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11. 发明授权

US08864816B2 Implantable medical devices incorporating x-ray mirrors 有权
标题翻译：可植入的医疗设备，包含x射线镜
公开(公告)号：US08864816B2
公开(公告)日：2014-10-21
申请号：US13419864
申请日：2012-03-14
申请人： Jan Weber , Aiden Flanagan
发明人： Jan Weber , Aiden Flanagan
IPC分类号： A61F2/06 , A61L27/10 , A61L29/18 , A61L31/02 , A61L27/04 , A61L31/18 , G21K1/06 , A61F2/915
CPC分类号： A61L31/18 , A61F2/915 , A61F2002/91575 , A61F2230/0054 , A61L27/04 , A61L27/10 , A61L29/18 , A61L31/022 , A61L31/026 , B82Y10/00 , G21K1/062
摘要： An implantable medical device includes a radiolucent member provided with an x-ray mirror that reflects incident x-ray radiation to enable visualization of the device. The x-ray mirror includes a multilayer nanolaminate having alternating layers of a first metal or ceramic layer deposited by atomic layer deposition having a first refractive index, and a second metal or ceramic layer deposited by atomic layer deposition having a second refractive index that is different from the first refractive index. The nanolaminate includes a total of at least four layers.
摘要翻译：可植入医疗装置包括设置有x射线反射镜的射线可透射部件，该X射线反射镜反射入射的X射线辐射以使装置可视化。 x射线镜包括具有通过具有第一折射率的原子层沉积沉积的第一金属或陶瓷层的交替层的多层纳米材料，以及通过原子层沉积而沉积的第二金属或陶瓷层，其具有不同的第二折射率从第一折射率。纳米层压材料总共包括至少四层。

12. 发明授权

US08852146B2 Reinforced medical balloon 有权
标题翻译：加强医疗气球
公开(公告)号：US08852146B2
公开(公告)日：2014-10-07
申请号：US13285518
申请日：2011-10-31
申请人： Daniel J. Horn , John Jianhua Chen , Jan Weber , Thomas J. Holman
发明人： Daniel J. Horn , John Jianhua Chen , Jan Weber , Thomas J. Holman
IPC分类号： A61M25/10 , A61L29/12 , A61F2/958
CPC分类号： A61M25/104 , A61F2002/9583 , A61F2250/0068 , A61L29/126 , A61M2025/1086
摘要： The invention relates to medical balloons, and methods of modifying said balloons by forming a void pattern in their exterior surfaces and filling the voids with a material, such as a fiber or a nanomaterial (e.g., nanotubes, such as carbon nanotubes) and a matrix material, e.g., a polymer.
摘要翻译：本发明涉及医用气囊，以及通过在其外表面上形成空隙图案并用诸如纤维或纳米材料（例如纳米管，例如碳纳米管）和基体材料，例如聚合物。

13. 发明授权

US08747529B2 Device for drying a medium flow 有权
标题翻译：用于干燥介质流的装置
公开(公告)号：US08747529B2
公开(公告)日：2014-06-10
申请号：US13261263
申请日：2010-10-01
申请人： Volker Backes , Achim Pfeiffer , Jan Weber
发明人： Volker Backes , Achim Pfeiffer , Jan Weber
IPC分类号： B01D53/02
CPC分类号： B01D53/261 , B01D2253/104 , B01D2253/106 , B01D2253/108 , B01D2259/4148 , B01J20/103 , B01J20/18 , B01J20/28052 , B01J2220/42
摘要： A device for drying medium flow (8), in particular an air flow, includes a device housing (2), in which at least first and second drying agents (4, 6) are received. The first and second drying agents have a high moisture absorption capacity in the case of low and high moisture values of the medium flow (8), respectively. The amount of the respective drying agent (4, 6) can be selectively set depending on the actual moisture present in the medium flow (8).
摘要翻译：用于干燥介质流（8），特别是空气流的装置包括装置壳体（2），其中至少接收第一和第二干燥剂（4,6）。第一和第二干燥剂分别在中等流量（8）的低和高水分值的情况下具有高的吸湿能力。可以根据存在于介质流（8）中的实际水分来选择性地设定各干燥剂（4,6）的量。

