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11. 发明授权

US07399877B2 Phospholipid derivative 有权
标题翻译：磷脂衍生物
公开(公告)号：US07399877B2
公开(公告)日：2008-07-15
申请号：US10549630
申请日：2004-03-19
申请人： Chika Itoh , Syunsuke Ohhashi , Kazuhiro Kubo , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Takahashi , Hitoshi Yamauchi
发明人： Chika Itoh , Syunsuke Ohhashi , Kazuhiro Kubo , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Takahashi , Hitoshi Yamauchi
IPC分类号： C07F9/02
CPC分类号： A61K9/127 , C07F9/10 , C11D1/345
摘要： A phospholipid derivative represented by the following formula (I) wherein R1CO and R2CO independently represent an acyl group; R3 represents hydrogen atom, or a hydrocarbon group; symbol “a” represents an integer of 0 to 4; symbol “b” represents 0 or 1, provided that when a is 0, b is 0; X represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium; A1O and A3O represent an oxyalkylene group containing oxyethylene group, wherein the ratio of the oxyethylene group to the oxyalkylene group in A1O and A3O is 0.5 or larger in terms of a weight ratio; A2O represents an oxyalkylene group; symbols “m” and “q” represent an average molar number of added oxyalkylene groups; and symbol “n” represent an average molar number of added oxyalkylene groups; provided that m, n and q satisfy the following conditions: 5≦m≦600, 1≦n≦45, 0≦q≦200, 10≦m+n+q≦600, 0.04≦n/(m+n+q), and q/(m+n+q)≦0.8, which can thicken the water shell of liposome surface by suppressing the spreading of the polyalkylene oxide structure on the surface and thus increase stability of the liposome
摘要翻译：由下式（I）表示的磷脂衍生物，其中R 1 CO和R 2 CO独立地表示酰基; R 3表示氢原子或烃基; 符号“a”表示0〜4的整数，符号“b”表示0或1，条件是当a为0时，b为0; X表示氢原子，碱金属原子，铵或有机铵; A 1 O和A 3 O表示含氧化乙烯基的氧化烯基，其中A 1 O 3中的氧乙烯基与氧化烯基的比例 O和A 3 O以重量比计为0.5以上; O 2表示氧化烯基; 符号“m”和“q”表示加成的氧化烯基团的平均摩尔数; 符号“n”表示加成的氧化烯基的平均摩尔数; 条件是m，n和q满足以下条件：5 <= m <= 600,1 <= n <= 45,0 <= q <= 200,10 <= m + n + q <= 600,0.04 < = n /（m + n + q）和q /（m + n + q）<= 0.8，这可以通过抑制聚环氧烷结构在表面上的扩散而增加脂质体表面的水壳，从而增加稳定性的脂质体

12. 发明申请

US20050079188A1 Base for external preparations for the skin and cosmetic containing the same 审中-公开
标题翻译：用于皮肤和化妆品的外用制剂的基础含有相同的
公开(公告)号：US20050079188A1
公开(公告)日：2005-04-14
申请号：US10490960
申请日：2002-09-27
申请人： Takashi Ohmori , Hiroyuki Kakoki , Reiji Miyahara , Tomiyuki Nanba , Toshihiko Nakane , Kei-chi Maruyama , Takeshi Sakoda , Tohru Yasukohchi , Yoji Tezuka
发明人： Takashi Ohmori , Hiroyuki Kakoki , Reiji Miyahara , Tomiyuki Nanba , Toshihiko Nakane , Kei-chi Maruyama , Takeshi Sakoda , Tohru Yasukohchi , Yoji Tezuka
IPC分类号： A61K8/72 , A61K8/39 , A61K8/86 , A61K8/90 , A61Q19/00 , A61K7/075 , A61K7/08
CPC分类号： A61Q19/00 , A61K8/39 , A61K8/86 , A61K8/90
摘要： A base for a skin external composition comprises, as a main ingredient, an alkylene oxide derivative represented by the following formula (I): R1O—[(AO)m(EO)n]—R2 (I) wherein AO is an oxyalkylene group having a carbon number of 3 to 4; EO is an oxyethylene group; and R1 and R2 may be the same or different, and are a hydrocarbon group having a carbon number of 1 to 4, or a hydrogen atom. The base is a water-soluble base that can exert both of the smooth feeling and the moist feeling.
摘要翻译：皮肤外用组合物的基质包含作为主要成分的由下式（I）表示的环氧烷衍生物：R 1 O - [（AO）m（EO）n] -R 2（I ）其中AO是碳数为3〜4的氧化烯基; EO是氧化乙烯基; R 1和R 2可以相同或不同，为碳数为1〜4的烃基或氢原子。该基质是可以发挥光滑感和潮湿感的水溶性基质。

