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11. 发明申请

US20070087032A1 Composition of cartilage therapeutic agents and its application 审中-公开
标题翻译：软骨治疗剂的组成及其应用
公开(公告)号：US20070087032A1
公开(公告)日：2007-04-19
申请号：US10578719
申请日：2004-12-07
申请人： Cheong-Ho Chang , Chang-Kwon Ko , Jae-Deog Jang , Eun-Young Lee , Jeong-Yong Choi
发明人： Cheong-Ho Chang , Chang-Kwon Ko , Jae-Deog Jang , Eun-Young Lee , Jeong-Yong Choi
IPC分类号： A61F2/00
CPC分类号： A61K35/32 , A61F2/30756 , A61K35/36 , A61K35/39 , A61L27/225 , A61L27/3817 , A61L27/3852 , A61L27/3895 , A61K2300/00
摘要： A cartilage therapeutic composition is developed for clinical transplantation into articulatio genu (knee joints) or ankle joints. It has clinical significance for symptomatic cartilage defects of the femoral condyle (medial, lateral, or trochlear) and bone cartilage defects of the talus (anklebone) in human or animal hosts, The cartilage therapeutic composition comprises a mixture of components of chondrocytes isolated and expanded or differentiated from a host such as a human or animal, and thrombin and a fibrinogen matrix containing fibrinogen. An application of the cartilage therapeutic composition is that a mixture of thrombin, chondrocyte components and a fibrinogen matrix is injected into a cartilage defect region followed by solidification therein. It provides rapid healing and effective regeneration of cartilage without surgical operation. It has the merits of safety and simplicity by allowing the use of an arthroscope for transplantation.
摘要翻译：软骨治疗组合物被开发用于临床移植到关节（膝关节）或踝关节。对于人或动物宿主中的距骨（踝骨）的股骨髁（内侧，外侧或滑车）和骨软骨缺损的症状性软骨缺损具有临床意义。软骨治疗组合物包含分离和扩大的软骨细胞成分的混合物或与宿主如人或动物分化，以及含有纤维蛋白原的凝血酶和纤维蛋白原基质。软骨治疗组合物的应用是将凝血酶，软骨细胞成分和纤维蛋白原基质的混合物注射到软骨缺损区域中，随后在其中固化。它可以快速愈合，有效地再生软骨，无需外科手术。通过允许使用关节镜进行移植，具有安全和简单的优点。

12. 发明申请

US20090254065A1 Simple method of transplanting injectable chordrocyte for autologous chondrocyte transplantation 审中-公开
标题翻译：移植注射性软骨细胞用于自体软骨细胞移植的简单方法
公开(公告)号：US20090254065A1
公开(公告)日：2009-10-08
申请号：US11988924
申请日：2005-09-23
申请人： Chang-Kwon Ko , Eun-Young Lee , Jeong-Yong Choi , Jae-Deog Jang , Cheong-Ho Chang , Pyoung-Min Kim
发明人： Chang-Kwon Ko , Eun-Young Lee , Jeong-Yong Choi , Jae-Deog Jang , Cheong-Ho Chang , Pyoung-Min Kim
IPC分类号： A61M37/00
CPC分类号： A61K38/363 , A61K38/39 , A61L27/3817 , A61L27/3852 , A61L27/50 , A61L2430/06 , A61K2300/00
摘要： A method of transplanting an injectable chondrocyte is developed for autologous chondrocyte transplantation, comprising mixing matrices including fibrin, hyaluronic acid and collagen, which are the main ingredients of animal cartilage, and injecting the resulting mixture into a damaged cartilage region. One 1 ml syringe is prepared by mixing 1 ml of a chondrocyte culture with white or light-yellow lyophilized powder (fibrinogen). A second 1 ml syringe is prepared by mixing 1 ml of chondrocyte culture with white lyophilized powder (thrombin), adding 0.1 cc of that mixture to the entire contents of two vials containing chondrocyte suspension, and mixing well. The two syringes are then mounted on a syringe stand, and a mixing tip is mounted to their tips. The contents are mixed in the mixing tip while injecting the resulting mixture into a damaged cartilage region of an animal.
摘要翻译：开发了用于自体软骨细胞移植的移植注射软骨细胞的方法，包括混合作为动物软骨的主要成分的纤维蛋白，透明质酸和胶原的基质，并将所得混合物注入损伤的软骨区域。通过将1ml软骨细胞培养物与白色或浅黄色冻干粉末（纤维蛋白原）混合来制备1ml注射器。通过将1ml软骨细胞培养物与白色冻干粉末（凝血酶）混合，将0.1cc该混合物加入到含有软骨细胞悬液的两个小瓶的全部内容物中并混合，制备第二个1ml注射器。然后将两个注射器安装在注射器支架上，并将混合头安装到其尖端。将内容物混合在混合尖端中，同时将所得混合物注入动物的损伤的软骨区域。

