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11. 发明授权

US06881423B2 Powdery composition for nasal administration 失效
标题翻译：用于鼻腔给药的粉状组合物
公开(公告)号：US06881423B2
公开(公告)日：2005-04-19
申请号：US09125814
申请日：1997-02-26
申请人： Masahiko Dohi , Yoshihisa Nishibe , Yuji Makino , Tako Fujii
发明人： Masahiko Dohi , Yoshihisa Nishibe , Yuji Makino , Tako Fujii
IPC分类号： A61K9/00 , A61K9/50 , A61K9/14
CPC分类号： A61K9/0043
摘要： A powdery composition for nasal administration, where (1) the composition contains (i) a drug, (ii) a water-absorbing and gel-forming base material such as hydroxyprophyl cellulose or hydroxpropylmethyl cellulose and (iii) a water-absorbing and water-insoluble base material such as crystalline cellulose or α-cellulose, (2) wherein the amount of water-absorbing and gel-forming base material is about 5-40 wt. % based on the total of the water-absorbing and gel-forming base material and the water-absorbing and water-insoluble base material, and (3) wherein the drug is unevenly dispersed more on/in the water-absorbing and water-insoluble base material than on/in the water-absorbing and gel-forming base material.
摘要翻译：一种用于鼻腔给药的粉末组合物，其中（1）组合物包含（i）药物，（ii）吸水和凝胶形成基材如羟丙基纤维素或羟丙基甲基纤维素和（iii）吸水和水不溶性基材如结晶纤维素或α-纤维素，（2）其中吸水和凝胶形成基材的量为约5-40wt。基于吸水和凝胶形成基材和吸水性和水不溶性基材的总量的％，和（3）其中药物不均匀地分散在吸水性和水不溶性的/ 基材比吸水和凝胶形成基材上/上。

12. 发明授权

US4789667A External pharmaceutical composition and methods of use 失效
标题翻译：外用药物组成及使用方法
公开(公告)号：US4789667A
公开(公告)日：1988-12-06
申请号：US771764
申请日：1985-09-03
申请人： Yuji Makino , Hideo Matugi , Yoshiki Suzuki
发明人： Yuji Makino , Hideo Matugi , Yoshiki Suzuki
IPC分类号： A61K47/22 , A61K31/40 , A61K31/56 , A61K31/60 , A61K31/62
CPC分类号： A61K9/0014 , A61K47/22 , Y10S514/946 , Y10S514/947 , Y10S514/969
摘要： A pharmaceutical composition for external use with the enhanced penetration of a pharmacologically active agent through the skin or mucosa of a warm-blooded animal, said composition comprising(A) a pharmaceutically effective amount of the pharmacologically active agent, and(B) an optically active or inactive pyroglutamate of the following formula ##STR1## wherein R represents a linear, branched or cyclic alkyl or alkenyl group having 10 to 14 carbon atoms,as a penentration enhancer.
摘要翻译：一种外用的药物组合物，其具有通过温血动物的皮肤或粘膜增强的药理活性剂渗透性，所述组合物包含（A）药学有效量的药理活性剂，和（B）光学活性剂或不活泼的焦谷氨酸盐，其中R表示具有10至14个碳原子的直链，支链或环状烷基或烯基作为缩合增强剂。

13. 发明授权

US4729895A Composition for solid pharmaceutical preparations of active vitamins D.sub. 3 失效
标题翻译：活性维生素D3的固体药物制剂的组合物及其制备方法
公开(公告)号：US4729895A
公开(公告)日：1988-03-08
申请号：US27082
申请日：1987-03-16
申请人： Yuji Makino , Yoshiki Suzuki
发明人： Yuji Makino , Yoshiki Suzuki
IPC分类号： C07D319/02 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/26 , A61K9/50 , A61K31/59 , A61K47/26 , A61K47/28 , A61K47/30 , C07D307/33
CPC分类号： A61K31/59 , A61K9/146 , A61K9/1676 , Y10S514/96
摘要： This invention is concerned with a composition for solid pharmaceutical preparations of active vitamins D.sub.3, having the remarkably improved stability of active vitamins D.sub.3, and an extremely advantageous process for the preparation thereof from the industrial viewpoint. The composition of this invention is a composition for solid pharmaceutical preparations of active vitamins D.sub.3 prepared by forming an outer layer comprising active vitamins D.sub.3 and an excipient, which is readily soluble in an organic solvent, around an inner layer comprising an excipient which is slightly soluble in an organic solvent.
摘要翻译：本发明涉及活性维生素D3的固体药物制剂的组合物，具有显着提高的活性维生素D3的稳定性，并且从工业观点出发，其制备方法非常有利。本发明的组合物是一种活性维生素D3的固体药物制剂的组合物，其通过在包含微溶性赋形剂的内层上形成包含活性维生素D3的外层和容易溶于有机溶剂的赋形剂，在有机溶剂中。

