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    • 16. 发明授权
    • Methods and systems for managing clinical research information
    • 临床研究信息管理方法和系统
    • US07870006B2
    • 2011-01-11
    • US10065159
    • 2002-09-23
    • John Eric TkaczykMaria IatrouNaresh Kesavan Rao
    • John Eric TkaczykMaria IatrouNaresh Kesavan Rao
    • G06Q50/00G06F19/00
    • G06Q50/24G06F19/00G06F19/3418G06Q50/22G16H10/20G16H10/60
    • A method for managing clinical study (CS) information for a clinical research entity using a server system coupled to a centralized database and at least one client system is provided. The centralized database has a plurality of templates stored therein. The method includes receiving at the server system CS information relating to at least one patient involved in a clinical study wherein the CS information is entered through a user selected template displayed on the client system, storing CS information received at the server system in the centralized database, tracking CS information stored in the centralized database, updating the centralized database periodically with newly received CS information to maintain CS information, and providing CS information in response to an inquiry.
    • 提供了一种使用耦合到集中式数据库和至少一个客户端系统的服务器系统来管理临床研究实体的临床研究(CS)信息的方法。 集中式数据库中存储有多个模板。 该方法包括在服务器系统CS处接收与临床研究中涉及的至少一个患者有关的信息,其中通过在客户端系统上显示的用户选择的模板输入CS信息,将在服务器系统接收的CS信息存储在中央数据库中 跟踪存储在集中式数据库中的CS信息,以新接收的CS信息周期性地更新集中式数据库,以维护CS信息,并响应于查询提供CS信息。
    • 18. 发明申请
    • MULTI-LAYERED DETECTOR SYSTEM FOR HIGH RESOLUTION COMPUTED TOMOGRAPHY
    • 用于高分辨率计算机图像的多层检测器系统
    • US20100252742A1
    • 2010-10-07
    • US12750159
    • 2010-03-30
    • John Eric Tkaczyk
    • John Eric Tkaczyk
    • G01T1/164G01T1/161G01T1/24
    • G01T1/2018G01T1/2985
    • X-ray detector system with improved spatial resolution for a computed tomography systems is provided. The detector system may include pairs of first and second detector arrays, with each array containing detector elements of a different design. In one embodiment, the first array may comprise a first, relatively thin and continuous (i.e., monolithic) scintillation layer with an array of individual diodes positioned to receive light generated within the scintillation layer. The second array may comprise a second, relatively thick scintillation layer formed of separate scintillator elements. An array of diodes may be positioned to receive radiation from the scintillation layer such that each diode element is aligned to primarily receive radiation from one scintillator element in the layer. The structural arrangements of the detector system may also be adapted for applications involving direct conversion of x-ray energy.
    • 提供了一种用于计算机断层摄影系统的具有改进的空间分辨率的X射线探测器系统。 检测器系统可以包括成对的第一和第二检测器阵列,每个阵列包含不同设计的检测器元件。 在一个实施例中,第一阵列可以包括第一相对薄且连续(即整体)的闪烁层,其具有被定位成接收闪烁层内产生的光的单独二极管阵列。 第二阵列可以包括由分离的闪烁体元件形成的第二相对厚的闪烁层。 二极管阵列可以定位成接收来自闪烁层的辐射,使得每个二极管元件对准以主要接收来自该层中的一个闪烁体元件的辐射。 检测器系统的结构布置也可适用于涉及X射线能量的直接转换的应用。
    • 19. 发明授权
    • Material decomposition image noise reduction
    • 材料分解图像降噪
    • US07734076B2
    • 2010-06-08
    • US11609262
    • 2006-12-11
    • Yanfeng DuJohn Eric Tkaczyk
    • Yanfeng DuJohn Eric Tkaczyk
    • G06K9/00A61B6/00
    • A61B6/4241A61B6/032A61B6/4085A61B6/482A61B6/583
    • A diagnostic imaging system in an example includes a high frequency electromagnetic energy source, a detector, a data acquisition system (DAS), and a computer. The high frequency electromagnetic energy source emits a beam of high frequency electromagnetic energy toward an object to be imaged. The detector receives high frequency electromagnetic energy emitted by the high frequency electromagnetic energy source. The DAS is operably connected to the detector and programmed to employ a threshold to trigger a filter operation on a pixel, in a basis material decomposition (BMD) image of a plurality of BMD images, through comparison of an actual noise ratio between a pair of BMD images, of the plurality of BMD images, to a theoretical BMD noise ratio value. The computer is programmed to employ a correlation in noise distribution of the plurality of BMD images to reduce image noise in the plurality of BMD images.
    • 示例中的诊断成像系统包括高频电磁能量源,检测器,数据采集系统(DAS)和计算机。 高频电磁能源朝向要成像的物体发射高频电磁能束。 检测器接收高频电磁能源发出的高频电磁能。 DAS可操作地连接到检测器,并且被编程为通过比较多个BMD图像中的实际噪声比,在多个BMD图像的基础材料分解(BMD)图像中采用阈值来触发像素上的滤波器操作 多个BMD图像中的BMD图像达到理论BMD噪声比值。 计算机被编程为在多个BMD图像的噪声分布中采用相关性,以减少多个BMD图像中的图像噪声。