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11. 发明授权

US06335328B2 Process for the isolation of galanthamine 有权
标题翻译：加兰他敏分离方法
公开(公告)号：US06335328B2
公开(公告)日：2002-01-01
申请号：US09741436
申请日：2000-12-21
申请人： Thomas Hille , Hans-Rainer Hoffmann , Mirko Kreh , Rudolf Matusch
发明人： Thomas Hille , Hans-Rainer Hoffmann , Mirko Kreh , Rudolf Matusch
IPC分类号： A61K3155
CPC分类号： C07D491/04
摘要： The subject matter of the present invention concerns a process for the isolation of the alkaloid galanthamine; the galanthamine itself which has been produced according to this process; the use of the galanthamine thus produced in galenic preparations; and the galanthamine thus produced for treating narrow-angle glaucoma, Alzheimer's disease, as well as alcohol and nicotine dependence.
摘要翻译：本发明的主题涉及分离生物碱雪花胺的方法; 根据该方法生产的雪花胺本身; 使用如此在galenic制剂中产生的雪花胺; 和由此产生的雪花胺用于治疗狭窄的青光眼，阿尔茨海默病以及酒精和尼古丁依赖。

12. 发明授权

US08256631B2 Closure system for containers 有权
标题翻译：集装箱封闭系统
公开(公告)号：US08256631B2
公开(公告)日：2012-09-04
申请号：US12283231
申请日：2008-09-10
申请人： Hans-Rainer Hoffmann , Rudolf Matusch
发明人： Hans-Rainer Hoffmann , Rudolf Matusch
IPC分类号： B65D39/02 , B65D41/00
CPC分类号： A61J1/065 , A61J1/062 , A61J1/1468 , B65D2251/0093
摘要： A closure system is provided for containers used for storing or administering substances in the form of liquids, pastes or powders, which includes a cap, provided with a through-hole, and a closure element, wherein the cap holds the closure element with a force fit and/or form fit on the container, in the area of the container opening that is to be closed, by a catch element present on the container. The end face which surrounds the container opening, and on which the closure element bears, comprises a depression. The closure element is a virus-proof, bacteria-proof and spore-proof film that lies on the end face and, at least in some areas, over the depression. The cap is then fitted in place, an elastomer ring or adhesive ring is arranged between the closure element and the depression and fills the depression.
摘要翻译：提供封闭系统用于容纳用于储存或施用液体，糊剂或粉末形式的物质的容器，所述容器包括设置有通孔的盖子和封闭元件，其中盖子用力通过存在于容器上的捕获元件，在容器开口的区域中，在容器上配合和/或形状配合。围绕容器开口并且封闭元件承载的端面包括凹陷。封闭元件是防病毒，防细菌和防孢子膜，位于端面，至少在某些区域，位于凹陷上。然后将盖安装在适当位置，弹性体环或粘合环布置在封闭元件和凹陷之间并填充凹陷。

13. 发明授权

US08167850B2 Cylinder/piston unit with at least three sealing elements 有权
标题翻译：具有至少三个密封元件的气缸/活塞单元
公开(公告)号：US08167850B2
公开(公告)日：2012-05-01
申请号：US12380385
申请日：2009-02-26
申请人： Hans-Rainer Hoffmann , Rudolf Matusch
发明人： Hans-Rainer Hoffmann , Rudolf Matusch
IPC分类号： A61M5/315
CPC分类号： A61M5/31513 , A61M5/30 , A61M5/3007
摘要： A cylinder/piston unit is disclosed for pre-fill, storage and release when desired of an active substance, such as a medicament. The cylinder/piston unit is provided with a cylinder and with a piston which is guided therein and which is sealed off in a sterile manner by a rubber seal, the cylinder and the piston enclosing a chamber that can be filled at least temporarily with active substance, and the cylinder having at least one discharge element at its front end. For this purpose, the piston resting in a rear position is sealed off relative to the cylinder in a sterile manner by a static front sealing element and by a static rear sealing element. Arranged spatially behind each static sealing element, there is a parking area for receiving the respective sealing element. When the piston is actuated, the individual static sealing elements are transferred from their respective sealing position into a parked position located in the parking area, and each sealing element in the parked position touches only the cylinder wall or only the piston wall. With the present invention, a cylinder/piston unit is developed which can be pre-filled and in which, despite a sterile sealing of the piston, only a slight force has to be applied in order to accelerate and/or move the piston.
摘要翻译：公开了一种用于在需要活性物质（例如药物）时进行预填充，储存和释放的气缸/活塞单元。气缸/活塞单元设置有气缸，并具有被引导到其中并且通过橡胶密封件以无菌方式密封的活塞，气缸和活塞包围可以至少临时填充活性物质的室并且该气缸在其前端具有至少一个排出元件。为此目的，静止在后部位置的活塞通过静态前密封元件和静态后密封元件以无菌方式相对于气缸被密封。在每个静态密封元件之后空间布置，存在用于接收相应的密封元件的停车区域。当活塞被致动时，各个静态密封元件从其相应的密封位置转移到位于停车区域中的停放位置，并且停放位置中的每个密封元件仅接触气缸壁或仅触及活塞壁。利用本发明，开发了可以预填充的气缸/活塞单元，并且其中尽管活塞的无菌密封，但是仅仅需要施加微小的力以加速和/或移动活塞。