14. 发明授权

US5634900A Multi-dose powdered medicine administering device and method thereof 失效
标题翻译：多剂量粉末给药装置及其方法
公开(公告)号：US5634900A
公开(公告)日：1997-06-03
申请号：US373202
申请日：1995-01-12
申请人： Yuji Makino , Yoshiki Suzuki
发明人： Yuji Makino , Yoshiki Suzuki
IPC分类号： A61M13/00 , A61M15/00
CPC分类号： A61M15/0065 , A61M13/00 , A61M2202/064 , A61M2205/075
摘要： An administering device capable of quantitatively spraying a multi-dose of powdered medicine includes a device body (1), a storage chamber (3) detachably provided in the device body, the storage chamber (3) being capable of storing powdered medicine, the amount of which corresponds to a plurality of administering operations, an accommodation chamber (10) capable of accommodating powdered medicine, the amount of which corresponds to a single administering operation, and a medicine dispensing rotor (6) movably attached to the device body. The medicine dispensing rotor communicates the accommodation chamber with the storage chamber at a charging position (3a) and communicates the accommodation chamber with the outside of the device body at an administering position (5a) so that the powdered medicine in the accommodation chamber can be administered. A cap (20) is provided for moving the medicine dispensing rotor between the charging position and the administering position. A pump means (8) is provided for injecting air into the storage chamber through the accommodation chamber at the charging position so that the powdered medicine in the storage chamber can be stirred and a predetermined quantity of powdered medicine that has been stirred can be charged from the storage chamber to the accommodation chamber by the suction force of the pump means and/or gravity.
摘要翻译： PCT No.PCT / JP94 / 00771 Sec。 371日期1995年1月12日 102（e）日期1995年1月12日PCT提交1994年5月12日PCT公布。 WO94 / 26338 PCT公开号日期：1994年11月24日能够定量喷雾多剂粉末药物的给药装置包括装置本体（1），可拆卸地设置在装置主体中的储存室（3），储存室（3）能够储存粉末药剂，其数量对应于多个给药操作，能够容纳粉末药物的容纳室（10），其量相当于单次给药操作;以及药剂分配转子（6），其可移动地附接到装置体。药剂分配转子将收纳室与储藏室连通在充电位置（3a），并将容纳室与装置主体的外部在给药位置（5a）连通，使得容纳室中的粉末药物能够被施用。提供盖（20），用于在充电位置和给药位置之间移动药物分配转子。提供了一种泵装置（8），用于通过充电位置处的容纳室将空气喷射到储存室中，使得可以搅拌储藏室中的粉末药物，并且可以从预定量的搅拌器中加入预定量的粉末药物通过泵装置的吸力和/或重力将储存室释放到容纳室。

15. 发明授权

US5395916A Biodegradable copolymer from hydroxy proline 失效
标题翻译：由羟基脯氨酸生物降解的共聚物
公开(公告)号：US5395916A
公开(公告)日：1995-03-07
申请号：US62335
申请日：1993-05-17
申请人： Seiji Mochizuki , Kiyoshi Nawata , Yuji Makino , Yoshiki Suzuki
发明人： Seiji Mochizuki , Kiyoshi Nawata , Yuji Makino , Yoshiki Suzuki
IPC分类号： C08G63/06 , A61K9/16 , A61K9/50 , C08G63/685 , C08L101/16 , C08G69/10
CPC分类号： C08G63/6852 , A61K9/1647 , A61K9/5031
摘要： A biodegradable copolymer having the constituent units represented by the structures (I) and (II): ##STR1## wherein X represents a hydrogen atom, an acyl group having the formula RCO-- where R is a hydrocarbon group having 1 to 20 carbon atoms, an alkoxy group having to 20 carbon atoms, and Y represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, and m and n are independently integers of 1 or more, m+n is at least 10, and m/(m+n) is at least 0.01 and a pharmaceutical composition containing the same.
摘要翻译：具有由结构（I）和（II）表示的构成单元的生物可降解共聚物：ts氢原子，具有式RCO-的酰基，其中R是具有1至20个碳原子的烃基，烷氧基必须具有 20个碳原子，Y表示氢原子或碳原子数1〜8的烷基，m和n分别为1以上的整数，m + n为10以上，m /（m + n）为至少0.01和含有该组合物的药物组合物。