13. 发明申请

US20100034783A1 Medical kit and using method thereof 审中-公开
标题翻译：医疗套件及其使用方法
公开(公告)号：US20100034783A1
公开(公告)日：2010-02-11
申请号：US12311783
申请日：2006-11-03
申请人： Hyun-Mi Son , Cheong-Ho Chang , Jae-Deog Jang
发明人： Hyun-Mi Son , Cheong-Ho Chang , Jae-Deog Jang
IPC分类号： A61K35/12 , A61B10/00 , B65D81/18 , B65B7/28 , A61B5/15 , C12N5/02 , A01N1/02
CPC分类号： A61L27/3847 , A61F2/28 , A61F2/30756 , A61L27/3817 , A61L27/3821 , A61L27/3834 , A61L27/3852
摘要： An aseptic/sterile medical kits are comprising a cartilage regeneration kit, a bone regeneration kit or an umbilical cord blood storage kit in a configuration that each process performs according to functionally-specialized kit sets for each step, via division of overall processes into corresponding steps for isolation, culture, collection and storage of cells, and implantation of desired cells into target sites of the body. The cartilage is regenerated by cartilage tissue collection; chondrocyte isolation; chondrocyte medium change and subculture; preparation of chondrocyte therapy product; media for isolation/culture/preparation/cryopreservation of cells; and media for isolation/culture/cryopreservation of cells, using the cartilage regeneration kit. The bone is regenerated by bone marrow collection; osteoblast isolation; osteoblast medium change and subculture; and preparation of osteoblast therapy product, using the bone regeneration kit. Additionally, the umbilical cord blood is stored by umbilical cord blood collection; hematopoietic stem cell isolation; and cryopreservation of hematopoietic stem cells, using the umbilical cord blood storage kit.
摘要翻译：无菌/无菌医疗试剂盒包括软骨再生试剂盒，骨再生试剂盒或脐带血液存储试剂盒，其配置为每个过程根据功能上专门用于每一步骤的试剂盒进行，通过将整个过程分为对应步骤用于细胞的分离，培养，收集和储存，以及将期望的细胞植入人体的靶位点。软骨通过软骨组织收集再生; 软骨细胞分离; 软骨细胞培养基变化和亚文化; 软骨细胞治疗产品的制备; 介质用于分离/培养/制备/冷冻保存细胞; 和培养基用于细胞的分离/培养/冷冻保存，使用软骨再生试剂盒。骨骼通过骨髓采集再生; 成骨细胞分离; 成骨细胞介质变化和亚文化; 并使用骨再生试剂盒制备成骨细胞治疗产品。另外，脐带血通过脐带血采集储存; 造血干细胞分离; 并使用脐带血液储存试剂盒对造血干细胞进行冷冻保存。

