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11. 发明授权

US08314613B2 Electrochemical biosensor measuring system 有权
标题翻译：电化学生物传感器测量系统
公开(公告)号：US08314613B2
公开(公告)日：2012-11-20
申请号：US12672596
申请日：2008-02-26
申请人： Gang Cui , Keun Ki Kim , Dong Hoon Han , Moon Hwan Kim , Hakhyun Nam , Geun Sig Cha
发明人： Gang Cui , Keun Ki Kim , Dong Hoon Han , Moon Hwan Kim , Hakhyun Nam , Geun Sig Cha
IPC分类号： G01V3/00
CPC分类号： G01N33/48771 , A61B5/14532 , A61B5/1486 , C12Q1/004
摘要： Disclosed are an electrochemical biosensor which comprises a production lot information identification portion, on which information is recorded in a magnetization mark, and a measuring device which can automatically identify the production lot information of the biosensor with the insertion of the electrochemical biosensor into the measuring device. The electrochemical biosensor and the measuring device thereof can record production lot information in the form of magnetization marks on an electrochemical biosensor strip and read the information as digital signals through a magnetoresistance sensor device, which can be mounted on the surface of a circuit board using Surface Mounted Technology (SMT). Without the need for a high-priced filter or a complicated calculation system, the magnetic detector system has a simple construction and realizes economic efficiency in the construction of the measuring device. Also, the measuring device automatically identifies the production lot information recorded on the biosensor, so that inconvenience and the frequency of errors, which occur when a user personally inputs the production lot information, can be reduced, with the result that the measured values can be conveniently and accurately acquired.
摘要翻译：公开了一种电化学生物传感器，其包括将信息记录在磁化标记中的生产批次信息识别部分和能够通过将电化学生物传感器插入到测量装置中来自动识别生物传感器的生产批次信息的测量装置。电化学生物传感器及其测量装置可以在电化学生物传感器条上以磁化标记的形式记录生产批量信息，并通过磁阻传感器装置读取作为数字信号的信息，该磁阻传感器装置可以使用表面安装在电路板的表面上安装技术（SMT）。不需要高价格的过滤器或复杂的计算系统，磁检测系统结构简单，实现了测量装置结构的经济效益。此外，测量装置自动识别记录在生物传感器上的生产批次信息，从而可以减少当用户亲自输入生产批次信息时出现的不便和错误频率，结果是测量值可以是方便准确地获取。

12. 发明申请

US20100126882A1 ELECTROCHEMICAL BIOSENSOR MEASURING SYSTEM 有权
标题翻译：电化学传感器测量系统
公开(公告)号：US20100126882A1
公开(公告)日：2010-05-27
申请号：US12530128
申请日：2008-02-26
申请人： Moon Hwan Kim , Keun Ki Kim , Gang Cui , Hakhyun Nam , Geun Sig Cha
发明人： Moon Hwan Kim , Keun Ki Kim , Gang Cui , Hakhyun Nam , Geun Sig Cha
IPC分类号： G01N27/26
CPC分类号： G01N33/48771 , A61B5/14532 , A61B5/1486 , A61B2562/08 , B01L3/545 , B01L2200/148 , B01L2300/0645 , B01L2300/0825 , G01N2035/00752 , G01N2035/00811
摘要： Disclosed herein is an electrochemical biosensor measuring device which comprises at least two photodiodes for emitting light beams at regular time intervals in a sequential manner, with the insertion of an electrochemical biosensor thereto, and a detector for sensing the emitted light beams, thereby identifying the production lot information recorded on a production lot information identification portion on the electrochemical biosensor. Thus, the device enjoys economic advantages of not requiring a high-priced optical filter in detecting the light absorbed through or reflected from the production identification information recorded in biosensor and a complicated software algorithm to recover the production lot information. Also, the measuring device automatically identifies the production lot information recorded on the biosensor, so that the frequency of inconvenience and error that occur when a user personally inputs the production lot information of the biosensor can be reduced, with the result that the measured values can be conveniently and accurately acquired.
摘要翻译：本文公开了一种电化学生物传感器测量装置，其包括至少两个光电二极管，用于以顺序方式以规则的时间间隔发射光束，同时插入电化学生物传感器，以及用于感测发射的光束的检测器，从而识别生产记录在电化学生物传感器上的生产批次信息识别部分上的批次信息。因此，该设备具有经济上的优点，即不需要高价格的光学滤波器来检测由生物传感器中记录的生产识别信息吸收或反射的光，以及复杂的软件算法来恢复生产批次信息。此外，测量装置自动识别记录在生物传感器上的生产批次信息，从而可以减少当用户亲自输入生物传感器的生产批次信息时发生的不便和错误的频率，结果是测量值可以方便，准确地获得。

