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11. 发明申请

US20120071809A1 OCULAR IMPLANT SYSTEMS 有权
标题翻译： OCULAR植物系统
公开(公告)号：US20120071809A1
公开(公告)日：2012-03-22
申请号：US13301648
申请日：2011-11-21
申请人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
发明人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
IPC分类号： A61F9/00
CPC分类号： A61M27/00 , A61F9/00781
摘要： Implants and methods for treating ocular disorders are disclosed. One implant has a tubular member, with inlet and outlet ends, and a cutting member connected thereto. The tubular member is configured to extend through eye tissue such that the inlet and outlet ends reside respectively in an anterior chamber and a physiologic outflow pathway of the eye. Desirably, the cutting member is configured to make an incision in the eye tissue for receiving at least a portion of the tubular member. One method involves introducing an implant, with proximal and distal ends, into the anterior chamber and penetrating eye tissue using an implant distal portion. The implant is advanced from the anterior chamber into the penetrated eye tissue to locate the distal and proximal ends respectively in the physiologic outflow pathway and the anterior chamber. Aqueous humor is conducted between the proximal and distal ends.
摘要翻译：公开了用于治疗眼部疾病的植入物和方法。一个植入物具有管状构件，其具有入口端和出口端以及与其连接的切割构件。管状构件构造成延伸穿过眼睛组织，使得入口端和出口端分别位于眼睛的前房和生理流出路径中。期望地，切割构件被配置为在眼组织中进行切口以接收管状构件的至少一部分。一种方法包括使用植入物远端部分将具有近端和远端的植入物引入前房和穿透眼组织。植入物从前房进入穿透的眼组织，将远端和近端分别定位在生理流出道和前房中。在近端和远端之间进行水性幽默。

12. 发明授权

US07857782B2 Ocular implant delivery system and method thereof 有权
标题翻译：眼植入物递送系统及其方法
公开(公告)号：US07857782B2
公开(公告)日：2010-12-28
申请号：US12366585
申请日：2009-02-05
申请人： Hosheng Tu , Gregory T Smedley , David Haffner , Barbara A Niksch
发明人： Hosheng Tu , Gregory T Smedley , David Haffner , Barbara A Niksch
IPC分类号： A61M5/00 , A61F11/00
CPC分类号： A61M27/00 , A61F9/00781
摘要： Systems and methods for treating ocular disorders are disclosed. One system has a delivery instrument, with a non-linear axis, configured to be inserted into an anterior chamber of an eye and moved to a location proximate a physiologic outflow pathway of the eye. The delivery instrument carries an implant that has a distal end sized for insertion into tissue such that aqueous humor drains from the anterior chamber to the physiologic outflow pathway. One method involves inserting a non-linear portion of a delivery device into the anterior chamber to position an implant within the eye. Another method involves using a delivery device with a curved distal portion to implant an implant at a location communicating with the physiologic outflow pathway. The delivery can be through a corneal incision and the implant can comprise a drug.
摘要翻译：公开了用于治疗眼部疾病的系统和方法。一个系统具有带非线性轴线的输送器具，其配置成插入眼睛的前房并移动到靠近眼睛生理流出路径的位置。递送仪器携带植入物，其具有大小适于插入组织的远端，使得房水从前房排出至生理流出路径。一种方法包括将输送装置的非线性部分插入前房以将植入物定位在眼睛内。另一种方法包括使用具有弯曲远端部分的递送装置，以在与生理流出路径连通的位置处植入植入物。输送可以通过角膜切口并且植入物可以包含药物。

