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12. 发明专利

DE10211555A1 未知
公开(公告)号：DE10211555A1
公开(公告)日：2003-10-02
申请号：DE10211555
申请日：2002-03-15
申请人： IMTM INST FUER MEDIZINTECHNOLO , ANSORGE SIEGFRIED , GOLLNICK HARALD , NEUBERT KLAUS , ZOUBOULIS CHRISTOS C
发明人： ANSORGE SIEGFRIED , NEUBERT KLAUS , FAUST JUERGEN , REINHOLD DIRK , GOLLNICK HARALD , ZOUBOULIS CHRISTOS C , LENDECKEL UWE , VETTER ROBERT
IPC分类号： C12N9/99 , A61K31/195 , A61K31/40 , A61K31/426 , A61K31/4453 , A61K38/55 , A61K45/00 , A61P17/00 , A61P17/08 , A61P17/10 , A61P17/14 , A61P35/00 , A61P43/00 , A61K38/05
摘要： The invention relates to a process for the-inhibition of the DNA synthesis necessary for the proliferation of human sebaceous cells (sebocytes) by the isolated or joint effect of inhibitors of alanyl aminopeptidase (APN) and dipetidyl peptidase IV (DP IV) expressed by these cells. The DNA synthesis (proliferation) of human sebaceous cells is inhibited by the administration of the inhibitors of APN and/or of DP IV depending on the dose. Our invention shows that, for a therapy and for a prevention of dermatological diseases with sebaceous hyperproliferation and modified conditions of differentiation, the application of inhibitors of the above-mentioned enzymes and of corresponding pharmaceutical preparations and dosage forms thereof is suitable.

13. 发明专利

CA2436724C USE OF INHIBITORS OF DIPEPTIDYL PEPTIDASE IV (DP IV) IN COMBINATION WITH INHIBITORS OF ALANYL-AMINOPEPTIDASE (APN) 未知
公开(公告)号：CA2436724C
公开(公告)日：2010-03-16
申请号：CA2436724
申请日：2001-12-21
申请人： INST MEDIZINTECHNOLOGIE MAGDEB
发明人： ANSORGE SIEGFRIED , LENDECKEL UWE , NEUBERT KLAUS , REINHOLD DIRK , VETTER ROBERT , GOLLNICK HARALD
IPC分类号： A61K45/06 , C12N9/99 , A61K38/55 , A61K45/00 , A61P9/10 , A61P17/00 , A61P17/06 , A61P35/00 , A61P37/06 , A61P37/08
摘要： Combined Use of Enzyme Inhibitors and of Pharmaceutical Compositions thereof for a Therapy and a Prophylactic Treatment of Arteriosclerosis, for a Therapy and Prevention of Allergic Reactions of the Type I according to the Gell and Coombs Classification and for a Therapy and Prevention of Dermatological Diseases with Follicular and Epidermal Hyperceratoses and an Enhanced Proliferation of Keratinocytes The present invention relates to the use of inhibitors of dipeptidyl peptidase IV (DP IV) and of enzymes having the same substrate specifity (DP IV-analogous enzymatic activity) in combination with inhibitors of alanyl aminopeptidase (aminopeptidase N, APN) and of enzymes having the same substrate specifity (APN-analoguos enzymatic activity) for a more than additive to superadditive inhibition of the activation and proliferation (DNA synthesis) of human T lymphocytes and mononuclear cells and of the production of T H2 cytokines for a therapy and prevention of allergic reactions of the type I according to the Gell and Coombs classification and for a more than additive to superadditive inhibition of the activation, proliferation (DNA synthesis) of human epidermal and follicular keratinocytes and of keratinocytes of the transitional zone between the skin and the mucous membranes as well as for a therapy and prevention of dermatological diseases with follicular and epidermal hyperkeratoses and an enhanced proliferation of keratinocytes. The invention also relates to the use of inhibitors of dipeptidyl peptidase IV (DP IV) as well as of enzymes having the same substrate specifity (DP IV--analogous enzymatic activity) in combination with inhibitors of alanyl aminopeptidase (aminopeptidase N, APN) and of enzymes having the same substrate specifity (APN--analogous enzymatic activity), respectively, of X-Pro-aminopeptidase (aminopeptidase P, APP), of the "angiotensin-converting enzyme" (ACE) and/or of the prolyl oligopeptidase (POP, prolyl endopeptidase, PEP) for a more than additive to superadditive inhibition of activation, DNA synthesis and proliferation of human T lymphocytes and mononuclear cells for a therapy and prophylaxis of arteriosclerosis. The invention also relates to pharmaceutical preparations comprising more than one of said inhibitors of enzymes of the above group.