13. 发明申请

US20110210726A1 ELECTROCHEMICAL BIOSENSOR MEASURING SYSTEM 有权
标题翻译：电化学传感器测量系统
公开(公告)号：US20110210726A1
公开(公告)日：2011-09-01
申请号：US12672596
申请日：2008-02-26
申请人： Gang Cui , Keun Ki Kim , Dong Hoon Han , Moon Hwan Kim , Hakhyun Nam , Geun Sig Cha
发明人： Gang Cui , Keun Ki Kim , Dong Hoon Han , Moon Hwan Kim , Hakhyun Nam , Geun Sig Cha
IPC分类号： G01R33/02
CPC分类号： G01N33/48771 , A61B5/14532 , A61B5/1486 , C12Q1/004
摘要： Disclosed are an electrochemical biosensor which comprises a production lot information identification portion, on which information is recorded in a magnetization mark, and a measuring device which can automatically identify the production lot information of the biosensor with the insertion of the electrochemical biosensor into the measuring device. The electrochemical biosensor and the measuring device thereof can record production lot information in the form of magnetization marks on an electrochemical biosensor strip and read the information as digital signals through a magnetoresistance sensor device, which can be mounted on the surface of a circuit board using Surface Mounted Technology (SMT). Without the need for a high-priced filter or a complicated calculation system, the magnetic detector system has a simple construction and realizes economic efficiency in the construction of the measuring device. Also, the measuring device automatically identifies the production lot information recorded on the biosensor, so that inconvenience and the frequency of errors, which occur when a user personally inputs the production lot information, can be reduced, with the result that the measured values can be conveniently and accurately acquired.
摘要翻译：公开了一种电化学生物传感器，其包括将信息记录在磁化标记中的生产批次信息识别部分和能够通过将电化学生物传感器插入到测量装置中来自动识别生物传感器的生产批次信息的测量装置。电化学生物传感器及其测量装置可以在电化学生物传感器条上以磁化标记的形式记录生产批量信息，并通过磁阻传感器装置读取作为数字信号的信息，该磁阻传感器装置可以使用表面安装在电路板的表面上安装技术（SMT）。不需要高价格的过滤器或复杂的计算系统，磁检测系统结构简单，实现了测量装置结构的经济效益。此外，测量装置自动识别记录在生物传感器上的生产批次信息，从而可以减少当用户亲自输入生产批次信息时出现的不便和错误频率，结果是测量值可以是方便准确地获取。

14. 发明申请

US20110147457A1 BIOSENSOR MEASURING APPARATUS AND A METHOD THEREOF 有权
标题翻译：生物传感器测量装置及其方法
公开(公告)号：US20110147457A1
公开(公告)日：2011-06-23
申请号：US13060049
申请日：2008-11-11
申请人： Geun Sig Cha , Hakhyun Nam , Gang Cui , Keun-Ki Kim , Shim-Ho Lee
发明人： Geun Sig Cha , Hakhyun Nam , Gang Cui , Keun-Ki Kim , Shim-Ho Lee
IPC分类号： G06K7/10
CPC分类号： G01N33/48771 , A61B5/14532 , A61B2560/0276 , G01N2035/00772
摘要： A biosensor can be measured by a method that includes: determining malfunction of a production lot information sensing unit; alerting malfunction when the production lot information sensing unit malfunctions; encoding the production lot information through the production lot information sensing unit when the production lot information sensing unit does not malfunction; and detecting a component of a sample through a biosensor strip by using the encoded production lot information.
摘要翻译：可以通过以下方法测量生物传感器：包括：确定生产批次信息感测单元的故障; 当生产批量信息传感单元发生故障时发出警报故障; 当生产批次信息感测单元不发生故障时，通过生产批次信息感测单元对生产批次信息进行编码; 以及通过使用编码的生产批次信息通过生物传感器条检测样品的成分。

