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11. 发明申请

US20050202494A1 Catalases 审中-公开
标题翻译：过氧化氢酶
公开(公告)号：US20050202494A1
公开(公告)日：2005-09-15
申请号：US11096819
申请日：2005-04-01
申请人： Jay Short , Dan Robertson , Indrajit Sanyal , Robert Adhikari , Eric Mathur
发明人： Jay Short , Dan Robertson , Indrajit Sanyal , Robert Adhikari , Eric Mathur
IPC分类号： C12N1/15 , C12N1/19 , C12N1/21 , C12N9/08 , C12Q1/30 , C12Q1/68 , C07H21/04 , C12N15/09
CPC分类号： C12N9/0065 , A01K2217/05 , C12Q1/30
摘要： The invention relates to catalases and to polynucleotides encoding the catalases. In addition methods of designing new catalases and method of use thereof are also provided. The catalases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及过氧化氢酶和编码该过氧化氢酶的多核苷酸。另外还提供了设计新的过氧化氢酶的方法及其使用方法。过氧化氢酶在增加的pH和温度下具有增加的活性和稳定性。

12. 发明申请

US20080032378A1 POLYPEPTIDES HAVING AMYLASE ACTIVITY AND METHODS OF MAKING AND USING THEM 有权
标题翻译：具有AMYLASE活性的多肽和制备和使用它们的方法
公开(公告)号：US20080032378A1
公开(公告)日：2008-02-07
申请号：US11621534
申请日：2007-01-09
申请人： Walter CALLEN , Toby Richardson , Gerhard Frey , Jay Short , Eric Mathur , Kevin Gray , Janne Kerovuo , Malgorzata Slupska
发明人： Walter CALLEN , Toby Richardson , Gerhard Frey , Jay Short , Eric Mathur , Kevin Gray , Janne Kerovuo , Malgorzata Slupska
IPC分类号： C12N9/26 , A01H3/00 , C12N1/00 , C12N1/21 , C12N5/04 , C12N5/06 , C12N5/10
CPC分类号： C12N9/2417 , A21D8/042 , C12N9/2414 , C12P19/04 , C12P19/14 , C12Y302/01001 , Y02E50/16 , Y02E50/17
摘要： This invention relates generally to polypeptides and peptides having an amylase activity, e.g., enzymes, polynucleotides encoding the enzymes, the use of such polypeptides and peptides. In one aspect, the polypeptides having amylase activity have increased activity and stability at acidic, neutral and alkaline pH and increased temperature. In one aspect, the invention provides methods for producing an alcohol, for producing a high-maltose or a high-glucose syrup or a mixed syrup, for liquifying a starch-comprising composition, comprising use of polypeptides having amylase activity of the invention.
摘要翻译：本发明一般涉及具有淀粉酶活性的多肽和肽，例如酶，编码酶的多核苷酸，这种多肽和肽的用途。一方面，具有淀粉酶活性的多肽在酸性，中性和碱性pH和升高的温度下具有增加的活性和稳定性。一方面，本发明提供了用于生产用于液化包含淀粉的组合物的高麦芽糖或高葡萄糖浆或混合糖浆的醇的方法，其包括使用具有本发明的具有淀粉酶活性的多肽。

