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11. 发明专利

JP2008081503A Death domain-containing receptor 5 审中-公开
标题翻译：死亡受体受体5
公开(公告)号：JP2008081503A
公开(公告)日：2008-04-10
申请号：JP2007260427
申请日：2007-10-03
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： NI JIAN , GENTZ REINER L , YU GUO-LIANG , SU JEFFREY Y , ROSEN CRAIG A
IPC分类号： C07K14/705 , C12N15/09 , A61K38/00 , A61K39/395 , A61P9/10 , A61P25/28 , A61P35/00 , A61P37/06 , C07K14/715 , C07K16/28 , C12N1/21 , C12N5/10 , C12N15/12
CPC分类号： C07K14/7151 , A61K38/00 , C07K2319/00
摘要： PROBLEM TO BE SOLVED: To provide a novel death domain-containing receptor 5 (DR5) protein. SOLUTION: The novel death domain-containing receptor 5 (DR5) proteins which are members of the tumor necrosis (TNF) receptor family and bind to TRAIL are provided. Precisely, isolated nucleic acid molecules encoding the human DR5 proteins are provided. The DR5 peptide is also provided and, in addition, vectors, host cells and recombinant methods for producing the same are provided. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供一种新型的含有死亡结构域的受体5（DR5）蛋白。解决方案：提供作为肿瘤坏死（TNF）受体家族成员并结合TRAIL的新型死亡结构域受体5（DR5）蛋白。正确地，提供了编码人类DR5蛋白质的分离的核酸分子。还提供了DR5肽，并且还提供了用于制备DR5肽的载体，宿主细胞和重组方法。本发明还涉及用于鉴定DR5活性的拮抗剂和拮抗剂的筛选方法。版权所有（C）2008，JPO＆INPIT

12. 发明专利

JP2007222174A Neutrokine-alpha 审中-公开
标题翻译： NEUTROKINE-ALPHA
公开(公告)号：JP2007222174A
公开(公告)日：2007-09-06
申请号：JP2007089954
申请日：2007-03-29
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： YU GUO-LIANG , EBINER REINHARD , NI JIAN
IPC分类号： C12N15/09 , C07K14/52
CPC分类号： Y02A50/412
摘要： PROBLEM TO BE SOLVED: To provide isolated nucleic acids encoding a neutrokine-α protein. SOLUTION: The invention relates to the isolated nucleic acid molecule at least having 95% of homology with the following sequences. (a) A sequence encoding neutrokine-α polypeptide having complete amino acid sequence in figure 1. (b) A sequence encoding neutrokine-α having complete amino acid sequence encoded by cDNA clone included in deposition to the ATCC on October 22, 1996. (c) A sequence encoding neutrokine-α polypeptide extracellular domain. (d) A sequence encoding neutrokine-α polypeptide transmembrane domain. (e) A sequence encoding neutrokine-α polypeptide intracellular domain. (f) A sequence encoding soluble neutrokine-α polypeptide deleted of transmembrane domain. (g) A complementary sequence to an optional sequence of (a), (b), (c), (d), (e), or (f). COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供编码中性粒细胞α蛋白的分离的核酸。解决方案：本发明涉及至少与以下序列具有95％同源性的分离的核酸分子。（a）编码具有图1中完整氨基酸序列的中性粒细胞-α多肽的序列。（b）编码具有由cDNA克隆编码的完整氨基酸序列的中性粒细胞α的序列，其包括在1996年10月22日向ATCC的沉积中。 c）编码中性粒细胞-α多肽细胞外结构域的序列。（d）编码中性粒细胞-α多肽跨膜结构域的序列。（e）编码中性粒细胞-α多肽细胞内结构域的序列。（f）编码跨膜结构域缺失的可溶性中性粒细胞-α多肽的序列。（g）与（a），（b），（c），（d），（e）或（f）的任选序列的互补序列。版权所有（C）2007，JPO＆INPIT

