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11. 发明申请

US20120276382A1 ADHESIVE COMPOSITE SYSTEM FOR COVERING, CLOSING OR GLUING CELLULAR TISSUE 审中-公开
标题翻译：用于覆盖，封闭或糊状细胞组织的粘合复合体系
公开(公告)号：US20120276382A1
公开(公告)日：2012-11-01
申请号：US13515100
申请日：2010-12-06
申请人： Sebastian Dörr , Heike Heckroth , Christoph Eggert
发明人： Sebastian Dörr , Heike Heckroth , Christoph Eggert
IPC分类号： B32B27/40 , C09J7/02 , B32B27/08 , B32B37/12
CPC分类号： C09J175/04 , A61L24/046 , C08G18/10 , C08G2170/00 , C08G2190/00 , C08G2210/00 , C08G2230/00 , C09D175/04 , C09D175/12 , C09J7/21 , C09J7/30 , C09J175/12 , C09J2475/00 , Y10T428/2896 , Y10T428/31551 , C08G18/3821 , C08L75/04
摘要： The invention relates to an adhesive composite system comprising an adhesive layer of a tissue adhesive and a protective layer which is applied to the surface of the adhesive layer, said tissue adhesive being based on hydrophilic polyurethane polymers and the protective layer is water-proof. The invention also relates to a method for producing said adhesive composite system, to an adhesive composite system obtained according to said method, an adhesive composite system which can be used for covering, closing or gluing cellular tissue and to the use of the adhesive composite system for producing a product for covering, closing or gluing cellular tissue.
摘要翻译：本发明涉及一种粘合剂复合体系，其包括组织粘合剂的粘合剂层和施加到粘合剂层的表面的保护层，所述组织粘合剂基于亲水性聚氨酯聚合物，并且保护层是防水的。本发明还涉及一种用于生产所述粘合剂复合体系的方法，根据所述方法获得的粘合剂复合体系，可用于覆盖，封闭或胶合细胞组织的粘合剂复合体系以及粘合剂复合体系用于生产用于覆盖，闭合或胶合细胞组织的产品。

12. 发明授权

US09254347B2 Tissue adhesive with accelerated curing 有权
标题翻译：组织粘合剂加速固化
公开(公告)号：US09254347B2
公开(公告)日：2016-02-09
申请号：US14112132
申请日：2012-04-17
申请人： Heike Heckroth , Christoph Eggert
发明人： Heike Heckroth , Christoph Eggert
IPC分类号： C08G18/32 , C08G18/38 , C08G18/10 , A61L24/04 , A61B17/03 , C09J175/02 , A61M5/19 , C08G18/12 , C08G18/73 , A61L24/00 , A61B17/00
CPC分类号： A61L24/046 , A61B17/00491 , A61B2017/00495 , A61L24/0015 , A61M5/19 , C08G18/10 , C08G18/12 , C08G18/325 , C08G18/3821 , C08G18/73 , C09J175/02 , C08L75/02
摘要： The present invention relates to a polyurea system encompassing as component A) isocyanate-functional prepolymers obtainable by reaction of aliphatic isocyanates A1) with polyols A2), which can in particular have a number average molecular weight of ≧400 g/mol and an average OH functionality of 2 to 6, as component B) amino-functional compounds of general formula (I) in which X is an organic residue comprising a tertiary amino function, having no Zerewitinoff active hydrogen, R1 is a CH2—COOR3 residue, in which R3 is an organic residue having no Zerewitinoff active hydrogen, a linear or branched C1 to C4 alkyl residue, a cyclopentyl or cyclohexyl residue or H, R2 is an organic residue having no Zerewitinoff active hydrogen, n is an integer ≧2 or ≦3, in particular for closing, binding, bonding or covering cell tissue, and to a metering system for the polyurea system according to the invention.
摘要翻译：本发明涉及一种包含作为组分A）的异氰酸酯官能预聚物，该聚脲体系可通过脂族异氰酸酯A1）与多元醇A2）的反应获得，该多异氰酸酯官能的预聚物特别是数均分子量≥400g/ mol，平均OH 2至6的官能团，作为组分B）通式（I）的氨基官能化合物，其中X是包含叔氨基官能团的有机残基，不具有泽瑞维诺夫活性氢，R 1是CH 2 -COOR 3残基，其中R 3 是不具有齐维诺夫活性氢的有机残基，直链或支链C 1至C 4烷基残基，环戊基或环己基残基或H，R 2是不具有齐维诺夫活性氢的有机残基，n为整数≥2或nlE; 3，特别是用于封闭，结合，粘合或覆盖细胞组织，以及用于根据本发明的聚脲系统的计量系统。

