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11. 发明授权

US09014423B2 Method and system for catheter tracking in fluoroscopic images using adaptive discriminant learning and measurement fusion 有权
标题翻译：使用自适应判别学习和测量融合的荧光镜图像中导管跟踪的方法和系统
公开(公告)号：US09014423B2
公开(公告)日：2015-04-21
申请号：US13412882
申请日：2012-03-06
申请人： Peng Wang , Yefeng Zheng , Matthias John , Jan Boese , Gareth Funka-Lea , Dorin Comaniciu
发明人： Peng Wang , Yefeng Zheng , Matthias John , Jan Boese , Gareth Funka-Lea , Dorin Comaniciu
IPC分类号： G06K9/00 , A61B6/00 , A61B6/12 , G06T7/20
CPC分类号： A61B6/487 , A61B6/12 , A61B6/503 , G06T7/246 , G06T2207/10016 , G06T2207/10064 , G06T2207/20076 , G06T2207/20081 , G06T2207/30021 , G06T2207/30048
摘要： A method and system for adaptive discriminant learning and measurement fusion for image based catheter tracking is disclosed. An adaptive discriminant model is trained online based on a tracked object, such as a pigtail catheter tip, in at least one previous frame of a fluoroscopic image sequence. The object is tracked in the current frame of the fluoroscopic image sequence based at least on the adaptive discriminant model trained online. The object may be tracked in the current frame based on a fusion of three types of measurement models including the adaptive discriminant model trained online, an object detection model trained offline, and an online appearance model.
摘要翻译：公开了一种用于基于图像的导管跟踪的自适应判别学习和测量融合的方法和系统。在荧光镜像图像序列的至少一个先前帧中，基于跟踪对象（例如尾纤导管尖端）在线训练自适应判别模型。至少基于在线训练的自适应判别模型，在透视图像序列的当前帧中跟踪对象。基于三种类型的测量模型的融合，可以在当前帧中跟踪对象，包括在线训练的自适应判别模型，离线训练的对象检测模型和在线外观模型。

12. 发明授权

US08428319B2 Automatic measurement of morphometric and motion parameters of the coronary tree from a rotational X-ray sequence 有权
标题翻译：从旋转X射线序列自动测量冠状动脉树的形态和运动参数
公开(公告)号：US08428319B2
公开(公告)日：2013-04-23
申请号：US12764225
申请日：2010-04-21
申请人： Yanghai Tsin , Klaus J. Kirchberg , Günter Lauritsch , Chenyang Xu , Jan Boese , Rui Liao
发明人： Yanghai Tsin , Klaus J. Kirchberg , Günter Lauritsch , Chenyang Xu , Jan Boese , Rui Liao
IPC分类号： G06K9/00
CPC分类号： G06T7/251 , G06T7/60 , G06T7/62 , G06T2207/10116 , G06T2207/30101 , G06T2207/30172
摘要： Automatic measurement of morphometric and motion parameters of a coronary target includes extracting reference frames from input data of a coronary target at different phases of a cardiac cycle, extracting a three-dimensional centerline model for each phase of the cardiac cycle based on the references frames and projection matrices of the coronary target, tracking a motion of the coronary target through the phases based on the three-dimensional centerline models, and determining a measurement of morphologic and motion parameters of the coronary target based on the motion.
摘要翻译：自动测量冠状动脉靶标的形态测量和运动参数包括：在心脏周期的不同阶段从冠状动脉靶的输入数据提取参考帧，基于参考帧提取心动周期的每个相位的三维中心线模型，以及冠状动脉靶的投影矩阵，基于三维中心线模型跟踪通过相位的冠状动脉靶的运动，以及基于运动确定冠状动脉靶标的形态和运动参数的测量。

13. 发明授权

US08428221B2 Medical x-ray acquisition system 有权
标题翻译：医疗x射线采集系统
公开(公告)号：US08428221B2
公开(公告)日：2013-04-23
申请号：US12893189
申请日：2010-09-29
申请人： Jan Boese , Michael Maschke
发明人： Jan Boese , Michael Maschke
IPC分类号： H01J35/06 , H05G1/02
CPC分类号： H01J35/065 , A61B6/4007 , A61B6/4028 , A61B6/4441 , A61B6/4458 , A61B6/4464 , A61B6/548 , H01J2235/068
摘要： A medical x-ray acquisition system has an x-ray source and an x-ray detector, the x-ray source having at least one field emission radiator with at least one field emission cathode. The field emission cathode can be formed by a nanostructured material with carbon nanotubes.
摘要翻译：医用x射线摄取系统具有x射线源和x射线检测器，该x射线源具有至少一个具有至少一个场发射阴极的场发射辐射器。场发射阴极可以由具有碳纳米管的纳米结构材料形成。