13. 发明申请

US20070161099A1 METHODS FOR USING POLYPEPTIDES HAVING AMYLASE ACTIVITY AND NUCLEIC ACIDS ENCODING THEM 有权
标题翻译：使用具有AMYLASE活性的多肽和编码其的核酸的方法
公开(公告)号：US20070161099A1
公开(公告)日：2007-07-12
申请号：US11621543
申请日：2007-01-09
申请人： Walter Callen , Toby Richardson , Gerhard Frey , Jay Short , Eric Mathur , Kevin Gray , Janne Kerovuo , Malgorzata Slupska
发明人： Walter Callen , Toby Richardson , Gerhard Frey , Jay Short , Eric Mathur , Kevin Gray , Janne Kerovuo , Malgorzata Slupska
IPC分类号： C12P7/06 , C12N9/32 , C12N5/10 , C12N5/06 , C12N1/21
CPC分类号： C12N9/2417 , A21D8/042 , C12N9/2414 , C12P19/04 , C12P19/14 , C12Y302/01001 , Y02E50/16 , Y02E50/17
摘要： The invention relates to uses of polypeptides having amylase activity, nucleic acids encoding them, and methods for making and using them. For example, in one aspect, the invention provides methods for making alcohol using polypeptides of the invention. In one aspect, the polypeptides having amylase activity have increased activity and stability at acidic, neutral and alkaline pH and increased temperature. In one aspect, the invention provides methods for producing an alcohol, for producing a high-maltose or a high-glucose syrup or a mixed syrup, for liquifying a starch-comprising composition, for hydrolyzing a starch, comprising use of polypeptides of the invention, or polypeptides encoded by the nucleic acids of this invention.
摘要翻译：本发明涉及具有淀粉酶活性的多肽的用途，编码它们的核酸以及制备和使用它们的方法。例如，一方面，本发明提供了使用本发明多肽制备醇的方法。一方面，具有淀粉酶活性的多肽在酸性，中性和碱性pH和升高的温度下具有增加的活性和稳定性。一方面，本发明提供用于生产高麦芽糖或高葡萄糖浆或混合糖浆的醇的方法，用于液化包含淀粉的组合物，用于水解淀粉，包括使用本发明的多肽，或由本发明的核酸编码的多肽。

14. 发明申请

US20080047037A1 NUCLEIC ACIDS ENCODING POLYPEPTIDES HAVING AMYLASE ACTIVITY AND METHODS OF MAKING AND USING THEM 有权
标题翻译：编码具有淀粉酶活性的多肽的核酸及其制备和使用方法
公开(公告)号：US20080047037A1
公开(公告)日：2008-02-21
申请号：US11621528
申请日：2007-01-09
申请人： Walter Callen , Toby Richardson , Gerhard Frey , Jay Short , Eric Mathur , Kevin Gray , Janne Kerovuo , Malgorzata Slupska
发明人： Walter Callen , Toby Richardson , Gerhard Frey , Jay Short , Eric Mathur , Kevin Gray , Janne Kerovuo , Malgorzata Slupska
IPC分类号： C12P21/04 , A01H5/00 , C12N1/20 , C12N15/00 , C12N15/11 , C12N5/04 , C12N5/06
CPC分类号： C12N9/2417 , A21D8/042 , C12N9/2414 , C12P19/04 , C12P19/14 , C12Y302/01001 , Y02E50/16 , Y02E50/17
摘要： The invention relates to nucleic acids encoding polypeptides having amylase activity, and methods for making and using them. In one aspect, the polypeptides having amylase activity have increased activity and stability at acidic, neutral and alkaline pH and increased temperature. In one aspect, the invention provides methods for producing an alcohol, for producing a high-maltose or a high-glucose syrup or a mixed syrup, for liquifying a starch-comprising composition, comprising use of polypeptides encoded by the nucleic acids of this invention.
摘要翻译：本发明涉及编码具有淀粉酶活性的多肽的核酸，以及制备和使用它们的方法。一方面，具有淀粉酶活性的多肽在酸性，中性和碱性pH和升高的温度下具有增加的活性和稳定性。一方面，本发明提供用于生产用于液化含淀粉组合物的高麦芽糖或高葡萄糖浆或混合糖浆的醇的方法，其包括使用由本发明的核酸编码的多肽。

15. 发明申请

US20120006716A1 HUMANIZED ANTI-IL-6 ANTIBODIES 失效
标题翻译：人类抗IL-6抗体
公开(公告)号：US20120006716A1
公开(公告)日：2012-01-12
申请号：US13243915
申请日：2011-09-23
申请人： Gerhard Frey , Hwai Wen Chang , Jay Short
发明人： Gerhard Frey , Hwai Wen Chang , Jay Short
IPC分类号： B65D85/00 , A61K39/395 , A61P29/00 , A61P21/02 , A61P25/04 , A61P23/00 , A61P25/20 , A61P21/00 , A61P31/00 , A61P17/06 , A61P3/10 , A61P3/02 , A61P5/14 , A61P5/00 , A61P1/12 , A61P11/14 , A61P1/08 , A61P1/04 , A61P1/10 , A61P7/02 , A61P37/06 , A61P5/24 , A61P3/00 , A61P25/24 , A61P25/18 , A61P25/22 , A61P11/06 , A61P23/02 , C12P21/02 , C07K16/24
CPC分类号： C07K16/248 , C07K2317/24 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译：本发明涉及新颖的嵌合，人源化或CDR移植的抗IL-6抗体，包括编码至少一种这样的抗IL-6抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及包括治疗组合物，方法和装置。