13. 发明申请

US20130325062A1 TISSUE ADHESIVE BASED ON NITROGEN-MODIFIED ASPARTATES 有权
标题翻译：基于硝酸改性乳膏的组织粘合剂
公开(公告)号：US20130325062A1
公开(公告)日：2013-12-05
申请号：US13984186
申请日：2012-02-06
申请人： Heike Heckroth , Christoph Eggert
发明人： Heike Heckroth , Christoph Eggert
IPC分类号： A61L24/04 , A61L24/00
CPC分类号： A61L24/046 , A61L24/0015 , C08G18/10 , C08G18/3821 , C08G18/4252 , C08G18/73 , C08L75/04
摘要： The invention relates to a polyurea system comprising as component A) isocyanate-functional prepolymers which can be obtained by reacting aliphatic isocyanates A1) with polyols A2) that can have a number-average molecular weight of =400 g/mol and an average OH functionality of 2 to 6 in particular; and as component B) amino-functional aspartic acid esters of the general formula (I) in which X is an organic group containing a secondary amino function, R1, R2 are the same or different organic groups that do not have Zerewitinoff-active hydrogen, and n is a whole number of at least 2, in particular for sealing, bonding, gluing, or covering cell tissue. The invention also relates to a metering system for the polyurea system according to the invention.
摘要翻译：本发明涉及一种包含作为组分A）异氰酸酯官能的预聚物的聚脲体系，该异氰酸酯官能的预聚物可通过使脂族异氰酸酯A1）与数均分子量为400g / mol和平均OH官能度的多元醇A2）特别是2到6; 和作为组分B）通式（I）的氨基官能天冬氨酸酯，其中X是含有仲氨基官能团的有机基团，R 1，R 2是相同或不同的不具有齐维诺芬活性氢的有机基团，并且n是至少为2的整数，特别是用于密封，粘合，胶合或覆盖细胞组织。本发明还涉及根据本发明的聚脲系统的计量系统。

14. 发明授权

US08822479B2 6-cyclylmethyl-and 6-alkylmethyl-substituted pyrazolepyrimidines 有权
标题翻译： 6-环甲基 - 和6-烷基甲基取代的吡唑嘧啶
公开(公告)号：US08822479B2
公开(公告)日：2014-09-02
申请号：US12950386
申请日：2010-11-19
申请人： Martin Hendrix , Lars Bärfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
发明人： Martin Hendrix , Lars Bärfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC分类号： A61K31/519 , A61P25/28 , A61P25/18 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention relates to 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines, process for their preparation, and their use for producing medicaments for improving learning and/or memory. The 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines are of the formula (I): with the variables as defined in the claims.
摘要翻译：本发明涉及6-环甲基 - 和6-烷基甲基取代的吡唑并嘧啶，其制备方法及其用于生产改善学习和/或记忆的药物的用途。 6-环甲基 - 和6-烷基甲基取代的吡唑并嘧啶具有式（I）：与权利要求中所定义的变量。

15. 发明授权

US08088769B2 Cyanopyrimidinones 有权
标题翻译：氰基嘧啶酮
公开(公告)号：US08088769B2
公开(公告)日：2012-01-03
申请号：US10586501
申请日：2004-12-31
申请人： Martin Hendrix , Lars Bärfacker , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen
发明人： Martin Hendrix , Lars Bärfacker , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D239/47 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D491/10
摘要： The invention relates to novel cyanopyrimidinones, process for their preparation, and the use thereof for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译：本发明涉及新颖的氰基嘧啶酮，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。