14. 发明申请

US20090254036A1 Single-use injector with at least one draw hook 有权
标题翻译：一次性注射器至少有一个拉钩
公开(公告)号：US20090254036A1
公开(公告)日：2009-10-08
申请号：US12455964
申请日：2009-06-10
申请人： Bado Asmussen , Hans-Rainer Hoffmann , Rudolf Matusch , Uwe Wortmann
发明人： Bado Asmussen , Hans-Rainer Hoffmann , Rudolf Matusch , Uwe Wortmann
IPC分类号： A61M5/20
CPC分类号： A61M5/30 , A61M5/2033 , A61M5/24 , A61M5/3007 , A61M5/31515 , A61M2005/2073 , A61M2005/2488 , A61M2005/2492 , A61M2005/312
摘要： A single-use injector is disclosed comprising a housing (10), arranged in which are at least one mechanical spring energy store (50), at least one piston-cylinder unit (100), which can be effectively filled at least for a certain time, at least one piston-actuating ram (60) and at least one triggering unit (80). The spring energy store comprises at least one pre-tensioned spring element. The spring-loaded piston-actuating ram (60) has at least one retaining rod or hook (62), which can be moved transversely, at least in certain regions, and by means of a supporting portion supports the tensioned spring energy store on at least one resting surface of the housing. When actuation occurs, the triggering unit (80) releases the supporting portion to allow it to move away from the resting surface.
摘要翻译：公开了一种一次性注射器，其包括壳体（10），其布置有至少一个机械弹簧能量存储器（50），至少一个活塞 - 气缸单元（100），其至少可以有效地填充至少一定的至少一个活塞致动柱塞（60）和至少一个触发单元（80）。弹簧能量储存器包括至少一个预张紧弹簧元件。弹簧加载的活塞致动冲头（60）具有至少一个保持杆或钩（62），其可以至少在某些区域中横向移动，并且借助于支撑部分支撑张紧的弹簧能量储存在壳体的至少一个搁置表面。当致动发生时，触发单元（80）释放支撑部分以允许其移动远离静止表面。

15. 发明授权

US06194404B1 Process for the isolation of galanthamine 有权
标题翻译：加兰他敏分离方法
公开(公告)号：US06194404B1
公开(公告)日：2001-02-27
申请号：US09130883
申请日：1998-08-07
申请人： Thomas Hille , Hans-Rainer Hoffmann , Mirko Kreh , Rudolf Matusch
发明人： Thomas Hille , Hans-Rainer Hoffmann , Mirko Kreh , Rudolf Matusch
IPC分类号： A01N4346
CPC分类号： C07D491/04
摘要： The subject matter of the present invention concerns a process for the isolation of the alkaloid galanthamine; the galanthamine itself which has been produced according to this process; the use of the galanthamine thus produced in galenic preparations; and the galanthamine thus produced for treating narrow-angle glaucoma, Alzheimer's disease, as well as alcohol and nicotine dependence.
摘要翻译：本发明的主题涉及分离生物碱雪花胺的方法; 根据该方法生产的雪花胺本身; 使用如此在galenic制剂中产生的雪花胺; 和由此产生的雪花胺用于治疗狭窄的青光眼，阿尔茨海默病以及酒精和尼古丁依赖。

