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    • 13. 发明授权
    • Method for diagnosis of crohn's disease
    • 克罗恩病诊断方法
    • US06762021B2
    • 2004-07-13
    • US09725752
    • 2001-05-22
    • Katsushi TokunagaNaoyuki Tsuchiya
    • Katsushi TokunagaNaoyuki Tsuchiya
    • C12Q168
    • C12Q1/26C12Q1/37C12Q1/42C12Q1/485C12Q1/6883C12Q2600/158
    • The present invention provides a reagent for diagnosing Crohn's disease, which contains at least one member selected from the group consisting of a group of substances having a specific affinity for a protein (or a gene thereof) whose expression is potentiated in a lesion-specific manner, such as a substance having a specific affinity for PP6 regulated by IL-2 (or a gene thereof), a substance having a specific affinity for TNIK (or a gene thereof), a substance having a specific affinity for FLIP (or a gene thereof), a substance having a specific affinity for GR&agr; (or a gene thereof) and the like. By taking note of a gene whose expression is potentiated in a lesion-specific manner, and examining the behavior thereof by the use of this diagnostic reagent, the disease can be diagnosed easily and quickly.
    • 本发明提供了一种用于诊断克罗恩病的试剂,其含有至少一种选自对病毒特异性表达增强的蛋白质(或其基因)具有特异性亲和力的物质组成的组 例如对由IL-2(或其基因)调节的PP6具有特异性亲和力的物质,对TNIK具有特异性亲和力的物质(或其基因),对FLIP具有特异性亲和力的物质(或基因 ),对GRalpha(或其基因)具有特异性亲和力的物质等。 通过注意到以病变特异性方式增强其表达的基因,并通过使用该诊断试剂检查其行为,可以容易且快速地诊断该疾病。