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11. 发明申请

US20060193800A1 Variable tint cosmetics 审中-公开
标题翻译：变色调化妆品
公开(公告)号：US20060193800A1
公开(公告)日：2006-08-31
申请号：US11340297
申请日：2006-01-26
申请人： John Reinhardt , John Hill , Michele Ward , J. Brown
发明人： John Reinhardt , John Hill , Michele Ward , J. Brown
IPC分类号： A61K8/02 , A61K8/97
CPC分类号： A61Q1/02 , A61K8/0241 , A61K8/11 , A61K8/31 , A61K8/37 , A61K8/8111 , A61K8/922 , A61K8/97 , A61K2800/31 , A61K2800/412 , A61K2800/43 , A61Q1/12
摘要： The disclosed systems and methods for delivery of variable tint pigment materials in cosmetic concealer/foundation products generally include anhydrous carrier particles adapted to carry pigment. The pigmentation carrier particles may be optionally admixed with anhydrous (optionally tinted) base formulation material that is suitably adapted to suspend and/or separate the pigmentation carrier particles. Disclosed features and specifications may be variously controlled, adapted or otherwise modified to realize improved site-specific delivery of pigment in customized concentrations in order to achieve a desired result. Exemplary embodiments of the present invention generally provide anhydrous pigmentation carrier particles that may be mixed with substantially anhydrous topical base formulations that allow a user to deliver a selected concentration of concealer/foundation tint to a specific region of the skin, for example, in order to obscure a blemish.
摘要翻译：用于在化妆品遮瑕膏/粉底产品中递送可变色素材料的所公开的系统和方法通常包括适于承载颜料的无水载体颗粒。色素载体颗粒可以任选地与适当地适于悬浮和/或分离着色载体颗粒的无水（任选着色的）基础制剂材料混合。公开的特征和规格可以被不同地控制，适应或以其他方式修饰，以实现改变的定制浓度的颜料的位置特异性递送，以获得期望的结果。本发明的示例性实施方案通常提供可与基本上无水的局部基础制剂混合的无水色素沉淀载体颗粒，其允许使用者将选定浓度的遮瑕膏/基质着色剂递送至皮肤的特定区域，以便晦涩难懂

12. 发明申请

US20050202384A1 Interactive computer model of the heart 审中-公开
标题翻译：交互式电脑模型的心脏
公开(公告)号：US20050202384A1
公开(公告)日：2005-09-15
申请号：US11122665
申请日：2005-05-05
申请人： Michael DiCuccio , Richard Cunningham , Gregory Merril , J. Brown , Hugh Connacher , Philip Feldman , Joseph Tasto
发明人： Michael DiCuccio , Richard Cunningham , Gregory Merril , J. Brown , Hugh Connacher , Philip Feldman , Joseph Tasto
IPC分类号： G09B23/28
CPC分类号： G09B23/285
摘要： A surgical simulator comprises a display of a graphical surgical instrument, a user manipulatable object, a sensor to detect a manipulation of the object, the sensor providing a signal to the simulator to control the graphical image, and a model of a heart, the model comprising a model of the electrical activity of the heart.
摘要翻译：手术模拟器包括图形外科器械的显示器，用户可操纵物体，用于检测物体的操纵的传感器，传感器向模拟器提供信号以控制图形图像，以及心脏模型，模型包括心脏的电活动的模型。

13. 发明申请

US20050153961A1 1, 2, 4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents 审中-公开
标题翻译： 1,2,4-苯并三嗪氧化物作为放射增敏剂和选择性细胞毒性剂
公开(公告)号：US20050153961A1
公开(公告)日：2005-07-14
申请号：US11003809
申请日：2004-12-03
申请人： William Lee , J. Brown , Edward Grange , Abelardo Martinez , Michael Tracy , Daniel Pollart
发明人： William Lee , J. Brown , Edward Grange , Abelardo Martinez , Michael Tracy , Daniel Pollart
IPC分类号： A61K31/53 , A61K31/5377 , A61K41/00 , C07D253/10
CPC分类号： A61K31/53 , A61K31/5377 , A61K41/0038 , C07D253/10
摘要： A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed to be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4-benzotriazine oxides is also disclosed.
摘要翻译：公开了使用其中一些是新化合物的1,2,4-苯并三嗪氧化物作为放射增敏剂和选择性细胞毒性剂的方法。这些化合物显示出对缺氧性肿瘤细胞的特异性放射增敏作用。还公开了一些可用作这些细胞的特异性细胞毒性剂。它们还显示了在细胞与药物的缺氧孵育之后或之前对需氧细胞进行放射增敏的突发能力。与正常细胞相比，这为肿瘤的选择性放射增敏提供了依据。还公开了一种制备1,2,4-苯并三嗪氧化物的新方法。

