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11. 发明授权

US3963613A Blood purification means 失效
标题翻译：血液净化手段
公开(公告)号：US3963613A
公开(公告)日：1976-06-15
申请号：US536641
申请日：1974-12-26
申请人： Ichiro Chibata , Tetsuya Tosa , Takao Mori
发明人： Ichiro Chibata , Tetsuya Tosa , Takao Mori
IPC分类号： A61F2/02 , A61M1/16 , A61M1/36 , B01D31/00
CPC分类号： A61F2/022 , A61M1/1696 , A61M1/3687
摘要： A blood purification means whereby blood of a patient to be treated is led around an external circuit connecting to the patient's blood stream and is brought into direct or indirect contact with a fumarate solution, and is further brought into direct or indirect contact with an enzymic preparation, which is suitably an aspartase preparation, which catalyzes a reaction of L-aspartic acid formation from fumaric acid and ammonia. The purification means may further include a preliminary stage or stages whereat an unrequired substance in a patient's blood is decomposed to a non toxic substance and ammonia subsequently convertable to aspartic acid, and may also include a low molecular sieve means preventing re-entry of aspartic acid produced into the patient's blood stream.
摘要翻译：一种血液净化装置，其特征在于，将待治疗的患者的血液引导到连接患者血液流的外部回路，并与富马酸盐溶液直接或间接接触，并进一步与酶制剂直接或间接接触其合适地是天冬氨酰胺酶制剂，其催化由富马酸和氨形成的L-天冬氨酸的反应。净化装置还可以包括预备阶段或阶段，其中将患者血液中的不需要物质分解成无毒物质，然后氨转化成天冬氨酸，还可以包括防止天冬氨酸再次进入的低分子筛产生到患者的血液中。

12. 发明授权

US3935072A Purification of coenzyme A 失效
标题翻译：辅酶A的纯化
公开(公告)号：US3935072A
公开(公告)日：1976-01-27
申请号：US384212
申请日：1973-07-31
申请人： Ichiro Chibata , Tetsuya Tosa , Yuhsi Matuo
发明人： Ichiro Chibata , Tetsuya Tosa , Yuhsi Matuo
IPC分类号： C12P19/32 , C07G7/02 , C07G3/00 , C07G7/00
CPC分类号： C12P19/32 , Y10S530/825
摘要： Coenzyme A is purified by a process involving contacting a cyanogen halide-activated water-insoluble polysaccharide with a cell-free extract of a coenzyme A-producing microorganism to immobilize proteins such as enzymes having affinity for coenzyme A on the polysaccharide. The immobilized proteins are then contacted with a coenzyme A-containing solution to absorb coenzyme A followed by eluting coenzyme A from the immobilized proteins. Alternatively, the proteins having affinity for coenzyme A may be isolated from the cell-free extract prior to immobilization by absorbing the proteins on coenzyme A immobilized on a cyanogen halide-activated water-insoluble polysaccharide followed by eluting the proteins from the immobilized coenzyme A.
摘要翻译：辅酶A通过使卤化氰活化的水不溶性多糖与产生辅酶A的微生物的无细胞提取物接触的方法进行纯化，从而将对辅酶A具有亲和性的酶等蛋白质固定在多糖上。然后将固定的蛋白质与含辅酶A的溶液接触以吸收辅酶A，然后从固定化蛋白质洗脱辅酶A. 或者，可以通过将固定在氰卤化物活化的水不溶性多糖上的辅酶A上的蛋白质吸收固定化，然后从固定化的辅酶A洗脱蛋白质，在固定前从无细胞提取物中分离出对辅酶A具有亲和力的蛋白质。