16. 发明授权

US5229422A Extemporaneous preparation type kit of a pharmaceutical substance-containing fat emulsion 失效
标题翻译：含药物脂肪乳剂的临时制剂型试剂盒
公开(公告)号：US5229422A
公开(公告)日：1993-07-20
申请号：US715018
申请日：1991-06-13
申请人： Ken Takahashi , Yuji Makino , Yoshiki Suzuki , Tatsuyuki Naruchi
发明人： Ken Takahashi , Yuji Makino , Yoshiki Suzuki , Tatsuyuki Naruchi
IPC分类号： A61K9/107
CPC分类号： A61K9/1075 , Y10S514/943
摘要： An extemporaneous kit of pharmaceutical substance-containing fat emulsion which consists of a fat emulsion and (a) a pharmaceutical substance composition containing pharmaceutical substance and at least one solvent selected from the group consisting of water, liquid polyalkylene glycols, liquid alkylethanolamines, and liquid polyhydric alcohols, or (b) a pharmaceutical substance composition containing pharmaceutical substance and saccharides and/or 30 amino acids as an excipient, and a process for preparation of a pharmaceutical substance-containing fat emulsion therefrom.
摘要翻译： PCT No.PCT / JP88 / 00889 Sec。 371日期：1989年5月4日 102（e）日期1989年5月4日PCT提交1988年9月5日PCT公布。出版物WO89 / 02265 日期：1989年3月23日。一种含药物脂肪乳剂的临时试剂盒，由脂肪乳液和（a）含有药物和至少一种选自水，液体聚亚烷基二醇的溶剂的药物组合物组成，液体烷基乙醇胺和液体多元醇，或（b）含有药物和糖类和/或30个氨基酸作为赋形剂的药物组合物及其制备含药物的脂肪乳剂的方法。

17. 发明授权

US5211950A Stabilized calcitonin pharmaceutical composition 失效
标题翻译：稳定的CALCITONIN药物组合物
公开(公告)号：US5211950A
公开(公告)日：1993-05-18
申请号：US527461
申请日：1990-05-23
申请人： Hideki Kobayashi , Seiji Mochizuki , Yuji Makino , Yoshiki Suzuki
发明人： Hideki Kobayashi , Seiji Mochizuki , Yuji Makino , Yoshiki Suzuki
IPC分类号： A61K9/00 , A61K9/14 , A61K9/48 , A61K38/23 , A61K47/18 , A61P3/00 , A61P43/00
CPC分类号： A61K38/23 , A61K47/183 , A61K9/0043
摘要： A solid calcitonin pharmaceutical composition comprised of a therapeutically effective amount of calcitonins and ethylene diamine tetraacetates.

18. 发明授权

US4597915A Carburetor percolation prevention system 失效
标题翻译：化油器渗滤预防系统
公开(公告)号：US4597915A
公开(公告)日：1986-07-01
申请号：US573488
申请日：1984-01-24
申请人： Hidenobu Nagase , Yuji Makino
发明人： Hidenobu Nagase , Yuji Makino
IPC分类号： F02M5/10 , F02M37/00
CPC分类号： F02M5/10 , Y10S261/51 , Y10S261/81
摘要： The invention discloses a carburetor percolation prevention system which utilizes an electrically controlled fuel drain valve disposed in a fuel drain passage between the carburetor float chamber and the fuel tank. The electrical fuel drain valve is opened only when the engine condition sensor and the temperature sensor indicate that both the ignition switch is de-energized and the temperature near the float chamber exceeds a predetermined level.
摘要翻译：本发明公开了一种化油器渗滤防止系统，其利用设置在化油器浮子室和燃料箱之间的燃料排放通道中的电控燃油排放阀。只有当发动机状态传感器和温度传感器指示点火开关断电并且浮子室附近的温度超过预定水平时，电气排放阀才打开。