13. 发明授权

US07094225B2 Medical device and methods of use of glaucoma treatment 有权
标题翻译：医疗器械和青光眼治疗方法
公开(公告)号：US07094225B2
公开(公告)日：2006-08-22
申请号：US10139800
申请日：2002-05-03
申请人： Hosheng Tu , Gregory T. Smedley , Barbara A. Niksch , David S. Haffner
发明人： Hosheng Tu , Gregory T. Smedley , Barbara A. Niksch , David S. Haffner
IPC分类号： A61M35/00
CPC分类号： A61F2/16 , A61F9/00781 , A61K9/0048
摘要： The invention relates generally medical devices and methods for the treatment of glaucoma in an animal eye and, more particularly, to medical devices and methods for treating tissue of the trabecular meshwork and/or Schlemm's canal of the eye to restore or rejuvenate a portion or all of the normal physiological function of directing aqueous outflow for maintaining a normal intraocular pressure in the eye.
摘要翻译：本发明一般涉及用于治疗动物眼睛中的青光眼的医疗装置和方法，更具体地，涉及用于治疗小梁网和/或眼睛的施莱姆氏管的组织以恢复或恢复一部分或全部的医疗装置和方法引导水流出的正常生理功能，以维持眼中正常的眼内压。

14. 发明授权

US07273475B2 Medical device and methods of use for glaucoma treatment 失效
标题翻译：用于青光眼治疗的医疗器械和方法
公开(公告)号：US07273475B2
公开(公告)日：2007-09-25
申请号：US11255625
申请日：2005-10-21
申请人： Hosheng Tu , Gregory T. Smedley , Barbara A. Niksch , David S. Haffner
发明人： Hosheng Tu , Gregory T. Smedley , Barbara A. Niksch , David S. Haffner
IPC分类号： A61M35/00
CPC分类号： A61F2/16 , A61F9/00781 , A61K9/0048
摘要： The invention relates generally medical devices and methods for the treatment of glaucoma in an animal eye and, more particularly, to medical devices and methods for treating tissue of the trabecular meshwork and/or Schlemm's canal of the eye to restore or rejuvenate a portion or all of the normal physiological function of directing aqueous outflow for maintaining a normal intraocular pressure in the eye.
摘要翻译：本发明一般涉及用于治疗动物眼睛中的青光眼的医疗装置和方法，更具体地，涉及用于治疗小梁网和/或眼睛的施莱姆氏管的组织以恢复或恢复一部分或全部的医疗装置和方法引导水流出的正常生理功能，以维持眼中正常的眼内压。

15. 发明授权

US07563241B2 Implant and methods thereof for treatment of ocular disorders 有权
标题翻译：植入物及其治疗眼部疾病的方法
公开(公告)号：US07563241B2
公开(公告)日：2009-07-21
申请号：US11598542
申请日：2006-11-13
申请人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
发明人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
IPC分类号： A61M5/00
CPC分类号： A61M27/00 , A61F9/00781
摘要： Medical devices and methods for treating ocular disorders, such as glaucoma, are provided. One method involves inserting an implant on one side of an eye. The implant is advanced across the optic axis to the other side of the eye and implanted in contact with a choroid. In another method the implant is inserted through an incision in the eye into an anterior chamber of the eye. The implant is advanced from the incision and across the anterior chamber into eye tissue such that the implant is in contact with at least the choroid, or the implant drains aqueous humor from the anterior chamber toward the choroid.
摘要翻译：提供了用于治疗眼部疾病如青光眼的医疗装置和方法。一种方法是将植入物插入眼睛的一侧。植入物通过光轴前进到眼睛的另一侧并植入与脉络膜接触。在另一种方法中，植入物通过眼睛中的切口插入眼睛的前房。植入物从切口前进并穿过前房进入眼组织，使得植入物与至少脉络膜接触，或者植入物将房水从前房排出到脉络膜。