13. 发明授权

US4309362A Process for the optical resolution of DL-p-hydroxy-phenylglycine 失效
标题翻译： DL-对羟基苯基甘氨酸的光学拆分方法
公开(公告)号：US4309362A
公开(公告)日：1982-01-05
申请号：US885804
申请日：1978-03-13
申请人： Ichiro Chibata , Shigeki Yamada , Chikara Hongo
发明人： Ichiro Chibata , Shigeki Yamada , Chikara Hongo
IPC分类号： C07C145/00
摘要： Seed crystals of an optically active enantiomer of any one of p-hydroxyphenylglycine benzenesulfonate, p-hydroxyphenylglycine p-ethylbenzenesulfonate, p-hydroxyphenylglycine o-toluenesulfonate or p-hydroxyphenylglycine sulfosalicylate are added to a supersaturated solution of the racemic modification of the corresponding p-hydroxyphenylglycine salt. Crystallization of the optically active enantiomer results. Then, the crystals are recovered. Alternatively, crystals of the optically active enantiomer may be added to a hot solution of the racemic modification of the corresponding p-hydroxyphenylglycine salt to produce a supersaturated solution thereof. The solution is then cooled to crystallize out the optically active enantiomer. Optically active p-hydroxyphenylglycine benzenesulfonate, optically active p-hydroxyphenylglycine p-ethylbenzenesulfonate, optically active p-hydroxyphenylglycine o-toluenesulfonate or optically active p-hydroxyphenylglycine sulfosalicylate is thereby obtained.
摘要翻译：将对羟基苯基甘氨酸苯磺酸盐，对羟基苯基甘氨酸对乙基苯磺酸盐，对羟基苯基甘氨酸邻甲苯磺酸盐或对羟基苯基甘氨酸磺基水杨酸盐的光学活性对映异构体的晶种加入到相应对羟基苯基甘氨酸的外消旋体的过饱和溶液盐。导致光学活性对映异构体的结晶。然后，回收晶体。或者，可将光学活性对映异构体的晶体加入相应对羟基苯基甘氨酸盐的外消旋体的热溶液中以产生其过饱和溶液。然后将溶液冷却以使光学活性对映异构体结晶。由此得到光学活性对羟基苯基甘氨酸苯磺酸盐，光学活性对羟基苯基甘氨酸对乙基苯磺酸盐，光学活性对羟基苯基甘氨酸邻甲苯磺酸盐或光学活性对羟基苯基甘氨酸磺基水杨酸盐。

14. 发明授权

US4415504A p-Hydroxyphenylglycine..alpha.-phenylethanesulfonate, process for production thereof and utilization thereof in resolution of p-hydroxyphenylglycine 失效
标题翻译：对羟基苯基甘氨酸。 α-苯基乙烷磺酸盐，其制备方法和在分离对羟基苯基甘氨酸中的应用
公开(公告)号：US4415504A
公开(公告)日：1983-11-15
申请号：US416338
申请日：1982-09-09
申请人： Ichiro Chibata , Shigeki Yamada , Chikara Hongo , Ryuzo Yoshioka
发明人： Ichiro Chibata , Shigeki Yamada , Chikara Hongo , Ryuzo Yoshioka
IPC分类号： C07B57/00 , C07C143/26
CPC分类号： C07C229/36 , C07C227/34 , C07C303/44 , C07C309/24 , C07B2200/07 , Y02P20/582
摘要： p-Hydroxyphenylglycine..alpha.-phenylethanesulfonate which is useful for the production of optically active p-hydroxyphenylglycine and optically active .alpha.-phenylethanesulfonic acid is disclosed. p-Hydroxyphenylglycine..alpha.-phenylethanesulfonate is produced by either reacting DL-p-hydroxyphenylglycine with optically active .alpha.-phenylethanesulfonic acid or reacting (.+-.)-.alpha.-phentylethanesulfonic acid with optically active p-hydroxyphenylglycine to form two diastereomers of DL-p-hydroxyphenylglycine optically active .alpha.-phenylethanesulfonate or optically active p-hydroxyphenylglycine (.+-.)-.alpha.-phenylethanesulfonate, and isolating one diastereomer according to the difference between solubilities of the diastereomers, optionally, combining selective crystallization of one diastereomer and epimerization of another diastereomer in the case of reaction of DL-p-hydroxyphenylglycine and optically active .alpha.-phenylethanesulfonic acid. This reaction is utilized in the resolution of p-hydroxyphenylglycine or .alpha.-phenylethanesulfonic acid by deacidifying the resulting diastereomer.
摘要翻译：对羟基苯基甘氨酸。公开了可用于制备光学活性对羟基苯基甘氨酸和光学活性α-苯乙烷磺酸的α-苯基乙烷磺酸盐。对羟基苯基甘氨酸。 α-苯基乙烷磺酸盐通过使DL-对羟基苯基甘氨酸与光学活性α-苯基乙烷磺酸反应或使（+/-） - α-正丁基乙磺酸与光学活性对羟基苯基甘氨酸反应形成DL-对羟基苯基甘氨酸光学活性的两种非对映异构体 α-苯基乙烷磺酸盐或光学活性对羟基苯基甘氨酸（+/-） - α-苯基乙烷磺酸盐，并根据非对映异构体的溶解度之间的差异分离一种非对映异构体，任选地，将一种非对映异构体的选择性结晶和另一种非对映异构体的差向异构化在另一种非对映异构体的情况下 DL-对羟基苯基甘氨酸和光学活性α-苯基乙烷磺酸的反应。该反应用于通过使得到的非对映异构体脱酸来分离对羟基苯基甘氨酸或α-苯基乙烷磺酸。

