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11. 发明授权

US09878094B2 Medicament delivery device, capsule and in vivo medicine delivery or diagnostic system 有权
公开(公告)号：US09878094B2
公开(公告)日：2018-01-30
申请号：US12515383
申请日：2007-11-06
申请人： Johan Frederik Dijksman , Frits Tobi De Jongh , Michel Gerardus Pardoel , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Remus Albu , Ventzeslav Iordanov , Hans Marc Bert Boeve
发明人： Johan Frederik Dijksman , Frits Tobi De Jongh , Michel Gerardus Pardoel , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Remus Albu , Ventzeslav Iordanov , Hans Marc Bert Boeve
IPC分类号： A61M31/00 , A61B5/00 , A61M5/145 , A61B5/07 , A61B5/145 , A61B1/04 , A61B5/01 , A61M5/142
CPC分类号： A61M5/14593 , A61B1/041 , A61B5/01 , A61B5/073 , A61B5/14539 , A61B5/4839 , A61M5/14276 , A61M31/002 , A61M2005/14204 , A61M2205/3561
摘要： A medicament delivery device, which comprises a driving mechanism and a housing (1) having a reservoir (2), which is at least partly filled with a substance and which is sealed at least on one side with a flexible wall (21). The driving mechanism is adapted to press a piston (23) against the flexible wall (21) thereby releasing the substance from the reservoir (2) through an opening (25) in the reservoir (2). This provides for a safe and reliable medicament delivery device.

12. 发明授权

US09550050B2 Medicament delivery apparatus 有权
标题翻译：药物输送装置
公开(公告)号：US09550050B2
公开(公告)日：2017-01-24
申请号：US12442408
申请日：2007-09-20
申请人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Michel Pardoel , Frits Tobi De Jongh
发明人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Michel Pardoel , Frits Tobi De Jongh
IPC分类号： A61K9/22 , A61M31/00 , A61B5/07 , A61B5/00
CPC分类号： A61M31/002 , A61B5/073 , A61B5/4839 , A61M31/00
摘要： An electronic capsule (100) is provided. The capsule (100) has a discrete drive element (300) comprising: a housing (109), electronics for making the electronic capsule (100) operable, a pumping mechanism (115) for dosing and displacing a substance, a power source (105) for powering the electronic capsule (100) and enabling the electronics and the pumping mechanism (115) to operate, and a locking mechanism (130); and a discrete payload element (200) comprising: a housing (109), a reservoir (210) for storing the substance, one or more openings (250) in the housing (109) for releasing the substance from the reservoir (210) and a locking mechanism (230) for engaging the drive element locking mechanism (130). Engagement of the drive element locking mechanism (130) with the payload element locking mechanism (230) secures the drive element (300) to the payload element (200), thereby making the electronic capsule (100) operable and specific.
摘要翻译：提供电子胶囊（100）。所述胶囊（100）具有离散驱动元件（300），包括：壳体（109），用于使所述电子胶囊（100）可操作的电子设备，用于计量和移位物质的泵送机构（115），电源（105）），用于对所述电子胶囊（100）供电并使得所述电子设备和所述泵送机构（115）能够操作;以及锁定机构（130）。和离散有效载荷元件（200），包括：壳体（109），用于存储物质的储存器（210），用于将物质从储存器（210）释放的壳体（109）中的一个或多个开口（250）用于接合驱动元件锁定机构（130）的锁定机构（230）。驱动元件锁定机构（130）与有效载荷元件锁定机构（230）的接合将驱动元件（300）固定到有效载荷元件（200），从而使电子胶囊（100）可操作和特定。

