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11. 发明申请

US20120071942A1 Subcutaneous Cardiac Sensing and Stimulation System 有权
标题翻译：皮下心脏感觉和刺激系统
公开(公告)号：US20120071942A1
公开(公告)日：2012-03-22
申请号：US13237221
申请日：2011-09-20
申请人： Apurv Kamath , Paul Haefner , Darrell Orvin Wagner , Marina Brockway
发明人： Apurv Kamath , Paul Haefner , Darrell Orvin Wagner , Marina Brockway
IPC分类号： A61N1/365
CPC分类号： A61N1/3956 , A61B17/320068 , A61B17/3203 , A61B17/3415 , A61B17/3417 , A61B90/30 , A61B2017/00243 , A61B2017/00247 , A61B2017/320044 , A61B2017/320084 , A61B2018/00392 , A61B2090/3945 , A61B2090/3979 , A61B2217/005 , A61B2217/007 , A61N1/05 , A61N1/056 , A61N1/0568 , A61N1/0587 , A61N1/36542 , A61N1/36585 , A61N1/37 , A61N1/3925 , A61N1/3962 , A61N1/3987
摘要： Cardiac systems and methods using ECG and blood information for arrhythmia detection and discrimination. Detection circuitry is configured to produce an ECG. An implantable blood sensor configured to produce a blood sensor signal is coupled to a processor. The processor is coupled to the detection and energy delivery circuitry, and used to evaluate and treat cardiac rhythms using both the cardiac electrophysiologic and blood sensor signals. The blood sensor is configured for subcutaneous non-intrathoracic placement and provided in or on the housing, on a lead coupled to the housing, and/or separate to the housing and coupled to the processor via hardwire or wireless link. The blood sensor may be configured for optical sensing, using a blood oxygen saturation sensor or pulse oximeter. A cardiac rhythm may be evaluated using the electrocardiogram signal and the blood sensor signal, and tachyarrhythmias may be treated after confirmation using the blood sense signal.
摘要翻译：心脏系统和方法使用ECG和血液信息进行心律失常检测和辨别。检测电路被配置为产生ECG。构造成产生血液传感器信号的可植入血液传感器耦合到处理器。处理器耦合到检测和能量输送电路，并且用于使用心脏电生理学和血液传感器信号来评价和治疗心律。血液传感器被配置用于皮下非胸腔内放置并且设置在壳体中或壳体上，在耦合到壳体的引线上和/或分离到壳体并经由硬线或无线链路耦合到处理器。血液传感器可以被配置为使用血氧饱和度传感器或脉搏血氧计进行光学感测。可以使用心电图信号和血液传感器信号评估心律，并且可以在使用血液感测信号确认之后治疗快速性心律失常。

12. 发明授权

US08116868B2 Implantable device with cardiac event audio playback 失效
标题翻译：具有心脏事件音频播放的植入式设备
公开(公告)号：US08116868B2
公开(公告)日：2012-02-14
申请号：US10801139
申请日：2004-03-15
申请人： Paul Haefner
发明人： Paul Haefner
IPC分类号： A61N1/365
CPC分类号： A61B5/0031 , A61B5/0006 , A61B5/02 , A61B5/11 , A61B7/023 , A61N1/05 , A61N1/0568 , A61N1/0587 , A61N1/08 , A61N1/36542 , A61N1/36578 , A61N1/36585 , A61N1/3956 , A61N1/3962
摘要： Cardiac monitoring and stimulation methods and systems provide audio playback of cardiac events and transthoracic monitoring and therapy. A medical system includes a housing and electrodes configured for sensing cardiac electrical activity. Another sensor may be configured to sense heart movement and produce a signal in response, such as an audio signal. Memory stores the audio signal and the cardiac electrical signal. A controller and communications circuitry telemeter the cardiac electrical signal and the audio signal to a patient-external device. Energy delivery circuitry may deliver cardiac therapy. The device may further include a patient actuatable trigger configured to communicate to the controller via the communications circuitry. The controller may initiate storing of the cardiac electrical signal and the audio signal in response to the trigger. The patient-external device may further include a storage media.
摘要翻译：心脏监测和刺激方法和系统提供心脏事件和经胸监测和治疗的音频回放。医疗系统包括壳体和配置用于感测心脏电活动的电极。另一个传感器可以被配置为感测心脏运动并产生响应的信号，例如音频信号。存储器存储音频信号和心脏电信号。控制器和通信电路将心电信号和音频信号远程测量到病人 - 外部设备。能量输送电路可以提供心脏治疗。该设备还可以包括被配置为经由通信电路与控制器通信的患者致动触发器。响应于触发器，控制器可以开始存储心脏电信号和音频信号。患者外部设备还可以包括存储介质。