15. 发明申请

US20090308744A1 ELECTROCHEMICAL DETERMINATION SYSTEM OF GLYCATED PROTEINS 有权
标题翻译：糖化蛋白质电化学测定系统
公开(公告)号：US20090308744A1
公开(公告)日：2009-12-17
申请号：US12375635
申请日：2006-07-29
申请人： Hakhyun Nam , Fenghua Zhang , Soon Hye Yang , Bo Kyeong Kang , Gang Cui , Moon Hee Choi , Joung Su Lee , Geun Sig Cha
发明人： Hakhyun Nam , Fenghua Zhang , Soon Hye Yang , Bo Kyeong Kang , Gang Cui , Moon Hee Choi , Joung Su Lee , Geun Sig Cha
IPC分类号： G01N33/68 , G01N33/50 , G01N1/14
CPC分类号： G01N33/723 , G01N33/5308 , G01N33/5438
摘要： Disclosed relates to an electrochemical determination system of glycated proteins, the system comprising: a filtering means for filtering labeled compounds bound to glycated proteins and non-glycated proteins after adding labeling compounds, capable of selectively binding to the glycated proteins to a solution, in which glycated/non-glycated proteins coexist, to be bound all to the glycated proteins; and a quantifying means for quantifying the filtered labeling compounds, not bound to the glycated proteins. The system of the present invention filters the residual labeled compounds left after binding to glycated proteins to quantify, instead of directly quantifying glycated proteins via the known glycated protein determination methods, thus simplifying the configuration of the system that can provide exact determinations with a low cost. Moreover, the electrochemical determination system of glycated proteins of the present invention minimizes the interference that the proteins are absorbed to an analysis device and a sensor in the system, not using immune antibodies that are expensive and have limited lives and, furthermore, not modifying the electrodes of the electrode sensor with antibodies or enzymes, thus facilitating mass production, quality control and circulation of the products.
摘要翻译：本发明涉及一种糖化蛋白质的电化学测定系统，该系统包括：过滤装置，用于在加入能够选择性结合糖基化蛋白质至溶液的标记化合物之后过滤与糖化蛋白质和非糖基化蛋白质结合的标记化合物，其中糖化/非糖化蛋白共存，与糖基化蛋白结合; 以及用于定量未与糖基化蛋白结合的经过滤的标记化合物的定量方法。本发明的系统对结合糖化蛋白质后残留的残留标记化合物进行过滤以定量，而不是通过已知的糖化蛋白质测定方法直接定量糖化蛋白质，从而简化可以以低成本提供精确测定的系统的配置。此外，本发明的糖化蛋白质的电化学测定系统使得蛋白质被吸收到系统中的分析装置和传感器的干扰最小化，而不是使用昂贵的且具有有限寿命的免疫抗体，此外，不改变电极传感器的电极与抗体或酶，从而促进产品的大量生产，质量控制和循环。

16. 发明申请

US20080237062A1 Electrochemical biosensor and biosensor measuring device 有权
标题翻译：电化学生物传感器和生物传感器测量装置
公开(公告)号：US20080237062A1
公开(公告)日：2008-10-02
申请号：US11747945
申请日：2007-05-14
申请人： Keun Ki Kim , Jae Hyun Yoo , Gang Cui , Moon Hwan Kim , Hakhyun Nam , Geun Sig Cha
发明人： Keun Ki Kim , Jae Hyun Yoo , Gang Cui , Moon Hwan Kim , Hakhyun Nam , Geun Sig Cha
IPC分类号： C12Q1/00
CPC分类号： B01L3/545 , B01L3/5027 , B01L2300/0645 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , G01N27/3272 , G01N35/00732 , G01N2035/00772 , G01N2035/00851
摘要： An electrochemical biosensor and a biosensor measuring device. The electrochemical biosensor includes a plurality of electrodes, capillary sample cell portions, reaction reagent layers, electrode connection portions, and a production lot information identification portion. The production lot information identification portion is configured such that the production lot information is recorded thereon has one or more infrared absorption/reflection marks, which indicate information about differences between production lots through the printing and/or attachment of colored or colorless materials, having differences in absorbency or reflectivity of infrared rays, in conformity of a predetermined pattern or through the attachment of transparent films. The electrochemical biosensor measuring device includes a plurality of integrated photo-reflector sensing devices that emit and receive infrared rays to identify the production lot information recorded on the production lot information identification portion of the biosensor.
摘要翻译：电化学生物传感器和生物传感器测量装置。电化学生物传感器包括多个电极，毛细管样品池部分，反应试剂层，电极连接部分和生产批次信息识别部分。生产批次信息识别部被配置为使得生产批次信息被记录在其上，具有一个或多个红外吸收/反射标记，其表示通过有色或无色材料的印刷和/或附着的生产批次之间的差异的信息，其具有差异红外线的吸收性或反射率，符合预定图案或通过透明膜的附着。电化学生物传感器测量装置包括发射和接收红外线的多个集成光反射器感测装置，以识别记录在生物传感器的生产批次信息识别部分上的生产批次信息。