13. 发明授权

US08852172B2 Ingestible electronic capsule and in vivo drug delivery or diagnostic system 有权
标题翻译：可摄入电子胶囊和体内药物递送或诊断系统
公开(公告)号：US08852172B2
公开(公告)日：2014-10-07
申请号：US12515424
申请日：2007-11-05
申请人： Johan Frederik Dijksman , Frits Tobi De Jongh , Michel Gerardus Pardoel , Claude Jean-Marie Malaurie , Yvan O. J. G. Droinet , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Remus Albu
发明人： Johan Frederik Dijksman , Frits Tobi De Jongh , Michel Gerardus Pardoel , Claude Jean-Marie Malaurie , Yvan O. J. G. Droinet , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Remus Albu
IPC分类号： A61B5/07 , A61B1/04 , A61B5/00 , A61B1/00
CPC分类号： A61B5/073 , A61B1/00016 , A61B1/041 , A61B5/4839
摘要： An ingestible electronic capsule (100) for introduction into the bodily lumen comprises a circuit board with at least one electronic component (4, 5, 7, 8, 9, 11, 12, 13, 14). The circuit board is formed from a flex foil (10), thereby reducing the number of components and improving the robustness and reliability of the ingestible electronic capsule (100).
摘要翻译：用于引入到体腔内的可摄入电子胶囊（100）包括具有至少一个电子部件（4,5,7,8,9,11,12,13,14）的电路板。电路板由柔性箔（10）形成，从而减少了组件的数量并提高了可摄取电子胶囊（100）的坚固性和可靠性。

14. 发明申请

US20100228082A1 DEVICE, SYSTEM AND METHOD FOR INTERACTING WITH A CELL OR TISSUE IN A BODY 审中-公开
标题翻译：用于与身体中的细胞或组织相互作用的装置，系统和方法
公开(公告)号：US20100228082A1
公开(公告)日：2010-09-09
申请号：US12376460
申请日：2007-04-12
申请人： Hans Zou , Stein Kuiper , Bernardus Hendrikus Wilhelmus Hendriks , Jan Frederik Suijver , Anke Pierik , Judith Margreet Rensen , Johan Frederik Dijksman , Jeff Shimizu , Jacob Marinus Jan Den Toonder
发明人： Hans Zou , Stein Kuiper , Bernardus Hendrikus Wilhelmus Hendriks , Jan Frederik Suijver , Anke Pierik , Judith Margreet Rensen , Johan Frederik Dijksman , Jeff Shimizu , Jacob Marinus Jan Den Toonder
IPC分类号： A61B1/00
CPC分类号： A61B5/6882 , A61B1/041 , A61B5/0031 , A61B5/073 , A61B5/4839
摘要： A device or support, system and method are provided for precisely targeted and/or highly controlled interaction with a targeted cell or tissue in a body, with the support providing an ergonomic connecting interface for selectively connecting the support to a cell or tissue with at least minimal adverse affect to such cell or tissue, the system providing a remote facility that may be operatively associated with the support, and the method providing steps for employing the support and/or system so as to, inter alia, improve treatment, diagnostic and/or monitoring techniques and increase sensitivity and specificity with respect to interacting with, for example, diseased or abnormal cells or tissue without adversely effecting surrounding healthy cells or tissue, and/or the body in general.
摘要翻译：提供了一种装置或支撑件，系统和方法，用于与身体中的靶细胞或组织精确地靶向和/或高度受控的相互作用，其中所述支持物提供符合人体工程学的连接界面，用于至少选择性地将支持体连接到细胞或组织对这种细胞或组织的最小的不利影响，该系统提供可能与支持物可操作地相关联的远程设施，以及提供使用支持和/或系统的方法，以便除其他外改善治疗，诊断和/ 或监测技术，并提高与例如患病或异常细胞或组织的相互作用的灵敏度和特异性，而不会不利地影响周围的健康细胞或组织和/或身体。

15. 发明授权

US08990018B2 Method of preparing a swallowable capsule comprising a sensor 有权
标题翻译：制备包含传感器的吞咽胶囊的方法
公开(公告)号：US08990018B2
公开(公告)日：2015-03-24
申请号：US12933891
申请日：2009-03-24
申请人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Petrus Leonardus Adrianus Van Der Made , Michel Gerardus Pardoel , Frits Tobi De Jongh , Johan Gerard Kleibeuker
发明人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Petrus Leonardus Adrianus Van Der Made , Michel Gerardus Pardoel , Frits Tobi De Jongh , Johan Gerard Kleibeuker
IPC分类号： G06F19/00 , A61B5/04 , B65D83/04 , A61B5/07 , A61B5/145 , A61B5/1495
CPC分类号： A61B5/073 , A61B5/14539 , A61B5/1495 , A61B2560/0223
摘要： A kit includes a swallowable capsule (1, 45) with a potentiometric sensor (3), such as a pH sensor, with an unfilled electrolyte cell (31). The kit further includes a separate container (46) containing a liquid electrolyte. The kit can, e.g., be packed in a blister package. After unpacking the capsule the electrolyte cell (31) is filled with the electrolyte.
摘要翻译：试剂盒包括具有电位传感器（3）的吞咽胶囊（1,45），例如pH传感器，其具有未填充的电解质电池（31）。该试剂盒还包括含有液体电解质的单独的容器（46）。试剂盒可以例如包装在泡罩包装中。在拆开胶囊之后，电解质电池（31）充满电解质。

