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11. 发明授权

US08571687B2 Transcutaneous neurostimulator for modulating cardiovascular function 失效
标题翻译：用于调节心血管功能的经皮神经刺激器
公开(公告)号：US08571687B2
公开(公告)日：2013-10-29
申请号：US12869593
申请日：2010-08-26
申请人： Imad Libbus , Anthony V. Caparso , Andrew P. Kramer
发明人： Imad Libbus , Anthony V. Caparso , Andrew P. Kramer
IPC分类号： A61N1/18
CPC分类号： A61N1/36114 , A61N1/36017 , Y10S128/907
摘要： A neurostimulation device includes an external neurostimulator worn by a patient using a bracing element that braces a portion of the patient's body. The external neurostimulator delivers neurostimulation to modulate a cardiovascular function of the patient. In one embodiment, the external stimulator delivers the neurostimulation transcutaneously to a stimulation target in the patient's body using surface stimulation electrodes placed on the body approximately over the stimulation target.
摘要翻译：神经刺激装置包括由患者佩戴的外部神经刺激器，其使用支撑患者身体的一部分的支撑元件。外部神经刺激仪提供神经刺激来调节患者的心血管功能。在一个实施例中，外部刺激器将神经刺激经皮递送到患者身体中的刺激目标，其中使用位于身体上的表面刺激电极大致超过刺激目标。

12. 发明授权

US08396556B2 Transcutaneous neurostimulator for treating hypertension 有权
标题翻译：用于治疗高血压的经皮神经刺激器
公开(公告)号：US08396556B2
公开(公告)日：2013-03-12
申请号：US12969023
申请日：2010-12-15
申请人： Imad Libbus , Anthony V. Caparso , Andrew P. Kramer
发明人： Imad Libbus , Anthony V. Caparso , Andrew P. Kramer
IPC分类号： A61N1/18
CPC分类号： A61N1/36114 , A61N1/36017 , Y10S128/907
摘要： A neurostimulation device includes an external neurostimulator worn by a patient using a bracing element that braces a portion of the patient's body. The external neurostimulator delivers neurostimulation to modulate a cardiovascular function of the patient. In one embodiment, the external stimulator delivers the neurostimulation transcutaneously to a stimulation target in the patient's body using surface stimulation electrodes placed on the body approximately over the stimulation target.
摘要翻译：神经刺激装置包括由患者佩戴的外部神经刺激器，其使用支撑患者身体的一部分的支撑元件。外部神经刺激仪提供神经刺激来调节患者的心血管功能。在一个实施例中，外部刺激器将神经刺激经皮递送到患者身体中的刺激目标，其中使用位于身体上的表面刺激电极大致超过刺激目标。

13. 发明申请

US20080091256A1 TRANSCUTANEOUS NEUROSTIMULATOR FOR MODULATING CARDIOVASCULAR FUNCTION 有权
标题翻译：用于调节心脏功能的经视神经调节剂
公开(公告)号：US20080091256A1
公开(公告)日：2008-04-17
申请号：US11548359
申请日：2006-10-11
申请人： Imad Libbus , Anthony V. Caparso , Andrew P. Kramer
发明人： Imad Libbus , Anthony V. Caparso , Andrew P. Kramer
IPC分类号： A61N1/18
CPC分类号： A61N1/36114 , A61N1/36017 , Y10S128/907
摘要： A neurostimulation device includes an external neurostimulator worn by a patient using a bracing element that braces a portion of the patient's body. The external neurostimulator delivers neurostimulation to modulate a cardiovascular function of the patient. In one embodiment, the external stimulator delivers the neurostimulation transcutaneously to a stimulation target in the patient's body using surface stimulation electrodes placed on the body approximately over the stimulation target.
摘要翻译：神经刺激装置包括由患者佩戴的外部神经刺激器，其使用支撑患者身体的一部分的支撑元件。外部神经刺激仪提供神经刺激来调节患者的心血管功能。在一个实施例中，外部刺激器将神经刺激经皮递送到患者身体中的刺激目标，其中使用位于身体上的表面刺激电极大致超过刺激目标。