17. 发明申请

US20050000808A1 Electrochemical biosensor 有权
标题翻译：电化学生物传感器
公开(公告)号：US20050000808A1
公开(公告)日：2005-01-06
申请号：US10778685
申请日：2004-02-12
申请人： Gang Cui , Jae-Hyun Yoo , Moon-Hwan Kim , Ju-Yong Kim , Jung-Hee Uhm , Hakhyun Nam , Geun-Sig Cha
发明人： Gang Cui , Jae-Hyun Yoo , Moon-Hwan Kim , Ju-Yong Kim , Jung-Hee Uhm , Hakhyun Nam , Geun-Sig Cha
IPC分类号： G01N27/327 , C12Q1/00 , C12Q1/25 , G01N27/416 , G01N1/00 , C12M1/00 , C12M1/42
CPC分类号： C12Q1/004 , C12Q1/001
摘要： There is provided the reagent layer composition that can substantially reduce the measurement bias arising from hematocrits. The addition of fatty acid (4-20 carbons) and quaternary ammonium salt to a commonly used reagent layer composition composed of an enzyme, an electron transfer mediator, and several water soluble polymers not only reduce the hematocrit level-dependent bias but also provide very stable performance for an extended period of time. Disclosed are also various types of sub microliter sample volume electrochemical biosensors that are suitable to use with the reagent layer composition of present invention.
摘要翻译：提供了可以显着降低由血细胞比容引起的测量偏差的试剂层组合物。向酶，电子传递介质和几种水溶性聚合物组成的常用试剂层组合物中加入脂肪酸（4-20碳）和季铵盐不仅可降低血细胞比容水平依赖性偏倚，稳定的性能在较长的一段时间。还公开了适用于本发明的试剂层组合物的各种类型的微微升样品体积电化学生物传感器。

18. 发明授权

US08338183B2 Electrochemical determination system of glycated proteins 有权
标题翻译：糖化蛋白质的电化学测定系统
公开(公告)号：US08338183B2
公开(公告)日：2012-12-25
申请号：US12375635
申请日：2006-07-29
申请人： Hakhyun Nam , Fenghua Zhang , Soon Hye Yang , Bo Kyeong Kang , Gang Cui , Moon Hee Choi , Joung Su Lee , Geun Sig Cha
发明人： Hakhyun Nam , Fenghua Zhang , Soon Hye Yang , Bo Kyeong Kang , Gang Cui , Moon Hee Choi , Joung Su Lee , Geun Sig Cha
IPC分类号： G01N33/50 , G01N33/48
CPC分类号： G01N33/723 , G01N33/5308 , G01N33/5438
摘要： Disclosed relates to an electrochemical determination system of glycated proteins, the system comprising: a filtering means for filtering labeled compounds bound to glycated proteins and non-glycated proteins after adding labeling compounds, capable of selectively binding to the glycated proteins to a solution, in which glycated/non-glycated proteins coexist, to be bound all to the glycated proteins; and a quantifying means for quantifying the filtered labeling compounds, not bound to the glycated proteins. The system of the present invention filters the residual labeled compounds left after binding to glycated proteins to quantify, instead of directly quantifying glycated proteins via the known glycated protein determination methods, thus simplifying the configuration of the system that can provide exact determinations with a low cost. Moreover, the electrochemical determination system of glycated proteins of the present invention minimizes the interference that the proteins are absorbed to an analysis device and a sensor in the system, not using immune antibodies that are expensive and have limited lives and, furthermore, not modifying the electrodes of the electrode sensor with antibodies or enzymes, thus facilitating mass production, quality control and circulation of the products.
摘要翻译：本发明涉及一种糖化蛋白质的电化学测定系统，该系统包括：过滤装置，用于在加入能够选择性结合糖基化蛋白质至溶液的标记化合物之后过滤与糖化蛋白质和非糖基化蛋白质结合的标记化合物，其中糖化/非糖化蛋白共存，与糖基化蛋白结合; 以及用于定量未与糖基化蛋白结合的经过滤的标记化合物的定量方法。本发明的系统对结合糖化蛋白质后残留的残留标记化合物进行过滤以定量，而不是通过已知的糖化蛋白质测定方法直接定量糖化蛋白质，从而简化可以以低成本提供精确测定的系统的配置。此外，本发明的糖化蛋白质的电化学测定系统使得蛋白质被吸收到系统中的分析装置和传感器的干扰最小化，而不是使用昂贵的且具有有限寿命的免疫抗体，此外，不改变电极传感器的电极与抗体或酶，从而促进产品的大量生产，质量控制和循环。