16. 发明申请

US20110017612A1 METHOD OF PREPARING A SWALLOWABLE CAPSULE COMPRISING A SENSOR 有权
标题翻译：制备包含传感器的易碎胶囊的方法
公开(公告)号：US20110017612A1
公开(公告)日：2011-01-27
申请号：US12933891
申请日：2009-03-24
申请人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Petrus Leonardus Adrianus Van Der Made , Michel Gerardus Pardoel , Frits Tobi De Jongh , Johan Gerard Kleibeuker
发明人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Petrus Leonardus Adrianus Van Der Made , Michel Gerardus Pardoel , Frits Tobi De Jongh , Johan Gerard Kleibeuker
IPC分类号： G01N33/487 , G01N27/26
CPC分类号： A61B5/073 , A61B5/14539 , A61B5/1495 , A61B2560/0223
摘要： The inventions relates to a kit comprising a swallowable capsule (1, 45) with a potentiometric sensor (3), such as a pH sensor, with an unfilled electrolyte cell (31). The kit further includes a separate container (46) containing a liquid electrolyte. The kit can, e.g., be packed in a blister package. After unpacking the capsule the electrolyte cell (31) is filled with the electrolyte.
摘要翻译：本发明涉及一种试剂盒，其包括具有电位传感器（3）的可吞咽胶囊（1,45），例如具有未填充电解质电池（31）的pH传感器。该试剂盒还包括含有液体电解质的单独的容器（46）。试剂盒可以例如包装在泡罩包装中。在拆开胶囊之后，电解质电池（31）充满电解质。

17. 发明申请

US20100045309A1 METHOD AND APPARATUS FOR MEASURING FLUID PROPERTIES, INCLUDING PH 审中-公开
标题翻译：用于测量流体特性的方法和装置，包括PH
公开(公告)号：US20100045309A1
公开(公告)日：2010-02-25
申请号：US12521015
申请日：2007-12-26
申请人： Han Zou , Lucian Remus Albu , Jeff Shimizu , Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Adam Schleicher , Frits Tobi De Jongh
发明人： Han Zou , Lucian Remus Albu , Jeff Shimizu , Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Adam Schleicher , Frits Tobi De Jongh
IPC分类号： G01R27/26
CPC分类号： A61B5/053 , A61B5/073 , A61B5/14539 , A61B5/42
摘要： A fluid sensor for use within the gastro-intestinal tract of a human being is disclosed. The sensor includes a sensing coil which is immersible in the sample fluid of the gastro-intestinal tract; a signal generator in electrical with the sensing coil for applying an electrical current pulse to the sensing coil; a signal receiver in communication with the sensing coil for measuring an electrical reflection relative to said electrical current pulse; and a data processor for receiving the electrical reflection and for calculating data representative of at least one property, such as pH of the sample fluid based on the electrical reflection. The fluid sensor can also include a reference coil for calibrating the sensing coil. The sensor coil and reference coil can be encapsulated in a swallowable pill shell. The sensor coil can also function as an antenna for transmitting and receiving signals to/form a remote location.
摘要翻译：公开了一种在人胃肠道内使用的流体传感器。该传感器包括一感测线圈，该感测线圈可浸入胃肠道的样品流体中; 与所述感测线圈电连接以将电流脉冲施加到所述感测线圈的信号发生器; 与传感线圈通信的信号接收器，用于测量相对于所述电流脉冲的电反射; 以及数据处理器，用于接收电反射并且用于计算代表至少一个性质的数据，例如基于电反射的样品流体的pH。流体传感器还可以包括用于校准感测线圈的参考线圈。传感器线圈和参考线圈可以封装在可吞咽的药丸壳中。传感器线圈还可以用作用于向/形成远程位置发送和接收信号的天线。