14. 发明申请

US20080091255A1 IMPLANTABLE NEUROSTIMULATOR FOR MODULATING CARDIOVASCULAR FUNCTION 审中-公开
标题翻译：用于调节心脏功能的可植入神经细胞
公开(公告)号：US20080091255A1
公开(公告)日：2008-04-17
申请号：US11548354
申请日：2006-10-11
申请人： Anthony V. Caparso , Imad Libbus , Andrew P. Kramer
发明人： Anthony V. Caparso , Imad Libbus , Andrew P. Kramer
IPC分类号： A61N1/18
CPC分类号： A61N1/36114 , Y10T29/49204
摘要： An implantable medical device includes an implantable capsule housing a circuit that delivers neurostimulation to modulate one or more cardiovascular functions. To limit displacement after implantation, a fixation device is coupled to the implantable capsule to fix the miniature implantable medical device to a position in the body of a patient. In various embodiments, the fixation device include one or more of a suture loop, a cuff to wrap around a cylindrical structure such as a nerve of a vessel, and a transmural fixation device anchoring on the interior surface of a wall defining a cavity in the body.
摘要翻译：可植入医疗装置包括可植入的胶囊，其包含输送神经刺激以调节一种或多种心血管功能的电路。为了在植入之后限制位移，将固定装置联接到可植入胶囊以将微型可植入医疗装置固定到患者体内的位置。在各种实施例中，固定装置包括一个或多个缝合线环，围绕诸如血管的神经的圆柱形结构的袖带以及锚固在壁的内表面上的壁透视固定装置，身体。

15. 发明申请

US20100114226A1 SYSTEM TO PROVIDE MYOCARDIAL AND NEURAL STIMULATION 有权
标题翻译：系统提供心肌和神经刺激
公开(公告)号：US20100114226A1
公开(公告)日：2010-05-06
申请号：US12686704
申请日：2010-01-13
申请人： Imad Libbus , Qingsheng Zhu , Scott Vanderlinde , Andrew P. Kramer , Ankur Garg , Kristofer J. James
发明人： Imad Libbus , Qingsheng Zhu , Scott Vanderlinde , Andrew P. Kramer , Ankur Garg , Kristofer J. James
IPC分类号： A61N1/08 , A61N1/362
CPC分类号： A61N1/36114 , A61N1/36057 , A61N1/36117 , A61N1/36128 , A61N1/3621 , A61N1/3627
摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.
摘要翻译：各种方面提供可植入装置。在各种实施例中，该装置包括至少一个端口，其中每个端口适于将引线与电极连接到该装置。所述装置还包括刺激平台，包括连接到所述至少一个端口以感测固有心脏信号的感测电路和经由刺激通道连接到所述至少一个端口的刺激电路，以将刺激信号通过所述刺激通道传递到电极。刺激电路适于通过刺激通道递送刺激信号用于神经刺激治疗和CRM治疗。感测和刺激电路适用于执行CRM功能。该装置还包括连接到感测电路和刺激电路的控制器，以控制神经刺激疗法和CRM治疗。本文提供了其它方面和实施例。

16. 发明授权

US07660628B2 System to provide myocardial and neural stimulation 有权
标题翻译：系统提供心肌和神经刺激
公开(公告)号：US07660628B2
公开(公告)日：2010-02-09
申请号：US11087935
申请日：2005-03-23
申请人： Imad Libbus , Qingsheng Zhu , Scott Vanderlinde , Andrew P. Kramer , Ankur Garg , Kristofer J. James
发明人： Imad Libbus , Qingsheng Zhu , Scott Vanderlinde , Andrew P. Kramer , Ankur Garg , Kristofer J. James
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/36057 , A61N1/36117 , A61N1/36128 , A61N1/3621 , A61N1/3627
摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.
摘要翻译：各种方面提供可植入装置。在各种实施例中，该装置包括至少一个端口，其中每个端口适于将引线与电极连接到该装置。所述装置还包括刺激平台，包括连接到所述至少一个端口以感测固有心脏信号的感测电路和经由刺激通道连接到所述至少一个端口的刺激电路，以将刺激信号通过所述刺激通道传递到电极。刺激电路适于通过刺激通道递送刺激信号用于神经刺激治疗和CRM治疗。感测和刺激电路适用于执行CRM功能。该装置还包括连接到感测电路和刺激电路的控制器，以控制神经刺激疗法和CRM治疗。本文提供了其它方面和实施例。