19. 发明授权

US5987878A Fuel reforming apparatus and electric power generating system having the same 失效
标题翻译：燃料重整装置及其发电系统
公开(公告)号：US5987878A
公开(公告)日：1999-11-23
申请号：US115521
申请日：1998-07-15
申请人： Kazuhito Koyama , Shigehisa Sugita , Shinya Marushima , Yuji Makino , Kazuhiro Gonda
发明人： Kazuhito Koyama , Shigehisa Sugita , Shinya Marushima , Yuji Makino , Kazuhiro Gonda
IPC分类号： F02M27/02 , B01B1/00 , B01J8/02 , C01B3/38 , F01K21/04 , F01K23/10 , F02C3/22 , F02C3/24 , F02C3/28 , F02C3/30 , F02C3/32 , F02C6/18 , F02C7/22 , F02B43/00
CPC分类号： B01B1/005 , B01J8/0285 , C01B3/38 , C01B3/382 , F01K21/047 , F01K23/10 , F02C3/24 , F02C3/28 , F02C3/30 , F02C3/32 , B01J2208/00504 , Y02E20/14 , Y02P20/129
摘要： A cylindrical fuel reforming apparatus covered with a thermal insulating layer 16 comprises a fuel flow passage 1 contoured by a cylindrical contour wall 2 in its central axial direction and a reforming catalyst bed 3 in the middle of the flow passage for reforming gas to be reformed flowing from the upstream of the fuel flow passage 1 into a proper reformed gas. A cooling jacket 10 is arranged in the upstream of the reforming catalyst bed 3 so as to surround the fuel flow passage 1 and to be supplied with steam 11 for cooling the cylindrical contour wall 2. There are provided in the cylindrical contour wall 2 in the upstream of the reforming catalyst bed 3 a plurality of injection nozzles 15 communicating the cooling jacket 10 with the fuel flow passage 1 so that the steam 11 introduced into the cooling jacket 10 is allowed to flow into the fuel flow passage 1.
摘要翻译：被绝热层16覆盖的圆柱形燃料重整装置包括由中心轴线的圆柱形轮廓壁2构成的燃料流路1和流路中间的重整催化剂床3，用于使重整气流重整从燃料流路1的上游到适当的重整气体。在重整催化剂床3的上游设置有冷却套10，以围绕燃料流路1并供给蒸汽11，以冷却圆筒形轮廓壁2.在圆筒形轮廓壁2中设置有冷却套在重整催化剂床3的上游设置有使冷却套10与燃料流路1连通的多个喷嘴15，使得导入冷却套管10的蒸汽11能够流入燃料流路1。

20. 发明授权

US5873236A Fuel reforming apparatus and electric power generating system having the same 失效
公开(公告)号：US5873236A
公开(公告)日：1999-02-23
申请号：US822934
申请日：1997-03-21
申请人： Kazuhito Koyama , Shigehisa Sugita , Shinya Marushima , Yuji Makino , Kazuhiro Gonda
发明人： Kazuhito Koyama , Shigehisa Sugita , Shinya Marushima , Yuji Makino , Kazuhiro Gonda
IPC分类号： F02M27/02 , B01B1/00 , B01J8/02 , C01B3/38 , F01K21/04 , F01K23/10 , F02C3/22 , F02C3/24 , F02C3/28 , F02C3/30 , F02C3/32 , F02C6/18 , F02C7/22 , F02C7/12 , F02B43/00
CPC分类号： B01B1/005 , B01J8/0285 , C01B3/38 , C01B3/382 , F01K21/047 , F01K23/10 , F02C3/24 , F02C3/28 , F02C3/30 , F02C3/32 , B01J2208/00504 , Y02E20/14 , Y02P20/129
摘要： A cylindrical fuel reforming apparatus covered with a thermal insulating layer 16 comprises a fuel flow passage 1 contoured by a cylindrical contour wall 2 in its central axial direction and a reforming catalyst bed 3 in the middle of the flow passage for reforming gas to be reformed flowing from the upstream of the fuel flow passage 1 into a proper reformed gas. A cooling jacket 10 is arranged in the upstream of the reforming catalyst bed 3 so as to surround the fuel flow passage 1 and to be supplied with steam 11 for cooling the cylindrical contour wall 2. There are provided in the cylindrical contour wall 2 in the upstream of the reforming catalyst bed 3 a plurality of injection nozzles 15 communicating the cooling jacket 10 with the fuel flow passage 1 so that the steam 11 introduced into the cooling jacket 10 is allowed to flow into the fuel flow passage 1.

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