13. 发明申请

US20110098587A1 Subcutaneous Cardiac Signal Discrimination Employing Non-Electrophysiologic Signal 审中-公开
标题翻译：使用非电生理信号的皮下心脏信号鉴别
公开(公告)号：US20110098587A1
公开(公告)日：2011-04-28
申请号：US12983565
申请日：2011-01-03
申请人： Paul Haefner
发明人： Paul Haefner
IPC分类号： A61B5/02
CPC分类号： A61B5/0464 , A61B5/0428 , A61B5/7203 , A61N1/36585 , A61N1/3956
摘要： A cardiac monitoring and/or stimulation system includes a housing coupled to a plurality of electrodes configured for subcutaneous non-intrathoracic sensing. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal from the plurality of composite signals, and identifies the separated signal as a cardiac signal using information derived from a non-electrophysiologic sensor, such as an accelerometer or acoustic transducer. The signal processor may iteratively correlate separated signals from the plurality of composite signals with a non-electrophysiologic sensor signal until the cardiac signal is identified.
摘要翻译：心脏监测和/或刺激系统包括耦合到配置用于皮下非胸内感测的多个电极的壳体。信号处理器接收与多个源相关联的多个复合信号，从多个复合信号中分离信号，并使用从非电生理传感器（例如加速度计或者加速度计）得到的信息将分离的信号识别为心脏信号声换能器。信号处理器可以将来自多个复合信号的分离的信号与非电生理传感器信号迭代地相关，直到识别出心脏信号。

14. 发明授权

US07302294B2 Subcutaneous cardiac sensing and stimulation system employing blood sensor 失效
标题翻译：使用血液传感器的皮下心脏感知和刺激系统
公开(公告)号：US07302294B2
公开(公告)日：2007-11-27
申请号：US10817749
申请日：2004-04-02
申请人： Apurv Kamath , Paul Haefner , Darrell Orvin Wagner , Marina Brockway
发明人： Apurv Kamath , Paul Haefner , Darrell Orvin Wagner , Marina Brockway
IPC分类号： A61N1/365
CPC分类号： A61N1/3956 , A61B17/320068 , A61B17/3203 , A61B17/3415 , A61B17/3417 , A61B90/30 , A61B2017/00243 , A61B2017/00247 , A61B2017/320044 , A61B2017/320084 , A61B2018/00392 , A61B2090/3945 , A61B2090/3979 , A61B2217/005 , A61B2217/007 , A61N1/05 , A61N1/056 , A61N1/0568 , A61N1/0587 , A61N1/36542 , A61N1/36585 , A61N1/37 , A61N1/3925 , A61N1/3962 , A61N1/3987
摘要： Cardiac systems and methods using ECG and blood information for arrhythmia detection and discrimination. Detection circuitry is configured to produce an ECG. An implantable blood sensor configured to produce a blood sensor signal is coupled to a processor. The processor is coupled to the detection and energy delivery circuitry, and used to evaluate and treat cardiac rhythms using both the cardiac electrophysiologic and blood sensor signals. The blood sensor is configured for subcutaneous non-intrathoracic placement and provided in or on the housing, on a lead coupled to the housing, and/or separate to the housing and coupled to the processor via hardwire or wireless link. The blood sensor may be configured for optical sensing, using a blood oxygen saturation sensor or pulse oximeter. A cardiac rhythm may be evaluated using the electrocardiogram signal and the blood sensor signal, and tachyarrhythmias may be treated after confirmation using the blood sense signal.
摘要翻译：心脏系统和方法使用ECG和血液信息进行心律失常检测和辨别。检测电路被配置为产生ECG。构造成产生血液传感器信号的可植入血液传感器耦合到处理器。处理器耦合到检测和能量输送电路，并且用于使用心脏电生理学和血液传感器信号来评价和治疗心律。血液传感器被配置用于皮下非胸内放置并且设置在壳体中或外壳上，在耦合到壳体的引线上和/或分离到壳体并经由硬线或无线链路耦合到处理器。血液传感器可以被配置为使用血氧饱和度传感器或脉搏血氧计进行光学感测。可以使用心电图信号和血液传感器信号评估心律，并且可以在使用血液感测信号确认之后治疗快速性心律失常。

