The frame configuration provides enhanced longitudinal compliance, improved sealing against a vessel wall, low profile delivery, and a short deployed length. The looped support struts have a high degree of “radial” stiffness with a low degree of “longitudinal” stiffness. In the deployed state, the frame exerts a relatively high stress onto a vessel wall to maintain an effective seal, yet remains compliant in the longitudinal direction. The looped support struts elongate when tensioned and assume a compressed and essentially linear form. While constrained in this linear state by a delivery catheter, the support struts exert minimal stress onto the delivery system. The overall delivery profile and stiffness are therefore reduced. When the delivery catheter constraint is removed during deployment, the struts “snap open” and assume a looped configuration which exert a high degree of force onto the vessel wall.
摘要翻译：具有环状支撑支柱的栓塞框架。框架结构提供增强的纵向顺应性，改进的针对血管壁的密封，薄型输送和短部署长度。环形支撑支柱具有高度的径向刚度，并且具有低程度的纵向刚度。在展开状态下，框架在容器壁上施加相当高的应力以保持有效的密封，但在长度方向保持柔顺。环形支撑件在张紧时伸长并呈现压缩且基本线性的形式。虽然通过输送导管在这种线性状态下被约束，但是支撑支柱对输送系统施加最小的压力。因此，总体输送轮廓和刚度降低。当在展开期间移除输送导管约束时，支柱卡扣打开并且呈现向血管壁施加高度力的环形构造。

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