14. 发明授权

US08703168B2 Medical devices for releasing therapeutic agent and methods of making the same 有权
标题翻译：用于释放治疗剂的医疗装置及其制造方法
公开(公告)号：US08703168B2
公开(公告)日：2014-04-22
申请号：US12109677
申请日：2008-04-25
申请人： Aiden Flanagan , Robert Herrmann , Ken Merdan , Michael Kuehling , Barry O'Brien , Rajesh Radhakishnan , Torsten Scheuermann , Scott Schewe , Anurag Singhal , Young-Ho Song , Mary Joe Timm , Jan Weber , Yixin Xu
发明人： Aiden Flanagan , Robert Herrmann , Ken Merdan , Michael Kuehling , Barry O'Brien , Rajesh Radhakishnan , Torsten Scheuermann , Scott Schewe , Anurag Singhal , Young-Ho Song , Mary Joe Timm , Jan Weber , Yixin Xu
IPC分类号： A61F2/00
CPC分类号： A61F2/91 , A61F2/3094 , A61F2002/30677 , A61F2002/3068 , A61F2210/0076 , A61F2230/0013 , A61F2240/001 , A61F2250/0067 , A61F2250/0068
摘要： An implantable medical device for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted.
摘要翻译：一种用于释放具有医疗装置主体的治疗剂的可植入医疗装置和设置在身体表面上的多个储存器限定结构。储存器可以由储存器限定结构限定，并且治疗剂可以位于储存器中。覆盖物可以延伸到储存器上方，使得当植入医疗装置时治疗剂从储存器释放。用于制造医疗装置的方法还可以包括提供医疗装置主体，在身体的表面上定位多个储存器限定结构以形成储存器，将治疗剂装载到储存器中并覆盖储存器，使得治疗剂当植入医疗器械时可能释放。或者，储存器可覆盖有形成在盖中的盖和开口，使得治疗剂可以在植入医疗装置时释放。

15. 发明授权

US08620406B2 Medical devices visible by magnetic resonance imaging 有权
标题翻译：磁共振成像可见的医疗器械
公开(公告)号：US08620406B2
公开(公告)日：2013-12-31
申请号：US10763690
申请日：2004-01-23
申请人： Scott R. Smith , Steven E. Walak , Lixiao Wang , Jan Weber , Sheng-Ping Zhong
发明人： Scott R. Smith , Steven E. Walak , Lixiao Wang , Jan Weber , Sheng-Ping Zhong
IPC分类号： A61B5/05
CPC分类号： G01R33/285 , A61B2090/3954 , A61M25/0043 , A61M25/0127 , G01R33/286
摘要： Medical devices that are visible by magnetic resonance imaging (MRI), and optionally, other imaging techniques, are described. In some embodiments, a medical device adapted for insertion into the body includes an elongated shaft and an electrically conductive path extending spirally about a portion of the shaft. The conductive path is capable of being connected to a current source. The medical device can further include one or more contrast agents (such as MRI contrast agents, radiopaque materials, and/or ultrasound visible materials), which can be arranged in a predetermined manner.
摘要翻译：描述了通过磁共振成像（MRI）可视的医疗装置，以及可选的其他成像技术。在一些实施例中，适于插入到本体中的医疗装置包括细长轴和围绕轴的一部分螺旋地延伸的导电路径。导电路径能够连接到电流源。医疗装置还可以包括一种或多种可以以预定方式布置的造影剂（例如MRI造影剂，不透射线材料和/或超声可见材料）。

16. 发明授权

US08586072B2 Medical devices having coatings for controlled therapeutic agent delivery 有权
公开(公告)号：US08586072B2
公开(公告)日：2013-11-19
申请号：US11983796
申请日：2007-11-09
申请人： Jan Weber , Aiden Flanagan , Tim O'Connor , Barry J. O'Brien , John Clarke , David McMorrow
发明人： Jan Weber , Aiden Flanagan , Tim O'Connor , Barry J. O'Brien , John Clarke , David McMorrow
IPC分类号： A61F2/00 , A61L27/30 , A61L31/16 , A61N1/05
CPC分类号： A61F2/06 , A61F2250/0068 , A61L27/30 , A61L27/54 , A61L31/082 , A61L31/16 , A61L2300/00 , A61L2400/12 , A61N1/05
摘要： According to an aspect of the invention, medical devices are provided, which include a nanoparticle-derived inorganic layer disposed over a least a portion of structure that includes a substrate, and optionally, a therapeutic-agent-containing layer disposed over at least a portion of the substrate. In some embodiments, the inorganic layer is a nanoporous inorganic layer. Other aspects of the invention comprise methods for forming such medical device.