16. 发明申请

US20090166978A1 Cylinder/piston unit with at least three sealing elements 有权
标题翻译：具有至少三个密封元件的气缸/活塞单元
公开(公告)号：US20090166978A1
公开(公告)日：2009-07-02
申请号：US12380385
申请日：2009-02-26
申请人： Hans-Rainer Hoffmann , Rudolf Matusch
发明人： Hans-Rainer Hoffmann , Rudolf Matusch
IPC分类号： F16J15/32
CPC分类号： A61M5/31513 , A61M5/30 , A61M5/3007
摘要： A cylinder/piston unit is disclosed for pre-fill, storage and release when desired of an active substance, such as a medicament. The cylinder/piston unit is provided with a cylinder and with a piston which is guided therein and which is sealed off in a sterile manner by a rubber seal, the cylinder and the piston enclosing a chamber that can be filled at least temporarily with active substance, and the cylinder having at least one discharge element at its front end. For this purpose, the piston resting in a rear position is sealed off relative to the cylinder in a sterile manner by a static front sealing element and by a static rear sealing element. Arranged spatially behind each static sealing element, there is a parking area for receiving the respective sealing element. When the piston is actuated, the individual static sealing elements are transferred from their respective sealing position into a parked position located in the parking area, and each sealing element in the parked position touches only the cylinder wall or only the piston wall. With the present invention, a cylinder/piston unit is developed which can be pre-filled and in which, despite a sterile sealing of the piston, only a slight force has to be applied in order to accelerate and/or move the piston.
摘要翻译：公开了一种用于在需要活性物质（例如药物）时进行预填充，储存和释放的气缸/活塞单元。气缸/活塞单元设置有气缸，并具有被引导到其中并且通过橡胶密封件以无菌方式密封的活塞，气缸和活塞包围可以至少临时填充活性物质的室并且该气缸在其前端具有至少一个排出元件。为此目的，静止在后部位置的活塞通过静态前密封元件和静态后密封元件以无菌方式相对于气缸被密封。在每个静态密封元件之后空间布置，存在用于接收相应的密封元件的停车区域。当活塞被致动时，各个静态密封元件从其相应的密封位置转移到位于停车区域中的停放位置，并且停放位置中的每个密封元件仅接触气缸壁或仅触及活塞壁。利用本发明，开发了可以预填充的气缸/活塞单元，并且其中尽管活塞的无菌密封，但是仅仅需要施加微小的力以加速和/或移动活塞。

17. 发明申请

US20090159553A1 Closure system for containers 有权
标题翻译：集装箱封闭系统
公开(公告)号：US20090159553A1
公开(公告)日：2009-06-25
申请号：US12283231
申请日：2008-09-10
申请人： Hans-Rainer Hoffmann , Rudolf Matusch
发明人： Hans-Rainer Hoffmann , Rudolf Matusch
IPC分类号： B65D51/00 , B65D41/02
CPC分类号： A61J1/065 , A61J1/062 , A61J1/1468 , B65D2251/0093
摘要： A closure system for containers used for storing or administering substances in the form of liquids, pastes or powders, which system in one embodiment includes a cap, provided with a through-hole, and a closure element, wherein the cap holds the closure element with a force fit and/or form fit on the container, in the area of the container opening that is to be closed, by means of a catch element present on the container. For this purpose, the end face which surrounds the container opening, and on which the closure element bears, comprises a depression. The closure element is a virus-proof, bacteria-proof and spore-proof film that lies on the end face and, at least in some areas, over the depression. The cap is then fitted in place, an elastomer ring or adhesive ring is arranged between the closure element and the depression and fills the depression. With the present invention, a closure system for containers is provided that allows the container to be securely closed permanently and in a virus-proof, bacteria-proof and spore-proof manner.
摘要翻译：用于储存或施用液体，糊剂或粉末形式的物质的容器的封闭系统，在一个实施方案中，该系统包括设有通孔的盖，以及封闭元件，其中盖将封闭元件保持在通过存在于容器上的捕获元件，在容器开口中待密封的区域中的配合和/或形式配合在该容器上。为此目的，围绕容器开口并且封闭元件承载的端面包括凹陷。封闭元件是防病毒，防细菌和防孢子膜，位于端面，至少在某些区域，位于凹陷上。然后将盖安装在适当位置，弹性体环或粘合环布置在封闭元件和凹陷之间并填充凹陷。利用本发明，提供了一种用于容器的封闭系统，其允许容器永久地牢固地封闭并且以防病毒，防细菌和防孢子的方式。