16. 发明申请

US20100209995A1 Amylases, Nucleic Acids Encoding Them and Methods for Making and Using Them 有权
标题翻译：淀粉酶，编码它们的核酸及其制备和使用方法
公开(公告)号：US20100209995A1
公开(公告)日：2010-08-19
申请号：US12697907
申请日：2010-02-01
申请人： Walter Callen , Toby Richardson , Gerhard Frey , Carl Miller , Martin Kazaoka , Eric Mathur , Jay Short
发明人： Walter Callen , Toby Richardson , Gerhard Frey , Carl Miller , Martin Kazaoka , Eric Mathur , Jay Short
IPC分类号： C12N9/26
CPC分类号： C12N9/2411 , C12N9/2417 , C12P19/14
摘要： In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. In one aspect, the polypeptides of the invention can be used as amylases, for example, alpha amylases, to catalyze the hydrolysis of starch into sugars.
摘要翻译：一方面，本发明涉及具有淀粉酶活性的多肽，编码多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一个方面，本发明的多肽可用作淀粉酶，例如α-淀粉酶，以催化淀粉水解成糖。

17. 发明申请

US20050202426A1 Whole cell engineering using real-time metabolic flux analysis 审中-公开
标题翻译：全细胞工程使用实时代谢通量分析
公开(公告)号：US20050202426A1
公开(公告)日：2005-09-15
申请号：US10491358
申请日：2002-10-01
申请人： Jay Short , Martin Latterich , Michael Levin , Jing Wei , Pengcheng Fu
发明人： Jay Short , Martin Latterich , Michael Levin , Jing Wei , Pengcheng Fu
IPC分类号： G01N27/62 , A61K48/00 , B01J20/281 , B01J20/285 , C07K1/16 , C12N1/15 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/85 , C12Q1/00 , C12Q1/02 , C12Q1/68 , G01N27/64 , G01N30/04 , G01N30/06 , G01N30/26 , G01N30/34 , G01N30/46 , G01N30/60 , G01N30/72 , G01N30/84 , G01N30/86 , G01N30/88 , G01N31/00 , G01N31/22 , G01N33/48 , G01N33/50 , G01N33/569 , G01N33/58 , G01N33/68 , G06F19/00
CPC分类号： G01N33/56911 , G01N33/5091
摘要： The invention provides methods for whole cell engineering of new and modified phenotypes by using “on-line” or “real-time” metabolic flux analysis. The invention provides a method for whole cell engineering of new or modified phenotypes by using real-time metabolic flux analysis by making a modified cell by modifying the genetic composition of a cell and culturing the modified cell to generate a plurality of modified cells and measuring at least one metabolic parameter of the cell by monitoring the cell culture of in real time. The invention also provides articles comprising machine-readable medium including machine-executable instructions and systems, e.g., computer systems, to practice the methods of the invention.
摘要翻译：本发明通过使用“在线”或“实时”代谢通量分析提供新的和修饰的表型的全细胞工程的方法。本发明提供了一种通过使用实时代谢通量分析通过改变细胞的遗传组成并培养修饰的细胞以产生多个修饰的细胞并通过在通过实时监测细胞培养物，细胞的至少一种代谢参数。本发明还提供包括机器可读介质的文章，其包括机器可执行指令和系统，例如计算机系统，以实施本发明的方法。