16. 发明申请

US20090143712A1 SELF-TREPHINING IMPLANT AND METHODS THEREOF FOR TREATMENT OF OCULAR DISORDERS 有权
标题翻译：自体植入物及其治疗眼病的方法
公开(公告)号：US20090143712A1
公开(公告)日：2009-06-04
申请号：US12366508
申请日：2009-02-05
申请人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
发明人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
IPC分类号： A61M1/00 , A61B17/32
CPC分类号： A61M27/00 , A61F9/00781
摘要： Implants and methods for treating ocular disorders are disclosed. One implant has a tubular member, with inlet and outlet ends, and a cutting member connected thereto. The tubular member is configured to extend through eye tissue such that the inlet and outlet ends reside respectively in an anterior chamber and a physiologic outflow pathway of the eye. Desirably, the cutting member is configured to make an incision in the eye tissue for receiving at least a portion of the tubular member. One method involves introducing an implant, with proximal and distal ends, into the anterior chamber and penetrating eye tissue using an implant distal portion. The implant is advanced from the anterior chamber into the penetrated eye tissue to locate the distal and proximal ends respectively in the physiologic outflow pathway and the anterior chamber. Aqueous humor is conducted between the proximal and distal ends.
摘要翻译：公开了用于治疗眼部疾病的植入物和方法。一个植入物具有管状构件，其具有入口端和出口端以及与其连接的切割构件。管状构件构造成延伸穿过眼睛组织，使得入口端和出口端分别位于眼睛的前房和生理流出路径中。期望地，切割构件被配置为在眼组织中进行切口以接收管状构件的至少一部分。一种方法包括使用植入物远端部分将具有近端和远端的植入物引入前房和穿透眼组织。植入物从前房进入穿透的眼组织，将远端和近端分别定位在生理流出道和前房中。在近端和远端之间进行水性幽默。

17. 发明申请

US20090138022A1 OCULAR IMPLANT DELIVERY SYSTEM AND METHOD THEREOF 有权
标题翻译： OCULAR植物输送系统及其方法
公开(公告)号：US20090138022A1
公开(公告)日：2009-05-28
申请号：US12366585
申请日：2009-02-05
申请人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
发明人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
IPC分类号： A61F9/00
CPC分类号： A61M27/00 , A61F9/00781
摘要： Systems and methods for treating ocular disorders are disclosed. One system has a delivery instrument, with a non-linear axis, configured to be inserted into an anterior chamber of an eye and moved to a location proximate a physiologic outflow pathway of the eye. The delivery instrument carries an implant that has a distal end sized for insertion into tissue such that aqueous humor drains from the anterior chamber to the physiologic outflow pathway. One method involves inserting a non-linear portion of a delivery device into the anterior chamber to position an implant within the eye. Another method involves using a delivery device with a curved distal portion to implant an implant at a location communicating with the physiologic outflow pathway. The delivery can be through a corneal incision and the implant can comprise a drug.
摘要翻译：公开了用于治疗眼部疾病的系统和方法。一个系统具有带非线性轴线的输送器具，其配置成插入眼睛的前房并移动到靠近眼睛生理流出路径的位置。递送仪器携带植入物，其具有大小适于插入组织的远端，使得房水从前房排出至生理流出路径。一种方法包括将输送装置的非线性部分插入前房以将植入物定位在眼睛内。另一种方法包括使用具有弯曲远端部分的递送装置，以在与生理流出路径连通的位置处植入植入物。输送可以通过角膜切口并且植入物可以包含药物。