13. 发明授权

US08034981B2 Modified bio-related substance, process for producing the same, and intermediate 有权
标题翻译：改性生物相关物质，其生产方法和中间体
公开(公告)号：US08034981B2
公开(公告)日：2011-10-11
申请号：US12942554
申请日：2010-11-09
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： C07D249/18
CPC分类号： C08G65/329 , A61K47/60 , C08G65/2609
摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
摘要翻译：一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA1和OA2各自具有2至4个碳原子的氧化烯基，由一个分子中由R表示的基团彼此相同或不同，并且由OA2表示的基团在一个分子中彼此相同或不同，n和m各自为氧化烯基的平均加成摩尔数，n表示0〜1000，m表示10〜1000。

14. 发明授权

US07524875B2 Modified bio-related substance, process for producing the same, and intermediate 有权
标题翻译：改性生物相关物质，其生产方法和中间体
公开(公告)号：US07524875B2
公开(公告)日：2009-04-28
申请号：US11142255
申请日：2005-06-02
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： A61K31/075 , A61K31/4015 , A61K31/4164 , A61K31/4192 , C07C43/11 , C07D207/444 , C07D233/64 , C07D249/04 , C07D487/06
CPC分类号： C08G65/329 , A61K47/60 , C08G65/2609
摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
摘要翻译：一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA1和OA2各自具有2至4个碳原子的氧化烯基，由一个分子中由R表示的基团彼此相同或不同，并且由OA2表示的基团在一个分子中彼此相同或不同，n和m各自为氧化烯基的平均加成摩尔数，n表示0〜1000，m表示10〜1000。

15. 发明授权

US07495116B2 Phospholipid derivative 有权
标题翻译：磷脂衍生物
公开(公告)号：US07495116B2
公开(公告)日：2009-02-24
申请号：US10508704
申请日：2003-03-28
申请人： Chika Itoh , Kazuhiro Kubo , Syunsuke Ohhashi , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Takahashi , Hitoshi Yamauchi
发明人： Chika Itoh , Kazuhiro Kubo , Syunsuke Ohhashi , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Takahashi , Hitoshi Yamauchi
IPC分类号： C07C9/02
CPC分类号： A61K47/24 , A61K8/14 , A61K8/553 , A61K8/556 , A61K8/86 , A61K9/1271 , A61Q19/00 , C07F9/10 , C08G65/2609 , C08G65/3353
摘要： A phospholipid derivative represented by the formula (1) (Z represents a residue of a compound having 3 to 10 hydroxyl groups; AO represents an oxyalkylene group having 2 to 4 carbon atoms; R1CO and R2CO represent an acyl group having 8 to 22 carbon atoms; X represents hydrogen atom, an alkali metal atom, ammonium or an organic ammonium; “a” represents an integer of 0 to 4; “b” represents 0 or 1; Q represents hydrogen atom or methyl group; m represents an average number of moles of the oxyalkylene group added; and m, k1, k2, and k3 are numbers satisfying the following conditions: 3≦m≦200, 9≦m×(k1+k2+k3)≦1000, 1≦k1≦2, 0≦k2≦9 and 0≦k3≦9, and 3≦k1+k2+k3≦10), which is highly safe for living bodies, and is suitably used for solubilization and dispersion of physiologically active substances and the like, or in the fields of drug delivery systems such as liposomes and cosmetics.
摘要翻译：由式（1）表示的磷脂衍生物（Z表示具有3〜10个羟基的化合物的残基; AO表示碳原子数2〜4的氧化烯基）; R1CO和R2CO表示碳原子数为8〜22的酰基 ; X表示氢原子，碱金属原子，铵或有机铵;“a”表示0〜4的整数，“b”表示0或1; Q表示氢原子或甲基; m表示氧化亚烷基的摩尔数; m，k1，k2和k3是满足以下条件的数：3 <= m <= 200,9 [= mx（k1 + k2 + k3）<= 1000,1 1 = <= 2，0 <= k2 <= 9，0 <= k3 <= 9，3 <= k1 + k2 + k3 = 10），对生物体来说安全性高，适用于溶解分散的生理活性物质等，或药物递送系统如脂质体和化妆品领域。