18. 发明申请

US20050032054A1 Screening for novel bioactivities 审中-公开
标题翻译：筛选新生物活性
公开(公告)号：US20050032054A1
公开(公告)日：2005-02-10
申请号：US10423231
申请日：2003-04-25
申请人： Jay Short
发明人： Jay Short
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/10 , C12N15/52 , C12P19/34 , C12Q1/00 , C12Q1/02 , C12Q1/25 , C12Q1/68 , G01N33/50 , G01N33/566 , C12N15/74
CPC分类号： C12N15/1034 , C12N15/1086 , C12N15/1093 , C12N15/52 , C12Q1/00
摘要： Disclosed is a process for identifying clones having a specified activity of interest, which process comprises (i) generating one or more expression libraries derived from nucleic acid directly isolated from the environment; and (ii) screening said libraries utilizing an assay system. More particularly, this is a process for identifying clones having a specified activity of interest by (i) generating one or more expression libraries derived from nucleic acid directly or indirectly isolated from the environment; (ii) exposing said libraries to a particular substrate or substrates of interest; and (iii) screening said exposed libraries utilizing a fluorescence activated cell sorter to identify clones which react with the substrate or substrates. Also provided is a process for identifying clones having a specified activity of interest by (i) generating one or more expression libraries derived from nucleic acid directly or indirectly isolated from the environment; and (ii) screening said exposed libraries utilizing an assay requiring a binding event or the covalent modification of a target, and a fluorescence activated cell sorter to identify positive clones.
摘要翻译：公开了用于鉴定具有特定的感兴趣活性的克隆的方法，该方法包括（i）产生一种或多种源自从环境直接分离的核酸的表达文库; 和（ii）使用测定系统筛选所述文库。更具体地说，这是通过（i）产生一种或多种从环境中直接或间接分离的核酸产生的表达文库来鉴定具有特定活性的克隆的方法; （ii）将所述文库暴露于感兴趣的特定底物或底物; 和（iii）使用荧光激活的细胞分选仪筛选所述暴露的文库，以鉴定与底物或底物反应的克隆。还提供了通过（i）生成从环境直接或间接分离的核酸产生的一种或多种表达文库来鉴定具有特定活性的克隆的方法; 和（ii）使用需要结合事件或靶共价修饰的测定法和荧光激活的细胞分选器筛选所述暴露的文库以鉴定阳性克隆。

19. 发明申请

US20070231820A1 P450 ENZYMES, NUCLEIC ACIDS ENCODING THEM AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译： P450酶，核酸编码和制备和使用它们的方法
公开(公告)号：US20070231820A1
公开(公告)日：2007-10-04
申请号：US11687606
申请日：2007-03-16
申请人： David Weiner , Mark Burk , Tim Hitchman , Catherine Pujol , Toby Richardson , Jay Short
发明人： David Weiner , Mark Burk , Tim Hitchman , Catherine Pujol , Toby Richardson , Jay Short
IPC分类号： C12Q1/68 , A01H5/00 , A01K67/027 , C07H21/04 , C07H5/04 , C07K1/02 , C07K1/04 , C07K1/06 , C07K1/107 , C07K1/12 , C07K16/40 , C12N1/08 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/63 , C12N5/10 , C12N5/12 , G06F17/30 , G06F17/00 , G01N33/573 , C12P13/02 , C12P21/06 , C12P5/00 , C12P7/02 , C12Q1/26
CPC分类号： C12N9/0071
摘要： The invention is directed to polypeptides having P450 activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. The P450 enzymes can be used to catalyze the hydrolysis of epoxides and arene oxides to their corresponding diols.
摘要翻译：本发明涉及具有P450活性的多肽，编码多肽的多核苷酸，与这些多肽结合的抗体，以及制备和使用这些多核苷酸和多肽的方法。 P450酶可用于催化环氧化物和芳烃氧化物水解成其相应的二醇。

20. 发明申请

US20050186605A1 Phosphatase -encoding nucleic acids and methods of making and using them 审中-公开
标题翻译：磷酸酶编码核酸及其制备和使用的方法
公开(公告)号：US20050186605A1
公开(公告)日：2005-08-25
申请号：US11047257
申请日：2005-01-31
申请人： Jay Short , Eric Mathur , Edd Lee , Edward Bylina
发明人： Jay Short , Eric Mathur , Edd Lee , Edward Bylina
IPC分类号： C12N9/16 , C12Q1/68 , C07H21/04
CPC分类号： C12N9/16
摘要： The invention relates to thermostable phosphatases and to polynucleotides encoding the thermostable phosphatases. In addition methods of designing new phosphatases and methods of use thereof are also provided. The thermostable phosphatases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及热稳定性磷酸酶和编码热稳定性磷酸酶的多核苷酸。此外，还提供了设计新的磷酸酶的方法及其使用方法。热稳定性磷酸酶在增加的pH和温度下具有增加的活性和稳定性。

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