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11. 发明授权

US08247613B2 Methods and compositions for the synergistic activation of latent HIV 有权
标题翻译：潜伏HIV协同激活的方法和组合物
公开(公告)号：US08247613B2
公开(公告)日：2012-08-21
申请号：US12297034
申请日：2007-04-17
申请人： Samuel A. F. Williams , Warner C. Greene
发明人： Samuel A. F. Williams , Warner C. Greene
IPC分类号： C07C45/00 , A61K38/00 , A61K38/12
CPC分类号： A61K45/06 , A61K31/165 , A61K31/19 , A61K31/22 , C12N2740/16011 , A61K2300/00
摘要： The present invention provides methods and compositions useful for the elimination of latent HIV reservoirs that persist despite HAART. The methods and compositions overcome this latent barrier by inducing the replication of HIV in latently infected T cells while preventing the spread of the newly produced virions to uninfected cells by providing HAART simultaneously. Compositions of the invention comprise an activator of latent HIV expression, such as prostratin, and an inhibitor of histone deacetylase, such as TSA. A surprising finding of this invention is that the inhibitor of the histone deacetylase synergizes the effect of prostratin thus, allowing administering to a patient a lower, non-toxic dose of prostratin.
摘要翻译：本发明提供了用于消除尽管HAART持续存在的潜伏性HIV储库的方法和组合物。方法和组合物通过在潜伏感染的T细胞中诱导HIV的复制来克服这种潜在的障碍，同时通过同时提供HAART来防止新产生的病毒粒子扩散到未感染的细胞。本发明的组合物包含潜伏的HIV表达的激活剂，例如前列腺素和组蛋白脱乙酰酶抑制剂，例如TSA。本发明的令人惊奇的发现是，组蛋白脱乙酰酶的抑制剂可促进前列腺素的作用，从而允许给予患者较低的无毒剂量的前列腺素。

12. 发明授权

US07081343B2 Methods for identifying modulators of NF-KB activity 有权
公开(公告)号：US07081343B2
公开(公告)日：2006-07-25
申请号：US09884875
申请日：2001-06-18
申请人： Lin-feng Chen , Wolfgang Fischle , Eric M. Verdin , Warner C. Greene
发明人： Lin-feng Chen , Wolfgang Fischle , Eric M. Verdin , Warner C. Greene
IPC分类号： G01N33/53 , C12Q1/34 , C12Q1/02
CPC分类号： C07K14/4702
摘要： The present invention provides methods for identification of agents that modulate NF-κB activity through modulation of the acetylation and deacetylation of the RelA subunit of NF-κB.

13. 发明授权

US06645728B2 Inhibitor of the inflammatory response induced by TNF&agr; and IL-1 有权
标题翻译： TNFalpha和IL-1诱导的炎症反应抑制剂
公开(公告)号：US06645728B2
公开(公告)日：2003-11-11
申请号：US09871889
申请日：2001-06-01
申请人： Warner C. Greene , Xin Lin , Romas Gelezuinas
发明人： Warner C. Greene , Xin Lin , Romas Gelezuinas
IPC分类号： G01N33567
CPC分类号： C12N9/1205
摘要： The present invention provides the molecular basis for cytokine induction of NF-&kgr;B-dependent immune and inflammatory responses, emphasizing a role for both NIK-NIK and NIK-IKK protein—protein interactions. A relatively small region of NIK selectively impairs the NIK-IKK interaction. The present invention provides a novel and highly specific method for modulating NF-&kgr;B-dependent immune, inflammatory, and anti-apoptotic responses, based on interruption of the critical protein—protein interaction of NIK and IKK. The present invention provides methods for inhibiting NF-&kgr;B-dependent gene expression, using mutant NIK proteins. One embodiment of the present invention provides kinase-deficient NIK mutant proteins that inhibit activation of IKK. Another embodiment of the invention provides N-terminus NIK mutant proteins that bind IKK, thus inhibiting NIK/IKK interaction.
摘要翻译：本发明提供NF-κB依赖性免疫和炎症反应的细胞因子诱导的分子基础，强调NIK-NIK和NIK-IKK蛋白质 - 蛋白质相互作用的作用。 NIK相对较小的区域选择性地损害NIK-IKK相互作用。本发明提供了一种基于NIK和IKK的关键蛋白质 - 蛋白质相互作用中断来调节NF-κB依赖性免疫，炎症和抗凋亡反应的新型和高度特异性的方法。本发明提供使用突变NIK蛋白抑制NF-κB依赖性基因表达的方法。本发明的一个实施方案提供抑制IKK活化的激酶缺陷型NIK突变蛋白。本发明的另一个实施方案提供结合IKK的N末端NIK突变蛋白，从而抑制NIK / IKK相互作用。

14. 发明授权

US5356795A Cloning cDNAs for the human interleukin-2 receptor (55 RD protein) 失效
标题翻译：克隆人白细胞介素2受体（55 RD蛋白）的cDNA
公开(公告)号：US5356795A
公开(公告)日：1994-10-18
申请号：US837563
申请日：1992-02-18
申请人： Warren J. Leonard , Warner C. Greene
发明人： Warren J. Leonard , Warner C. Greene
IPC分类号： C07K14/715 , C12N15/12
CPC分类号： C07K14/7155
摘要： The cDNA encoding the human interleukin-2 receptor has been produced, sequenced, and developed for diagnosis of certain T-cell leukemias, in particular the virus associated with adult T-cell leukemia.
摘要翻译：编码人白细胞介素-2受体的cDNA已经被产生，测序和发展用于诊断某些T细胞白血病，特别是与成人T细胞白血病相关的病毒。

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