19. 发明授权

US07704747B2 Dual blood glucose meter 失效
标题翻译：双血糖仪
公开(公告)号：US07704747B2
公开(公告)日：2010-04-27
申请号：US10825253
申请日：2004-04-15
申请人： Moon Hwan Kim , Keun Ki Kim , Gang Cui , Hakhyun Nam , Geun-Sig Cha
发明人： Moon Hwan Kim , Keun Ki Kim , Gang Cui , Hakhyun Nam , Geun-Sig Cha
IPC分类号： G01N33/48 , G01N33/00
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/150022 , A61B5/150358 , A61B5/157 , A61B2562/0295 , G01N33/48785 , Y10T436/14 , Y10T436/142222 , Y10T436/143333 , Y10T436/144444
摘要： Disclosed herein is a dual blood glucose meter. The dual blood glucose meter includes a meter body, a measurement strip, a variety of electronic parts and upper and lower strip receiving ports. The meter body is provided with a liquid crystal display panel on the front thereof to display measured numerical values and various pieces of pictorial information. The measurement strip is brought into contact with blood at a blood collection spot so as to measure blood glucose of the blood. The electronic parts are used to measure the blood glucose of the blood. The upper and lower strip receiving ports are formed at upper and lower ends of the meter body to receive the measurement strip, and are each electrically connected to the electric parts.
摘要翻译：这里公开了双血糖计。双血糖仪包括仪表体，测量条，各种电子部件和上下条接收口。仪表主体在其前面设置有液晶显示面板，以显示测量的数值和各种图形信息。测量条与血液收集点处的血液接触，以测量血液的血糖。电子部件用于测量血液中的血糖。上下条接收端口形成在仪表主体的上端和下端以接收测量条，并且各自电连接到电气部件。

20. 发明申请

US20100032321A1 ELECTROCHEMICAL BIOSENSOR MEASURING SYSTEM 有权
标题翻译：电化学传感器测量系统
公开(公告)号：US20100032321A1
公开(公告)日：2010-02-11
申请号：US12529008
申请日：2008-02-26
申请人： Keun Ki Kim , Moon Hwan Kim , Jae Hyun Yoo , Gang Cui , Hakhyun Nam , Geun Sig Cha
发明人： Keun Ki Kim , Moon Hwan Kim , Jae Hyun Yoo , Gang Cui , Hakhyun Nam , Geun Sig Cha
IPC分类号： G01N27/26
CPC分类号： A61B5/1486 , A61B5/14532 , G01N33/48771 , G01N2035/00851
摘要： Disclosed is an electrochemical biosensor measuring device which can be used together with an electrochemical biosensor. The biosensor measuring device comprises an electrical connection portion which is electrically connected with the electrodes of the biosensor upon the insertion of the biosensor there into, and a connector having a structure in which at least one light absorption or reflection path sequentially comprising a light emitter-production lot information identification portion-detector unit is provided to identify the production lot information recorded in the biosensor. The electrochemical biosensor measuring device can automatically identify the production lot information of the biosensor, encoded in the form of a hue or hole marks, upon the insertion of the electrochemical biosensor into the measuring device, thereby obviating the need to manually input the production lot information of the biosensor. Thus, inconvenience and the frequency of errors, which occur when a user personally inputs the production lot information, can be reduced, with the result that the measured values can be conveniently and accurately acquired.
摘要翻译：公开了一种可与电化学生物传感器一起使用的电化学生物传感器测量装置。生物传感器测量装置包括电连接部分，其在将生物传感器插入其中时与生物传感器的电极电连接;以及连接器，具有其中至少一个光吸收或反射路径顺序地包括发光 - 提供生产批次信息识别部分检测器单元以识别记录在生物传感器中的生产批次信息。当将电化学生物传感器插入到测量装置中时，电化学生物传感器测量装置可以自动识别以色调或孔痕形式编码的生物传感器的生产批次信息，从而避免了手动输入生产批次信息的需要的生物传感器。因此，可以减少当用户亲自输入生产批量信息时发生的不便和错误频率，结果可以方便和准确地获取测量值。

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