14. 发明申请

US20120296202A1 Method and System for Registration of Ultrasound and Physiological Models to X-ray Fluoroscopic Images 有权
标题翻译：超声和生理模型注射X射线荧光镜图像的方法和系统
公开(公告)号：US20120296202A1
公开(公告)日：2012-11-22
申请号：US13475048
申请日：2012-05-18
申请人： Peter Mountney , Markus Kaiser , Ingmar Voigt , Matthias John , Razvan Ioan Ionasec , Jan Boese , Dorin Comaniciu
发明人： Peter Mountney , Markus Kaiser , Ingmar Voigt , Matthias John , Razvan Ioan Ionasec , Jan Boese , Dorin Comaniciu
IPC分类号： A61B6/02 , A61B8/12
CPC分类号： A61B6/12 , A61B6/4417 , A61B6/4441 , A61B6/487 , A61B6/503 , A61B6/5247 , A61B8/0841 , A61B8/0883 , A61B8/12 , A61B8/4245 , A61B8/4416 , A61B8/5261
摘要： A method and system for registering ultrasound images and physiological models to x-ray fluoroscopy images is disclosed. A fluoroscopic image and an ultrasound image, such as a Transesophageal Echocardiography (TEE) image, are received. A 2D location of an ultrasound probe is detected in the fluoroscopic image. A 3D pose of the ultrasound probe is estimated based on the detected 2D location of the ultrasound probe in the fluoroscopic image. The ultrasound image is mapped to a 3D coordinate system of a fluoroscopic image acquisition device used to acquire the fluoroscopic image based on the estimated 3D pose of the ultrasound probe. The ultrasound image can then be projected into the fluoroscopic image using a projection matrix associated with the fluoroscopic image. A patient specific physiological model can be detected in the ultrasound image and projected into the fluoroscopic image.
摘要翻译：公开了一种用于将超声图像和生理模型记录到X射线透视图像的方法和系统。接收透视图像和超声图像，如经食道超声心动图（TEE）图像。在透视图像中检测超声探头的2D位置。基于在荧光镜图像中检测到的超声波探头的2D位置来估计超声探头的3D姿态。超声图像被映射到用于根据超声探头的估计3D姿势获取荧光镜图像的荧光镜图像采集装置的3D坐标系。然后可以使用与透视图像相关联的投影矩阵将超声图像投影到透视图像中。可以在超声图像中检测患者特异性生理模型并将其投影到透视图像中。

15. 发明申请

US20120123250A1 Method and System for Pigtail Catheter Motion Prediction 有权
标题翻译：猪尾导管运动预测方法与系统
公开(公告)号：US20120123250A1
公开(公告)日：2012-05-17
申请号：US13297373
申请日：2011-11-16
申请人： Yu Pang , Yefeng Zheng , Matthias John , Jan Boese , Dorin Comaniciu
发明人： Yu Pang , Yefeng Zheng , Matthias John , Jan Boese , Dorin Comaniciu
IPC分类号： A61B6/00
CPC分类号： A61B6/487 , A61B6/12 , A61B6/5264 , G06T7/246 , G06T7/277 , G06T2207/10121 , G06T2207/30021
摘要： A method and system for autoregressive model based pigtail catheter motion prediction in a fluoroscopic image sequence is disclosed. Parameters of an autoregressive model are estimated based on observed pigtail catheter tip positions in a plurality of previous frames of a fluoroscopic image sequence. A pigtail catheter tip position in a current frame of the fluoroscopic image sequence is predicted using the fitted autoregressive model. The predicted pigtail catheter tip position can be used to constrain pigtail catheter tip detection in the current frame. The predicted pigtail catheter tip position may also be used to predict abnormal motion in the fluoroscopic image sequence.
摘要翻译：公开了一种在透视图像序列中基于自回归模型的尾纤导管运动预测的方法和系统。基于在透视图像序列的多个先前帧中的观察到的尾纤导管尖端位置来估计自回归模型的参数。使用拟合的自回归模型预测荧光镜图像序列的当前帧中的尾纤导管尖端位置。预测的猪尾导管尖端位置可用于限制当前帧中的尾纤导管尖端检测。预测的猪尾导管尖端位置也可以用于预测荧光镜像图像序列中的异常运动。