14. 发明申请

US20070191372A1 Dna-targeted benzotriazine 1,4-dioxides and their use in cancer therapy 审中-公开
标题翻译： Dna靶向的苯并三嗪1,4-二氧化物及其在癌症治疗中的应用
公开(公告)号：US20070191372A1
公开(公告)日：2007-08-16
申请号：US10528156
申请日：2003-09-17
申请人： J. Brown , William Denny , Michael Hay , Kevin Hicks , Swarnalatha Gamage , Frederik Pruijn , William Wilson
发明人： J. Brown , William Denny , Michael Hay , Kevin Hicks , Swarnalatha Gamage , Frederik Pruijn , William Wilson
IPC分类号： A61K31/53
CPC分类号： C07D253/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The present invention relates to DNA-targeted 1,2,4-benzotriazine-1,4-dioxides and related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.
摘要翻译：本发明涉及DNA靶向的1,2,4-苯并三嗪-1,4-二氧化物及其相关类似物及其制备方法，以及它们作为用于癌症治疗的缺氧选择性药物和放射增敏剂的用途，其单独或与辐射和/或其他抗癌药物。

15. 发明申请

US20060188533A1 Delivery of bio-available compounds with anhydrous topical preparations 审中-公开
标题翻译：用无水局部制剂递送生物可用化合物
公开(公告)号：US20060188533A1
公开(公告)日：2006-08-24
申请号：US11340043
申请日：2006-01-26
申请人： J. Brown , John Hill , J. Tryon , Michele Ward
发明人： J. Brown , John Hill , J. Tryon , Michele Ward
IPC分类号： A61K36/18 , A61K8/02
CPC分类号： A61K8/02 , A61K8/676 , A61K8/922 , A61K36/00 , A61K2800/242 , A61K2800/31 , A61Q19/00 , A61K2300/00
摘要： The disclosed systems and methods for delivery of bio-available compounds in topical preparations generally include anhydrous carrier particles adapted to carry bio-available compounds. The carrier particles may be admixed with anhydrous formulation material that is suitably adapted to suspend and/or separate the carrier particles. Disclosed features and specifications may be variously controlled, adapted or otherwise optionally modified to realize improved production and/or use of carrier particles that may be employed to deliver bio-available compounds in order to achieve a desired purpose. Exemplary embodiments of the present invention generally provide anhydrous carrier particles that may be mixed with substantially anhydrous topical preparations.
摘要翻译：用于在局部制剂中递送生物可利用化合物的所公开的系统和方法通常包括适于携带生物可利用化合物的无水载体颗粒。载体颗粒可以与适于适于悬浮和/或分离载体颗粒的无水配方材料混合。公开的特征和规格可以被不同地控制，适应或以其他方式任意地修改以实现可用于递送生物可利用化合物以实现期望目的的载体颗粒的改进的生产和/或使用。本发明的示例性实施方案通常提供可与基本上无水的局部制剂混合的无水载体颗粒。

16. 发明申请

US20060161045A1 System and method for controlling force applied to and manipulation of medical instruments 有权
标题翻译：用于控制施加和操纵医疗器械的力的系统和方法
公开(公告)号：US20060161045A1
公开(公告)日：2006-07-20
申请号：US11262321
申请日：2005-10-27
申请人： Gregory Merril , Richard Cunningham , J. Brown , Robert Cohen , Philip Feldman
发明人： Gregory Merril , Richard Cunningham , J. Brown , Robert Cohen , Philip Feldman
IPC分类号： A61B1/00
CPC分类号： A61B17/3421 , A61B1/018 , A61B17/29 , A61B17/320068 , A61B17/3417 , A61B34/70 , A61B34/76 , A61B90/03 , A61B2017/003 , A61B2034/2059 , A61B2090/064 , A61B2090/065 , A61M2025/0008
摘要： Apparatus for controlling force applied to and for manipulation of a surgical instrument. Movement and/or forces applied to the surgical instrument are preferably sensed within the apparatus. An actuator is preferably used to apply force to the surgical instrument for control and manipulation of the instrument. The apparatus applies variable force feedback to apply force to the surgical instrument in one or more degrees of freedom to provide an enhanced haptic experience to the user.
摘要翻译：用于控制施加于外科器械并用于操纵外科器械的力的装置。优选地在装置内感测施加到手术器械的运动和/或力。优选地，致动器用于向外科器械施加力以控制和操纵器械。该装置以一个或多个自由度施加可变力反馈以向外科器械施加力，以向使用者提供增强的触觉体验。

