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11. 发明申请

US20090086321A1 ZOOM LENS SYSTEM, OPTICAL APPARATUS, AND METHOD FOR MANUFACTURING ZOOM LENS SYSTEM 有权
标题翻译：变焦镜头系统，光学设备和制造变焦镜头系统的方法
公开(公告)号：US20090086321A1
公开(公告)日：2009-04-02
申请号：US12211900
申请日：2008-09-17
申请人： Keiko MIZUGUCHI , Tomoki Ito
发明人： Keiko MIZUGUCHI , Tomoki Ito
IPC分类号： G02B27/64 , G02B15/16
CPC分类号： G02B27/646 , G02B15/173
摘要： Providing a zoom lens system having a vibration reduction function capable of performing quick focusing with excellent optical performance even upon vibration reduction. The system including, in order from an object, a first lens group G1 having positive refractive power, a second lens group G2 having negative refractive power, a third lens group G3 having positive refractive power, and a fourth lens group G4 having positive refractive power. Upon zooming from a wide-angle end state to a telephoto end state, a distance between the first lens group G1 and the second lens group G2 varies, and a distance between the second lens group G2 and the third lens group G3 varies. The third lens group G3 carries out focusing from an infinity object to a close object. At least a portion of the fourth lens group G4 moves in a direction perpendicular to the optical axis.
摘要翻译：提供具有减振功能的变焦透镜系统，即使在减振时也能够进行快速聚焦，具有出色的光学性能。该系统依次包括具有正折光力的第一透镜组G1，具有负折光力的第二透镜组G2，具有正折光力的第三透镜组G3和具有正折光力的第四透镜组G4 。在从广角端状态变焦到望远端状态时，第一透镜组G1和第二透镜组G2之间的距离变化，并且第二透镜组G2与第三透镜组G3之间的距离变化。第三透镜组G3从无限远物体执行聚焦到近距离物体。第四透镜组G4的至少一部分在垂直于光轴的方向上移动。

12. 发明申请

US20080286286A1 Methods to Treat Disease States by Influencing the Signaling of Ox-40-Receptors and High Throughput Screening Methods for Identifying Substances Therefor 审中-公开
标题翻译：通过影响Ox-40受体信号治疗疾病状态的方法和高通量筛选方法鉴定其物质
公开(公告)号：US20080286286A1
公开(公告)日：2008-11-20
申请号：US11659266
申请日：2007-01-16
申请人： Yong-Jun Liu , Tomoki Ito
发明人： Yong-Jun Liu , Tomoki Ito
IPC分类号： A61K39/395 , G01N33/535 , A61P37/02
CPC分类号： A61K38/177 , C07K16/2878 , G01N33/505 , G01N33/56972 , G01N2333/5428
摘要： OX40L inhibits the generation of IL-10-producing Tr1 cells from naïve and memory CD4+ T cells induced by the immunuosuppressive drugs dexamethasone and vitamin D3. This unique function of OX40L is not shared by two other costimulatory TNF-family members, GITR-ligand and 4-1BB-ligand. OX40L also strongly inhibits the generation of IL-10-producing Tr1 cells induced by two physiological stimuli provided by inducible costimulatory ligand and immature DCs and inhibits the production of IL-10 by regulatory T cells. It has thus been shown that signaling the OX40-receptor on human T cells by monoclonal antibodies, small molecules, or OX40L regulates the generation and function of IL-10 producing immunosuppressive T cells. Also provided are high throughput methods for identifying substances that promote or inhibit the generation and function of IL-10 producing T cells. Numerous disease states, such as human allergic, autoimmune, and autoimmune diseases, and cancer, may be treated by targeting OX40/OX40L.
摘要翻译： OX40L抑制由免疫抑制药物地塞米松和维生素D3诱导的初始和记忆的CD4 + T细胞产生产生IL-10的Tr1细胞。 OX40L的这种独特功能不是由另外两种共刺激的TNF-家族成员，GITR-配体和4-1BB-配体共享。 OX40L还强烈地抑制由诱导性共刺激配体和未成熟DC提供的两种生理刺激诱导的产生IL-10的Tr1细胞的产生，并通过调节性T细胞抑制IL-10的产生。因此，已经表明，通过单克隆抗体，小分子或OX40L信号传导人T细胞上的OX40-受体调节产生IL-10的免疫抑制性T细胞的产生和功能。还提供了用于鉴定促进或抑制产生IL-10和产生T细胞的功能的物质的高通量方法。可以通过靶向OX40 / OX40L来治疗许多疾病状态，例如人类过敏，自身免疫和自身免疫性疾病和癌症。