17. 发明申请

US20130150957A1 DECALCIFYING HEART VALVE 有权
标题翻译：分解心脏瓣膜
公开(公告)号：US20130150957A1
公开(公告)日：2013-06-13
申请号：US13708292
申请日：2012-12-07
申请人： Jan Weber
发明人： Jan Weber
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61L31/10 , A61L31/145
摘要： Vascular valve systems for treating calcified vascular vessel valves by delivery of one or more calcium chelating agents are described. Methods of making the vascular valve systems are also described.
摘要翻译：描述了通过递送一种或多种钙螯合剂治疗钙化的血管血管瓣膜的血管瓣膜系统。还描述了制造血管瓣膜系统的方法。

18. 发明授权

US08435281B2 Bioerodible, implantable medical devices incorporating supersaturated magnesium alloys 有权
标题翻译：可生物蚀刻的，可植入医疗器械的超饱和镁合金
公开(公告)号：US08435281B2
公开(公告)日：2013-05-07
申请号：US12421928
申请日：2009-04-10
申请人： Jan Weber
发明人： Jan Weber
IPC分类号： A61F2/06
CPC分类号： A61L27/047 , A61L31/022 , A61L31/148
摘要： A bioerodible, implantable medical device that includes a supersaturated magnesium alloy. The magnesium alloy includes magnesium and at least one alloying element present in a concentration in excess of the equilibrium solid solubility concentration of the alloying element in hexagonal close-packed magnesium [at 25° C.].
摘要翻译：包含过饱和镁合金的生物蚀刻可植入医疗器械。镁合金包括镁和至少一种合金元素，其浓度超过六方密堆积镁[25℃]中合金元素的平衡固溶度浓度。

19. 发明授权

US08354120B2 Using bucky paper as a therapeutic aid in medical applications 有权
公开(公告)号：US08354120B2
公开(公告)日：2013-01-15
申请号：US12608534
申请日：2009-10-29
申请人： Jan Weber , Tom Holman , Tracee Eidenschink , John Jianhua Chen
发明人： Jan Weber , Tom Holman , Tracee Eidenschink , John Jianhua Chen
IPC分类号： A61F2/02
CPC分类号： A61K31/01 , A61F2/0077 , A61F2/02 , A61F2/04 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2250/0067 , A61K9/00 , A61K45/06 , A61L27/303 , A61L31/084
摘要： Methods, systems, and uses of bucky paper are provided in the present invention. These embodiments include covering medical implants with single or multiple layers of bucky paper, treating bucky paper with various therapeutics to be released through the bucky paper to a target site, shaping bucky paper into non-conventional configurations for improved therapeutic deliver, and using bucky paper alone or in conjunction with other materials to treat a target site.

20. 发明授权

US08353944B2 Bifurcation delivery system 失效
标题翻译：分岔运送系统
公开(公告)号：US08353944B2
公开(公告)日：2013-01-15
申请号：US11079756
申请日：2005-03-14
申请人： Jan Weber , Karl A. Jagger , Tracee Eidenschink
发明人： Jan Weber , Karl A. Jagger , Tracee Eidenschink
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2/856 , A61F2/954 , A61F2002/30426 , A61F2220/0025 , A61M25/0043 , A61M2025/0058 , A61M2025/1045
摘要： A catheter assembly comprises a catheter shaft having a proximal region a distal region and a rotational seal therebetween. The rotational seal comprises a first component fixedly engaged to the proximal region and a second component fixedly engaged to the distal region. The components engaged in an overlapping arrangement. The rotational seal is actuatable between a non-activated and activated states. In the non-activated state the first component and the second component are separated by a gap which provides for the distal region of the catheter shaft to be rotatable relative to the proximal region. In the activated state at least a portion of the first component and the second component being sealingly engaged together such that distal region is made static relative to the proximal region.
摘要翻译：导管组件包括导管轴，所述导管轴具有近端区域和远端区域之间的旋转密封。旋转密封件包括固定地接合到近侧区域的第一部件和固定地接合到远侧区域的第二部件。组件从事重叠布置。旋转密封可在非激活状态和激活状态之间启动。在非活化状态下，第一部件和第二部件被间隙隔开，该间隙使得导管轴的远侧区域相对于近端区域可旋转。在激活状态下，第一部件和第二部件的至少一部分被密封地接合在一起，使得远侧区域相对于近端区域被制成静止的。

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