15. 发明授权

US07218966B2 Multi-parameter arrhythmia discrimination 有权
标题翻译：多参数心律失常辨别
公开(公告)号：US07218966B2
公开(公告)日：2007-05-15
申请号：US10804471
申请日：2004-03-19
申请人： Paul Haefner
发明人： Paul Haefner
IPC分类号： A61N1/365
CPC分类号： A61B17/320068 , A61B17/3203 , A61B17/3415 , A61B17/3417 , A61B90/30 , A61B2017/00243 , A61B2017/00247 , A61B2017/320044 , A61B2017/320084 , A61B2018/00392 , A61B2090/3945 , A61B2217/005 , A61B2217/007 , A61N1/05 , A61N1/056 , A61N1/0568 , A61N1/0587 , A61N1/08 , A61N1/36542 , A61N1/36585 , A61N1/3956 , A61N1/3962
摘要： An arrhythmia discrimination device and method involves receiving electrocardiogram signals and non-electrophysiologic signals at subcutaneous locations. Both the electrocardiogram-signals and non-electrophysiologic signals are used to discriminate between normal sinus rhythm and an arrhythmia. An arrhythmia may be detected using electrocardiogram signals, and verified using the non-electrophysiologic signals. A detection window may be initiated in response to receiving the electrocardiogram signal, and used to determine whether the non-electrophysiologic signal is received at a time falling within the detection window. Heart rates may be computed based on both the electrocardiogram signals and non-electrophysiologic signals. The rates may be used to discriminate between normal sinus rhythm and arrhythmia, and used to determining absence of an arrhythmia.
摘要翻译：心律失常鉴别装置和方法涉及在皮下位置接收心电图信号和非电生理信号。心电图信号和非电生理信号都用于区分正常窦性心律和心律失常。可以使用心电图信号检测心律不齐，并使用非电生理信号进行验证。可以响应于接收到心电图信号而启动检测窗口，并且用于确定在落在检测窗口内的时间是否接收到非电生理信号。可以基于心电图信号和非电生理信号计算心率。这些比率可用于区分正常窦性心律和心律不齐，并用于确定不存在心律失常。

16. 发明申请

US20060224188A1 Method and apparatus for synchronizing neural stimulation to cardiac cycles 有权
公开(公告)号：US20060224188A1
公开(公告)日：2006-10-05
申请号：US11099141
申请日：2005-04-05
申请人： Imad Libbus , Paul Haefner , Aaron McCabe , Yi Zhang
发明人： Imad Libbus , Paul Haefner , Aaron McCabe , Yi Zhang
IPC分类号： A61N1/32
CPC分类号： A61N1/36135 , A61N1/36114 , A61N1/365 , A61N1/36542 , A61N1/36564 , A61N1/36571
摘要： A neural stimulator senses a reference signal indicative of cardiac cycles each including a predetermined type timing reference event using a sensor external to the heart and blood vessels. The delivery of the neural stimulation pulses are synchronized to that timing reference event. Examples of the timing reference event include a predetermined cardiac event such as a P-wave or an R-wave detected from a subcutaneous ECG signal, a predetermined type heart sound detected from an acoustic signal, and a peak detected from a hemodynamic signal related to blood flow or pressure.