18. 发明申请

US20120143171A1 VALVELESS DRUG DELIVERY DEVICE 审中-公开
标题翻译：优质药物递送装置
公开(公告)号：US20120143171A1
公开(公告)日：2012-06-07
申请号：US13262861
申请日：2010-04-01
申请人： Jeff Shimizu , Hans Zou , Johan Frederik Dijksman
发明人： Jeff Shimizu , Hans Zou , Johan Frederik Dijksman
IPC分类号： A61M37/00 , A61M5/00
CPC分类号： A61M5/14244 , A61M5/14276 , A61M2206/12 , A61M2210/1042
摘要： A drug delivery device (10) comprising a drug reservoir (13), at least one dispensing hole (14), an actuator system (17) and an exit path (15). The drug reservoir (13) is provided for comprising a drug. The dispensing hole (14) delivers the drug to an environment of the drug delivery device (10) when the actuator system (17) pushes the drug from the drug reservoir (13) through the dispensing hole (14). The exit path (15) couples the drug reservoir (13) to the dispensing hole (14). The exit path (15) comprises at least one entry point (16) for coupling the exit path (15) to the drug reservoir (13) and is arranged in such a way that for any possible orientation of the drug delivery device (10) at least a part of the exit path (15) is situated above the gravity center of said drug reservoir or below the dispensing hole (14).
摘要翻译：包括药物储存器（13），至少一个分配孔（14），致动器系统（17）和出口路径（15）的药物输送装置（10）。提供药物储存器（13）以包含药物。当致动器系统（17）通过分配孔（14）将药物从药物储存器（13）推动时，分配孔（14）将药物输送到药物输送装置（10）的环境。出口路径（15）将药物储存器（13）连接到分配孔（14）。出口路径（15）包括用于将出口路径（15）耦合到药物储存器（13）的至少一个入口点（16），并且被布置成使得对于药物输送装置（10）的任何可能的取向，所述出口路径（15）的至少一部分位于所述药物储存器的重心的上方或所述分配孔（14）的下方。

19. 发明授权

US10046109B2 Drug delivery device with compressible drug reservoir 有权
公开(公告)号：US10046109B2
公开(公告)日：2018-08-14
申请号：US13390111
申请日：2010-08-10
申请人： Hans Zou , Jeff Shimizu , Johan Frederik Dijksman
发明人： Hans Zou , Jeff Shimizu , Johan Frederik Dijksman
IPC分类号： A61M5/145 , A61M31/00
摘要： A drug delivery device (50) is provided comprising a drug reservoir (10) and a piston (11). The drug reservoir (10) is provided for comprising a drug and comprises a flexible wall (22) and a dispensing hole (15) for dispensing the drug into an environment of the drug de delivery device (50). The piston (11) is provide for pressing against the flexible wall (22) to compress the drug reservoir (10) for pushing an amount of the drug through the dispensing hole (15). An adhesion interface (51) between a surface of the piston (11) and the flexible wall (22) prevents sliding between the surface of the piston (11) and the flexible wall (22).

20. 发明申请

US20130204233A1 DRUG DELIVERY DEVICE WITH COMPRESSIBLE DRUG RESERVOIR 审中-公开
标题翻译：具有可压缩药物储存的药物递送装置
公开(公告)号：US20130204233A1
公开(公告)日：2013-08-08
申请号：US13390111
申请日：2010-08-10
申请人： Hans Zou , Jeff Shimizu , Johan Frederik Dijksman
发明人： Hans Zou , Jeff Shimizu , Johan Frederik Dijksman
IPC分类号： A61M5/145
CPC分类号： A61M5/1452 , A61M31/002
摘要： A drug delivery device (50) is provided comprising a drug reservoir (10) and a piston (11). The drug reservoir (10) is provided for comprising a drug and comprises a flexible wall (22) and a dispensing hole (15) for dispensing the drug into an environment of the drug de delivery device (50). The piston (11) is provide for pressing against the flexible wall (22) to compress the drug reservoir (10) for pushing an amount of the drug through the dispensing hole (15). An adhesion interface (51) between a surface of the piston (11) and the flexible wall (22) prevents sliding between the surface of the piston (11) and the flexible wall (22).
摘要翻译：提供了药物输送装置（50），其包括药物储存器（10）和活塞（11）。药物储存器（10）被设置成包括药物并且包括柔性壁（22）和用于将药物分配到药物递送装置（50）的环境中的分配孔（15）。活塞（11）用于压靠柔性壁（22）以压缩药物储存器（10），用于推动一定量的药物通过分配孔（15）。在活塞（11）的表面和柔性壁（22）之间的粘合界面（51）防止活塞（11）的表面和柔性壁（22）之间的滑动。

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