13. 发明专利

JP2002085082A SUPEROXIDE DISMUTASE-4 失效
公开(公告)号：JP2002085082A
公开(公告)日：2002-03-26
申请号：JP2001163501
申请日：2001-05-30
申请人： HUMAN GENOME SCIENCES INC
发明人： YU GUO-LIANG , ROSEN CRAIG A , FRASER CLAIRE M , GOCAYNE JEANINE D
IPC分类号： C12N15/09 , A61K38/00 , A61K38/44 , A61K48/00 , A61P1/04 , A61P9/06 , A61P9/10 , A61P17/02 , A61P19/02 , A61P29/00 , A61P43/00 , C07H21/04 , C07K16/40 , C12N9/02 , C12N9/04 , C12N15/53 , C12P21/08 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To provide a new superoxide dismutase(SOD) polypeptide, an antibody against the polypeptide, a polynucleotide encoding the polypeptide, a recombination technique for forming these, and a process for utilizing these for therapy. SOLUTION: The objective isolated polynucleotide is provided, which is selected from a group consisting of (a) a polynucleotide having a sequence encoding sequence 2 (see Specification) or a fragment thereof, (b) a polynucleotide having a sequence encoding the amino acid sequence encoded by the cDNA alone of ATCC deposition no.75716 or a fragment thereof, (c) a polynucleotide having a sequence identical to the polynucleotide shown by sequence 1 (see specification) at 95% or more, and (d) a polynucleotide having a sequence identical to the nucleotide sequence of the cDNA clone of ATCC deposition no.75716 at 95% or more.

14. 发明专利

JP2003047491A Colon-specific gene and protein 审中-公开
标题翻译：特异性基因和蛋白质
公开(公告)号：JP2003047491A
公开(公告)日：2003-02-18
申请号：JP2002154776
申请日：2002-05-28
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッド
发明人： YU GUO-LIANG , ROSEN CRAIG A
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61K48/00 , A61P35/00
摘要： PROBLEM TO BE SOLVED: To obtain a colon-specific gene and a protein. SOLUTION: Isolated polynucleotides selected from the group consisting of (a) a polynucleotide coding for a polypeptide same as the polynucleotide expressed in figure 9; (b) a polynucleotide coding for a mature polypeptide same as a human gene having a code part containing a DNA having at least 90% identity with one DNA expressed in figure 1, figure 3 to figure 7 or figure 11 to figure 13; (c) a polynucleotide hybridizing with the polynucleotide (a) and having at least 70% identity with the polypeptide (a) and (d) a polynucleotide coding for a mature polypeptide same as a human gene having a code part including a DNA having at least 90% identity with a DNA included in ATCC deposit No.97 and No.102 are disclosed (all the figures refer to the specification).
摘要翻译：要解决的问题：获得结肠特异性基因和蛋白质。解决方案：选自（a）编码与图9中表达的多核苷酸相同的多肽的多核苷酸的分离的多核苷酸; （b）编码与人基因相同的成熟多肽的多核苷酸，其编码部分含有与图1，图3至图7或图11至图13所示的一个DNA具有至少90％同一性的DNA; （c）与多核苷酸（a）杂交并与多肽（a）具有至少70％同一性的多核苷酸和（d）编码与人基因相同的成熟多肽的多核苷酸，其具有包含DNA的代码部分公开了与ATCC保藏号97和102中包含的DNA的最少90％同一性（所有附图参考说明书）。