17. 发明授权

US08478397B2 System to provide myocardial and neural stimulation 有权
标题翻译：系统提供心肌和神经刺激
公开(公告)号：US08478397B2
公开(公告)日：2013-07-02
申请号：US12686704
申请日：2010-01-13
申请人： Imad Libbus , Qingsheng Zhu , Scott Vanderlinde , Andrew P. Kramer , Ankur Garg , Kristofer J. James
发明人： Imad Libbus , Qingsheng Zhu , Scott Vanderlinde , Andrew P. Kramer , Ankur Garg , Kristofer J. James
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/36057 , A61N1/36117 , A61N1/36128 , A61N1/3621 , A61N1/3627
摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.
摘要翻译：各种方面提供可植入装置。在各种实施例中，该装置包括至少一个端口，其中每个端口适于将引线与电极连接到该装置。所述装置还包括刺激平台，包括连接到所述至少一个端口以感测固有心脏信号的感测电路和经由刺激通道连接到所述至少一个端口的刺激电路，以将刺激信号通过所述刺激通道传递到电极。刺激电路适于通过刺激通道递送刺激信号用于神经刺激治疗和CRM治疗。感测和刺激电路适用于执行CRM功能。该装置还包括连接到感测电路和刺激电路的控制器，以控制神经刺激疗法和CRM治疗。本文提供了其它方面和实施例。

18. 发明授权

US09409025B2 Cardiac rhythm management device with neural sensor 有权
公开(公告)号：US09409025B2
公开(公告)日：2016-08-09
申请号：US12840449
申请日：2010-07-21
申请人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
IPC分类号： A61N1/36 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36117
摘要： Various aspects of the present subject matter relate to a device. In various embodiments, the device comprises at least one port adapted to connect at least one lead, a CRM functions module connected to the port and adapted to provide at least one CRM function using the lead, a neural function module, and a controller connected to the CRM functions module and the neural function module. The at least one CRM function includes a function to provide an electrical signal to the lead to capture cardiac tissue. The neural function module includes a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The controller is adapted to implement a CRM therapy based on the signal indicative of the nerve traffic. Other aspects are provided herein.

19. 发明申请

US20130211471A1 METHOD AND APPARATUS FOR CONTROLLING AUTONOMIC BALANCE USING NEURAL STIMULATION 有权
公开(公告)号：US20130211471A1
公开(公告)日：2013-08-15
申请号：US13841593
申请日：2013-03-15
申请人： Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
发明人： Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61N1/365
CPC分类号： A61N1/36057 , A61N1/36114 , A61N1/36139 , A61N1/3621 , A61N1/3627 , A61N1/36585
摘要： A neural stimulation system senses autonomic activities and applies neural stimulation to sympathetic and parasympathetic nerves to control autonomic balance. The neural stimulation system is capable of delivering neural stimulation pulses for sympathetic excitation, sympathetic inhibition, parasympathetic excitation, and parasympathetic inhibition.

20. 发明申请

US20130165998A1 SYSTEM AND METHOD FOR CLOSED-LOOP NEURAL STIMULATION 审中-公开
标题翻译：闭环神经刺激的系统和方法
公开(公告)号：US20130165998A1
公开(公告)日：2013-06-27
申请号：US13709271
申请日：2012-12-10
申请人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61N1/36117
摘要： Various device embodiments comprise a pulse generator, a signal processing module and a controller. The pulse generator is adapted to provide a neural stimulation signal to be applied at a neural simulation site within an autonomic nervous system (ANS). The signal processing module is adapted to receive and process sensed neural traffic at a neural sensing site within the ANS. The controller is connected to the pulse generator and adapted to provide a neural stimulation control signal to the pulse generator to generate the neural stimulation signal, and to the signal processing module to receive a feedback control signal indicative of the sensed neural traffic. The controller is adapted to adjust the neural stimulation control signal to adjust at least one parameter of the neural stimulation signal to converge on desired sensed neural traffic at the neural sensing site. Other aspects and embodiments are provided herein.
摘要翻译：各种装置实施例包括脉冲发生器，信号处理模块和控制器。脉冲发生器适于提供在自主神经系统（ANS）内的神经模拟部位应用的神经刺激信号。信号处理模块适于在ANS内的神经感测部位接收和处理感测到的神经流量。控制器连接到脉冲发生器并且适于向脉冲发生器提供神经刺激控制信号以产生神经刺激信号，并且向信号处理模块接收指示所感测的神经流量的反馈控制信号。控制器适于调整神经刺激控制信号以调整神经刺激信号的至少一个参数以收敛于神经感测位置处的期望感测的神经交通。本文提供了其它方面和实施例。

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