13. 发明授权

US08611761B2 Method to control temperature of LD 有权
标题翻译：控制LD温度的方法
公开(公告)号：US08611761B2
公开(公告)日：2013-12-17
申请号：US12984095
申请日：2011-01-04
申请人： Ryutaro Takei , Takeshi Irie , Tomoki Ito , Kazuhisa Ozaki , Masatsugu Togasaki
发明人： Ryutaro Takei , Takeshi Irie , Tomoki Ito , Kazuhisa Ozaki , Masatsugu Togasaki
IPC分类号： H04B10/00 , H04B10/50
CPC分类号： H04B10/503 , H04B10/572
摘要： New method to control the optical transmitter is disclosed. The optical transmitter provides both of the ATC feedback loop and the APC feedback loop. When a failure occurs in the ATC feedback loop and the temperature sensor is unable to output an adequate signal any longer, the optical transmitter cuts the APC loop and operates the LD in constant conditions. The output of the monitor PD is transferred to the ATC loop to control the TEC based on the optical output of the LD.
摘要翻译：公开了一种控制光发射机的新方法。光发射机提供ATC反馈环路和APC反馈环路。当ATC反馈回路发生故障，温度传感器不能再输出足够的信号时，光发射器切断APC回路并在恒定条件下操作LD。监视器PD的输出被传送到ATC环路，以基于LD的光输出来控制TEC。

14. 发明申请

US20130258495A1 ZOOMING OPTICAL SYSTEM, OPTICAL APPARATUS HAVING THE ZOOMING OPTICAL SYSTEM, AND METHOD FOR MANUFACTURING ZOOMING OPTICAL SYSTEM 有权
标题翻译：变焦光学系统，具有变焦光学系统的光学装置及其制造光学系统的方法
公开(公告)号：US20130258495A1
公开(公告)日：2013-10-03
申请号：US13994730
申请日：2011-12-14
申请人： Tomoki Ito
发明人： Tomoki Ito
IPC分类号： G02B15/16
CPC分类号： G02B15/16 , G02B15/173 , G02B27/646 , Y10T29/49826
摘要： A zoom optical system ZL to be mounted on an optical apparatus such as a single lens reflex camera 1, comprising, in order from an object side, a first lens group G1 having positive refractive power, a second lens group G2 having negative refractive power, a third lens group G3 having positive refractive power, a fourth lens group G4 having negative refractive power, a fifth lens group G5 having positive refractive power, and a sixth lens group G6 having negative refractive power. The zoom optical system is configured such that at least a portion of any one lens group among these lens group G1 to G6 may be moved such that a component in a direction perpendicular to the optical axis may be included. Thus, there are provided a zoom optical system that can suppress well variation in aberrations upon zooming, an optical apparatus equipped therewith and a method for manufacturing the zoom optical system.
摘要翻译：安装在诸如单个透镜反射照相机1的光学装置上的变焦光学系统ZL包括从物体侧开始具有正折光力的第一透镜组G1，具有负折光力的第二透镜组G2，具有正折光力的第三透镜组G3，具有负折光力的第四透镜组G4，具有正折光力的第五透镜组G5和具有负折光力的第六透镜组G6。变焦光学系统被配置为使得这些透镜组G1至G6中的任何一个透镜组的至少一部分可以移动，使得可以包括在垂直于光轴的方向上的分量。因此，提供了可以抑制变焦时的像差的良好变化的变焦光学系统，配备有其的光学装置以及用于制造变焦光学系统的方法。

15. 发明申请

US20110008368A1 METHODS OF MODULATING THE OX40 RECEPTOR TO TREAT CANCER 审中-公开
标题翻译：调节OX40受体治疗癌症的方法
公开(公告)号：US20110008368A1
公开(公告)日：2011-01-13
申请号：US12861135
申请日：2010-08-23
申请人： Yong-Jun Liu , Tomoki Ito
发明人： Yong-Jun Liu , Tomoki Ito
IPC分类号： A61K39/395 , A61P35/00 , A61P37/04 , C40B30/04
CPC分类号： G01N33/5011 , A61K2039/505 , C07K16/2878 , C07K2317/73 , C07K2317/75 , G01N2333/5434 , G01N2333/70578
摘要： Numerous disease states, such as human allergic, autoimmune, and autoimmune diseases, and cancer, may be treated by targeting OX40/OX4OL. OX4OL inhibits the generation of Tr1 cells from naïve and memory CD4+ T cells. This unique function of OX4OL is not shared by two other costimulatory TNF-family members, GITR-ligand and 4-1BB-ligand. It has been shown that signaling the OX40-receptor on human T cells by antibodies, small molecules, or the OX4OL modulates the generation and function of IL-10 producing Foxp3+ Treg immunosuppressive T cells and blocks Foxp3+ Treg function. Further, provided are high throughput methods for identifying compounds that can inhibit the immunosuppressive function of IL-10 producing Tr1 cells.
摘要翻译：可以通过靶向OX40 / OX4OL来治疗许多疾病状态，例如人类过敏，自身免疫和自身免疫性疾病以及癌症。 OX4OL抑制从初始和记忆的CD4 + T细胞产生Tr1细胞。 OX4OL的这种独特功能不是由另外两种共刺激的TNF-家族成员GITR-配体和4-1BB-配体共享。已经表明，通过抗体，小分子或OX4OL来传递人T细胞上的OX40-受体，调节产生IL-10的产生和功能的Foxp3 + Treg免疫抑制性T细胞并阻断Foxp3 + Treg功能。此外，提供了用于鉴定可以抑制产生IL-10的Tr1细胞的免疫抑制功能的化合物的高通量方法。