17. 发明申请

US20050119708A1 Subcutaneous cardiac signal discrimination employing non-electrophysiologic signal 有权
标题翻译：使用非电生理信号的皮下心脏信号鉴别
公开(公告)号：US20050119708A1
公开(公告)日：2005-06-02
申请号：US10784478
申请日：2004-02-23
申请人： Paul Haefner
发明人： Paul Haefner
IPC分类号： A61B5/0428 , A61B5/0464 , A61N1/05 , A61N1/365 , A61N1/39
CPC分类号： A61B5/0464 , A61B5/0428 , A61B5/7203 , A61N1/36585 , A61N1/3956
摘要： A cardiac monitoring and/or stimulation system includes a housing coupled to a plurality of electrodes configured for subcutaneous non-intrathoracic sensing. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal from the plurality of composite signals, and identifies the separated signal as a cardiac signal using information derived from a non-electrophysiologic sensor, such as an accelerometer or acoustic transducer. The signal processor may iteratively correlate separated signals from the plurality of composite signals with a non-electrophysiologic sensor signal until the cardiac signal is identified.
摘要翻译：心脏监测和/或刺激系统包括耦合到配置用于皮下非胸内感测的多个电极的壳体。信号处理器接收与多个源相关联的多个复合信号，从多个复合信号中分离信号，并使用从非电生理传感器（例如加速度计或者加速度计）得到的信息将分离的信号识别为心脏信号声换能器。信号处理器可以将来自多个复合信号的分离的信号与非电生理传感器信号迭代地相关，直到识别出心脏信号。

18. 发明授权

US08843196B2 Subcutaneous cardiac sensing and stimulation system 有权
标题翻译：皮下心脏感知和刺激系统
公开(公告)号：US08843196B2
公开(公告)日：2014-09-23
申请号：US13237221
申请日：2011-09-20
申请人： Apurv Kamath , Paul Haefner , Darrell O. Wagner , Marina Brockway
发明人： Apurv Kamath , Paul Haefner , Darrell O. Wagner , Marina Brockway
IPC分类号： A61N1/05 , A61N1/39 , A61N1/365 , A61B17/00 , A61B19/00 , A61B17/34 , A61N1/37 , A61B17/32 , A61B17/3203 , A61B18/00
CPC分类号： A61N1/3956 , A61B17/320068 , A61B17/3203 , A61B17/3415 , A61B17/3417 , A61B90/30 , A61B2017/00243 , A61B2017/00247 , A61B2017/320044 , A61B2017/320084 , A61B2018/00392 , A61B2090/3945 , A61B2090/3979 , A61B2217/005 , A61B2217/007 , A61N1/05 , A61N1/056 , A61N1/0568 , A61N1/0587 , A61N1/36542 , A61N1/36585 , A61N1/37 , A61N1/3925 , A61N1/3962 , A61N1/3987
摘要： Cardiac systems and methods using ECG and blood information for arrhythmia detection and discrimination. Detection circuitry is configured to produce an ECG. An implantable blood sensor configured to produce a blood sensor signal is coupled to a processor. The processor is coupled to the detection and energy delivery circuitry, and used to evaluate and treat cardiac rhythms using both the cardiac electrophysiologic and blood sensor signals. The blood sensor is configured for subcutaneous non-intrathoracic placement and provided in or on the housing, on a lead coupled to the housing, and/or separate to the housing and coupled to the processor via hardwire or wireless link. The blood sensor may be configured for optical sensing, using a blood oxygen saturation sensor or pulse oximeter. A cardiac rhythm may be evaluated using the electrocardiogram signal and the blood sensor signal, and tachyarrhythmias may be treated after confirmation using the blood sense signal.
摘要翻译：心脏系统和方法使用ECG和血液信息进行心律失常检测和辨别。检测电路被配置为产生ECG。构造成产生血液传感器信号的可植入血液传感器耦合到处理器。处理器耦合到检测和能量输送电路，并且用于使用心脏电生理学和血液传感器信号来评价和治疗心律。血液传感器被配置用于皮下非胸内放置并且设置在壳体中或外壳上，在耦合到壳体的引线上和/或分离到壳体并经由硬线或无线链路耦合到处理器。血液传感器可以被配置为使用血氧饱和度传感器或脉搏血氧计进行光学感测。可以使用心电图信号和血液传感器信号评估心律，并且可以在使用血液感测信号确认之后治疗快速性心律失常。