14. 发明专利

DE10330842A1 未知
公开(公告)号：DE10330842A1
公开(公告)日：2005-02-10
申请号：DE10330842
申请日：2003-07-08
申请人： INST MEDIZINTECHNOLOGIE MAGDEB
发明人： ANSORGE SIEGFRIED , GOLLNICK HARALD , LENDECKEL UWE , NEUBERT KLAUS , REINHOLD DIRK , VETTER ROBERT , SCHRAVEN BURKHART , THIELITZ ANJA , FAUST JUERGEN
IPC分类号： A61K45/06 , A61P17/00 , A61K38/55
摘要： The invention relates to a process for the inhibition of the DNA synthesis (essential for the proliferation) of human fibroblasts by a single or joint effect of inhibitors of alanyl aminopeptidase (APN) and dipeptidyl peptidase IV (DPIV) expressed by those cells. The DNA synthesis (proliferation) of human fibroblasts is inhibited, in a dose dependent manner, by an administration of inhibitors of APN or/and DPIV. The invention shows that the application of substances inhibiting the above enzymes or of compositions and administration forms thereof are well suitable for a therapy and a prevention of dermatological diseases associated with fibroblast hyperproliferation and changed fibroblast differentiation states.

15. 发明专利

CA2436724A1 COMBINED USE OF ENZYME INHIBITORS AND PHARMACEUTICAL PREPARATIONS THEREOF FOR THE TREATMENT AND PROPHYLAXIS OF ARTERIOSCLEROSIS, FOR THETREATMENT AND PREVENTION OF ALLERGIC REACTIONS OF TYPE I ACCORDING TO THE GELL AND COOMBS CLASSIFICATION, AND FOR THE TREATMENT AND PREVENTION OF DERMATOLOGICAL DISEASES ASSOCIATED WITH FO 未知
公开(公告)号：CA2436724A1
公开(公告)日：2002-07-11
申请号：CA2436724
申请日：2001-12-21
申请人： INST MEDIZINTECHNOLOGIE MAGDEB
发明人： LENDECKEL UWE , NEUBERT KLAUS , REINHOLD DIRK , GOLLNICK HARALD , VETTER ROBERT , ANSORGE SIEGFRIED
IPC分类号： C12N9/99 , A61K38/55 , A61K45/00 , A61P9/10 , A61P17/00 , A61P17/06 , A61P35/00 , A61P37/06 , A61P37/08 , A61K45/06
摘要： The invention relates to the use of inhibitors of dipeptidyl peptidase IV (D P IV) and enzymes having the same specific nature of substrate (DP IV enzyme activity), combined with inhibitors of alanyl aminopeptidase (aminopeptidase N, APN), or enzymes having the same specific nature of substrate (APN enzyme activity), for the additive to superadditive inhibition of the activation an d proliferation (DNS synthesis) of human T lymphocytes or mononuclear cells an d of the production of TH2 cytokines for the treatment and prevention of allergic reactions of type I according to the Gell and Coombs classification , for the additive to superadditive inhibition of the activation and proliferation (DNS synthesis) of human epidermal and follicular keratinocyte s and those of the transitional region between the skin and the mucosa, and fo r the treatment and prevention of dermatological diseases associated with follicular and epidermal hyperkeratosis and reinforced keratinocyte proliferation. The invention also relates to the use of inhibitors of dipeptidyl peptidase IV (DP IV) and enzymes having the same specific nature of substrate (DP IV enzyme activity), combined with inhibitors of alanyl aminopeptidase (aminopeptidase N, APN), or enzymes having the same specific nature of substrate (APN enzyme activity), inhibitors of X-pro-aminopeptidas e (aminopeptidase P, APP), inhibitors of the angiotensin-converting enzyme (AC E) and/or of prolyoligopeptidase (POP, prolylendopeptidase, PEP) for the additi ve to superadditive inhibition of the activation, DNS synthesis and proliferati on of human T lymphocytes or mononuclear cells for the treatment and prophylaxi s of arteriosclerosis. The invention further relates to pharmaceutical preparations comprising a plurality of inhibitors of enzymes of the above- mentioned groups.

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