16. 发明申请

US20060061240A1 Piezoelectric/electrostrictive device 审中-公开
标题翻译：压电/电致伸缩器件
公开(公告)号：US20060061240A1
公开(公告)日：2006-03-23
申请号：US11266434
申请日：2005-11-03
申请人： Koji Ikeda , Kazuyoshi Shibata , Tomoki Ito , Fumitake Takahashi
发明人： Koji Ikeda , Kazuyoshi Shibata , Tomoki Ito , Fumitake Takahashi
IPC分类号： H01L41/08
CPC分类号： H01L41/43 , H01L41/094 , H01L41/314 , H01L41/338 , Y10T29/42 , Y10T29/43 , Y10T29/49005 , Y10T29/49126 , Y10T29/49128
摘要： A piezoelectric/electrostrictive device includes a pair of thin plates confronting each other, a fixing member supporting the thin plates thereon, and movable portions disposed on end portions of the pair of thin plates. Protrusions are formed on principal surfaces of first ceramic green sheets according to at least a single thick film forming process. The protrusions will subsequently serve as the movable portions, and the first ceramic green sheets will subsequently serve as the thin plates. The first ceramic green sheets and a second ceramic green sheet which will subsequently serve as the fixing member are stacked into a ceramic green laminated body. The ceramic green laminated body is baked into an integral ceramic laminated body. Piezoelectric/electrostrictive elements are formed on the ceramic laminated body. After the piezoelectric/electrostrictive elements are baked, unnecessary-portions are removed from the piezoelectric/electrostrictive elements to fabricate the piezoelectric/electrostrictive device.
摘要翻译：压电/电致伸缩器件包括彼此面对的一对薄板，支撑薄板的固定部件和设置在该对薄板的端部上的可动部。根据至少一个厚膜形成方法，在第一陶瓷生片的主表面上形成突起。这些突起随后将用作可动部分，并且第一陶瓷生片将随后用作薄板。第一陶瓷生片和随后用作定影构件的第二陶瓷生片堆叠成陶瓷绿色层压体。陶瓷绿色层压体被烘烤成一体的陶瓷层压体。在陶瓷层叠体上形成压电/电致伸缩元件。在压电/电致伸缩元件被烘烤之后，不必要的部分从压电/电致伸缩元件去除以制造压电/电致伸缩器件。

17. 发明授权

US09091841B2 Zooming optical system, optical apparatus having the zooming optical system, and method for manufacturing zooming optical system 有权
标题翻译：变焦光学系统，具有变焦光学系统的光学装置以及用于制造变焦光学系统的方法
公开(公告)号：US09091841B2
公开(公告)日：2015-07-28
申请号：US13994730
申请日：2011-12-14
申请人： Tomoki Ito
发明人： Tomoki Ito
IPC分类号： G02B15/14 , G02B15/16 , G02B15/173 , G02B27/64
CPC分类号： G02B15/16 , G02B15/173 , G02B27/646 , Y10T29/49826
摘要： A zoom optical system ZL to be mounted on an optical apparatus such as a single lens reflex camera 1, comprising, in order from an object side, a first lens group G1 having positive refractive power, a second lens group G2 having negative refractive power, a third lens group G3 having positive refractive power, a fourth lens group G4 having negative refractive power, a fifth lens group G5 having positive refractive power, and a sixth lens group G6 having negative refractive power. The zoom optical system is configured such that at least a portion of any one lens group among these lens group G1 to G6 may be moved such that a component in a direction perpendicular to the optical axis may be included. Thus, there are provided a zoom optical system that can suppress well variation in aberrations upon zooming, an optical apparatus equipped therewith and a method for manufacturing the zoom optical system.
摘要翻译：安装在诸如单个透镜反射照相机1的光学装置上的变焦光学系统ZL包括从物体侧开始具有正折光力的第一透镜组G1，具有负折光力的第二透镜组G2，具有正折光力的第三透镜组G3，具有负折光力的第四透镜组G4，具有正折光力的第五透镜组G5和具有负折光力的第六透镜组G6。变焦光学系统被配置为使得这些透镜组G1至G6中的任何一个透镜组的至少一部分可以移动，使得可以包括在垂直于光轴的方向上的分量。因此，提供了可以抑制变焦时的像差的良好变化的变焦光学系统，配备有其的光学装置以及用于制造变焦光学系统的方法。