14. 发明申请

US20090099548A1 Device for Regenerating Adipose Tissue and Method for Utilizing Thereof 审中-公开
标题翻译：用于再生脂肪组织的装置及其使用方法
公开(公告)号：US20090099548A1
公开(公告)日：2009-04-16
申请号：US12224738
申请日：2006-03-15
申请人： Hyun-Mi Son , Jae-Deog Jang , Cheong-Ho Chang
发明人： Hyun-Mi Son , Jae-Deog Jang , Cheong-Ho Chang
IPC分类号： A61K35/12 , A61M5/31
CPC分类号： A61K35/35 , A61B50/31 , A61B2050/3008 , A61B2050/3011 , A61M39/10
摘要： A device and method for regenerating adipose tissue has developed comprising: a washing container filled with an sterile solution for washing the adipose tissues; a syringe container holding syringes for washing and separating adipose tissues; injecting the wash solution and mixing the Bio-Gel, respectively; a second syringe container containing Bio-Gel syringes filled with materials to induce adipogenesis; and connector containers holding connectors for injection of the wash solution, and mixing of washed tissues and Bio-Gel. These containers are restrained in the kit by grooves in the bottom of the box. The box top holds needle containers for transplantation needles; and a protocol for fat transplantation, restrained by grooves. The kit minimizes risk of infection in fat transplantations using the patient's own tissues. It enables stable tissue transplantation as well as adipose tissue regeneration via use of aseptic/sterile implements, and a protocol for fat transplantation, solving the problems associated with conventional adipose tissue transplantation.
摘要翻译：开发了用于再生脂肪组织的装置和方法，其包括：填充有用于洗涤脂肪组织的无菌溶液的洗涤容器; 注射器容器，其容纳用于洗涤和分离脂肪组织的注射器; 注入洗涤溶液并分别混合Bio-Gel; 包含填充有诱导脂肪形成的材料的生物凝胶注射器的第二注射器容器; 和用于注入洗涤溶液的连接器的连接器容器，以及洗涤的组织和Bio-Gel的混合。这些容器通过盒底部的槽限制在套件中。盒顶装有移植针针头容器; 和脂肪移植方案，由槽限制。该套件使用患者自己的组织将脂肪移植中的感染风险降至最低。它通过使用无菌/无菌器具实现稳定的组织移植和脂肪组织再生，以及用于脂肪移植的方案，解决与常规脂肪组织移植相关的问题。

15. 发明申请

US20110111032A1 MANUFACTURING METHOD OF COLLAGEN GEL COMPOSITION FOR BONE REGENERATION 审中-公开
标题翻译：用于骨再生的胶原凝胶组合物的制备方法
公开(公告)号：US20110111032A1
公开(公告)日：2011-05-12
申请号：US13003157
申请日：2008-07-23
申请人： Jae-Deog Jang , Hun Kim , Ji-Chul Yu , Se-Geun Yeo , Tae-Hyoung Kim , Hyun-Shin Park , Seon-Ae Kim , Jang-Hoon Kim , Seong-Soo Kim
发明人： Jae-Deog Jang , Hun Kim , Ji-Chul Yu , Se-Geun Yeo , Tae-Hyoung Kim , Hyun-Shin Park , Seon-Ae Kim , Jang-Hoon Kim , Seong-Soo Kim
IPC分类号： A61K9/14 , A61K35/12 , A61P19/00
CPC分类号： A61L27/24 , A61L27/12 , A61L27/3804 , A61L27/3847 , A61L27/46 , A61L27/52 , A61L27/56
摘要： Disclosed herein is a method for preparing a collagen gel composition for bone regeneration comprising collecting bone marrow from animal tissues and isolating nucleated cells from the bone marrow; and mixing the nucleated cells and a bio-matrix composed of type I collagen and apatite.
摘要翻译：本文公开了一种制备用于骨再生的胶原凝胶组合物的方法，包括从动物组织收集骨髓并从骨髓中分离有核细胞; 并将有核细胞和由I型胶原和磷灰石组成的生物基质混合。

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