18. 发明授权

US07495096B2 Processes for the production of chinazoline alkaloids 失效
标题翻译：生产喹唑啉生物碱的方法
公开(公告)号：US07495096B2
公开(公告)日：2009-02-24
申请号：US10544265
申请日：2004-01-22
申请人： Joachim Moormann , Hans-Rainer Hoffmann , Rudolf Matusch
发明人： Joachim Moormann , Hans-Rainer Hoffmann , Rudolf Matusch
IPC分类号： C07D498/00 , C07D265/12 , C07D265/26 , C07D239/00 , C07D239/70 , C07D471/00 , C07D487/00 , C07D491/00
CPC分类号： C07D487/04
摘要： Processes for the production of a compound of the following formula (I) by converting a compound of formula (II) with 2-pyrrolidone used in excess relative to compound (II) and processes for the production of a compound of formula (III). The latter process includes preparing compound (I); a reduction reaction which yields compound (III) in salt form; and liberating compound (III) from the salt.
摘要翻译：通过使用相对于化合物（II）过量使用的2-吡咯烷酮转化式（II）化合物和制备式（III）化合物的方法，制备下式（I）的化合物的方法。后一种方法包括制备化合物（I）; 得到盐形式的化合物（III）的还原反应; 并从盐中释放化合物（III）。

19. 发明申请

US20060084669A1 PROCESSES FOR THE PRODUCTION OF CHINAZOLINE ALKALOIDS 失效
标题翻译：生产中氮唑烷酮的方法
公开(公告)号：US20060084669A1
公开(公告)日：2006-04-20
申请号：US10544265
申请日：2004-01-22
申请人： Joachim Moormann , Hans-Rainer Hoffmann , Rudolf Matusch
发明人： Joachim Moormann , Hans-Rainer Hoffmann , Rudolf Matusch
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D487/04
摘要： Processes for the production of a compound of the following formula (I) by converting a compound of formula (II) with 2-pyrrolidone used in excess relative to compound (II) and processes for the production of a compound of formula (III). The latter process includes preparing compound (I); a reduction reaction which yields compound (III) in salt form; and liberating compound (III) from the salt.
摘要翻译：通过使用相对于化合物（II）过量使用的2-吡咯烷酮转化式（II）化合物和制备式（III）化合物的方法，制备下式（I）的化合物的方法。后一种方法包括制备化合物（I）; 产生盐形式的化合物（III）的还原反应; 并从盐中释放化合物（III）。

20. 发明授权

US08534477B2 Closure system for containers 有权
标题翻译：集装箱封闭系统
公开(公告)号：US08534477B2
公开(公告)日：2013-09-17
申请号：US13546034
申请日：2012-07-11
申请人： Hans-Rainer Hoffmann , Rudolf Matusch
发明人： Hans-Rainer Hoffmann , Rudolf Matusch
IPC分类号： B65D41/62 , B65D51/18
CPC分类号： A61J1/065 , A61J1/062 , A61J1/1468 , B65D2251/0093
摘要： A closure system for containers used for storing or administering substances in the form of liquids, pastes or powders that allows the container to be securely closed permanently and in a virus-proof, bacteria-proof and spore-proof manner. The container having an opening that is to be closed, a cap provided with a through-hole, the cap including a substantially cylindrical securing area, and a closure element for sealing the opening. The container includes an end face which surrounds the opening and on which the closure element bears. The closure element comprises a virus-proof, bacteria-proof and spore-proof film, and the cap comprises at least one closed, elastic sealing lip bearing resiliently in a direction towards the closure element in the operative position.
摘要翻译：用于储存或管理液体，糊剂或粉末形式的容器的容器封闭系统，其允许容器永久地牢固地封闭并且以防病毒，防细菌和防孢子的方式。具有要封闭的开口的容器，设置有通孔的盖，所述盖包括基本上圆柱形的固定区域和用于密封开口的封闭元件。容器包括围绕开口的端面，封闭元件承载在该端面上。闭合元件包括防病毒，防细菌和防孢子的膜，并且帽包括在操作位置沿朝向闭合元件的方向弹性地弹性地延伸的至少一个封闭的弹性密封唇。

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