16. 发明授权

US07737153B2 Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors 失效
标题翻译：杂环氧基取代的苯基氨基嘧啶作为rho激酶抑制剂
公开(公告)号：US07737153B2
公开(公告)日：2010-06-15
申请号：US10531889
申请日：2003-10-16
申请人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Mark Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Heimo Ehmke
发明人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Mark Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Heimo Ehmke
IPC分类号： A01N43/90 , A61K31/519 , A61K31/505 , C07D487/00 , C07D239/02 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D401/14 , C07D403/12 , C07D471/04
摘要： The invention relates to heteroaryloxy-substituted phenylaminopyrimidines, to methods for the production thereof, and to the use of the same for producing medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular diseases. The inventive compounds inhibit Rho-Kinase.
摘要翻译：本发明涉及杂芳氧基取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物。本发明化合物抑制Rho-激酶。

17. 发明申请

US20100034861A1 DISPERSIONS OF NANOUREAS COMPRISING BIOLOGICALLY ACTIVE COMPOUNDS 审中-公开
标题翻译：包含生物活性化合物的纳米颗粒的分布
公开(公告)号：US20100034861A1
公开(公告)日：2010-02-11
申请号：US12579003
申请日：2009-10-14
申请人： Sebastian Dörr , Michael Mager , Burkhard Köhler , Heike Heckroth
发明人： Sebastian Dörr , Michael Mager , Burkhard Köhler , Heike Heckroth
IPC分类号： A61K9/14 , B05D3/00 , A61K47/16 , A61K9/00 , A61P43/00
CPC分类号： A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , A61L2400/12 , C08G18/0823 , C08G18/73 , C08L75/04
摘要： The present invention relates to dispersions of nanoureas comprising biologically active compounds, a process for their preparation, and their use.
摘要翻译：本发明涉及包含生物活性化合物的纳米脲的分散体，其制备方法及其应用。

18. 发明申请

US20070161662A1 6-Arylmethyl-substituted pyrazolopyrimidines 有权
标题翻译： 6-芳基甲基取代的吡唑并嘧啶
公开(公告)号：US20070161662A1
公开(公告)日：2007-07-12
申请号：US10556437
申请日：2004-04-27
申请人： Martin Hendrix , Lars Barfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
发明人： Martin Hendrix , Lars Barfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention relates to novel 6-arylmethyl-substituted pyrazolopyrimidines, process for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译：本发明涉及新的6-芳基甲基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。

19. 发明申请

US20070105876A1 6-Cyclylmethyl- and 6-alkylmethyl-substituted pyrazolepyrimidines 有权
标题翻译： 6-环己基甲基和6-烷基甲基取代的吡唑嘧啶
公开(公告)号：US20070105876A1
公开(公告)日：2007-05-10
申请号：US10556224
申请日：2004-04-28
申请人： Martin Hendrix , Lars Barfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
发明人： Martin Hendrix , Lars Barfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention relates to novel 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines, process for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译：本发明涉及新的6-环甲基 - 和6-烷基甲基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。

20. 发明授权

US08809348B2 6-arylmethyl substituted pyrazolo[3,4-d]pyrimidines 有权
标题翻译： 6-芳基甲基取代的吡唑并[3,4-d]嘧啶
公开(公告)号：US08809348B2
公开(公告)日：2014-08-19
申请号：US12580725
申请日：2009-10-16
申请人： Martin Hendrix , Lars Barfacker , Christine Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
发明人： Martin Hendrix , Lars Barfacker , Christine Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC分类号： A61K31/519 , A61P25/28 , A61P25/18 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention relates to novel 6-arylmethyl-substituted pyrazolopyrimidines, process for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译：本发明涉及新的6-芳基甲基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。

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