17. 发明申请

US20070156079A1 Glaucoma Treatment Devices and Methods 审中-公开
标题翻译：青光眼治疗装置及方法
公开(公告)号：US20070156079A1
公开(公告)日：2007-07-05
申请号：US11531965
申请日：2006-09-14
申请人： J. Brown
发明人： J. Brown
IPC分类号： A61M5/00
CPC分类号： A61F9/00781 , A61B3/16 , B82Y30/00
摘要： This document provides methods and materials related to treating glaucoma. For example, devices that can be implanted into a human's eye to treat glaucoma, methods for treating glaucoma, compositions for reducing polypeptide clogging of implanted devices, and methods for making devices for treating glaucoma are provided.
摘要翻译：本文件提供治疗青光眼的方法和材料。例如，提供了可以植入人眼以治疗青光眼的装置，用于治疗青光眼的方法，用于减少植入装置的多肽堵塞的组合物，以及用于制备用于治疗青光眼的装置的方法。

18. 发明申请

US20070102155A1 Propped Fracture with High Effective Surface Area 有权
标题翻译：支撑有效表面积的断裂
公开(公告)号：US20070102155A1
公开(公告)日：2007-05-10
申请号：US11565123
申请日：2006-11-30
申请人： Keng Chan , J. Brown , Arthur Milne , Brett Rimmer , Mark Brady
发明人： Keng Chan , J. Brown , Arthur Milne , Brett Rimmer , Mark Brady
IPC分类号： E21B43/267 , E21B43/27
CPC分类号： C09K8/72 , C09K8/80 , E21B43/267 , Y10S507/923 , Y10S507/933 , Y10S507/934
摘要： Propped fractures in formations from which fluids are produced are described that have wormholes extending out into the formations from the faces of the fractures at locations distant from boreholes. Methods are given for creating such propped fractures having wormholes in which either a closed propped fracture is formed and then the wormholes are formed, or the entire fracture and channel system is formed before the closure occurs.
摘要翻译：描述了产生流体的地层中的支撑的裂缝，其具有从远离钻孔的位置处的裂缝的表面延伸到地层中的虫洞。给出了创建具有蠕虫洞的这种支撑裂缝的方法，其中形成闭合的支撑断裂，然后形成虫洞，或者在闭合发生之前形成整个断裂和通道系统。

19. 发明申请

US20070078371A1 Bypass for glaucoma drainage device 审中-公开
标题翻译：旁路青光眼引流装置
公开(公告)号：US20070078371A1
公开(公告)日：2007-04-05
申请号：US11633916
申请日：2006-12-05
申请人： J. Brown , Tingrui Pan , Babak Ziaie
发明人： J. Brown , Tingrui Pan , Babak Ziaie
IPC分类号： A61M5/00
CPC分类号： A61M27/002 , A61F9/00781 , A61M5/141
摘要： Aqueous humor flow control for managing intraocular pressure in an eye. Excessive pressure due to formation of a fibrous capsule and valve resistance is relieved by bypassing the valve element or by providing a secondary discharge port. Removal of resistance is enabled by physical manipulation, external stimulus, chemical action or biological action. A resistor inserted in an intake conduit provides a predetermined resistance to flow and thus, a desired intraocular pressure.
摘要翻译：用于管理眼中眼内压的水性幽默流量控制。由于形成纤维胶囊而导致的过大压力和阀门阻力通过绕过阀元件或通过提供二次排出口来释放。通过物理操纵，外部刺激，化学作用或生物作用可以消除抵抗力。插入进气管道中的电阻器提供预定的流动阻力，从而提供所需的眼内压。

20. 发明申请

US20060276739A1 Glaucoma treatment device and method 审中-公开
标题翻译：青光眼治疗装置及方法
公开(公告)号：US20060276739A1
公开(公告)日：2006-12-07
申请号：US11311444
申请日：2005-12-19
申请人： J. Brown
发明人： J. Brown
IPC分类号： A61M5/00
CPC分类号： A61F9/00781
摘要： A device for treating glaucoma in an eye is described. The device includes a body defining a lumen and having first and second ends and external and lumenal surfaces, wherein the body has a length sufficient to provide fluid communication between the anterior chamber and tear film of the eye through the lumen when the device is implanted in the sclera. The device further includes a filter membrane capable of providing outflow resistance to aqueous humor flowing through the lumen. The device further includes a debris filter positioned either at the first end or between the first end and the filter providing outflow resistance. Methods of treating glaucoma wherein the device is implanted in the sclera of an afflicted eye are also described.
摘要翻译：描述了用于治疗眼睛中的青光眼的装置。该装置包括限定内腔并具有第一和第二端以及外部和内腔表面的主体，其中，当所述装置被植入时，所述主体具有足以在所述眼睛的前房和泪膜之间通过所述内腔提供流体连通的长度巩膜所述装置还包括能够提供流过所述内腔的房水的流出阻力的过滤膜。该装置还包括位于第一端处或位于第一端和过滤器之间的碎屑过滤器，提供流出阻力。还描述了将装置植入患有眼睛的巩膜中的治疗青光眼的方法。

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