19. 发明授权

US07715916B2 Multi-parameter arrhythmia discrimination 有权
标题翻译：多参数心律失常辨别
公开(公告)号：US07715916B2
公开(公告)日：2010-05-11
申请号：US11803548
申请日：2007-05-15
申请人： Paul Haefner
发明人： Paul Haefner
IPC分类号： A61N1/365
CPC分类号： A61B17/320068 , A61B17/3203 , A61B17/3415 , A61B17/3417 , A61B90/30 , A61B2017/00243 , A61B2017/00247 , A61B2017/320044 , A61B2017/320084 , A61B2018/00392 , A61B2090/3945 , A61B2217/005 , A61B2217/007 , A61N1/05 , A61N1/056 , A61N1/0568 , A61N1/0587 , A61N1/08 , A61N1/36542 , A61N1/36585 , A61N1/3956 , A61N1/3962
摘要： An arrhythmia discrimination device and method involves receiving electrocardiogram signals and non-electrophysiologic signals at subcutaneous locations. Both the electrocardiogram signals and non-electrophysiologic signals are used to discriminate between normal sinus rhythm and an arrhythmia. An arrhythmia may be detected using electrocardiogram signals, and verified using the non-electrophysiologic signals. A detection window may be initiated in response to receiving the electrocardiogram signal, and used to determine whether the non-electrophysiologic signal is received at a time falling within the detection window. Heart rates may be computed based on both the electrocardiogram signals and non-electrophysiologic signals. The rates may be used to discriminate between normal sinus rhythm and an arrhythmia, and used to determine absence of an arrhythmia.
摘要翻译：心律失常鉴别装置和方法涉及在皮下位置接收心电图信号和非电生理信号。使用心电图信号和非电生理信号来区分正常窦性心律和心律失常。可以使用心电图信号检测心律不齐，并使用非电生理信号进行验证。可以响应于接收到心电图信号而启动检测窗口，并且用于确定在落在检测窗口内的时间是否接收到非电生理信号。可以基于心电图信号和非电生理信号计算心率。可以使用这些比率来区分正常窦性心律和心律失常，并用于确定不存在心律失常。

20. 发明申请

US20090270750A1 Biopotential Signal Source Separation Using Source Impedances 失效
标题翻译：使用源阻抗的生物电位信号源分离
公开(公告)号：US20090270750A1
公开(公告)日：2009-10-29
申请号：US12494768
申请日：2009-06-30
申请人： Apurv Kamath , Darrel Orvin Wagner , Paul Haefner , Marina Brockway
发明人： Apurv Kamath , Darrel Orvin Wagner , Paul Haefner , Marina Brockway
IPC分类号： A61B5/0464 , A61B5/0428
CPC分类号： A61B5/0464 , A61B5/042 , A61B5/0428 , A61N1/36585 , A61N1/3956
摘要： Cardiac methods and devices that separate signals using at least two composite signals acquired at least at two input impedances. A target source impedance may be selected, and a cardiac signal may be separated from composite signals using the selected target source impedance. Medical systems include a cardiac device having a housing that provides amplification circuitry configured to have a first amplifier input impedance and a second amplifier input impedance, such as using two separate circuits or switching between two input impedances. One or more electrode assemblies are coupled to the amplification circuitry. A signal processor is provided in the housing configured to separate a source signal using a first composite signal detected at the first input impedance and a second composite signal detected at the second input impedance. The phase response of the first input amplifier circuit is about equal to that of the second input amplifier circuit.
摘要翻译：使用至少两个输入阻抗获取的至少两个复合信号分离信号的心脏方法和装置。可以选择目标源阻抗，并且可以使用所选择的目标源阻抗将心脏信号与复合信号分离。医疗系统包括具有壳体的心脏装置，其提供被配置为具有第一放大器输入阻抗和第二放大器输入阻抗的放大电路，例如使用两个分离的电路或在两个输入阻抗之间切换。一个或多个电极组件耦合到放大电路。信号处理器设置在壳体中，配置成使用在第一输入阻抗处检测到的第一复合信号和在第二输入阻抗处检测到的第二复合信号来分离源信号。第一输入放大器电路的相位响应大约等于第二输入放大器电路的相位响应。

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