16. 发明申请

US20060210618A1 Phospholipid derivatives and process for the production there 有权
标题翻译：磷脂衍生物及其生产工艺
公开(公告)号：US20060210618A1
公开(公告)日：2006-09-21
申请号：US10541309
申请日：2003-12-12
申请人： Kazuhiro Kubo , Chika Itoh , Syunsuke Ohhashi , Tohru Yasukohchi , Yusuke Ohkawa , Hiroshi Kikuchi , Norio Suzuki , Miho Takahashi , Hitoshi Yamauchi
发明人： Kazuhiro Kubo , Chika Itoh , Syunsuke Ohhashi , Tohru Yasukohchi , Yusuke Ohkawa , Hiroshi Kikuchi , Norio Suzuki , Miho Takahashi , Hitoshi Yamauchi
IPC分类号： A61K9/127 , C07F9/02 , A61K31/66
CPC分类号： A61K9/127 , A61K8/14 , A61K8/553 , A61K9/0014 , A61K9/1273 , A61K47/24 , A61Q19/00 , C07F9/10 , C08G65/2609 , C08G65/3353 , C08G2650/34
摘要： A phospholipid derivative represented by the following formula (1): wherein [PG]k represents a residue of polyglycerin having a polymerization degree of k, wherein k is 2 to 50, R1CO and R2CO independently represent an acyl group having 8 to 22 carbon atoms, symbol “a” independently represents an integer of 0 to 5, symbol “b” independently represents 0 or 1, M represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium, and k1, k2, and k3 represent numbers satisfying the following conditions: 1≦k1≦(k+2)/2, 0≦k2, and k1+k2+k3=k+2. The phospholipid derivative is highly safe for living bodies and can be suitably utilized in drug delivery systems such as liposome, and the like.
摘要翻译：由下式（1）表示的磷脂衍生物：其中[PG] k表示聚合度为k的聚甘油的残基，其中k为2至50，R 1 CO和R SUP > 2 CO独立地表示具有8至22个碳原子的酰基，符号“a”独立地表示0至5的整数，符号“b”独立地表示0或1，M表示氢原子，碱金属原子，铵或有机铵，k1，k2和k3表示满足以下条件的数：1 <= k1 <=（k + 2）/ 2,0 <= k2，k1 + k2 + k3 = k + 2。磷脂衍生物对于活体是高度安全的，并且可以适用于药物递送系统如脂质体等。

17. 发明申请

US20060115450A1 Polyalkylene glycol derivative and modified bio-related substance 有权
标题翻译：聚亚烷基二醇衍生物和改性生物相关物质
公开(公告)号：US20060115450A1
公开(公告)日：2006-06-01
申请号：US11142683
申请日：2005-06-02
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： A61K31/765 , C08F283/00
CPC分类号： C08G65/2609 , A61K47/48215 , A61K47/60 , C08G65/329 , C08G65/333
摘要： A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the above oxyalkylene group added, m represents 10 to 1000, X represents a functional group capable of chemically reacting with a bio-related substance, and Y is a linker and represents an ether bond, an amide bond, a urethane bond, an ester bond, a secondary amino group, a carbonate bond, or an alkylene group containing these bonds, polydispersity Mw/Mn of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn≦1.08 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.
摘要翻译：含有式（1）化合物的聚亚烷基二醇衍生物：其中R为碳原子数为1〜24的烃基，OA 1和O 2各自为氧化烯具有2至4个碳原子的基团，由R表示的基团在一个分子中彼此相同或不同，在一个分子中由OA 2表示的基团彼此相同或不同， m是上述氧化烯基的平均加成摩尔数，m表示10〜1000，X表示与生物相关物质发生化学反应的官能团，Y为连接基，表示醚键，酰胺键氨基甲酸酯键，酯键，仲氨基，碳酸酯键或含有这些键的亚烷基，上述聚亚烷基二醇衍生物在凝胶渗透色谱中的多分散性Mw / Mn满足以下关系： -formulae description =“In-line Formulas”end =“lead”？> Mw / Mn <= 1.08 < in-line-formula description =“In-line Formulas”end =“tail”？>其中Mw表示重均分子量，Mn表示数均分子量。