15. 发明授权

US4032641A Nicotinoyl carnitine derivatives 失效
标题翻译：烟酰基肉碱衍生物
公开(公告)号：US4032641A
公开(公告)日：1977-06-28
申请号：US694363
申请日：1976-06-09
申请人： Ichiro Chibata , Munetsugu Miyoshi , Kohki Takashima , Shoji Moriya
发明人： Ichiro Chibata , Munetsugu Miyoshi , Kohki Takashima , Shoji Moriya
IPC分类号： C07D213/80 , A61K31/455 , C07D213/55 , C07D213/56
CPC分类号： C07D213/80
摘要： A nicotinoyl carnitine compound of the formula: ##STR1## wherein R is lower alkoxy, benzyloxy or amino and X is an anionic residue of a pharmaceutically acceptable acid, is prepared by reacting a carnitine derivative of the formula: ##STR2## wherein R is the same as defined above, with nicotinic acid or a functional derivative thereof. The derivative [I] and the pharmaceutically acceptable acid addition salts of said compound are useful as hypolipidemic agents.
摘要翻译：通过使下式的肉碱衍生物：其中R是低级烷氧基，苄氧基或氨基，X是药学上可接受的酸的阴离子残基，通过下式得到的烟酰基肉碱化合物：其中R是低级烷氧基， II]其中R与上述定义相同，与烟酸或其功能衍生物。所述化合物的衍生物[I]和药学上可接受的酸加成盐可用作降血脂药。

16. 发明授权

US4519955A Method for optical resolution of DL-.alpha.-amino acid or (.+-.)-.alpha.-phenylethanesulfonic acid 失效
标题翻译： DL-α-氨基酸或（+/-） - α-苯基乙烷磺酸的光学拆分方法
公开(公告)号：US4519955A
公开(公告)日：1985-05-28
申请号：US585767
申请日：1984-03-02
申请人： Ichiro Chibata , Shigeki Yamada , Chikara Hongo , Ryuzo Yoshioka
发明人： Ichiro Chibata , Shigeki Yamada , Chikara Hongo , Ryuzo Yoshioka
IPC分类号： C07C309/24 , C07B57/00 , C07C67/00 , C07C227/00 , C07C227/18 , C07C227/34 , C07C229/02 , C07C229/08 , C07C229/26 , C07C277/08 , C07C279/14 , C07C301/00 , C07C303/22 , C07C303/32 , C07C143/26 , C07B19/00 , C07D207/16 , C07D209/20
CPC分类号： C07B57/00
摘要： .alpha.-(S)-amino acid..alpha.-phenylethanesulfonate compounds and methods of optical resolution of .alpha.-amino acids and .alpha.-phenylethanesulfonic acids are described.
摘要翻译： α-（S） - 氨基酸。描述了α-苯基乙烷磺酸盐化合物和α-氨基酸和α-苯基乙烷磺酸的光学拆分方法。

17. 发明授权

US4438044A Di-L-cysteine L-malate and process for the production thereof 失效
标题翻译：二L-半胱氨酸L-苹果酸盐及其生产方法
公开(公告)号：US4438044A
公开(公告)日：1984-03-20
申请号：US284119
申请日：1981-07-16
申请人： Ichiro Chibata , Akihiko Sumi , Osamu Ohtsuki , Nozomu Izutsu
发明人： Ichiro Chibata , Akihiko Sumi , Osamu Ohtsuki , Nozomu Izutsu
IPC分类号： A61K31/195 , A61K31/19 , A61P43/00 , C07C51/00 , C07C59/245 , C07C67/00 , C07C313/00 , C07C323/58 , C07C51/02
CPC分类号： C07C59/245
摘要： Novel di-L-cysteine L-malate of the formula:[HS--CH.sub.2 --CH(NH.sub.3).sup.+ --COOH].sub.2.(.sup.- OOC--CHOH--CH.sub.2 --COO.sup.-)which has excellent storage stability and excellent pharmacological activities and is useful for the preparation of the amino acid infusion solutions, and process for the preparation of the di-L-cysteine L-malate by reacting 2 moles of L-cysteine L-malate and more than 0.9 mole of L-malic acid in an aqueous medium and collecting the resulting crystalline di-L-cysteine L-malate.
摘要翻译：新型二-L-半胱氨酸L-苹果酸盐，其具有优良的储存稳定性和优异的药理活性，具有下式：[HS-CH2-CH（NH3）+ -COOH] 2（ - OOC-CHOH-CH2-COO-）可用于制备氨基酸输液的方法，以及通过使2摩尔L-半胱氨酸L-苹果酸酯与大于0.9摩尔L-苹果酸的水溶液反应来制备二-L-半胱氨酸L-苹果酸L- 收集所得结晶二L-半胱氨酸L-苹果酸盐。