15. 发明专利

JPH11170A DEATH DOMAIN-CONTAINING RECEPTOR 失效
公开(公告)号：JPH11170A
公开(公告)日：1999-01-06
申请号：JP5750397
申请日：1997-03-12
申请人： HUMAN GENOME SCIENCES INC , UNIV MICHIGAN
发明人： YU GUO-LIANG , NI JIAN , DIXIT VISHVA , GENTZ REINER L , DILLON PATRICK J
IPC分类号： C12N15/09 , A61K38/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/00 , A61P43/00 , C07H21/04 , C07K14/705 , C07K14/715 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/19 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To obtain an isolated nucleic acid molecule that has antiviral activity and immunoregulation activity and is useful for treating diseases relating to the increase in apoptosis by allowing the nucleic acid to include a polynucleotide containing a nucleotide sequence encoding death domain-containing receptor polypeptide. SOLUTION: The objective isolated nucleic acid molecule contains (i) the nucleotide sequence encoding the full-length death domain-containing receptor polypeptide having the perfect amino acid sequence of formula I (DR3-V1), (ii) the nucleotide sequence encoding the full-length death domain-containing receptor (DR3) polypeptide including the leader sequence to be expected to have the perfect amino acid sequence of formula II and (iii) the polynucleotide having the nucleotide sequence encoding the DR3-V1 polypeptide having the amino acid sequence from about 36 to about 428 positions of formula I. The separated nucleic acid molecule is introduced into a vector and the resultant recombinant vector is introduced into the host cells and the transformed host cells are cultured to produce the objective death domain-containing receptor polypeptide.

16. 发明专利

JP2003265176A HUMAN TUMOR NECROSIS FACTORS delta AND epsilon 审中-公开
公开(公告)号：JP2003265176A
公开(公告)日：2003-09-24
申请号：JP2003067375
申请日：2003-03-12
申请人： HUMAN GENOME SCIENCES INC
发明人： NI JIAN , YU GUO-LIANG , GENTZ REINER L , DILLON PATRICK J
IPC分类号： C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide polypeptides of human tumor necrosis factor (TNF) δand TNF ε, polynucleotides encoding the polypeptides and a method for producing the polypeptides. SOLUTION: Disclosed is an isolated polynucleotide including a polynucleotide having at least 70% identity to a member selected from the following groups: (a) a polynucleotide encoding a polypeptide including an amino acid sequence represented by SEQ ID NO.2 (refer to the specification); (b) a polynucleotide encoding a polypeptide including an amino acid sequence represented by SEQ ID NO.4 (refer to the specification); (c) a polynucleotide encoding a polypeptide including the amino acid numbers 39 to 233 of the amino acid sequence represented by SEQ ID NO.2 (refer to the specification); (d) a polynucleotide complementary to the polynucleotides of (a), (b) or (c); and (e) a polynucleotide including at least 15 bases of the polynucleotides of (a), (b), (c) or (d). COPYRIGHT: (C)2003,JPO

17. 发明专利

JP2003033193A Hitoshi statin e 审中-公开
标题翻译：人类科学
公开(公告)号：JP2003033193A
公开(公告)日：2003-02-04
申请号：JP2002149817
申请日：2002-05-23
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッド
发明人： NI JIAN , YU GUO-LIANG , GENTZ REINER , ROSEN CRAIG A
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K48/00 , A61P19/10 , A61P21/00 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/04
摘要： PROBLEM TO BE SOLVED: To obtain a polypeptide for use in a treatment of osteoporosis, neoplasm metastasis, bacterial infection, viral infection, septic shock, inflammation, hyperaesthesia retinae, caries, cachexia and muscular emaciation, and to develop a diagnostic method for detecting the mutation in the coding sequence of the polypeptide and the change in the concentration of the polypeptide in a host- derived sample. SOLUTION: This polypeptide is produced by the gene recombinant technique through identifying the human cystatin E(Cys E) polypeptide and a DNA (RNA) encoding such a polypeptide.
摘要翻译：要解决的问题：为了获得用于治疗骨质疏松症，肿瘤转移，细菌感染，病毒感染，败血性休克，炎症，视觉觉觉，感觉异常，龋齿，恶病质和肌肉消瘦的多肽，并开发用于检测多肽的编码序列中的突变和宿主衍生的样品中多肽的浓度变化。解决方案：通过鉴定人类半胱氨酸蛋白酶抑制剂E（Cys E）多肽和编码这种多肽的DNA（RNA），通过基因重组技术产生该多肽。