18. 发明授权

US06313201B1 Modified catalase, a composition thereof and process for preparing the catalase 失效
标题翻译：改性过氧化氢酶，其组合物和制备过氧化氢酶的方法
公开(公告)号：US06313201B1
公开(公告)日：2001-11-06
申请号：US09218892
申请日：1998-12-22
申请人： Satoshi Nanba , Tomomi Suzuki , Syunsuke Ohhashi , Tohru Yasukohchi
发明人： Satoshi Nanba , Tomomi Suzuki , Syunsuke Ohhashi , Tohru Yasukohchi
IPC分类号： C08L8900
CPC分类号： C12N9/0065 , A61K47/60
摘要： A composition is provided which comprises catalase modified with a copolymer (A) and a second copolymer, i.e., copolymer (B). The copolymer (A) comprises an alkenyl ether, maleic anhydride, and at least one monomer selected from the group consisting of unsaturated carboxylic acid, vinyl compound and olefin, and copolymer (B) consists of an ethylenically unsaturated monomer and a monomer selected from the group consisting of a monomer having a carboxyl group and a monomer having an acid anhydride group, or a salt of the copolymer (B).
摘要翻译：提供了包含用共聚物（A）和第二共聚物（即共聚物（B））改性的过氧化氢酶的组合物。共聚物（A）包含链烯基醚，马来酸酐和至少一种选自不饱和羧酸，乙烯基化合物和烯烃的单体，共聚物（B）由烯键式不饱和单体和选自由具有羧基的单体和具有酸酐基的单体组成的组，或共聚物（B）的盐组成的组。

19. 发明授权

US5463066A Phospholipid derivative and reactive vesicle-forming agent 失效
标题翻译：磷脂衍生物和反应性囊泡形成剂
公开(公告)号：US5463066A
公开(公告)日：1995-10-31
申请号：US349368
申请日：1994-12-05
申请人： Tsuyoshi Miyazaki , Kouzoh Sanchika , Mitsuhiro Nishida , Tohru Yasukohchi , Shigeru Kitano , Akinori Suginaka , Yoshihito Kadoma
发明人： Tsuyoshi Miyazaki , Kouzoh Sanchika , Mitsuhiro Nishida , Tohru Yasukohchi , Shigeru Kitano , Akinori Suginaka , Yoshihito Kadoma
IPC分类号： A61K9/127 , A61K47/48 , C07D233/64 , C07F9/6506 , C08G65/332 , C08G65/335
CPC分类号： C08G65/3328 , A61K47/48238 , A61K47/48815 , A61K9/1271 , C07F9/65061 , C08G65/335
摘要： A novel and useful phospholipid derivative to be used for a reactive vesicle-forming agent, which is represented by the following general formula (1): ##STR1## in which R.sup.1 C(.dbd.O) and R.sup.2 C(.dbd.O) represent each an aliphatic acyl group, R.sup.3 denotes hydrogen atom or methyl group, OA represents an oxyalkylene group of 2-4 carbon atoms, n indicates the average addition mole number of added oxyalkylene group and is 1-1,000, p is 0 or 1, X represents ##STR2## with q and r being each an integer of 0 to 4 or 1 to 4, respectively, and M denotes hydrogen atom or an alkali metal atom.
摘要翻译：用于反应性泡囊形成剂的新型有用的磷脂衍生物，其由以下通式（1）表示：各自为脂族酰基，R 3表示氢原子或甲基，OA表示氧化烯基 2-4个碳原子，n表示加成的氧化烯基的平均加成摩尔数，为1-1000，p为0或1，X为4或1〜4，M为氢原子或碱金属原子。

20. 发明授权

US08003117B2 Polyalkylene glycol derivative and modified bio-related substance 有权
标题翻译：聚亚烷基二醇衍生物和改性生物相关物质
公开(公告)号：US08003117B2
公开(公告)日：2011-08-23
申请号：US11142678
申请日：2005-06-02
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： C07C41/00 , C07C43/00
CPC分类号： C08G65/333 , C08G65/2609 , C08G65/329
摘要： A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA2 is an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the oxyalkylene group added, m represents 10 to 1000, and X represents a functional group capable of chemically reactive with a bio-related substance, polydispersity Mw/Mn of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn≦1.07 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.
摘要翻译：含有式（1）化合物的聚亚烷基二醇衍生物：其中R为碳原子数1〜24的烃基，OA2为碳原子数2〜4的氧化烯基，由R表示的基团相同或不同，在一个分子中，由一个分子表示的基团彼此相同或不同，m是加成的氧化烯基的平均摩尔数，m表示10〜1000，X表示能够与生物相关物质化学反应，上述聚亚烷基二醇衍生物的多分散性Mw / Mn在凝胶渗透色谱中满足以下关系式：Mw / Mn＆nlE 1.07其中Mw表示重均分子量，Mn表示数均分子量。

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