16. 发明授权

US08050483B2 Method for image registration processes and X-ray angiography system 有权
标题翻译：图像配准过程和X射线血管造影系统的方法
公开(公告)号：US08050483B2
公开(公告)日：2011-11-01
申请号：US12070484
申请日：2008-02-19
申请人： Jan Boese , Jörn Justiz , Andreas Meyer , Marcus Pfister
发明人： Jan Boese , Jörn Justiz , Andreas Meyer , Marcus Pfister
IPC分类号： G06K9/00
CPC分类号： G06T7/38 , A61B2090/364 , G06T2207/10072 , G06T2207/10081 , G06T2207/10088 , G06T2207/30004 , G06T2207/30012 , G06T2207/30048
摘要： Registration of preoperatively acquired MRI images of soft parts to intraoperatively acquired X-ray images of soft parts is not possible. The invention shows a way of nevertheless using such preoperatively acquired images for superimposition with 2D projections of the soft parts, taking an indirect route via 3D/3D registration of images of the spinal column. For this purpose, 3D image data sets of the spinal column must be obtained separately on the one hand using MRI and on the other using the X-ray imaging system so that the 3D/3D registration produces a mapping rule which then also applies to the preoperatively acquired images of the soft part if the soft part images and the spinal images are acquired without intervening change in the patient position in the MRI scanner.
摘要翻译：将软件部分术前获取的MRI图像注册到软组件的术中获得的X射线图像是不可能的。本发明示出了一种使用这种预先获取的图像与软部件的2D投影叠加的方式，通过经脊柱的图像的3D / 3D对准进行间接路线。为此，必须使用MRI单独获得脊柱的3D图像数据集，另一方面必须使用X射线成像系统获得脊柱的3D图像数据集，使得3D / 3D注册产生映射规则，其然后也适用于如果获取软部分图像和脊柱图像而不在MRI扫描仪中的患者位置的中间改变，则在术前获取软部分的图像。

17. 发明授权

US08023616B2 Method and apparatus for setting a dynamically adjustable position of an imaging system 有权
标题翻译：用于设置成像系统的动态可调位置的方法和装置
公开(公告)号：US08023616B2
公开(公告)日：2011-09-20
申请号：US12501539
申请日：2009-07-13
申请人： Jan Boese
发明人： Jan Boese
IPC分类号： G01N23/00 , H05G1/62
CPC分类号： A61B6/504 , A61B6/4441
摘要： The invention relates to a method and an apparatus for setting a dynamically adjustable position of an imaging system for providing an optimum view onto a moving object during a medical intervention. A time-resolved at least three-dimensional data record of the moving object is generated. A position of the imaging system for each period of time is determined from the time-resolved data record from which the optimum view onto a structure of interest of the moving object is produced and automatically setting a calculated position of the imaging system in real-time so that the optimum view onto the structure of interest can be shown at any time. Optionally prior to determining the position of the imaging system, a structure of interest of the moving object can be segmented with this structure being segmented for each period of time from the time-resolved data record.
摘要翻译：本发明涉及一种用于设置成像系统的动态可调节位置以在医疗介入期间向运动物体提供最佳视野的方法和装置。生成移动对象的时间分辨的至少三维数据记录。从时间分辨数据记录确定成像系统的每个时间段的位置，从该时间分辨数据记录生成关于移动物体的感兴趣结构的最佳视图，并且自动地将计算出的成像系统的位置实时地设置从而可以随时显示关注结构的最佳视图。可选择地，在确定成像系统的位置之前，可以将该结构从时间分辨数据记录分割为每段时间段来分割移动对象的感兴趣结构。

18. 发明申请

US20110085637A1 Reconstruction of 3D image datasets from x-ray and cone-beam data 有权
标题翻译：从X射线和锥束数据重建3D图像数据集
公开(公告)号：US20110085637A1
公开(公告)日：2011-04-14
申请号：US12902237
申请日：2010-10-12
申请人： Jan Boese , Frank Dennerlein , Holger Kunze
发明人： Jan Boese , Frank Dennerlein , Holger Kunze
IPC分类号： A61B6/03 , G06T17/00
CPC分类号： G06T11/006 , A61B6/027
摘要： A method for producing a 3D image dataset of an object with an imaging system having an x-ray source and an x-ray detector is provided. A series of two-dimensional arrays of cone beam data from the detector is acquired while the source moves along a substantially planar trajectory around the object. The trajectory is described by a series of source points serially numbered by a counter parameter. The cone beam data is differentiated with respect to the counter parameter at a fixed ray direction to produce a derivative of the cone beam data. The derivative is filtered with a Hilbert-like filter to produce filtered cone beam data. The acquired or the filtered cone beam data is multiplied with a redundancy weighting function. The cone beam data is back-projected to reconstruct a 3D image dataset.
摘要翻译：提供了一种使用具有X射线源和X射线检测器的成像系统来生成物体的3D图像数据集的方法。来自检测器的一系列锥形束数据的二维阵列被获取，同时源沿着物体周围的基本上平面的轨迹移动。轨迹由一系列通过计数器参数串行编号的源点描述。锥形束数据在固定的射线方向上相对于计数器参数微分，以产生锥形束数据的导数。用希尔伯特滤波器滤波导数，以产生滤波的锥束数据。所获取的或经滤波的锥束数据与冗余加权函数相乘。锥形束数据被反投影以重建3D图像数据集。