18. 发明授权

US4434107A Process for preparing an optically active p-hydroxyphenylglycine or a salt thereof 失效
标题翻译：制备光学活性对羟基苯基甘氨酸或其盐的方法
公开(公告)号：US4434107A
公开(公告)日：1984-02-28
申请号：US392535
申请日：1982-06-28
申请人： Ichiro Chibata , Shigeki Yamada , Chikara Hongo , Ryuzo Yoshioka
发明人： Ichiro Chibata , Shigeki Yamada , Chikara Hongo , Ryuzo Yoshioka
IPC分类号： C07B55/00 , C07B31/00 , C07B57/00 , C07C67/00 , C07C227/34 , C07C229/36 , C07C143/30 , C07C101/72
CPC分类号： C07C227/34
摘要： The present invention relates to the optical resolution of a p-hydroxyphenylglycine salt with simultaneous racemization of the undesired enantiomer thereof. The invention is carried out by preferential crystallizing out the desired enantiomer from a supersaturated solution of the racemic modification thereof in a lower aliphatic acid in the presence of an aliphatic or aromatic aldehyde.
摘要翻译：本发明涉及对羟基苯基甘氨酸盐的光学拆分，同时使其不需要的对映异构体进行外消旋化。本发明通过优选在脂族或芳族醛存在下将其外消旋化合物的过饱和溶液在低级脂族酸中结晶出所需的对映体来进行。

19. 发明授权

US4350765A Method for producing ethanol with immobilized microorganism 失效
标题翻译：用固定化微生物生产乙醇的方法
公开(公告)号：US4350765A
公开(公告)日：1982-09-21
申请号：US156868
申请日：1980-06-05
申请人： Ichiro Chibata , Jyoji Kato , Mitsuru Wada
发明人： Ichiro Chibata , Jyoji Kato , Mitsuru Wada
IPC分类号： C12M1/40 , C12P7/06 , C12N11/04 , C12N11/10
CPC分类号： C12P7/06 , C12M21/12 , C12M23/58 , C12M25/14 , C12M25/18 , C12M47/10 , Y02E50/17
摘要： Ethanol is produced in high concentration of 75 mg/ml or above such as 200 mg/ml by using an immbolized ethanol-producing microorganism to convert sugar to ethanol in a nutrient culture broth containing not more than 100 mg/ml sugar until the concentration of sugar is not more than 20% of its initial concentration, then adding a fresh culture broth containing not less than 100 mg/ml sugar and converting sugar to ethanol with the immobilized microorganism to produce the desired high concentration of ethanol. The microorganism is preferably immobilized in a sulfated polysaccharide gel as a dense layer near the surface of the gel.
摘要翻译：通过使用模拟的乙醇生产微生物，以75mg / ml以上的高浓度（如200mg / ml）生产乙醇，将蔗糖转化为含有不超过100mg / ml糖的营养培养液中的糖，直到浓度为糖不超过其初始浓度的20％，然后加入含有不少于100mg / ml糖的新鲜培养液，并用固定化微生物将糖转化为乙醇以产生所需的高浓度乙醇。微生物优选固定在硫酸化多糖凝胶中作为凝胶表面附近的致密层。

20. 发明授权

US4401820A Process for racemizing optically active .alpha.-amino acids or a salt thereof 失效
标题翻译：外消旋光学活性α-氨基酸或其盐的方法
公开(公告)号：US4401820A
公开(公告)日：1983-08-30
申请号：US337322
申请日：1982-01-05
申请人： Ichiro Chibata , Shigeki Yamada , Chikara Hongo , Ryuzo Yoshioka
发明人： Ichiro Chibata , Shigeki Yamada , Chikara Hongo , Ryuzo Yoshioka
IPC分类号： C07B55/00 , C07D233/64 , C07B20/00 , C07D207/12 , C07D209/20
CPC分类号： C07B55/00
摘要： DL-.alpha.-amino acids or a salt thereof can be obtained by racemizing an optically active .alpha.-amino acid or a salt thereof in the presence of an aliphatic acid and an aldehyde.
摘要翻译： DL-α-氨基酸或其盐可以通过在脂肪酸和醛的存在下使光学活性的α-氨基酸或其盐进行外消旋化获得。

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