18. 发明申请

WO0196528A3 HUMAN TUMOR NECROSIS FACTOR DELTA AND EPSILON 审中-公开
标题翻译：人类肿瘤坏死因子DELTA和EPSILON
公开(公告)号：WO0196528A3
公开(公告)日：2002-08-08
申请号：PCT/US0119026
申请日：2001-06-14
申请人： HUMAN GENOME SCIENCES INC , YU GUO-LIANG , NI JIAN , GENTZ REINDER L , DILLON PATRICK J , HILBERT DAVID
发明人： YU GUO-LIANG , NI JIAN , GENTZ REINDER L , DILLON PATRICK J , HILBERT DAVID
IPC分类号： A61K47/48 , A61K49/00 , C07K14/52 , C07K14/705 , C07K16/28 , G01N33/564 , C12Q1/68 , A61K38/00 , C07H21/02
CPC分类号： A61K49/0004 , A61K47/6849 , A61K2039/505 , C07K14/52 , C07K14/70575 , C07K16/2875 , C07K2317/21 , C07K2317/622 , G01N33/564
摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及人TNFδ和TNFε多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

19. 发明申请

WO0050620A3 HUMAN ENDOKINE ALPHA AND METHODS OF USE 审中-公开
标题翻译：人类内啡肽和使用方法
公开(公告)号：WO0050620A3
公开(公告)日：2000-11-30
申请号：PCT/US0004722
申请日：2000-02-25
申请人： HUMAN GENOME SCIENCES INC , YU GUO LIANG , NI JIAN , ROSEN CRAIG A
发明人： YU GUO-LIANG , NI JIAN , ROSEN CRAIG A
IPC分类号： A61K38/00 , C07K14/525 , C07K14/52 , A61K38/16 , A61K38/19 , C12N5/10 , C12N5/16 , C12N15/12 , C12N15/19 , C12N15/63
CPC分类号： C07K14/5255 , A61K38/00
摘要： The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.
摘要翻译：本发明涉及肿瘤坏死因子（TNF）家族细胞因子的新成员。具体而言，提供了编码内因子α蛋白的分离的核酸分子。还提供了内因子α多肽，如载体，宿主细胞和用于生产它们的重组方法。还提供了关于TNF家族相关疾病的诊断和治疗方法。

20. 发明申请

WO9923105A9 VEGI, AN INHIBITOR OF ANGIOGENESIS AND TUMOR GROWTH 审中-公开
标题翻译： VEGI，ANGIOGENESIS和肿瘤生长抑制剂
公开(公告)号：WO9923105A9
公开(公告)日：1999-09-02
申请号：PCT/US9823191
申请日：1998-11-02
申请人： HUMAN GENOME SCIENCES INC , UNIV GEORGETOWN MED CENTER , LI LU YUAN , ZHAI YIFAN , YU GUO LIANG , NI JIAN , LIPPMAN MARC E , ROSEN CRAIG A
发明人： LI LU-YUAN , ZHAI YIFAN , YU GUO-LIANG , NI JIAN , LIPPMAN MARC E , ROSEN CRAIG A
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K48/00 , A61P9/10 , A61P17/02 , A61P17/06 , A61P27/02 , A61P27/06 , A61P35/00 , A61P37/06 , A61P43/00 , C07K14/47 , C07K14/705 , C12Q1/68 , C07H21/00 , A01N43/04 , A61K31/70 , C07H21/02 , C07H21/04
CPC分类号： C07K14/70575 , A61K38/00 , C12N2799/026
摘要： The present invention relates to a vascular endothelial cell inhibitor, VEGI, capable of inhibiting angiogenesis in cellular models and tumourigenesis in animal models, and methods of use.
摘要翻译：本发明涉及能够抑制动物模型中的细胞模型中的血管生成和肿瘤发生的血管内皮细胞抑制剂VEGI及其使用方法。

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