19. 发明申请

US20110075798A1 Method for correcting truncated projection data 有权
标题翻译：用于校正截断的投影数据的方法
公开(公告)号：US20110075798A1
公开(公告)日：2011-03-31
申请号：US12891849
申请日：2010-09-28
申请人： Jan Boese , Klaus Klingenbeck
发明人： Jan Boese , Klaus Klingenbeck
IPC分类号： G06K9/00 , A61B6/03
CPC分类号： A61B6/5241 , A61B6/032 , A61B6/4441 , A61B6/4458 , G06T11/005 , G06T2211/432
摘要： A method for correcting truncated projection data of a rotation for a reconstruction technique for computed tomography scans with truncated projection data in the computed tomography images produced by a C-arm is proposed. At least one truncated projection is recorded. The truncated portions prior to acquisition of the rotation for the at least one truncated projection is captured. The truncated projection and the truncated portions are assembled into at least one complete projection. Truncated projection data is acquired during the rotation. The truncated data is estimated based on a model of the patient geometry from the at least one complete projection. A reconstruction technique is performed on the basis of the acquired and the estimated data.
摘要翻译：提出了一种通过C臂产生的计算机断层图像中的截断的投影数据来校正用于计算机断层摄影扫描的重建技术的旋转的截断投影数据的方法。至少记录一个截断的投影。捕获用于至少一个截断投影的旋转获取之前的截断部分。截头突起和截头部分组装成至少一个完整的突起。截断的投影数据在旋转期间获取。基于来自至少一个完整投影的患者几何形状的模型来估计截断的数据。基于获取的和估计的数据执行重建技术。

20. 发明申请

US20110046725A1 METHOD OF IMAGING FOR HEART VALVE IMPLANT PROCEDURE 失效
标题翻译：心瓣植入手术成像方法
公开(公告)号：US20110046725A1
公开(公告)日：2011-02-24
申请号：US12545435
申请日：2009-08-21
申请人： Alois Noettling , Jan Boese , Matthias John , Volkmar Falk , Thomas Walther
发明人： Alois Noettling , Jan Boese , Matthias John , Volkmar Falk , Thomas Walther
IPC分类号： A61F2/24 , A61B6/03 , A61B6/00 , G01N23/04 , H05G1/60 , G06K9/00 , G09G5/00
CPC分类号： A61B6/032 , A61B6/503 , A61B8/0883 , A61F2/24
摘要： A method as a workflow for imaging for a heart valve implant procedure includes positioning the patient and an articulated imaging apparatus relative to one another, inducing rapid ventricular pacing in the patient, and imaging a region of the patient's heart to obtain image date for a three-dimensional image. The three-dimensional data is used to construct a three-dimensional image of the region of the patient's heart an the three-dimensional image is displayed for use in the implanting of the replacement heart valve. Optional steps may include obtaining a real time two-dimensional image of the patient's heart and superimposing the real time two-dimensional image with the constructed three dimensional image. The replacement valve is moved into position in the patient's heart during rapid ventricular pacing and breath hold using the superimposed two-dimensional and three-dimensional image information.
摘要翻译：作为用于心脏瓣膜植入程序的成像工作流程的方法包括相对于彼此定位患者和关节成像装置，在患者体内引起快速心室起搏，以及对患者心脏的区域进行成像以获得三维图像的图像日期维度图像。三维数据用于构建患者心脏区域的三维图像，显示三维图像以用于置换心脏瓣膜的植入。可选步骤可以包括获得患者心脏的实时二维图像，并且用构建的三维图像叠加实时二维图像。使用重叠的二维和三维图像信息，在快速心室起搏和呼吸保持期间将置换瓣膜移动到患者心脏中的位置。

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