18. 发明申请

US20080200860A1 SYSTEM FOR TREATING OCULAR DISORDERS AND METHODS THEREOF 有权
标题翻译：用于治疗眼部疾病的系统及其方法
公开(公告)号：US20080200860A1
公开(公告)日：2008-08-21
申请号：US12111033
申请日：2008-04-28
申请人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
发明人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
IPC分类号： A61M5/00
CPC分类号： A61M27/00 , A61F9/00781
摘要： Systems and methods for treating ocular disorders are disclosed. One system has an implant and a delivery device. The implant has inlet and outlet portions, a lumen extending therebetween and communicating with inlet and outlet ports. The implant is sized so that in use aqueous humor flows from an anterior chamber of an eye through the implant and into a uveal scleral outflow path of the eye. The delivery device is configured to advance the implant from within the anterior chamber, with the outlet portion leading the inlet portion, to a location where the outlet and inlet ports respectively communicate with the uveal scleral outflow path and the anterior chamber. One method involves advancing an implant from within the anterior chamber, and draining fluid from therein such that fluid flows into an implant inlet port and out through an implant outlet port and into the uveal scleral outflow path.
摘要翻译：公开了用于治疗眼部疾病的系统和方法。一个系统具有植入物和递送装置。植入物具有入口和出口部分，在其间延伸并与入口和出口连通的内腔。植入物的大小使得在使用中，房水从眼睛的前房通过植入物流入眼睛的葡萄膜巩膜流出道。输送装置构造成使得植入物从前室中前进，出口部分将入口部分引导到出口和入口分别与葡萄膜巩膜流出道和前房连通的位置。一种方法包括从前房中推进植入物，并从其中排出流体，使得流体流入植入物入口并通过植入物出口并流入葡萄膜巩膜流出道。

19. 发明授权

US07135009B2 Glaucoma stent and methods thereof for glaucoma treatment 有权
公开(公告)号：US07135009B2
公开(公告)日：2006-11-14
申请号：US10118578
申请日：2002-04-08
申请人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
发明人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
IPC分类号： A61M5/00 , A61M1/00 , A61F11/00 , A61M31/00
CPC分类号： A61M27/00 , A61F9/00781
摘要： The invention relates generally to medical devices and methods for reducing the intraocular pressure in an animal eye and, more particularly, to stent type devices for permitting aqueous outflow from the eye's anterior chamber and associated methods thereof for the treatment of glaucoma. Some aspects provide a self-trephining glaucoma stent and methods thereof which advantageously allow for a “one-step” procedure in which the incision and placement of the stent are accomplished by a single device and operation. This desirably allows for a faster, safer, and less expensive surgical procedure.

20. 发明授权

US08062244B2 Self-trephining implant and methods thereof for treatment of ocular disorders 有权
标题翻译：自植物植入物及其治疗眼部疾病的方法
公开(公告)号：US08062244B2
公开(公告)日：2011-11-22
申请号：US12366508
申请日：2009-02-05
申请人： Hosheng Tu , Gregory T Smedley , David Haffner , Barbara A Niksch
发明人： Hosheng Tu , Gregory T Smedley , David Haffner , Barbara A Niksch
IPC分类号： A61M5/00
CPC分类号： A61M27/00 , A61F9/00781
摘要： Implants and methods for treating ocular disorders are disclosed. One implant has a tubular member, with inlet and outlet ends, and a cutting member connected thereto. The tubular member is configured to extend through eye tissue such that the inlet and outlet ends reside respectively in an anterior chamber and a physiologic outflow pathway of the eye. Desirably, the cutting member is configured to make an incision in the eye tissue for receiving at least a portion of the tubular member. One method involves introducing an implant, with proximal and distal ends, into the anterior chamber and penetrating eye tissue using an implant distal portion. The implant is advanced from the anterior chamber into the penetrated eye tissue to locate the distal and proximal ends respectively in the physiologic outflow pathway and the anterior chamber. Aqueous humor is conducted between the proximal and distal ends.
摘要翻译：公开了用于治疗眼部疾病的植入物和方法。一个植入物具有管状构件，其具有入口端和出口端以及与其连接的切割构件。管状构件构造成延伸穿过眼睛组织，使得入口端和出口端分别位于眼睛的前房和生理流出路径中。期望地，切割构件被配置为在眼组织中进行切口以接收管状构件的至少一部分。一种方法包括使用植入物远端部分将具有近端和远端的植入物引入前房和穿透眼组织。植入物从前房进入穿透的眼组织，将远端和近端分别定位在生理流出道和前房中。在近端和远端之间进行水性幽默。

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