18. 发明授权

US08144403B2 Zoom lens system, optical apparatus, and method for zooming 有权
标题翻译：变焦镜头系统，光学设备和缩放方法
公开(公告)号：US08144403B2
公开(公告)日：2012-03-27
申请号：US12139461
申请日：2008-06-14
申请人： Tomoki Ito , Takeshi Suzuki , Hiroshi Yamamoto
发明人： Tomoki Ito , Takeshi Suzuki , Hiroshi Yamamoto
IPC分类号： G02B15/14
CPC分类号： G02B15/177 , G02B27/646
摘要： Providing a zoom lens system having excellent optical performance, an optical apparatus, and a method for zooming the zoom lens system. The zoom lens system includes, in order from an object, a first lens group G1 having negative refractive power, a second lens group G2 having positive refractive power, and a third lens group G3 having negative refractive power. Upon zooming from a wide-angle end state W to a telephoto end state T, each distance between adjacent lens groups is varied. The first lens group G1 includes, in order from the object, a front group G1a, and a rear group G1b having negative refractive power. Focusing on the object is carried out by moving the rear group G1b along the optical axis.
摘要翻译：提供具有优异的光学性能的变焦透镜系统，光学装置和用于变焦变焦透镜系统的变焦方法。变焦透镜系统从物体起依次包括具有负折光力的第一透镜组G1，具有正折光力的第二透镜组G2和具有负折光力的第三透镜组G3。在从广角端状态W变焦到望远端状态T时，相邻透镜组之间的每个距离变化。第一透镜组G1从物体依次包括具有负屈光力的前组G1a和后组G1b。通过沿着光轴移动后组G1b来实现对象的聚焦。

19. 发明申请

US20110164885A1 METHOD TO CONTROL TEMPERATURE OF LD 有权
标题翻译：控制LD温度的方法
公开(公告)号：US20110164885A1
公开(公告)日：2011-07-07
申请号：US12984095
申请日：2011-01-04
申请人： Ryutaro TAKEI , Takeshi Irie , Tomoki Ito , Kazuhisa Ozaki , Masatsugu Togasaki
发明人： Ryutaro TAKEI , Takeshi Irie , Tomoki Ito , Kazuhisa Ozaki , Masatsugu Togasaki
IPC分类号： H04B10/04
CPC分类号： H04B10/503 , H04B10/572
摘要： New method to control the optical transmitter is disclosed. The optical transmitter provides both of the ATC feedback loop and the APC feedback loop. When a failure occurs in the ATC feedback loop and the temperature sensor is unable to output an adequate signal any longer, the optical transmitter cuts the APC loop and operates the LD in constant conditions. The output of the monitor PD is transferred to the ATC loop to control the TEC based on the optical output of the LD.
摘要翻译：公开了一种控制光发射机的新方法。光发射机提供ATC反馈环路和APC反馈环路。当ATC反馈回路发生故障，温度传感器不能再输出足够的信号时，光发射器切断APC回路并在恒定条件下操作LD。监视器PD的输出被传送到ATC环路，以基于LD的光输出来控制TEC。

20. 发明授权

US07905339B2 Operation mechanism of working machine 有权
标题翻译：作业机械操作机构
公开(公告)号：US07905339B2
公开(公告)日：2011-03-15
申请号：US11987171
申请日：2007-11-28
申请人： Tomoki Ito , Kazuyoshi Miyahara , Nobuo Yamazaki
发明人： Tomoki Ito , Kazuyoshi Miyahara , Nobuo Yamazaki
IPC分类号： B60K23/02
CPC分类号： A01B33/082 , A01B33/028 , B62D51/001 , B62D51/002 , F16D23/12 , Y10T74/20213
摘要： Operation mechanism of a working machine includes a main clutch lever pivotably provided on an operating handle, and a pivot member operable in interlocked relation to pivoting operation of the main clutch lever. The pivot member pivots about a pivot point differing in position from a pivot point of the main clutch lever. When fully pulled by pivoting operation of the main clutch lever, the cable member is located nearest to the pivot point of the pivot member, so that force reverse-pivoting the pivot member is reduced.
摘要翻译：工作机械的操作机构包括可枢转地设置在操作手柄上的主离合器杆和可与主离合杆的枢转操作联动操作的枢转构件。枢转构件围绕与主离合器杆的枢转点不同的枢转点枢转。当通过主离合器杆的枢转操作完全拉动时，电缆构件定位成最靠近枢转构件的枢转点，使得枢转构件的反向枢转力减小。

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